Detailed information for compound 738026

Basic information

Technical information
  • TDR Targets ID: 738026
  • Name: N-(4-chlorophenyl)-2-[[5-(4-methylphenyl)-[1, 3]thiazolo[3,2-d][1,2,4]triazol-3-yl]sulfanyl ]acetamide
  • MW: 414.932 | Formula: C19H15ClN4OS2
  • H donors: 1 H acceptors: 3 LogP: 5.68 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)Cl)CSc1nnc2n1c(cs2)c1ccc(cc1)C
  • InChi: 1S/C19H15ClN4OS2/c1-12-2-4-13(5-3-12)16-10-26-18-22-23-19(24(16)18)27-11-17(25)21-15-8-6-14(20)7-9-15/h2-10H,11H2,1H3,(H,21,25)
  • InChiKey: NEFSBZUMNVEZOI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-chlorophenyl)-2-[5-(4-methylphenyl)thiazolo[3,2-d][1,2,4]triazol-3-yl]sulfanyl-acetamide
  • N-(4-chlorophenyl)-2-[[5-(4-methylphenyl)-3-thiazolo[3,2-d][1,2,4]triazolyl]thio]acetamide
  • N-(4-chlorophenyl)-2-[[5-(4-methylphenyl)thiazolo[3,2-d][1,2,4]triazol-3-yl]thio]acetamide
  • N-(4-chlorophenyl)-2-[[5-(4-methylphenyl)-[1,3]thiazolo[3,2-d][1,2,4]triazol-3-yl]sulfanyl]ethanamide
  • CBKinase1_019584
  • CBKinase1_007184
  • ZINC02859334

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0138 0.0583 0.079
Trypanosoma brucei glucose transporter, putative 0.0139 0.0592 0.3975
Trypanosoma brucei THT1 - hexose transporter, putative 0.0139 0.0592 0.3975
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Echinococcus granulosus synaptic vesicle 2 protein 0.0063 0.0187 0.0254
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0112 0.0152
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Onchocerca volvulus 0.0063 0.0187 0.1713
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0931 0.4146
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0138 0.0583 0.088
Onchocerca volvulus 0.0063 0.0187 0.1713
Leishmania major myo-inositol/proton symporter (MIT) 0.0063 0.0187 0.1029
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0006 0.0008
Schistosoma mansoni sugar transporter 0.0063 0.0187 0.0251
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.1199 0.163
Echinococcus multilocularis solute carrier family 22 0.0063 0.0187 0.0251
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0045 0.0043
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0135 0.0568 0.2526
Toxoplasma gondii sugar transporter ST3 0.0063 0.0187 0.028
Trichomonas vaginalis myo-inositol transporter, putative 0.0063 0.0187 0.0645
Loa Loa (eye worm) hypothetical protein 0.0049 0.0112 0.049
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0135 0.0568 0.9554
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0135 0.0568 1
Brugia malayi hypothetical protein 0.0063 0.0187 0.0824
Echinococcus granulosus chromobox protein 1 0.0068 0.0213 0.029
Schistosoma mansoni sugar transporter 0.0063 0.0187 0.0251
Trypanosoma cruzi sugar transporter, putative 0.0063 0.0187 0.1029
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.0677 0.3011
Trypanosoma cruzi glucose transporter, putative 0.0063 0.0187 0.1029
Loa Loa (eye worm) hypothetical protein 0.0063 0.0187 0.0824
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.0677 0.3011
Echinococcus granulosus chromobox protein 1 0.0068 0.0213 0.029
Schistosoma mansoni sugar transporter 0.0063 0.0187 0.0251
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0063 0.0187 0.0185
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Echinococcus multilocularis solute carrier family 22 0.0063 0.0187 0.0251
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0157 0.0687 0.4663
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0449 0.2242 0.3048
Loa Loa (eye worm) hypothetical protein 0.0037 0.0045 0.0192
Mycobacterium ulcerans hypothetical protein 0.0156 0.0678 1
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.0677 0.3011
Plasmodium falciparum calcium-dependent protein kinase 1 0.0138 0.0583 0.0581
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Onchocerca volvulus 0.0063 0.0187 0.1713
Echinococcus granulosus solute carrier family 22 0.0063 0.0187 0.0254
Trypanosoma cruzi hexose transporter, putative 0.0076 0.0256 0.1532
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0085 0.0304 0.2466
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0048 0.0104 0.0929
Trypanosoma brucei glucose transporter, putative 0.0139 0.0592 0.3975
