TDR Targets

Basic information

Technical information

TDR Targets ID: 737990
Name: N-(4-iodophenyl)-1-(4-methylphenyl)sulfonyl-5 -oxopyrrolidine-2-carboxamide
MW: 484.308 | Formula: C18H17IN2O4S
H donors: 1 H acceptors: 4 LogP: 2.87 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)S(=O)(=O)N1C(=O)CCC1C(=O)Nc1ccc(cc1)I
InChi: 1S/C18H17IN2O4S/c1-12-2-8-15(9-3-12)26(24,25)21-16(10-11-17(21)22)18(23)20-14-6-4-13(19)5-7-14/h2-9,16H,10-11H2,1H3,(H,20,23)
InChiKey: FPFVTBZAWAEYEA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-iodophenyl)-1-(4-methylphenyl)sulfonyl-5-oxo-pyrrolidine-2-carboxamide
N-(4-iodophenyl)-1-(4-methylphenyl)sulfonyl-5-oxo-2-pyrrolidinecarboxamide
N-(4-iodophenyl)-5-keto-1-(4-methylphenyl)sulfonyl-pyrrolidine-2-carboxamide
CBKinase1_007214
STK151351
CBKinase1_019614

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0101	0.0521	0.0525
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0075	0.0336	0.5988
Echinococcus granulosus	solute carrier family 22	0.0047	0.0138	0.014
Plasmodium vivax	SET domain protein, putative	0.0029	0.0008	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0138	0.0612
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0103	0.0536	0.0809
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0061	0.0262
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0061	0.0073
Plasmodium vivax	lysine--tRNA ligase, putative	0.0075	0.0336	0.0333
Schistosoma mansoni	glucose transport protein	0.0337	0.2203	0.2232
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0061	0.0262
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0047	0.0138	0.5
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0046	0.0043
Brugia malayi	Major Facilitator Superfamily protein	0.0047	0.0138	0.0612
Onchocerca volvulus		0.0047	0.0138	0.0932
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0105	0.0545	0.2626
Echinococcus granulosus	synaptic vesicle 2 protein	0.0047	0.0138	0.014
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0295	0.1905	1
Toxoplasma gondii	protein kinase, putative	0.0952	0.659	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0103	0.0536	0.054
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0148	0.066
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Schistosoma mansoni	transcription factor LCR-F1	0.0073	0.032	0.0321
Leishmania major	lysyl-tRNA synthetase, putative	0.0075	0.0336	0.1494
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Plasmodium falciparum	hexose transporter	0.0337	0.2203	0.2201
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0337	0.2203	0.2235
Trypanosoma cruzi	hexose transporter, putative	0.0057	0.0207	0.0794
Trichomonas vaginalis	set domain proteins, putative	0.0231	0.1448	0.6476
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0047	0.0138	0.0418
Echinococcus granulosus	lysyl tRNA synthetase	0.0075	0.0336	0.0341
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0049	0.015	0.0149
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0083	0.0081
Echinococcus multilocularis	microtubule associated protein 2	0.141	0.9859	1
Trypanosoma cruzi	hexose transporter, putative	0.0105	0.0545	0.2626
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0093	0.015
Trichomonas vaginalis	myo-inositol transporter, putative	0.0047	0.0138	0.036
Brugia malayi	chromobox protein homolog 3	0.0038	0.0072	0.0314
Loa Loa (eye worm)	hypothetical protein	0.003	0.0013	0.0046
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0286	0.0287
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0093	0.015
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0545	0.2626
Echinococcus multilocularis	calcium dependent protein kinase	0.0097	0.049	0.0494
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0138	0.0612
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0105	0.0545	0.2626
Brugia malayi	jmjC domain containing protein	0.0034	0.0046	0.0194
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0286	0.1049
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.0096	0.0191
Echinococcus granulosus	microtubule associated protein 2	0.141	0.9859	1
Onchocerca volvulus		0.0047	0.0138	0.0932
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.0796	0.3988
Onchocerca volvulus		0.0231	0.1448	1
Trypanosoma cruzi	hexose transporter, putative	0.0105	0.0545	0.2626
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0337	0.2203	0.2232
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0061	0.0058
Giardia lamblia	Lysyl-tRNA synthetase	0.0075	0.0336	0.6435
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0072	0.0478
Giardia lamblia	Sugar-proton symporter	0.0047	0.0138	0.2601
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.0096	0.0191
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0047	0.0138	0.0612
Trypanosoma brucei	glucose transporter 1E	0.0105	0.0545	0.2626
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0061	0.0073
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0103	0.0536	0.054
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0101	0.0521	0.9311
