Detailed information for compound 73586

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 344.425 | Formula: C19H20O4S
  • H donors: 1 H acceptors: 1 LogP: 3.65 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc2c(c1)[C@@H](O)C=Cc1c2c(OC)c(c(c1)OC)OC
  • InChi: 1S/C19H20O4S/c1-21-16-9-11-5-8-15(20)14-10-12(24-4)6-7-13(14)17(11)19(23-3)18(16)22-2/h5-10,15,20H,1-4H3/t15-/m0/s1
  • InChiKey: CDKHSZIFDFCQIW-HNNXBMFYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Tubulin alpha chain Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii alpha-tubulin I, putative Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin alpha-1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin isotype 2 Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei gambiense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha-tubulin II, putative Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii alpha tubulin TUBA1 Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans cytoskeletal structural protein Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-1C chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium parvum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha-3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii Tubulin/FtsZ family, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-2/alpha-4 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi tubulin alpha chain - mouse Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis Tubulin beta 2C chain Tubulin alpha chain   451 aa 434 aa 41.5 %
Onchocerca volvulus Tubulin alpha chain   451 aa 438 aa 84.7 %
Neospora caninum tubulin alpha chain, putative Tubulin alpha chain   451 aa 436 aa 37.4 %
Plasmodium berghei tubulin epsilon chain, putative Tubulin alpha chain   451 aa 455 aa 27.7 %
Schistosoma mansoni tubulin subunit epsilon Tubulin alpha chain   451 aa 469 aa 27.9 %
Onchocerca volvulus Tubulin alpha chain   451 aa 441 aa 74.4 %
Schistosoma japonicum ko:K10389 tubulin gamma, putative Tubulin alpha chain   451 aa 434 aa 31.8 %
Onchocerca volvulus Tyrosine kinase homolog Tubulin alpha chain   451 aa 439 aa 87.7 %
Leishmania braziliensis epsilon tubulin, putative Tubulin alpha chain   451 aa 469 aa 29.4 %
Onchocerca volvulus Tubulin alpha chain   451 aa 434 aa 41.5 %
Leishmania mexicana epsilon tubulin, putative Tubulin alpha chain   451 aa 469 aa 27.7 %
Babesia bovis tubulin gamma chain Tubulin alpha chain   451 aa 429 aa 31.7 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin alpha chain   451 aa 434 aa 40.3 %
Onchocerca volvulus Putative cytochrome c-type heme lyase Tubulin alpha chain   451 aa 434 aa 39.2 %
Trypanosoma congolense epsilon tubulin Tubulin alpha chain   451 aa 472 aa 26.5 %
Plasmodium yoelii tubulin beta chain Tubulin alpha chain   451 aa 455 aa 26.8 %
Echinococcus multilocularis tubulin gamma 1 chain Tubulin alpha chain   451 aa 455 aa 31.4 %
Entamoeba histolytica tubulin family protein Tubulin alpha chain   451 aa 434 aa 39.4 %
Echinococcus granulosus Tubulin beta 2C chain Tubulin alpha chain   451 aa 434 aa 41.5 %
Giardia lamblia Gamma tubulin Tubulin alpha chain   451 aa 467 aa 29.6 %
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Tubulin alpha chain   451 aa 436 aa 38.8 %
Trichomonas vaginalis tubulin gamma chain, putative Tubulin alpha chain   451 aa 422 aa 28.4 %
Echinococcus multilocularis tubulin delta chain Tubulin alpha chain   451 aa 401 aa 22.9 %
Echinococcus granulosus tubulin beta 4A class IVa Tubulin alpha chain   451 aa 388 aa 38.9 %
Schistosoma mansoni tubulin subunit beta Tubulin alpha chain   451 aa 434 aa 40.1 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin alpha chain   451 aa 474 aa 27.4 %
Leishmania major epsilon tubulin, putative Tubulin alpha chain   451 aa 469 aa 27.5 %
Leishmania donovani epsilon tubulin, putative Tubulin alpha chain   451 aa 471 aa 27.0 %
Dictyostelium discoideum beta tubulin Tubulin alpha chain   451 aa 443 aa 40.4 %
Echinococcus multilocularis tubulin alpha Tubulin alpha chain   451 aa 436 aa 40.1 %
Schistosoma mansoni tubulin subunit gamma Tubulin alpha chain   451 aa 451 aa 31.5 %
Neospora caninum Beta-tubulin, related Tubulin alpha chain   451 aa 417 aa 31.4 %
Trypanosoma brucei epsilon tubulin Tubulin alpha chain   451 aa 478 aa 25.7 %
Schistosoma mansoni tubulin subunit beta Tubulin alpha chain   451 aa 435 aa 40.9 %
Plasmodium vivax tubulin gamma chain, putative Tubulin alpha chain   451 aa 429 aa 30.8 %
Loa Loa (eye worm) tubulin beta-1 chain Tubulin alpha chain   451 aa 437 aa 39.4 %