Loa Loa (eye worm) hypothetical protein 0.0063 0.0187 0.0824
Echinococcus multilocularis calcium dependent protein kinase 0.0129 0.0538 0.0728
Entamoeba histolytica hypothetical protein 0.01 0.0385 0.4032
Schistosoma mansoni chromobox protein 0.0068 0.0213 0.0287
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0138 0.0583 0.2592
Plasmodium falciparum calcium-dependent protein kinase 4 0.0138 0.0583 0.0581
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Plasmodium vivax SET domain protein, putative 0.0029 0.0006 0.0003
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0138 0.0583 0.3907
Schistosoma mansoni lysyl-tRNA synthetase 0.01 0.0385 0.052
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0126 0.0551
Loa Loa (eye worm) hypothetical protein 0.011 0.0434 0.1926
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Brugia malayi major facilitator superfamily protein 0.0063 0.0187 0.0824
Echinococcus multilocularis solute carrier family 22 0.0063 0.0187 0.0251
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0138 0.0583 0.0581
Echinococcus multilocularis GPCR, family 2 0.0049 0.0112 0.0149
Loa Loa (eye worm) hypothetical protein 0.0037 0.0045 0.0192
Echinococcus granulosus calcium dependent protein kinase 0.0129 0.0538 0.0731
Loa Loa (eye worm) hypothetical protein 0.0135 0.0568 0.2526
Loa Loa (eye worm) hypothetical protein 0.0063 0.0187 0.0824
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0006 0.0005
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Entamoeba histolytica protein kinase, putative 0.0138 0.0583 1
Plasmodium vivax sugar transporter, putative 0.0063 0.0187 0.0185
Trichomonas vaginalis sugar transporter, putative 0.0139 0.0592 0.249
Trypanosoma cruzi hexose transporter, putative 0.0063 0.0187 0.1029
Chlamydia trachomatis lysine--tRNA ligase 0.01 0.0385 1
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0112 0.049
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0112 0.0149
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0063 0.0187 0.5
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0157 0.0687 0.4663
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.025 0.034
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0088 0.0319 0.1244
Onchocerca volvulus 0.0063 0.0187 0.1713
Trypanosoma brucei glucose transporter, putative 0.0139 0.0592 0.3975
Schistosoma mansoni glucose transport protein 0.0449 0.2242 0.3046
Trypanosoma cruzi hexose transporter, putative 0.0139 0.0592 0.3975
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0187 0.0645
Schistosoma mansoni protein kinase 0.0138 0.0583 0.079
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0063 0.0187 0.1029
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Loa Loa (eye worm) hypothetical protein 0.0063 0.0187 0.0824
Plasmodium vivax lysine--tRNA ligase, putative 0.01 0.0385 0.0382
Mycobacterium ulcerans lysyl-tRNA synthetase 0.01 0.0385 0.536
Onchocerca volvulus 0.0063 0.0187 0.1713
Loa Loa (eye worm) hypothetical protein 0.0049 0.0111 0.0484
Schistosoma mansoni glucose transporter 0.0063 0.0187 0.0251
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.1199 0.1627
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0045 0.0058
Loa Loa (eye worm) hypothetical protein 0.0106 0.0415 0.1844
Leishmania major hypothetical protein, conserved 0.0063 0.0187 0.1029
Onchocerca volvulus 0.0063 0.0187 0.1713
Echinococcus granulosus solute carrier family 22 0.0063 0.0187 0.0254
Trypanosoma brucei glucose transporter, putative 0.0139 0.0592 0.3975
Loa Loa (eye worm) hypothetical protein 0.0038 0.0054 0.023
Brugia malayi Sugar transporter family protein 0.0449 0.2242 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0138 0.0583 0.079
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Onchocerca volvulus 0.0063 0.0187 0.1713
Schistosoma mansoni hypothetical protein 0.0049 0.0112 0.0149
Plasmodium falciparum proline--tRNA ligase 0.0157 0.0687 0.0685
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0726 0.3715 0.5621
Echinococcus multilocularis microtubule associated protein 2 0.141 0.7355 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0157 0.0687 0.1037
Schistosoma mansoni hypothetical protein 0.0049 0.0112 0.0149