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Brugia malayi	latrophilin 2 splice variant baaae	0.0106	0.0557	0.2516
Brugia malayi	hypothetical protein	0.0239	0.1502	0.6811
Schistosoma mansoni	sugar transporter	0.0047	0.0138	0.0137
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0234	0.1467	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0101	0.0521	0.0525
Brugia malayi	hypothetical protein	0.0073	0.032	0.1438
Onchocerca volvulus		0.0047	0.0138	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0061	0.0262
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0075	0.0336	0.3298
Schistosoma mansoni	protein kinase	0.0103	0.0536	0.054
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0061	0.0058
Echinococcus granulosus	peregrin	0.0029	0.0003	0.0003
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Brugia malayi	Sugar transporter family protein	0.0047	0.0138	0.0612
Echinococcus multilocularis	General substrate transporter	0.029	0.1865	0.1889
Trypanosoma brucei	sugar transporter, putative	0.0047	0.0138	0.0418
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0047	0.0138	0.0612
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0008	0.0005
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0295	0.1905	1
Plasmodium vivax	CDK-related protein kinase 6, putative	0.143	1	1
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0286	0.0287
Toxoplasma gondii	transporter, major facilitator family protein	0.0047	0.0138	0.0204
Loa Loa (eye worm)	sugar transporter	0.0337	0.2203	1
Echinococcus multilocularis	solute carrier family 22	0.0047	0.0138	0.0137
Onchocerca volvulus		0.0047	0.0138	0.0932
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0118	0.064	0.3142
Trichomonas vaginalis	conserved hypothetical protein	0.0337	0.2203	1
Toxoplasma gondii	hypothetical protein	0.0048	0.014	0.0207
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0008	0.0008
Onchocerca volvulus	Putative transporter	0.0047	0.0138	0.0932
Onchocerca volvulus		0.0037	0.0061	0.0399
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0047	0.0138	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0138	0.0612
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0047	0.0138	0.0137
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0061	0.0262
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0072	0.0053
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0337	0.2203	0.2232
Brugia malayi	Cam kinase protein 1	0.0103	0.0536	0.2421
Giardia lamblia	Prolyl-tRNA synthetase	0.0101	0.0521	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0008	0.002
Toxoplasma gondii	lysine-tRNA ligase	0.0075	0.0336	0.0506
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0075	0.0336	0.1286
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Schistosoma mansoni	hypothetical protein	0.0049	0.015	0.0149
Brugia malayi	major facilitator superfamily protein	0.0047	0.0138	0.0612
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0061	0.0262
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0093	0.0621
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0061	0.0062
Schistosoma mansoni	lysyl-tRNA synthetase	0.0075	0.0336	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0061	0.0262
Onchocerca volvulus		0.0047	0.0138	0.0932
Plasmodium falciparum	protein kinase 7	0.0952	0.659	0.6589
Trypanosoma cruzi	hexose transporter	0.0105	0.0545	0.2626
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0072	0.0053
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0103	0.0536	0.0533
Treponema pallidum	prolyl-tRNA synthetase	0.0036	0.0055	0.5
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0118	0.064	0.3142
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0047	0.0138	0.0548
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0073	0.032	0.0321
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0047	0.0138	0.014
Leishmania major	glucose transporter, lmgt1	0.0105	0.0545	0.2626
Onchocerca volvulus		0.0047	0.0138	0.0932
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0064	0.0255	0.4231
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0337	0.2203	0.2232
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0103	0.0536	0.0533
Onchocerca volvulus		0.0047	0.0138	0.0932
Schistosoma mansoni	sugar transporter	0.0047	0.0138	0.0137
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0066	0.027	0.0977
Entamoeba histolytica	protein kinase, putative	0.0103	0.0536	1
Trichomonas vaginalis	glucose transporter, putative	0.0105	0.0545	0.2261
Trichomonas vaginalis	sugar transporter, putative	0.0105	0.0545	0.2261
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Schistosoma mansoni	hypothetical protein	0.0337	0.2203	0.2232
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0103	0.0536	0.0533
Echinococcus multilocularis	GPCR, family 2	0.0049	0.015	0.0149
Brugia malayi	beta-lactamase	0.0037	0.0061	0.0262
Echinococcus granulosus	GPCR family 2	0.0049	0.015	0.0152
Echinococcus granulosus	chromobox protein 1	0.0068	0.0286	0.029
Trichomonas vaginalis	sugar transporter, putative	0.0105	0.0545	0.2261
