Detailed information for compound 737992

Basic information

Technical information
  • TDR Targets ID: 737992
  • Name: 2-[(5-ethyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N- (3-nitrophenyl)acetamide
  • MW: 308.313 | Formula: C12H12N4O4S
  • H donors: 1 H acceptors: 5 LogP: 2.16 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1nnc(o1)SCC(=O)Nc1cccc(c1)[N+](=O)[O-]
  • InChi: 1S/C12H12N4O4S/c1-2-11-14-15-12(20-11)21-7-10(17)13-8-4-3-5-9(6-8)16(18)19/h3-6H,2,7H2,1H3,(H,13,17)
  • InChiKey: OIOLWBKYTMZTHP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(5-ethyl-1,3,4-oxadiazol-2-yl)thio]-N-(3-nitrophenyl)acetamide
  • 2-[(5-ethyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(3-nitrophenyl)ethanamide
  • CBKinase1_019496
  • CBKinase1_007096
  • ZINC00611823

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis solute carrier family 22 0.0063 0.0217 0.0266
Leishmania major glucose transporter, lmgt3 0.0139 0.0621 0.4289
Mycobacterium ulcerans lysyl-tRNA synthetase 0.01 0.0414 0.5856
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0135 0.0597 0.0768
Loa Loa (eye worm) hypothetical protein 0.0063 0.0217 0.0938
Loa Loa (eye worm) hypothetical protein 0.0025 0.0016 0.0049
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0152 0.018
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0085 0.0333 0.2974
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0088 0.0348 0.1536
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0025 0.0016 0.0183
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0157 0.0715 0.4941
Plasmodium falciparum calcium-dependent protein kinase 4 0.0138 0.0612 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0157 0.0715 0.4941
Echinococcus multilocularis chromobox protein 1 0.0068 0.0243 0.03
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0449 0.2266 0.2974
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0076 0.0674
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0959 0.4219
Echinococcus granulosus solute carrier family 22 0.0063 0.0217 0.0266
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0217 0.0956
Brugia malayi beta-lactamase family protein 0.0037 0.0076 0.0314
Loa Loa (eye worm) hypothetical protein 0.0063 0.0217 0.0938
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0025 0.0016 0.0221
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0268 0.0334
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0025 0.0016 0.0183
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0157 0.0715 0.4941
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0063 0.0217 0.0266
Loa Loa (eye worm) hypothetical protein 0.0063 0.0217 0.0938
Leishmania major hypothetical protein, conserved 0.0063 0.0217 0.1497
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0157 0.0715 0.4941
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0005 0.0064
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0268 0.0334
Loa Loa (eye worm) hypothetical protein 0.0063 0.0217 0.0938
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0005 0.0064
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0135 0.0597 0.2619
Loa Loa (eye worm) major facilitator superfamily transporter 0.0063 0.0217 0.0938
Schistosoma mansoni hypothetical protein 0.0051 0.0152 0.018
Echinococcus granulosus solute carrier family 22 0.0063 0.0217 0.0266
Loa Loa (eye worm) hypothetical protein 0.0135 0.0597 0.2619
Loa Loa (eye worm) hypothetical protein 0.0063 0.0217 0.0938
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0135 0.0597 0.0768
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0025 0.0016 0.0108
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0076 0.0333
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Trichomonas vaginalis sugar transport protein, putative 0.0063 0.0217 0.0956
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1447 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0063 0.0217 0.3068
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0076 0.0079
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0033 0.0023
Onchocerca volvulus 0.0063 0.0217 0.1924
Brugia malayi Sugar transporter family protein 0.0063 0.0217 0.0938
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0005 0.0076
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0063 0.0217 1
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0138 0.0611 0.2685