Leishmania mexicana beta tubulin Tubulin alpha chain   451 aa 434 aa 42.4 %
Plasmodium falciparum tubulin gamma chain Tubulin alpha chain   451 aa 431 aa 31.8 %
Echinococcus multilocularis Tubulin beta 2C chain Tubulin alpha chain   451 aa 434 aa 40.6 %
Babesia bovis tubulin, putative Tubulin alpha chain   451 aa 463 aa 20.7 %
Trypanosoma cruzi epsilon tubulin, putative Tubulin alpha chain   451 aa 474 aa 27.4 %
Echinococcus granulosus tubulin gamma 1 chain Tubulin alpha chain   451 aa 455 aa 31.4 %
Onchocerca volvulus Regulatory-associated protein of mTOR homolog Tubulin alpha chain   451 aa 439 aa 76.3 %
Trypanosoma brucei gambiense epsilon tubulin Tubulin alpha chain   451 aa 479 aa 25.7 %
Entamoeba histolytica tubulin family protein Tubulin alpha chain   451 aa 434 aa 40.1 %
Plasmodium knowlesi tubulin gamma chain, putative Tubulin alpha chain   451 aa 429 aa 30.8 %
Dictyostelium discoideum gamma tubulin Tubulin alpha chain   451 aa 436 aa 32.8 %
Plasmodium vivax tubulin epsilon chain, putative Tubulin alpha chain   451 aa 458 aa 26.2 %
Plasmodium yoelii tubulin gamma chain Tubulin alpha chain   451 aa 431 aa 31.3 %
Echinococcus multilocularis tubulin, beta 4A class IVa Tubulin alpha chain   451 aa 388 aa 38.9 %
Plasmodium falciparum tubulin epsilon chain, putative Tubulin alpha chain   451 aa 465 aa 25.8 %
Entamoeba histolytica tubulin gamma chain Tubulin alpha chain   451 aa 434 aa 30.9 %
Drosophila melanogaster gamma-Tubulin at 23C Tubulin alpha chain   451 aa 446 aa 32.3 %
Brugia malayi Tubulin beta-1 chain Tubulin alpha chain   451 aa 434 aa 39.6 %
Trypanosoma brucei epsilon tubulin Tubulin alpha chain   451 aa 478 aa 25.7 %
Giardia lamblia Epsilon tubulin Tubulin alpha chain   451 aa 457 aa 29.3 %
Cryptosporidium hominis gamma-tubulin Tubulin alpha chain   451 aa 443 aa 30.9 %
Theileria parva tubulin gamma chain, putative Tubulin alpha chain   451 aa 462 aa 29.7 %
Drosophila melanogaster beta-Tubulin at 60D Tubulin alpha chain   451 aa 439 aa 39.2 %
Loa Loa (eye worm) BEN-1 protein Tubulin alpha chain   451 aa 434 aa 41.5 %
Leishmania infantum epsilon tubulin, putative Tubulin alpha chain   451 aa 471 aa 27.0 %
Plasmodium knowlesi tubulin epsilon chain, putative Tubulin alpha chain   451 aa 454 aa 26.2 %
Trypanosoma brucei epsilon tubulin Tubulin alpha chain   451 aa 479 aa 25.5 %
Echinococcus granulosus tubulin alpha Tubulin alpha chain   451 aa 433 aa 40.0 %
Plasmodium berghei tubulin gamma chain, putative Tubulin alpha chain   451 aa 431 aa 31.1 %
Cryptosporidium parvum gamma tubulin Tubulin alpha chain   451 aa 443 aa 30.9 %
Onchocerca volvulus Putative methyltransferase KIAA1456 Tubulin alpha chain   451 aa 441 aa 31.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.1985 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0022 0.021 0.006
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0156 0.0117
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0156 0.5
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.021 0.0171
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.9946 1
Echinococcus multilocularis tubulin alpha chain 0.0022 0.021 0.006
Schistosoma mansoni tubulin subunit alpha 0.0022 0.021 0.0054
Brugia malayi RNA binding protein 0.0074 0.1985 1
Brugia malayi Cache domain containing protein 0.0057 0.1411 0.7105
Brugia malayi mbt repeat family protein 0.0051 0.1191 0.5997
Echinococcus granulosus tubulin alpha chain 0.0022 0.021 0.006
Echinococcus granulosus voltage dependent calcium channel subunit 0.0284 0.9057 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.031 0.9946 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.1985 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0156 0.0117
Trypanosoma brucei alpha tubulin 0.0022 0.021 1
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.021 0.0171
Echinococcus multilocularis tubulin alpha 1C chain 0.0022 0.021 0.006
Brugia malayi Tubulin alpha-2 chain 0.0022 0.021 0.1056
Loa Loa (eye worm) alpha-tubulin 0.0022 0.021 0.1056
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.9946 1
Echinococcus multilocularis tar DNA binding protein 0.0074 0.1985 0.2055
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.1427 0.1428
Echinococcus granulosus tubulin alpha chain 0.0022 0.021 0.006
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.1191 1
Brugia malayi intermediate filament protein 0.0029 0.0448 0.2258
Loa Loa (eye worm) alpha-tubulin 0.0022 0.021 0.1056
Brugia malayi mbt repeat family protein 0.0051 0.1191 0.5997