Echinococcus multilocularis	solute carrier family 22	0.0047	0.0138	0.0137
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0295	0.1905	1
Echinococcus granulosus	calcium dependent protein kinase	0.0097	0.049	0.0497
Plasmodium falciparum	proline--tRNA ligase	0.0118	0.064	0.0637
Echinococcus multilocularis	lysyl tRNA synthetase	0.0075	0.0336	0.0338
Brugia malayi	Latrophilin receptor protein 2	0.0049	0.015	0.0668
Brugia malayi	beta-lactamase family protein	0.0037	0.0061	0.0262
Onchocerca volvulus		0.0049	0.0147	0.0996
Brugia malayi	hypothetical protein	0.0047	0.0138	0.0612
Schistosoma mansoni	sugar transporter	0.0047	0.0138	0.0137
Schistosoma mansoni	chromobox protein	0.0068	0.0286	0.0287
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0155	0.0907	0.4108
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.014	0.0796	0.3988
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0093	0.0466	0.0472
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0061	0.0073
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0061	0.0058
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Onchocerca volvulus		0.0047	0.0138	0.0932
Onchocerca volvulus		0.004	0.0087	0.0581
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0103	0.0536	0.0543
Schistosoma mansoni	hypothetical protein	0.0049	0.015	0.0149
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0103	0.0536	0.0533
Trypanosoma cruzi	hexose transporter, putative	0.0105	0.0545	0.2626
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0008	0.0005
Schistosoma mansoni	glucose transporter	0.0047	0.0138	0.0137
Schistosoma mansoni	chromobox protein	0.0068	0.0286	0.0287
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0049	0.015	0.0152
Onchocerca volvulus		0.0047	0.0138	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0521	0.2353
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0545	0.2626
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0161	0.0542
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Mycobacterium ulcerans	sugar transporter	0.0047	0.0138	0.0974
Mycobacterium ulcerans	lipase LipD	0.0037	0.0061	0.0073
Echinococcus multilocularis	survival motor neuron protein 1	0.0239	0.1502	0.152
Brugia malayi	jmjC domain containing protein	0.0093	0.0466	0.2102
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Brugia malayi	hypothetical protein	0.0047	0.0138	0.0612
Onchocerca volvulus		0.0047	0.0138	0.0932
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0545	0.2626
Toxoplasma gondii	ABC1 family protein	0.0037	0.0061	0.0088
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0103	0.0536	0.2421
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0337	0.2203	0.2235
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0049	0.015	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0138	0.0612
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0155	0.0907	0.4108
Schistosoma mansoni	microtubule-associated protein tau	0.141	0.9859	1
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0545	0.3683	0.3681
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0155	0.0907	0.4108
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0118	0.064	0.3142
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0072	0.0314
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0047	0.0138	0.0974
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0041	0.0096	0.0421
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0337	0.2203	0.2232
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0545	0.3683	0.3681
Leishmania major	glucose transporter, lmgt3	0.0105	0.0545	0.2626
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0203	0.1248	0.5659
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Loa Loa (eye worm)	hypothetical protein	0.0239	0.1502	0.6811
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0049	0.015	0.0149
Mycobacterium ulcerans	integral membrane transport protein	0.0047	0.0138	0.0974
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0138	0.036
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0545	0.2626
Toxoplasma gondii	sugar transporter ST2	0.0047	0.0138	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0138	0.0612
Brugia malayi	lysyl-tRNA synthetase	0.0075	0.0336	0.1514
Echinococcus multilocularis	solute carrier family 22	0.0047	0.0138	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0138	0.0612
Schistosoma mansoni	lysyl-tRNA synthetase	0.0075	0.0336	0.0338
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0103	0.0536	0.0809
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0545	0.2626
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0337	0.2203	0.2235
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0105	0.0545	0.2626
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0557	0.2516
Echinococcus granulosus	lysine specific demethylase 5A	0.0034	0.0046	0.0047
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0103	0.0536	0.0533
Trypanosoma cruzi	glucose transporter, putative	0.0047	0.0138	0.0418