Onchocerca volvulus 0.0231 0.1107 1
Onchocerca volvulus 0.0063 0.0217 0.1924
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0152 0.0652
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0139 0.0621 0.4289
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0623 0.4301
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0138 0.0611 0.2685
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0005 0.0064
Echinococcus multilocularis lysyl tRNA synthetase 0.01 0.0414 0.0526
Onchocerca volvulus 0.0063 0.0217 0.1924
Mycobacterium ulcerans lysyl-tRNA synthetase 0.01 0.0414 0.5856
Onchocerca volvulus 0.003 0.004 0.0324
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0243 0.1071
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0025 0.0016 0.0108
Schistosoma mansoni sugar transporter 0.0063 0.0217 0.0266
Plasmodium vivax calcium-dependent protein kinase, putative 0.0138 0.0612 0.0597
Toxoplasma gondii ABC1 family protein 0.0037 0.0076 0.0114
Toxoplasma gondii transporter, major facilitator family protein 0.0063 0.0217 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.0449 0.2266 1
Trichomonas vaginalis sugar transporter, putative 0.0139 0.0621 0.274
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0005 0.004
Trypanosoma brucei glucose transporter, putative 0.0139 0.0621 0.4289
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0377 0.0477
Echinococcus multilocularis solute carrier family 22 0.0063 0.0217 0.0266
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0275 0.0343
Brugia malayi Pre-SET motif family protein 0.0203 0.0959 0.4219
Loa Loa (eye worm) hypothetical protein 0.0063 0.0217 0.0938
Loa Loa (eye worm) hypothetical protein 0.01 0.0414 0.1809
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0152 0.018
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0152 0.018
Trypanosoma brucei glucose transporter, putative 0.0139 0.0621 0.4289
Brugia malayi beta-lactamase 0.0037 0.0076 0.0314
Trypanosoma cruzi hexose transporter, putative 0.0063 0.0217 0.1497
Onchocerca volvulus 0.0063 0.0217 0.1924
Brugia malayi Bromodomain containing protein 0.0029 0.0033 0.0124
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0138 0.0612 0.0597
Brugia malayi jmjC domain containing protein 0.0034 0.0064 0.0265
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0314
Mycobacterium ulcerans integral membrane transport protein 0.0063 0.0217 0.3068
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0033 0.0049
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0138 0.0611 0.0788
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0135 0.0597 0.0768
Mycobacterium tuberculosis Conserved protein 0.0037 0.0076 0.0674
Plasmodium vivax SET domain protein, putative 0.0029 0.0036 0.002
Schistosoma mansoni hypothetical protein 0.0051 0.0152 0.018
Onchocerca volvulus 0.0037 0.0076 0.0644
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.0611 0.0788
Mycobacterium ulcerans sugar transporter 0.0063 0.0217 0.3068
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Plasmodium falciparum phd finger protein, putative 0.0029 0.0033 0.0017
Echinococcus granulosus calcium dependent protein kinase 0.0129 0.0566 0.0728
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0314
Loa Loa (eye worm) hypothetical protein 0.011 0.0463 0.2026
Brugia malayi Cam kinase protein 1 0.0138 0.0611 0.2685
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0076 0.0079
Echinococcus multilocularis peregrin 0.0029 0.0033 0.0023
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0138 0.0612 0.0925
Toxoplasma gondii sugar transporter ST1 0.0063 0.0217 0.0327
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0076 0.0314
Plasmodium falciparum calcium-dependent protein kinase 5 0.0138 0.0612 0.0597
Brugia malayi Heterochromatin protein 1 0.0068 0.0243 0.1054
Onchocerca volvulus 0.0063 0.0217 0.1924
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0139 0.0621 0.4289
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0135 0.0597 1
Onchocerca volvulus 0.0037 0.0076 0.0644
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0005 0.0076
Echinococcus granulosus lysyl tRNA synthetase 0.01 0.0414 0.0526
Brugia malayi PHD-finger family protein 0.0029 0.0033 0.0124
Schistosoma mansoni glucose transport protein 0.0449 0.2266 0.2974
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.01 0.0414 0.2858
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0076 0.0333