Brugia malayi tubulin alpha-2 chain 0.0022 0.021 0.1056
Echinococcus multilocularis tubulin alpha chain 0.0022 0.021 0.006
Trypanosoma brucei alpha tubulin 0.0022 0.021 1
Echinococcus granulosus tubulin alpha 3 chain 0.0022 0.021 0.006
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0448 0.2258
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0017 0.004 0.0201
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.0201
Echinococcus granulosus alpha tubulin 0.0022 0.021 0.006
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1985 0.1858
Loa Loa (eye worm) hypothetical protein 0.0028 0.0431 0.2169
Schistosoma mansoni lamin 0.0029 0.0448 0.0297
Echinococcus granulosus intermediate filament protein 0.0029 0.0448 0.0328
Trypanosoma brucei alpha tubulin 0.0022 0.021 1
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.1191 0.1051
Loa Loa (eye worm) TAR-binding protein 0.0074 0.1985 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.9946 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.1191 0.1162
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0124 0.366 0.3559
Leishmania major alpha tubulin 0.0022 0.021 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.021 0.1056
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.9946 1
Loa Loa (eye worm) tubulin alpha chain 0.0022 0.021 0.1056
Loa Loa (eye worm) hypothetical protein 0.0029 0.0448 0.2258
Schistosoma mansoni serine-rich repeat protein 0.0067 0.1732 0.1601
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0448 0.2258
Plasmodium falciparum alpha tubulin 2 0.0022 0.021 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.021 0.006
Leishmania major alpha tubulin 0.0022 0.021 1
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.021 0.0171
Loa Loa (eye worm) MBCTL1 0.0058 0.1427 0.7187
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.9946 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.021 0.006
Echinococcus multilocularis tubulin alpha chain 0.0022 0.021 0.006
Giardia lamblia Alpha-tubulin 0.0022 0.021 0.0055
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0284 0.9057 1
Schistosoma mansoni alpha tubulin 0.0022 0.021 0.0054
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.1191 0.1162
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.1191 0.1051
Onchocerca volvulus 0.0051 0.1191 1
Plasmodium vivax tubulin alpha chain, putative 0.0022 0.021 1
Echinococcus granulosus tubulin alpha 3 chain 0.0022 0.021 0.006
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0152 0.4594 1
Brugia malayi alpha-tubulin 0.0022 0.021 0.1056
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.1427 0.7187
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.021 0.0171
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0263 0.835 0.8369
Echinococcus granulosus tubulin alpha 1C chain 0.0022 0.021 0.006
Toxoplasma gondii alpha tubulin TUBA1 0.0022 0.021 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0022 0.021 0.006
Leishmania major alpha tubulin 0.0022 0.021 1
Leishmania major alpha tubulin 0.0022 0.021 1
Leishmania major alpha tubulin 0.0022 0.021 1
Echinococcus granulosus tubulin alpha chain 0.0022 0.021 0.006
Loa Loa (eye worm) tubulin alpha chain 0.0022 0.021 0.1056
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.021 0.0171
Loa Loa (eye worm) tubulin alpha 2 0.0017 0.004 0.0201
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0156 0.0786
Loa Loa (eye worm) hypothetical protein 0.0051 0.1191 0.5997
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0156 0.0786
Echinococcus multilocularis Tubulin alpha 1 chain 0.0022 0.021 0.006
Toxoplasma gondii alpha-tubulin I, putative 0.0022 0.021 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0204 0.6348 0.6956
Schistosoma mansoni alpha tubulin 0.0022 0.021 0.0054
Echinococcus granulosus lamin 0.0029 0.0448 0.0328
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1985 0.1858
Echinococcus granulosus lamin dm0 0.0029 0.0448 0.0328
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.1427 0.1428
Echinococcus granulosus peroxisome assembly protein 26 0.0022 0.021 0.006
Loa Loa (eye worm) RNA binding protein 0.0074 0.1985 1
Schistosoma mansoni lamin 0.0029 0.0448 0.0297
Schistosoma mansoni intermediate filament proteins 0.0029 0.0448 0.0297
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.021 0.006
Echinococcus multilocularis tubulin subunit TubB 0.0022 0.021 0.006
Echinococcus granulosus tubulin alpha chain 0.0022 0.021 0.006
Echinococcus multilocularis lamin dm0 0.0029 0.0448 0.0328
