TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 372.528 | Formula: C20H28N4OS
H donors: 1 H acceptors: 2 LogP: 2.91 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CSCC(N1CCC(CC1)n1nccc1NC(=O)Cc1ccccc1)C
InChi: 1S/C20H28N4OS/c1-16(15-26-2)23-12-9-18(10-13-23)24-19(8-11-21-24)22-20(25)14-17-6-4-3-5-7-17/h3-8,11,16,18H,9-10,12-15H2,1-2H3,(H,22,25)
InChiKey: FXDZKQBIWIZECH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0004	0.0026
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0044	0.0183	0.0183
Echinococcus granulosus	lysyl tRNA synthetase	0.007	0.0362	0.0362
Echinococcus multilocularis	lysyl tRNA synthetase	0.007	0.0362	0.0362
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0096	0.0542	0.0903
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0183	0.0894
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0149	0.0729
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0057	0.1565
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0059	0.0289	0.1794
Onchocerca volvulus	Putative transporter	0.0044	0.0183	0.0852
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0313	0.2046	0.2046
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0096	0.0542	0.0597
Trypanosoma cruzi	hexose transporter, putative	0.0097	0.055	0.8651
Echinococcus granulosus	solute carrier family 22	0.0044	0.0183	0.0183
Onchocerca volvulus		0.005	0.0223	0.1121
Brugia malayi	Calcitonin receptor-like protein seb-1	0.011	0.0642	0.3137
Trypanosoma brucei	glucose transporter, putative	0.0097	0.055	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0011	0.0056
Toxoplasma gondii	sugar transporter ST1	0.0044	0.0183	0.0305
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.007	0.0362	0.1769
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0149	0.0729
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0149	0.4123
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0096	0.0542	0.0597
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0004	0.0026
Brugia malayi	major facilitator superfamily protein	0.0044	0.0183	0.0894
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0044	0.0183	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0057	0.0277
Loa Loa (eye worm)	sugar transporter	0.0044	0.0183	0.0894
Plasmodium vivax	SET domain protein, putative	0.003	0.0087	0.0096
Schistosoma mansoni	hypothetical protein	0.0072	0.0376	0.0376
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0094	0.0528	0.0528
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0057	0.1565
Onchocerca volvulus		0.0039	0.0149	0.0625
Leishmania major	myo-inositol/proton symporter (MIT)	0.0044	0.0183	0.2874
Onchocerca volvulus		0.0044	0.0183	0.0852
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0096	0.0542	0.0597
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0149	0.0927
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0072	0.0376	0.0376
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0149	0.2346
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0011	0.0056
Entamoeba histolytica	hypothetical protein	0.0072	0.0376	0.6943
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0096	0.0542	0.0903
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0096	0.0542	0.0542
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0057	0.1565
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Leishmania major	protein kinase, putative	0.0096	0.0542	0.8517
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0011	0.0317
Brugia malayi	hypothetical protein	0.0044	0.0183	0.0894
Schistosoma mansoni	cellular tumor antigen P53	0.0054	0.0251	0.0251
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0059	0.0289	0.5469
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0149	0.0149
Onchocerca volvulus		0.0044	0.0183	0.0852
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0096	0.0542	0.0597
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.007	0.0362	1
Brugia malayi	hypothetical protein	0.0072	0.0376	0.1839
Echinococcus multilocularis	solute carrier family 22	0.0044	0.0183	0.0183
Plasmodium falciparum	proline--tRNA ligase	0.0109	0.0636	0.0701
Onchocerca volvulus		0.0044	0.0183	0.0852
Trichomonas vaginalis	conserved hypothetical protein	0.0097	0.055	0.269
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0149	0.0729
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0096	0.0542	0.0542
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.011	0.0642	0.3137
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0313	0.2046	0.2046
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0035	0.012	0.012
Echinococcus granulosus	solute carrier family 22	0.0044	0.0183	0.0183
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.0011	0.0317
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0149	0.0927
Echinococcus multilocularis	solute carrier family 22	0.0044	0.0183	0.0183
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Onchocerca volvulus		0.0044	0.0183	0.0852
Trypanosoma brucei	glucose transporter 2A	0.0097	0.055	0.8651
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0044	0.0183	0.0183
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0097	0.055	0.8651