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0314
Loa Loa (eye worm) hypothetical protein 0.0063 0.0217 0.0938
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0033 0.0023
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0138 0.0612 0.0597
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0076 0.0674
Trichomonas vaginalis glucose transporter, putative 0.0139 0.0621 0.274
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0064 0.0065
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0152 0.018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0036 0.0027
Brugia malayi Sugar transporter family protein 0.0449 0.2266 1
Trichomonas vaginalis sugar transporter, putative 0.0139 0.0621 0.274
Trypanosoma brucei glucose transporter 1E 0.0139 0.0621 0.4289
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0138 0.0611 0.2685
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0063 0.0217 0.1933
Onchocerca volvulus Putative transporter 0.0063 0.0217 0.1924
Plasmodium falciparum lysine--tRNA ligase 0.01 0.0414 0.0399
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0076 0.0079
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.01 0.0414 0.2858
Trypanosoma cruzi hexose transporter, putative 0.0139 0.0621 0.4289
Echinococcus granulosus solute carrier family 22 0.0063 0.0217 0.0266
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Brugia malayi hypothetical protein 0.0239 0.1147 0.5053
Loa Loa (eye worm) hypothetical protein 0.0063 0.0217 0.0938
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Leishmania major threonyl-tRNA synthetase, putative 0.0025 0.0016 0.0108
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0449 0.2266 0.2974
Plasmodium falciparum mitogen-activated protein kinase 2 0.0726 0.3734 0.3724
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0217 0.0956
Trypanosoma brucei THT1 - hexose transporter, putative 0.0139 0.0621 0.4289
Trichomonas vaginalis set domain proteins, putative 0.0231 0.1107 0.4888
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0102 0.0702
Loa Loa (eye worm) hypothetical protein 0.0063 0.0217 0.0938
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0048 0.0134 0.1899
Echinococcus granulosus GPCR family 2 0.0051 0.0152 0.018
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0025 0.0016 0.0049
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0161 0.0737 0.3238
Loa Loa (eye worm) hypothetical protein 0.0029 0.0033 0.0124
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0157 0.0715 0.4941
Brugia malayi glycyl-tRNA synthetase 0.0025 0.0016 0.0049
Brugia malayi Calcitonin receptor-like protein seb-1 0.0161 0.0737 0.3238
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0726 0.3734 0.3724
Echinococcus multilocularis microtubule associated protein 2 0.1452 0.7582 1
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0152 0.0652
Loa Loa (eye worm) major facilitator superfamily transporter 0.0063 0.0217 0.0938
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0449 0.2266 0.2974
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0005 0.0031
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0138 0.0611 0.4225
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0099 0.086
Trichomonas vaginalis conserved hypothetical protein 0.0139 0.0621 0.274
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0063 0.0217 0.1497
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0314
Brugia malayi Major Facilitator Superfamily protein 0.0063 0.0217 0.0938
Echinococcus multilocularis solute carrier family 22 0.0063 0.0217 0.0266
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0076 0.0674
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.1447 1
Brugia malayi latrophilin 2 splice variant baaae 0.011 0.0466 0.2041
Toxoplasma gondii glycyl-tRNA synthetase 0.0025 0.0016 0.0024
Schistosoma mansoni chromobox protein 0.0068 0.0243 0.03
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0036 0.0027
Loa Loa (eye worm) hypothetical protein 0.0063 0.0217 0.0938
Echinococcus multilocularis GPCR, family 2 0.0051 0.0152 0.018
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0243 0.1054
Onchocerca volvulus 0.0063 0.0217 0.1924
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.01 0.0414 0.1826
Giardia lamblia PHD finger protein 15 0.0029 0.0033 0.0293
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0095 0.0105