Loa Loa (eye worm) hypothetical protein 0.0155 0.0677 0.3011
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0054 0.0039
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0069 0.0109
Brugia malayi Major Facilitator Superfamily protein 0.0063 0.0187 0.0824
Schistosoma mansoni hypothetical protein 0.0449 0.2242 0.3046
Plasmodium falciparum mitogen-activated protein kinase 2 0.0726 0.3715 0.3713
Leishmania major glucose transporter, lmgt1 0.0139 0.0592 0.3975
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0187 0.0645
Brugia malayi Pre-SET motif family protein 0.0203 0.0931 0.4146
Brugia malayi hypothetical protein 0.0253 0.1199 0.5342
Onchocerca volvulus 0.0063 0.0187 0.1713
Trypanosoma brucei sugar transporter, putative 0.0063 0.0187 0.1029
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0055 0.0145 0.0638
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Trichomonas vaginalis glucose transporter, putative 0.0139 0.0592 0.249
Leishmania major lysyl-tRNA synthetase, putative 0.01 0.0385 0.2464
Loa Loa (eye worm) hypothetical protein 0.0063 0.0187 0.0824
Onchocerca volvulus Putative transporter 0.0063 0.0187 0.1713
Loa Loa (eye worm) hypothetical protein 0.0063 0.0187 0.0824
Echinococcus multilocularis lysyl tRNA synthetase 0.01 0.0385 0.052
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0138 0.0583 0.079
Leishmania major glucose transporter, lmgt3 0.0139 0.0592 0.3975
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0449 0.2242 0.3048
Trichomonas vaginalis sugar transporter, putative 0.0139 0.0592 0.249
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0112 0.049
Onchocerca volvulus 0.003 0.001 0.0071
Trypanosoma brucei glucose transporter, putative 0.0139 0.0592 0.3975
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0138 0.0583 0.0793
Brugia malayi major facilitator superfamily protein 0.0063 0.0187 0.0824
Brugia malayi Pre-SET motif family protein 0.0029 0.0006 0.0015
Giardia lamblia Lysyl-tRNA synthetase 0.01 0.0385 0.6754
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0449 0.2242 0.3046
Mycobacterium ulcerans lysyl-tRNA synthetase 0.01 0.0385 0.536
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0006 0.0005
Leishmania major glucose transporter/membrane transporter D2, putative 0.0139 0.0592 0.3975
Onchocerca volvulus 0.0063 0.0187 0.1713
Onchocerca volvulus 0.0063 0.0187 0.1713
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0135 0.0568 0.238
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0138 0.0583 0.2592
Loa Loa (eye worm) hypothetical protein 0.0135 0.0568 0.2526
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0072 0.0191
Schistosoma mansoni chromobox protein 0.0068 0.0213 0.0287
Brugia malayi jmjC domain containing protein 0.0034 0.0034 0.0142
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0006 0.0005
Brugia malayi Major Facilitator Superfamily protein 0.0063 0.0187 0.0824
Loa Loa (eye worm) hypothetical protein 0.0063 0.0187 0.0824
Trichomonas vaginalis conserved hypothetical protein 0.0449 0.2242 1
Schistosoma mansoni hypothetical protein 0.0049 0.0112 0.0149
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0449 0.2242 0.3046
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0187 0.0645
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.012 0.0542
Leishmania major protein kinase, putative 0.0138 0.0583 0.3907
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0157 0.0687 0.4663
Brugia malayi jmjC domain containing protein 0.0093 0.0347 0.154
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0157 0.0687 0.4663
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0726 0.3715 0.3713
Brugia malayi beta-lactamase 0.0037 0.0045 0.0192
Entamoeba histolytica protein kinase, putative 0.0138 0.0583 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0045 0.0192
Echinococcus granulosus solute carrier family 22 0.0063 0.0187 0.0254
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0213 0.0764
Brugia malayi hypothetical protein 0.0063 0.0187 0.0824
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Trypanosoma cruzi hexose transporter, putative 0.0139 0.0592 0.3975
Schistosoma mansoni protein kinase 0.0138 0.0583 0.079