Echinococcus granulosus	synaptic vesicle 2 protein	0.0044	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0075	0.04	0.1955
Schistosoma mansoni	sugar transporter	0.0044	0.0183	0.0183
Toxoplasma gondii	transporter, major facilitator family protein	0.0044	0.0183	0.0305
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Brugia malayi	Major Facilitator Superfamily protein	0.0044	0.0183	0.0894
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0149	0.0729
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0094	0.0528	0.9752
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0087	0.0087
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0149	0.0729
Echinococcus multilocularis	calcium dependent protein kinase	0.009	0.0501	0.0501
Brugia malayi	hypothetical protein	0.0044	0.0183	0.0894
Echinococcus granulosus	survival motor neuron protein 1	0.0244	0.1568	0.1568
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0044	0.0183	0.0894
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0044	0.0183	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0183	0.0894
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0057	0.1072
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0044	0.0183	0.0183
Onchocerca volvulus		0.0039	0.0149	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0183	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Loa Loa (eye worm)	hypothetical protein	0.011	0.0642	0.3137
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0094	0.0528	0.0528
Trypanosoma brucei	glucose transporter, putative	0.0097	0.055	0.8651
Leishmania major	glucose transporter, lmgt2	0.0097	0.055	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0183	0.0894
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0094	0.0528	0.2583
Chlamydia trachomatis	lysine--tRNA ligase	0.007	0.0362	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0035	0.012	0.012
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Onchocerca volvulus		0.0044	0.0183	0.0852
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.025	0.1611	1
Leishmania major	hypothetical protein, conserved	0.0039	0.0149	0.2346
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0044	0.0183	0.5052
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0096	0.0542	0.0542
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0057	0.089
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0149	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0011	0.0056
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0096	0.0542	0.0542
Chlamydia trachomatis	proline--tRNA ligase	0.0033	0.0108	0.2978
Plasmodium vivax	hexose transporter	0.0313	0.2046	0.2253
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0097	0.055	0.8651
Toxoplasma gondii	ABC1 family protein	0.0039	0.0149	0.0249
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0057	0.0277
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0096	0.0542	0.2648
Brugia malayi	Cam kinase protein 1	0.0096	0.0542	0.2648
Onchocerca volvulus		0.003	0.0087	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0542	0.2648
Brugia malayi	beta-lactamase	0.0039	0.0149	0.0729
Trypanosoma cruzi	hexose transporter	0.0097	0.055	0.8651
Schistosoma mansoni	protein kinase	0.0096	0.0542	0.0542
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0094	0.0528	0.0528
Echinococcus granulosus	General substrate transporter	0.0269	0.1741	0.1741
Trichomonas vaginalis	glucose transporter, putative	0.0097	0.055	0.269
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0011	0.0056
Trichomonas vaginalis	myo-inositol transporter, putative	0.0044	0.0183	0.0894
Brugia malayi	major facilitator superfamily protein	0.0044	0.0183	0.0894
Toxoplasma gondii	sugar transporter ST2	0.0044	0.0183	0.0305
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0109	0.0636	1
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0505	0.3381	0.3724
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0542	0.2648
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0035	0.012	0.0585
Echinococcus multilocularis	GPCR, family 2	0.0035	0.012	0.012
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0149	0.0729
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0094	0.0528	0.2583
Schistosoma mansoni	lysyl-tRNA synthetase	0.007	0.0362	0.0362
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0109	0.0636	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0313	0.2046	0.2046
Brugia malayi	beta-lactamase family protein	0.0039	0.0149	0.0729
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0044	0.0183	0.1135
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0313	0.2046	0.2046
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0149	0.0149
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0149	0.2346
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0087	0.0087
Trypanosoma cruzi	sugar transporter, putative	0.0044	0.0183	0.2874
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0057	0.089
Brugia malayi	Sugar transporter family protein	0.0044	0.0183	0.0894
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0096	0.0542	0.0903
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0094	0.0528	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0057	0.1565