Echinococcus granulosus voltage dependent calcium channel subunit 0.0129 0.3837 0.4136
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0022 0.021 0.0171
Loa Loa (eye worm) tubulin alpha-2 chain 0.0022 0.021 0.1056
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.1427 0.1428
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1985 0.1858
Echinococcus granulosus tubulin subunit TubB 0.0022 0.021 0.006
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.1191 0.1162
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.021 0.0171
Echinococcus multilocularis tubulin alpha 1C chain 0.0022 0.021 0.006
Trichomonas vaginalis tubulin epsilon chain, putative 0.0022 0.021 0.0171
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.1191 0.1162
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.9946 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0204 0.6348 0.6956
Echinococcus multilocularis tubulin alpha chain 0.0022 0.021 0.006
Loa Loa (eye worm) tubulin alpha 2 0.0017 0.004 0.0201
Echinococcus multilocularis lamin 0.0029 0.0448 0.0328
Leishmania major alpha tubulin 0.0022 0.021 1
Entamoeba histolytica tubulin alpha-1 chain 0.0022 0.021 0.0055
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.1427 0.1291
Schistosoma mansoni hypothetical protein 0.0067 0.1732 0.1601
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0152 0.4594 0.5
Giardia lamblia Alpha-tubulin 0.0022 0.021 0.0055
Trypanosoma cruzi alpha tubulin, putative 0.0022 0.021 1
Echinococcus multilocularis hypothetical protein 0.0022 0.021 0.006
Leishmania major alpha tubulin 0.0022 0.021 1
Echinococcus granulosus tubulin alpha chain 0.0022 0.021 0.006
Loa Loa (eye worm) hypothetical protein 0.0057 0.1411 0.7105
Giardia lamblia Fructose-bisphosphate aldolase 0.031 0.9946 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.021 0.006
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0448 0.2258
Leishmania major alpha tubulin 0.0022 0.021 1
Leishmania major alpha tubulin 0.0022 0.021 1
Leishmania major alpha tubulin 0.0022 0.021 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.9946 1
Trypanosoma brucei alpha tubulin 0.0022 0.021 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.1427 0.7187
Treponema pallidum fructose-bisphosphate aldolase 0.031 0.9946 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.031 0.9946 1
Echinococcus granulosus tar DNA binding protein 0.0074 0.1985 0.2055
Brugia malayi Tubulin alpha chain 0.0022 0.021 0.1056
Echinococcus multilocularis peroxisome assembly protein 26 0.0022 0.021 0.006
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1985 0.1858
Leishmania major alpha tubulin 0.0022 0.021 1
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.1191 0.1051
Entamoeba histolytica tubulin alpha chain, putative 0.0022 0.021 0.0055
Plasmodium vivax tubulin alpha chain, putative 0.0022 0.021 1
Schistosoma mansoni alpha tubulin 0.0022 0.021 0.0054
Echinococcus granulosus tubulin alpha 1C chain 0.0022 0.021 0.006
Leishmania major alpha tubulin 0.0022 0.021 1
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.1191 0.5997
Echinococcus multilocularis tubulin alpha chain 0.0022 0.021 0.006
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0152 0.4594 1
Echinococcus multilocularis musashi 0.0029 0.0448 0.0328
Brugia malayi tubulin alpha chain - mouse 0.0022 0.021 0.1056
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0129 0.3837 0.4136
Brugia malayi Tubulin alpha-2 chain 0.0022 0.021 0.1056
Plasmodium falciparum alpha tubulin 1 0.0022 0.021 1
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1985 0.1858
Echinococcus granulosus Tubulin alpha 1 chain 0.0022 0.021 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.9946 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.1427 0.1428
Schistosoma mansoni tubulin subunit alpha 0.0022 0.021 0.0054
Trichomonas vaginalis tubulin beta chain, putative 0.0022 0.021 0.0171
Schistosoma mansoni tubulin subunit alpha 0.0022 0.021 0.0054
Brugia malayi TAR-binding protein 0.0074 0.1985 1
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0062 0.1588 0.1455

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.74 Inhibition of tubulin polymerization interacting at the colchicine binding site. ChEMBL. 10649972
Log IC50 (binding) = 5.74 Inhibition of tubulin polymerization interacting at the colchicine binding site. ChEMBL. 10649972

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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