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0138 0.0583 0.088
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.1421 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0139 0.0592 0.3975
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0164 0.0721
Plasmodium falciparum calcium-dependent protein kinase 3 0.0138 0.0583 0.0581
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0138 0.0583 0.2592
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0034 0.0047
Schistosoma mansoni protein kinase 0.0138 0.0583 0.079
Brugia malayi beta-lactamase family protein 0.0037 0.0045 0.0192
Loa Loa (eye worm) sugar transporter 0.0449 0.2242 1
Trichomonas vaginalis glucose transporter, putative 0.0139 0.0592 0.249
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0112 0.049
Trichomonas vaginalis conserved hypothetical protein 0.0139 0.0592 0.249
Loa Loa (eye worm) hypothetical protein 0.0029 0.0006 0.0015
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0069 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.0583 0.079
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0069 0.0621
Loa Loa (eye worm) hypothetical protein 0.0063 0.0187 0.0824
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1421 1
Trichomonas vaginalis glucose transporter, putative 0.0063 0.0187 0.0645
Loa Loa (eye worm) hypothetical protein 0.01 0.0385 0.1706
Loa Loa (eye worm) hypothetical protein 0.0037 0.0045 0.0192
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0213 0.0764
Loa Loa (eye worm) hypothetical protein 0.0063 0.0187 0.0824
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0063 0.0187 0.2238
Echinococcus granulosus General substrate transporter 0.0386 0.1906 0.2591
Loa Loa (eye worm) hypothetical protein 0.0063 0.0187 0.0824
Plasmodium vivax CDK-related protein kinase 6, putative 0.1908 1 1
Echinococcus multilocularis chromobox protein 1 0.0068 0.0213 0.0287
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0449 0.2242 0.3048
Loa Loa (eye worm) hypothetical protein 0.0063 0.0187 0.0824
Onchocerca volvulus 0.0063 0.0187 0.1713
Plasmodium vivax hexose transporter 0.0449 0.2242 0.224
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0594 0.3988
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0006 0.0005
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0063 0.0187 0.0251
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0063 0.0187 0.0251
Onchocerca volvulus 0.0037 0.0045 0.0399
Schistosoma mansoni sugar transporter 0.0063 0.0187 0.0251
Onchocerca volvulus 0.0063 0.0187 0.1713
Toxoplasma gondii transporter, major facilitator family protein 0.0063 0.0187 0.028
Loa Loa (eye worm) hypothetical protein 0.0037 0.0045 0.0192
Echinococcus granulosus jumonji domain containing protein 0.004 0.0062 0.0084
Schistosoma mansoni glucose transport protein 0.0449 0.2242 0.3046
Plasmodium vivax calcium-dependent protein kinase, putative 0.0138 0.0583 0.0581
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0135 0.0568 0.2526
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0006 0.0005
Plasmodium falciparum lysine--tRNA ligase 0.01 0.0385 0.0382
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0347 0.0472
Onchocerca volvulus 0.0052 0.0126 0.1144
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Onchocerca volvulus 0.0063 0.0187 0.1713
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0072 0.0191
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0045 0.0058
Mycobacterium ulcerans integral membrane transport protein 0.0063 0.0187 0.2238
Onchocerca volvulus 0.0037 0.0045 0.0399
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.01 0.0385 0.2464
Onchocerca volvulus 0.0037 0.0045 0.0399
Loa Loa (eye worm) hypothetical protein 0.0063 0.0187 0.0824
Toxoplasma gondii protein kinase, putative 0.127 0.6607 1
Trypanosoma brucei glucose transporter 2A 0.0139 0.0592 0.3975
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0054 0.0039
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0138 0.0583 0.0793
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0063 0.0187 0.135
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0034 0.0142
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0594 0.3988
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0085 0.0304 0.4948