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0183	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0097	0.055	0.269
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0183	0.0894
Brugia malayi	latrophilin 2 splice variant baaae	0.0075	0.04	0.1955
Schistosoma mansoni	glucose transport protein	0.0313	0.2046	0.2046
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.007	0.0362	0.5689
Schistosoma mansoni	sugar transporter	0.0044	0.0183	0.0183
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0057	0.0352
Plasmodium falciparum	lysine--tRNA ligase	0.007	0.0362	0.0399
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0057	0.0277
Trypanosoma brucei	glucose transporter, putative	0.0097	0.055	0.8651
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0057	0.1045
Schistosoma mansoni	protein kinase	0.0096	0.0542	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0011	0.0056
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0149	0.0149
Trichomonas vaginalis	conserved hypothetical protein	0.0097	0.055	0.269
Schistosoma mansoni	glucose transport protein	0.0313	0.2046	0.2046
Leishmania major	glucose transporter, lmgt1	0.0097	0.055	0.8651
Onchocerca volvulus		0.0044	0.0183	0.0852
Onchocerca volvulus		0.0044	0.0183	0.0852
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.007	0.0362	1
Giardia lamblia	Prolyl-tRNA synthetase	0.0094	0.0528	1
Giardia lamblia	Hexose transporter	0.0044	0.0183	0.346
Trypanosoma brucei	glucose transporter, putative	0.0097	0.055	0.8651
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0011	0.0071
Plasmodium vivax	lysine--tRNA ligase, putative	0.007	0.0362	0.0399
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0044	0.0183	0.5052
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0505	0.3381	0.5632
Toxoplasma gondii	facilitative glucose transporter GT1	0.0313	0.2046	0.3408
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0149	0.0729
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.011	0.0642	0.3137
Trichomonas vaginalis	sugar transporter, putative	0.0097	0.055	0.269
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Trichomonas vaginalis	set domain proteins, putative	0.0239	0.1538	0.7518
Brugia malayi	hypothetical protein	0.0044	0.0183	0.0894
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0149	0.0729
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0038	0.0145	0.0709
Brugia malayi	Major Facilitator Superfamily protein	0.0044	0.0183	0.0894
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0149	0.0164
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0109	0.0636	1
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0505	0.3381	0.3724
Schistosoma mansoni	microtubule-associated protein tau	0.1459	1	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.0149	0.0927
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0109	0.0636	1
Trypanosoma brucei	glucose transporter, putative	0.0097	0.055	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0183	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0183	0.0894
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0149	0.0927
Brugia malayi	Latrophilin receptor protein 2	0.0035	0.012	0.0585
Trichomonas vaginalis	sugar transporter, putative	0.0097	0.055	0.269
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0096	0.0542	0.0597
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0313	0.2046	0.2046
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0057	0.1565
Schistosoma mansoni	glucose transporter	0.0044	0.0183	0.0183
Brugia malayi	hypothetical protein	0.0244	0.1568	0.7663
Schistosoma mansoni	hypothetical protein	0.0035	0.012	0.012
Entamoeba histolytica	hypothetical protein	0.0072	0.0376	0.6943
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Onchocerca volvulus		0.0044	0.0183	0.0852
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0149	0.2824
Brugia malayi	Major Facilitator Superfamily protein	0.0044	0.0183	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0528	0.2583
Trichomonas vaginalis	glucose transporter, putative	0.0097	0.055	0.269
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0011	0.0013
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Schistosoma mansoni	hypothetical protein	0.005	0.0223	0.0223
Onchocerca volvulus		0.0044	0.0183	0.0852
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0057	0.1565
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0096	0.0542	0.2648
Entamoeba histolytica	protein kinase, putative	0.0096	0.0542	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0149	0.2346
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0149	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0183	0.0894
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0044	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0528	0.2583
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0057	0.1072
Entamoeba histolytica	hypothetical protein	0.0072	0.0376	0.6943
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0087	0.0087
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0035	0.012	0.012
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0109	0.0636	1
Schistosoma mansoni	survival motor neuron protein	0.005	0.0223	0.0223