Trichomonas vaginalis myo-inositol transporter, putative 0.0063 0.0217 0.0956
Onchocerca volvulus 0.0048 0.0138 0.1212
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.1447 1
Brugia malayi hypothetical protein 0.0063 0.0217 0.0938
Loa Loa (eye worm) hypothetical protein 0.0048 0.0138 0.0591
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0064 0.0065
Schistosoma mansoni protein kinase 0.0138 0.0611 0.0788
Trypanosoma cruzi hexose transporter 0.0139 0.0621 0.4289
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0076 0.0674
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0076 0.1265
Mycobacterium leprae Probable lipase LipE 0.0037 0.0076 0.1265
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0449 0.2266 0.2974
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.015 0.1035
Trypanosoma brucei glucose transporter, putative 0.0139 0.0621 0.4289
Plasmodium falciparum calcium-dependent protein kinase 3 0.0138 0.0612 0.0597
Mycobacterium tuberculosis Conserved protein 0.0037 0.0076 0.0674
Plasmodium falciparum calcium-dependent protein kinase 1 0.0138 0.0612 0.0597
Schistosoma mansoni protein kinase 0.0138 0.0611 0.0788
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0063 0.0217 0.0201
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0036 0.0054
Echinococcus multilocularis tumor protein p63 0.0331 0.1635 0.214
Trypanosoma brucei glucose transporter 2A 0.0139 0.0621 0.4289
Trypanosoma brucei glucose transporter, putative 0.0139 0.0621 0.4289
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0138 0.0611 0.0788
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0138 0.0611 0.0788
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0025 0.0016 0.0262
Schistosoma mansoni glucose transporter 0.0063 0.0217 0.0266
Entamoeba histolytica hypothetical protein 0.0073 0.0268 0.4341
Onchocerca volvulus 0.0063 0.0217 0.1924
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0064 0.0065
Trypanosoma cruzi sugar transporter, putative 0.0063 0.0217 0.1497
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0138 0.0611 0.0788
Echinococcus granulosus jumonji domain containing protein 0.004 0.0092 0.0101
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0099 0.0439
Loa Loa (eye worm) hypothetical protein 0.0161 0.0737 0.3238
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0726 0.3734 0.5643
Entamoeba histolytica protein kinase, putative 0.0138 0.0611 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0157 0.0715 0.1081
Brugia malayi lysyl-tRNA synthetase 0.01 0.0414 0.1809
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0194 0.0836
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0449 0.2266 0.2974
Brugia malayi major facilitator superfamily protein 0.0063 0.0217 0.0938
Plasmodium vivax sugar transporter, putative 0.0063 0.0217 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Schistosoma mansoni glucose transport protein 0.0449 0.2266 0.2974
Schistosoma mansoni hypothetical protein 0.0051 0.0152 0.018
Onchocerca volvulus 0.0063 0.0217 0.1924
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0036 0.0027
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0076 0.1069
Schistosoma mansoni survival motor neuron protein 0.0049 0.014 0.0164
Echinococcus granulosus chromobox protein 1 0.0068 0.0243 0.03
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0076 0.0674
Loa Loa (eye worm) sugar transporter 0.0063 0.0217 0.0938
Entamoeba histolytica protein kinase, putative 0.0138 0.0611 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0138 0.0612 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Toxoplasma gondii facilitative glucose transporter GT1 0.0449 0.2266 0.3424
Schistosoma mansoni chromobox protein 0.0068 0.0243 0.03
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0055 0.0175 0.0754
Onchocerca volvulus 0.0063 0.0217 0.1924
Trypanosoma cruzi hexose transporter, putative 0.0139 0.0621 0.4289
Schistosoma mansoni sugar transporter 0.0063 0.0217 0.0266
Brugia malayi major facilitator superfamily protein 0.0063 0.0217 0.0938
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0085 0.0333 0.2974
Mycobacterium ulcerans hypothetical protein 0.0156 0.0706 1
Onchocerca volvulus 0.0063 0.0217 0.1924
Mycobacterium ulcerans beta-lactamase 0.0037 0.0076 0.1069
Brugia malayi beta-lactamase family protein 0.0037 0.0076 0.0314