Brugia malayi	Pre-SET motif family protein	0.0029	0.0008	0.002
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0075	0.0336	0.1494
Toxoplasma gondii	facilitative glucose transporter GT1	0.0337	0.2203	0.334
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0386	0.1739
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0008	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0049	0.015	0.0668
Onchocerca volvulus		0.0047	0.0138	0.0932
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0545	0.2626
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0101	0.0521	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0536	0.2421
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0103	0.0536	0.0543
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0064	0.0255	0.1385
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0096	0.0191
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0061	0.0262
Loa Loa (eye worm)	jmjC domain-containing protein	0.0034	0.0046	0.0194
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0047	0.0138	0.0548
Brugia malayi	Sugar transporter family protein	0.0337	0.2203	1
Trichomonas vaginalis	sugar transport protein, putative	0.0047	0.0138	0.036
Echinococcus granulosus	solute carrier family 22	0.0047	0.0138	0.014
Plasmodium vivax	hexose transporter	0.0337	0.2203	0.2201
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0138	0.036
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Leishmania major	protein kinase, putative	0.0103	0.0536	0.2575
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0336	0.1514
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.0796	0.3988
Loa Loa (eye worm)	hypothetical protein	0.0155	0.0907	0.4108
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0545	0.3683	0.5587
Onchocerca volvulus		0.0037	0.0061	0.0399
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0103	0.0536	0.0533
Onchocerca volvulus		0.0037	0.0061	0.0399
Onchocerca volvulus		0.0047	0.0138	0.0932
Echinococcus granulosus	chromobox protein 1	0.0068	0.0286	0.029
Leishmania major	hypothetical protein, conserved	0.0047	0.0138	0.0418
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0103	0.0536	0.0533
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0105	0.0545	0.2626
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0103	0.0536	0.0543
Leishmania major	mitochondrial DNA polymerase beta	0.0295	0.1905	1
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0545	0.2626
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0103	0.0536	0.2421
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0103	0.0536	0.054
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0046	0.0043
Schistosoma mansoni	protein kinase	0.0103	0.0536	0.054
Schistosoma mansoni	glucose transport protein	0.0337	0.2203	0.2232
Brugia malayi	beta-lactamase family protein	0.0037	0.0061	0.0262
Brugia malayi	hypothetical protein	0.0047	0.0138	0.0612
Leishmania major	glucose transporter, lmgt2	0.0105	0.0545	0.2626
Echinococcus multilocularis	lysine specific demethylase 5A	0.0034	0.0046	0.0043
Trichomonas vaginalis	glucose transporter, putative	0.0105	0.0545	0.2261
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.004	0.0087	0.0085
Schistosoma mansoni	protein kinase	0.0103	0.0536	0.054
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0138	0.0612
Echinococcus granulosus	General substrate transporter	0.029	0.1865	0.1892
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0083	0.0084
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0138	0.036
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0061	0.0058
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0075	0.0336	0.1494
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.022	0.0984
Trypanosoma cruzi	sugar transporter, putative	0.0047	0.0138	0.0418
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0103	0.0536	0.0543
Schistosoma mansoni	hypothetical protein	0.0106	0.0557	0.0562
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0147	0.0146
Trypanosoma brucei	glucose transporter 2A	0.0105	0.0545	0.2626
Onchocerca volvulus		0.0047	0.0138	0.0932
Trichomonas vaginalis	glucose transporter, putative	0.0047	0.0138	0.036
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0049	0.015	0.0668
Schistosoma mansoni	hypothetical protein	0.0049	0.015	0.0149
Brugia malayi	Pre-SET motif family protein	0.0203	0.1248	0.5659
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0103	0.0536	0.2421
Echinococcus multilocularis	solute carrier family 22	0.0047	0.0138	0.0137
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0003	0.0003
Trypanosoma cruzi	hexose transporter, putative	0.0047	0.0138	0.0418
Brugia malayi	major facilitator superfamily protein	0.0047	0.0138	0.0612
Echinococcus granulosus	survival motor neuron protein 1	0.0239	0.1502	0.1523
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0061	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0521	0.2353
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0138	0.036
Schistosoma mansoni	sugar transporter	0.0047	0.0138	0.0137