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0109	0.0636	0.106
Giardia lamblia	Lysyl-tRNA synthetase	0.007	0.0362	0.6849
Trypanosoma brucei	glucose transporter 1E	0.0097	0.055	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Loa Loa (eye worm)	hypothetical protein	0.003	0.0087	0.0426
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0004	0.0026
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0313	0.2046	0.2046
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0072	0.0376	0.0376
Trichomonas vaginalis	sugar transport protein, putative	0.0044	0.0183	0.0894
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0096	0.0542	0.0597
Trypanosoma cruzi	hexose transporter, putative	0.0053	0.0246	0.386
Plasmodium vivax	sugar transporter, putative	0.0044	0.0183	0.0201
Leishmania major	hypothetical protein, conserved	0.0044	0.0183	0.2874
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0183	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0044	0.0183	0.0183
Trichomonas vaginalis	conserved hypothetical protein	0.0313	0.2046	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0096	0.0542	0.0542
Onchocerca volvulus		0.0044	0.0183	0.0852
Schistosoma mansoni	hypothetical protein	0.0035	0.012	0.012
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0096	0.0542	0.0542
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0096	0.0542	0.2648
Schistosoma mansoni	protein kinase	0.0096	0.0542	0.0542
Echinococcus granulosus	solute carrier family 22	0.0044	0.0183	0.0183
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0011	0.0013
Mycobacterium ulcerans	integral membrane transport protein	0.0044	0.0183	0.5052
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0096	0.0542	0.8517
Onchocerca volvulus		0.0044	0.0183	0.0852
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0149	0.4123
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0149	0.2824
Brugia malayi	Sugar transporter family protein	0.0313	0.2046	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0183	0.0894
Onchocerca volvulus		0.0054	0.0251	0.1309
Mycobacterium ulcerans	lipase LipD	0.0039	0.0149	0.4123
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.0149	0.0927
Trypanosoma cruzi	hexose transporter, putative	0.0097	0.055	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0149	0.0729
Schistosoma mansoni	serine/threonine protein kinase	0.0096	0.0542	0.0542
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0096	0.0542	0.0542
Giardia lamblia	Sugar-proton symporter	0.0044	0.0183	0.346
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0057	0.0277
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0087	0.0087
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0044	0.0183	0.2874
Trypanosoma brucei	glucose transporter, putative	0.0097	0.055	0.8651
Schistosoma mansoni	hypothetical protein	0.0035	0.012	0.012
Trypanosoma brucei	sugar transporter, putative	0.0044	0.0183	0.2874
Plasmodium falciparum	protein kinase 7	0.0883	0.6003	0.6612
Brugia malayi	lysyl-tRNA synthetase	0.007	0.0362	0.1769
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0057	0.0277
Onchocerca volvulus		0.0044	0.0183	0.0852
Schistosoma mansoni	hypothetical protein	0.0035	0.012	0.012
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.0149	0.0927
Loa Loa (eye worm)	hypothetical protein	0.0035	0.012	0.0585
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0183	0.0894
Loa Loa (eye worm)	hypothetical protein	0.007	0.0362	0.1769
Leishmania major	lysyl-tRNA synthetase, putative	0.007	0.0362	0.5689
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0149	0.4123
Onchocerca volvulus		0.0044	0.0183	0.0852
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0057	0.1045
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0096	0.0542	0.0542
Echinococcus granulosus	calcium dependent protein kinase	0.009	0.0501	0.0501
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0149	0.4123
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0087	0.0087
Echinococcus granulosus	tumor protein p63	0.0367	0.2423	0.2423
Brugia malayi	Sugar transporter family protein	0.0044	0.0183	0.0894
Schistosoma mansoni	sugar transporter	0.0044	0.0183	0.0183
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0035	0.012	0.012
Onchocerca volvulus		0.0044	0.0183	0.0852
Trypanosoma cruzi	glucose transporter, putative	0.0044	0.0183	0.2874
Schistosoma mansoni	sugar transporter	0.0044	0.0183	0.0183
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0313	0.2046	0.2046
Trypanosoma brucei	glucose transporter, putative	0.0097	0.055	0.8651
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0057	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0183	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Loa Loa (eye worm)	sugar transporter	0.0313	0.2046	1
Onchocerca volvulus		0.0044	0.0183	0.0852
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0004	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0183	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0183	0.0894
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0057	0.1565
Plasmodium falciparum	hexose transporter	0.0313	0.2046	0.2253
Echinococcus multilocularis	microtubule associated protein 2	0.1459	1	1