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0102 0.0702
Leishmania major glucose transporter, lmgt1 0.0139 0.0621 0.4289
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0138 0.0612 0.0925
Brugia malayi Major Facilitator Superfamily protein 0.0063 0.0217 0.0938
Plasmodium falciparum protein kinase 7 0.127 0.6617 0.6612
Onchocerca volvulus 0.0063 0.0217 0.1924
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0084 0.0371
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0025 0.0016 0.0069
Chlamydia trachomatis lysine--tRNA ligase 0.01 0.0414 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.003 0.0019
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0025 0.0016 0.0049
Brugia malayi chromobox protein homolog 3 0.0038 0.0084 0.0352
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.014 0.0598
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0084 0.0371
Leishmania major hypothetical protein, conserved 0.0037 0.0076 0.0522
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0063 0.0217 0.1933
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0033 0.0124
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Plasmodium vivax lysine--tRNA ligase, putative 0.01 0.0414 0.0399
Leishmania major lysyl-tRNA synthetase, putative 0.01 0.0414 0.2858
Schistosoma mansoni sugar transporter 0.0063 0.0217 0.0266
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0076 0.0674
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0005 0.0064
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0005 0.0064
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0025 0.0016 0.0108
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0135 0.0597 0.2634
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0138 0.0611 0.0788
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0449 0.2266 0.2974
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0076 0.0522
Chlamydia trachomatis proline--tRNA ligase 0.0048 0.0134 0.2978
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Onchocerca volvulus 0.0063 0.0217 0.1924
Loa Loa (eye worm) hypothetical protein 0.0063 0.0217 0.0938
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0025 0.0016 0.0108
Loa Loa (eye worm) hypothetical protein 0.0063 0.0217 0.0938
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0092 0.0101
Onchocerca volvulus 0.0063 0.0217 0.1924
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0005 0.0031
Plasmodium vivax hexose transporter 0.0449 0.2266 0.2253
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.0706 0.63
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0076 0.0522
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Schistosoma mansoni glucose transport protein 0.0449 0.2266 0.2974
Onchocerca volvulus 0.0063 0.0217 0.1924
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0064 0.0065
Echinococcus multilocularis solute carrier family 22 0.0063 0.0217 0.0266
Echinococcus granulosus Sugar transporter ERD6 protein 0.0063 0.0217 0.0266
Plasmodium vivax CDK-related protein kinase 6, putative 0.1908 1 1
Entamoeba histolytica hypothetical protein 0.0073 0.0268 0.4341
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0076 0.0674
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Echinococcus multilocularis General substrate transporter 0.0386 0.193 0.2531
Trypanosoma brucei glucose transporter, putative 0.0139 0.0621 0.4289
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0036 0.0027
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0135 0.0597 0.9757
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0033 0.0017
Brugia malayi hypothetical protein 0.0073 0.0268 0.1165
Trypanosoma brucei sugar transporter, putative 0.0063 0.0217 0.1497
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0217 0.0956
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0025 0.0016 0.0221
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0064 0.0265
Brugia malayi hypothetical protein 0.0063 0.0217 0.0938
Loa Loa (eye worm) beta-lactamase 0.0037 0.0076 0.0314
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0138 0.0611 0.0788
Leishmania major protein kinase, putative 0.0138 0.0611 0.4225
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0138 0.0162
Echinococcus multilocularis synaptic vesicle 2 protein 0.0063 0.0217 0.0266
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Trichomonas vaginalis CAMK family protein kinase 0.0138 0.0611 0.2699