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Trypanosoma brucei glucose transporter, putative 0.0139 0.0592 0.3975
Onchocerca volvulus 0.0063 0.0187 0.1713
Brugia malayi Heterochromatin protein 1 0.0068 0.0213 0.0941
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0112 0.0149
Schistosoma mansoni hypothetical protein 0.0052 0.0126 0.0168
Schistosoma mansoni glucose transport protein 0.0449 0.2242 0.3046
Plasmodium falciparum calcium-dependent protein kinase 2 0.0138 0.0583 0.0581
Loa Loa (eye worm) sugar transporter 0.0063 0.0187 0.0824
Echinococcus granulosus solute carrier family 22 0.0063 0.0187 0.0254
Echinococcus multilocularis chromobox protein 1 0.0068 0.0213 0.0287
Brugia malayi Cam kinase protein 1 0.0138 0.0583 0.2592
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0138 0.0583 0.0793
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0138 0.0583 0.0581
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0063 0.0187 0.135
Loa Loa (eye worm) hypothetical protein 0.0063 0.0187 0.0824
Plasmodium falciparum hexose transporter 0.0449 0.2242 0.224
Loa Loa (eye worm) hypothetical protein 0.0138 0.0583 0.2592
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0045 0.0192
Trypanosoma brucei glucose transporter, putative 0.0139 0.0592 0.3975
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.025 0.0337
Loa Loa (eye worm) major facilitator superfamily transporter 0.0063 0.0187 0.0824
Loa Loa (eye worm) major facilitator superfamily transporter 0.0063 0.0187 0.0824
Toxoplasma gondii sugar transporter ST1 0.0063 0.0187 0.028
Echinococcus multilocularis General substrate transporter 0.0386 0.1906 0.2589
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0415 0.1844
Onchocerca volvulus 0.0063 0.0187 0.1713
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0594 0.3988
Toxoplasma gondii lysine-tRNA ligase 0.01 0.0385 0.0579
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0034 0.0043
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0063 0.0187 0.2238
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0157 0.0687 0.4663
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.025 0.0337
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.0678 0.6033
Brugia malayi lysyl-tRNA synthetase 0.01 0.0385 0.1706
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0054 0.0478
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0045 0.0058
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0112 0.0152
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0062 0.0081
Onchocerca volvulus 0.0063 0.0187 0.1713
Plasmodium falciparum calcium-dependent protein kinase 5 0.0138 0.0583 0.0581
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0138 0.0583 0.088
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0138 0.0583 0.0793
Echinococcus granulosus peregrin 0.0029 0.0002 0.0003
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0245 0.033
Loa Loa (eye worm) hypothetical protein 0.0063 0.0187 0.0824
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0135 0.0568 0.077
Leishmania major glucose transporter, lmgt2 0.0139 0.0592 0.3975
Giardia lamblia Prolyl-tRNA synthetase 0.0135 0.0568 1
Schistosoma mansoni lysyl-tRNA synthetase 0.01 0.0385 0.052
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0135 0.0568 0.077
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Toxoplasma gondii ABC1 family protein 0.0037 0.0045 0.0065
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.01 0.0385 0.1544
Brugia malayi beta-lactamase family protein 0.0037 0.0045 0.0192
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0045 0.0062
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Toxoplasma gondii facilitative glucose transporter GT1 0.0449 0.2242 0.3391
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0034 0.0043
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Mycobacterium ulcerans sugar transporter 0.0063 0.0187 0.2238
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.1421 1
Giardia lamblia Sugar-proton symporter 0.0063 0.0187 0.3263
Trypanosoma brucei glucose transporter, putative 0.0139 0.0592 0.3975
Plasmodium falciparum protein kinase 7 0.127 0.6607 0.6606