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0044	0.0183	1
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Echinococcus multilocularis	survival motor neuron protein 1	0.0244	0.1568	0.1568
Entamoeba histolytica	protein kinase, putative	0.0096	0.0542	1
Echinococcus granulosus	GPCR family 2	0.0035	0.012	0.012
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0057	0.1045
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0061	0.0302	0.1477
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0251	0.1225
Mycobacterium ulcerans	sugar transporter	0.0044	0.0183	0.5052
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0087	0.0145
Trichomonas vaginalis	glucose transporter, putative	0.0044	0.0183	0.0894
Onchocerca volvulus		0.0239	0.1538	1
Schistosoma mansoni	transcription factor LCR-F1	0.0072	0.0376	0.0376
Trypanosoma brucei	glucose transporter, putative	0.0097	0.055	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0244	0.1568	0.7663
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0149	0.0729
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0033	0.0108	0.2978
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0094	0.0528	0.2583
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0406	0.1987
Onchocerca volvulus		0.0044	0.0183	0.0852
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0097	0.055	0.8651
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0183	0.0894
Trichomonas vaginalis	esterase, putative	0.0039	0.0149	0.0729
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.007	0.0362	0.5689
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.0149	0.0927
Schistosoma mansoni	glucose transport protein	0.0313	0.2046	0.2046
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0035	0.012	0.0585
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0044	0.0183	0.0183
Brugia malayi	Pre-SET motif family protein	0.021	0.1337	0.6533
Plasmodium vivax	proline--tRNA ligase, putative	0.0109	0.0636	0.0701
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0096	0.0542	0.0597
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0149	0.0149
Plasmodium vivax	CDK-related protein kinase 6, putative	0.1327	0.9079	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.008	0.008
Trypanosoma cruzi	hexose transporter, putative	0.0097	0.055	0.8651
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0223	0.1089
Entamoeba histolytica	hypothetical protein	0.0072	0.0376	0.6943
Echinococcus granulosus	solute carrier family 22	0.0044	0.0183	0.0183
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.0149	0.0927
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0097	0.055	0.8651
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0057	0.089
Toxoplasma gondii	sugar transporter ST3	0.0044	0.0183	0.0305
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0183	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0149	0.0729
Brugia malayi	beta-lactamase family protein	0.0039	0.0149	0.0729
Plasmodium falciparum	protein kinase 6	0.1327	0.9079	1
Onchocerca volvulus		0.0039	0.0149	0.0625
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.0149	0.0927
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0096	0.0542	0.0597
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0044	0.0183	0.1135
Entamoeba histolytica	hypothetical protein	0.007	0.0362	0.6679
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.021	0.1337	0.6533
Echinococcus multilocularis	tumor protein p63	0.0367	0.2423	0.2423
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.007	0.0362	0.6849
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0059	0.0289	0.1794
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0149	0.0729
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0313	0.2046	0.2046
Trypanosoma cruzi	hexose transporter, putative	0.0044	0.0183	0.2874
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Echinococcus multilocularis	General substrate transporter	0.0269	0.1741	0.1741
Leishmania major	glucose transporter, lmgt3	0.0097	0.055	0.8651
Toxoplasma gondii	protein kinase, putative	0.0883	0.6003	1
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0096	0.0542	0.0597
Brugia malayi	Pre-SET motif family protein	0.003	0.0087	0.0426
Trichomonas vaginalis	sugar transporter, putative	0.0044	0.0183	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0057	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0183	0.0894
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0087	0.0087
Schistosoma mansoni	lysyl-tRNA synthetase	0.007	0.0362	0.0362
Treponema pallidum	prolyl-tRNA synthetase	0.0033	0.0108	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0183	0.0894
Schistosoma mansoni	hypothetical protein	0.0313	0.2046	0.2046
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0087	0.0087
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.0149	0.0927
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0057	0.1565
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0183	0.0894
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0094	0.0528	0.0528
Schistosoma mansoni	hypothetical protein	0.0075	0.04	0.04
Toxoplasma gondii	lysine-tRNA ligase	0.007	0.0362	0.0603

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 732273