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0152 0.0652
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0099 0.0439
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0076 0.0314
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0025 0.0016 0.0139
Schistosoma mansoni hypothetical protein 0.011 0.0466 0.0595
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0033 0.0023
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0076 0.0079
Plasmodium vivax proline--tRNA ligase, putative 0.0157 0.0715 0.0701
Echinococcus granulosus synaptic vesicle 2 protein 0.0063 0.0217 0.0266
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0161 0.0737 0.3238
Entamoeba histolytica hypothetical protein 0.0073 0.0268 0.4341
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Schistosoma mansoni sugar transporter 0.0063 0.0217 0.0266
Schistosoma mansoni lysyl-tRNA synthetase 0.01 0.0414 0.0526
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0623 0.4301
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0076 0.006
Brugia malayi Pre-SET motif family protein 0.0029 0.0036 0.0139
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0158
Echinococcus multilocularis calcium dependent protein kinase 0.0129 0.0566 0.0728
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0033 0.0049
Echinococcus granulosus General substrate transporter 0.0386 0.193 0.2531
Onchocerca volvulus 0.0063 0.0217 0.1924
Leishmania major myo-inositol/proton symporter (MIT) 0.0063 0.0217 0.1497
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0025 0.011
Trypanosoma brucei THT1 - hexose transporter, putative 0.0139 0.0621 0.4289
Trypanosoma cruzi hexose transporter, putative 0.0076 0.0286 0.1973
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0243 0.1071
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0138 0.0612 0.0925
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0084 0.0721
Toxoplasma gondii sugar transporter ST2 0.0063 0.0217 0.0327
Plasmodium falciparum hexose transporter 0.0449 0.2266 0.2253
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0139 0.0621 0.274
Trichomonas vaginalis conserved hypothetical protein 0.0139 0.0621 0.274
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0138 0.0611 0.0788
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0076 0.0522
Brugia malayi Major Facilitator Superfamily protein 0.0063 0.0217 0.0938
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0268 0.0334
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Schistosoma mansoni protein kinase 0.0138 0.0611 0.0788
Loa Loa (eye worm) hypothetical protein 0.0049 0.0141 0.0602
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0025 0.0016 0.0049
Trichomonas vaginalis glucose transporter, putative 0.0139 0.0621 0.274
Loa Loa (eye worm) hypothetical protein 0.0063 0.0217 0.0938
Entamoeba histolytica hypothetical protein 0.0073 0.0268 0.4341
Mycobacterium tuberculosis Conserved protein 0.0037 0.0076 0.0674
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0102 0.0702
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0217 0.0956
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0005 0.004
Toxoplasma gondii hypothetical protein 0.0048 0.0134 0.0203
Leishmania major glucose transporter/membrane transporter D2, putative 0.0139 0.0621 0.4289
Echinococcus granulosus microtubule associated protein 2 0.1452 0.7582 1
Treponema pallidum prolyl-tRNA synthetase 0.0048 0.0134 1
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0217 0.0956
Mycobacterium ulcerans hypothetical protein 0.0023 0.0005 0.0064
Onchocerca volvulus 0.0063 0.0217 0.1924
Giardia lamblia Lysyl-tRNA synthetase 0.01 0.0414 0.6849
Echinococcus granulosus peregrin 0.0029 0.0033 0.0023
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.1147 0.1495
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0025 0.011
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0036 0.0027
Echinococcus granulosus chromobox protein 1 0.0068 0.0243 0.03
Schistosoma mansoni hypothetical protein 0.0449 0.2266 0.2974
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0449 0.2266 0.2974
Brugia malayi jmjC domain containing protein 0.0093 0.0377 0.1646
Loa Loa (eye worm) hypothetical protein 0.0051 0.0152 0.0652
Toxoplasma gondii lysine-tRNA ligase 0.01 0.0414 0.0625
Echinococcus multilocularis chromobox protein 1 0.0068 0.0243 0.03