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0101	0.0521	0.0525
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0101	0.0521	0.2148
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0138	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0138	0.036
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0286	0.1049
Onchocerca volvulus		0.0047	0.0138	0.0932
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0118	0.064	0.0967
Loa Loa (eye worm)	sugar transporter	0.0047	0.0138	0.0612
Brugia malayi	Heterochromatin protein 1	0.0068	0.0286	0.1284
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0047	0.0138	0.0135
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0118	0.064	0.3142
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Giardia lamblia	Hexose transporter	0.0047	0.0138	0.2601
Brugia malayi	Major Facilitator Superfamily protein	0.0047	0.0138	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0138	0.0612
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0156	0.0909	0.6033
Schistosoma mansoni	glucose transport protein	0.0337	0.2203	0.2232
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0061	0.0262
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0118	0.064	0.3142
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0147	0.0654
Plasmodium vivax	proline--tRNA ligase, putative	0.0118	0.064	0.0637
Trichomonas vaginalis	CAMK family protein kinase	0.0103	0.0536	0.2217
Echinococcus granulosus	solute carrier family 22	0.0047	0.0138	0.014
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0138	0.0612
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0047	0.0138	0.0974
Schistosoma mansoni	hypothetical protein	0.0073	0.032	0.0321
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0073	0.032	0.0324
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0096	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0138	0.0612
Trichomonas vaginalis	sugar transporter, putative	0.0105	0.0545	0.2261
Entamoeba histolytica	hypothetical protein	0.0075	0.0336	0.0773
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0101	0.0521	1
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0103	0.0536	0.0533
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0064	0.0255	0.1385
Entamoeba histolytica	protein kinase, putative	0.0103	0.0536	1
Plasmodium vivax	sugar transporter, putative	0.0047	0.0138	0.0135
Onchocerca volvulus		0.003	0.0013	0.0071
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0103	0.0536	0.0533
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0093	0.0466	0.0469
Brugia malayi	Sugar transporter family protein	0.0047	0.0138	0.0612
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0101	0.0521	0.2353
Toxoplasma gondii	sugar transporter ST3	0.0047	0.0138	0.0204
Onchocerca volvulus		0.0047	0.0138	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0138	0.0612
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0103	0.0536	0.0809
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0008	0.0005
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0061	0.0073
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0103	0.0536	0.054
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0101	0.0521	0.2353
Onchocerca volvulus		0.0047	0.0138	0.0932
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0008	0.0005
Schistosoma mansoni	hypothetical protein	0.0049	0.015	0.0149
Schistosoma mansoni	serine/threonine protein kinase	0.0103	0.0536	0.054
Leishmania major	myo-inositol/proton symporter (MIT)	0.0047	0.0138	0.0418
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0545	0.2626
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0138	0.0612
Chlamydia trachomatis	lysine--tRNA ligase	0.0075	0.0336	1
Brugia malayi	Major Facilitator Superfamily protein	0.0047	0.0138	0.0612
Trichomonas vaginalis	sugar transporter, putative	0.0047	0.0138	0.036
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0138	0.0612
Mycobacterium ulcerans	hypothetical protein	0.0156	0.0909	1
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.0286	0.1284
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.0329	0.033
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0047	0.0138	0.0137
Trichomonas vaginalis	conserved hypothetical protein	0.0105	0.0545	0.2261
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0337	0.2203	0.2235
Trichomonas vaginalis	conserved hypothetical protein	0.0105	0.0545	0.2261
Echinococcus granulosus	solute carrier family 22	0.0047	0.0138	0.014
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0008	0.0005
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0103	0.0536	0.2575
Toxoplasma gondii	sugar transporter ST1	0.0047	0.0138	0.0204
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0049	0.015	0.0668
Schistosoma mansoni	hypothetical protein	0.0049	0.0147	0.0146
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0075	0.0336	0.3298
Plasmodium falciparum	lysine--tRNA ligase	0.0075	0.0336	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0138	0.0612

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 737990