Trichomonas vaginalis CAMK family protein kinase 0.0138 0.0583 0.2447
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Brugia malayi Major Facilitator Superfamily protein 0.0063 0.0187 0.0824
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0085 0.0304 0.2466
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.01 0.0385 0.2464
Echinococcus granulosus GPCR family 2 0.0049 0.0112 0.0152
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0449 0.2242 0.3048
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0449 0.2242 0.3046
Trichomonas vaginalis sugar transport protein, putative 0.0063 0.0187 0.0645
Onchocerca volvulus 0.0231 0.108 1
Brugia malayi Sugar transporter family protein 0.0063 0.0187 0.0824
Echinococcus granulosus lysyl tRNA synthetase 0.01 0.0385 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0187 0.0645
Schistosoma mansoni microtubule-associated protein tau 0.141 0.7355 1
Onchocerca volvulus 0.004 0.0065 0.0581
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0072 0.0191
Trypanosoma cruzi hexose transporter 0.0139 0.0592 0.3975
Schistosoma mansoni survival motor neuron protein 0.0052 0.0126 0.0168
Brugia malayi chromobox protein homolog 3 0.0038 0.0054 0.023
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0002 0.0003
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0213 0.0941
Brugia malayi hypothetical protein 0.0063 0.0187 0.0824
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0072 0.0191
Trichomonas vaginalis sugar transporter, putative 0.0139 0.0592 0.249
Schistosoma mansoni hypothetical protein 0.0106 0.0415 0.0562
Echinococcus granulosus Sugar transporter ERD6 protein 0.0063 0.0187 0.0254
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.0034
Trypanosoma brucei THT1 - hexose transporter, putative 0.0139 0.0592 0.3975
Schistosoma mansoni hypothetical protein 0.0075 0.025 0.0337
Treponema pallidum prolyl-tRNA synthetase 0.0048 0.0104 0.5
Echinococcus granulosus microtubule associated protein 2 0.141 0.7355 1
Echinococcus multilocularis solute carrier family 22 0.0063 0.0187 0.0251
Plasmodium vivax proline--tRNA ligase, putative 0.0157 0.0687 0.0685
Trichomonas vaginalis set domain proteins, putative 0.0231 0.108 0.4711
Trypanosoma cruzi hexose transporter, putative 0.0139 0.0592 0.3975
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0449 0.2242 0.3046
Giardia lamblia Hexose transporter 0.0063 0.0187 0.3263
Loa Loa (eye worm) hypothetical protein 0.0037 0.0045 0.0192
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.01 0.0385 0.6487
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0065 0.0085
Toxoplasma gondii hypothetical protein 0.0048 0.0104 0.0154
Brugia malayi Sugar transporter family protein 0.0063 0.0187 0.0824
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Echinococcus multilocularis synaptic vesicle 2 protein 0.0063 0.0187 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0139 0.0592 0.249
Loa Loa (eye worm) hypothetical protein 0.0037 0.0045 0.0192
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0138 0.0583 0.079
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0135 0.0568 0.0773
Schistosoma mansoni hypothetical protein 0.0049 0.0112 0.0149
Trypanosoma brucei glucose transporter 1E 0.0139 0.0592 0.3975
Loa Loa (eye worm) hypothetical protein 0.0253 0.1199 0.5342
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0187 0.0645
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.1094 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0135 0.0568 0.077
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0034 0.0043
Brugia malayi hypothetical protein 0.0075 0.025 0.1107
Loa Loa (eye worm) hypothetical protein 0.0063 0.0187 0.0824
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0347 0.0469
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0138 0.0583 0.0581
Loa Loa (eye worm) beta-lactamase 0.0037 0.0045 0.0192
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0006 0.0005
Toxoplasma gondii sugar transporter ST2 0.0063 0.0187 0.028
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0187 0.0645
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1421 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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