Loa Loa (eye worm) hypothetical protein 0.0063 0.0217 0.0938
Loa Loa (eye worm) hypothetical protein 0.0138 0.0611 0.2685
Toxoplasma gondii protein kinase, putative 0.127 0.6617 1
Brugia malayi hypothetical protein 0.0063 0.0217 0.0938
Trypanosoma brucei glucose transporter, putative 0.0139 0.0621 0.4289
Echinococcus granulosus tumor protein p63 0.0331 0.1635 0.214
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0314
Trichomonas vaginalis glucose transporter, putative 0.0063 0.0217 0.0956
Mycobacterium ulcerans lipase LipD 0.0037 0.0076 0.1069
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Mycobacterium ulcerans hypothetical protein 0.0037 0.0076 0.1069
Loa Loa (eye worm) sugar transporter 0.0449 0.2266 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0076 0.0333
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0076 0.1069
Entamoeba histolytica hypothetical protein 0.01 0.0414 0.674
Loa Loa (eye worm) hypothetical protein 0.0029 0.0036 0.0139
Onchocerca volvulus 0.0037 0.0076 0.0644
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0135 0.0597 0.2619
Toxoplasma gondii sugar transporter ST3 0.0063 0.0217 0.0327
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.01 0.0414 0.6932
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0025 0.0016 0.0024
Giardia lamblia Prolyl-tRNA synthetase 0.0135 0.0597 1
Giardia lamblia Sugar-proton symporter 0.0063 0.0217 0.346
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1447 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0063 0.0217 0.3068
Loa Loa (eye worm) hypothetical protein 0.0037 0.0076 0.0314
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0138 0.0611 0.0788
Onchocerca volvulus 0.004 0.0095 0.0821
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0377 0.0477
Onchocerca volvulus Alhambra homolog 0.0029 0.0033 0.0255
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0076 0.0333
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0085 0.0333 0.5587
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.1147 0.1495
Loa Loa (eye worm) hypothetical protein 0.0135 0.0597 0.2619
Echinococcus granulosus solute carrier family 22 0.0063 0.0217 0.0266
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0623 0.4301
Loa Loa (eye worm) hypothetical protein 0.0239 0.1147 0.5053
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0005 0.0031
Schistosoma mansoni hypothetical protein 0.0051 0.0152 0.018
Plasmodium falciparum calcium-dependent protein kinase 2 0.0138 0.0612 0.0597
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0135 0.0597 0.0768
Schistosoma mansoni hypothetical protein 0.0029 0.0033 0.0023
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0076 0.0333
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0025 0.0016 0.0049
Trypanosoma cruzi hexose transporter, putative 0.0139 0.0621 0.4289
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0005 0.0064
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0217 0.0956
Brugia malayi Sugar transporter family protein 0.0063 0.0217 0.0938
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0036 0.0027
Schistosoma mansoni hypothetical protein 0.0049 0.014 0.0164
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0005 0.0064
Giardia lamblia Hexose transporter 0.0063 0.0217 0.346
Schistosoma mansoni lysyl-tRNA synthetase 0.01 0.0414 0.0526
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0102 0.0702
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0449 0.2266 0.2974
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0063 0.0217 0.0266
Loa Loa (eye worm) hypothetical protein 0.0038 0.0084 0.0352
Trypanosoma cruzi glucose transporter, putative 0.0063 0.0217 0.1497
Leishmania major glucose transporter, lmgt2 0.0139 0.0621 0.4289
Plasmodium falciparum proline--tRNA ligase 0.0157 0.0715 0.0701
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.1121 1
Schistosoma mansoni microtubule-associated protein tau 0.1452 0.7582 1
Onchocerca volvulus 0.0049 0.014 0.1225
Schistosoma mansoni hypothetical protein 0.0073 0.0268 0.0334
Trypanosoma brucei THT1 - hexose transporter, putative 0.0139 0.0621 0.4289
Trichomonas vaginalis esterase, putative 0.0037 0.0076 0.0333
Loa Loa (eye worm) hypothetical protein 0.0063 0.0217 0.0938
Loa Loa (eye worm) hypothetical protein 0.011 0.0466 0.2041

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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