TDR Targets

Basic information

Technical information

TDR Targets ID: 756336
Name: ethyl 2-(4-nitro-1,3-dioxoisoindol-2-yl)aceta te
MW: 278.218 | Formula: C12H10N2O6
H donors: 0 H acceptors: 5 LogP: 1.02 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)CN1C(=O)c2c(C1=O)cccc2[N+](=O)[O-]
InChi: 1S/C12H10N2O6/c1-2-20-9(15)6-13-11(16)7-4-3-5-8(14(18)19)10(7)12(13)17/h3-5H,2,6H2,1H3
InChiKey: GKFMLXIUJKKVSZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 2-(4-nitro-1,3-dioxo-isoindolin-2-yl)acetate
2-(4-nitro-1,3-dioxo-2-isoindolinyl)acetic acid ethyl ester
2-(1,3-diketo-4-nitro-isoindolin-2-yl)acetic acid ethyl ester
ethyl 2-(4-nitro-1,3-dioxo-isoindol-2-yl)ethanoate
ZINC00178058
Oprea1_188503

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	blooms syndrome DNA helicase	0.001	0.0001	0.0001
Loa Loa (eye worm)	RecQ helicase	0.002	0.0029	0.0028
Trichomonas vaginalis	glucosylceramidase, putative	0.0258	0.0724	0.9645
Entamoeba histolytica	recQ family helicase, putative	0.002	0.0029	0.3767
Brugia malayi	Peroxidasin	0.344	1	1
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Trichomonas vaginalis	glucosylceramidase, putative	0.0258	0.0724	0.9645
Onchocerca volvulus	Slit protein homolog	0.1034	0.2987	0.2952
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0096	0.0251	0.0237
Mycobacterium ulcerans	glutaminase	0.0267	0.075	1
Brugia malayi	EGF-like domain containing protein	0.1034	0.2987	0.2978
Schistosoma mansoni	hypothetical protein	0.0096	0.0251	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0008	0.0007
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Echinococcus multilocularis	protein jagged 1	0.1034	0.2987	0.298
Schistosoma mansoni	intermediate filament proteins	0.0027	0.005	0.005
Echinococcus granulosus	notch	0.1034	0.2987	0.298
Echinococcus granulosus	slit 2 protein	0.1034	0.2987	0.298
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.005	0.0049
Echinococcus granulosus	fibropellin Ia	0.1034	0.2987	0.298
Brugia malayi	follicle stimulating hormone receptor	0.0457	0.1305	0.1294
Loa Loa (eye worm)	Notch2	0.1034	0.2987	0.2986
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0077	0.0068
Echinococcus multilocularis	muscleblind protein 1	0.015	0.041	0.0401
Echinococcus granulosus	survival motor neuron protein 1	0.0469	0.1338	0.133
Brugia malayi	EGF-like domain containing protein	0.1034	0.2987	0.2978
Loa Loa (eye worm)	hypothetical protein	0.344	1	1
Brugia malayi	Animal haem peroxidase family protein	0.344	1	1
Trichomonas vaginalis	glutaminase, putative	0.0267	0.075	1
Brugia malayi	Cadherin domain containing protein	0.1034	0.2987	0.2978
Loa Loa (eye worm)	notch protein	0.1034	0.2987	0.2986
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0052	0.0124	0.0123
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0077	0.0068
Onchocerca volvulus		0.1034	0.2987	0.2952
Loa Loa (eye worm)	hypothetical protein	0.344	1	1
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.002	0.0029	0.002
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Echinococcus granulosus	protein jagged 1	0.1034	0.2987	0.298
Brugia malayi	EGF-like domain containing protein	0.1034	0.2987	0.2978
Schistosoma mansoni	laminin gamma-3 chain	0.1034	0.2987	0.2987
Brugia malayi	Delta serrate ligand family protein	0.1034	0.2987	0.2978
Echinococcus multilocularis	fibropellin Ia	0.1034	0.2987	0.298
Echinococcus multilocularis	neurogenic locus notch protein	0.1034	0.2987	0.298
Echinococcus granulosus	neurogenic locus notch protein 4	0.1034	0.2987	0.298
Echinococcus multilocularis	neurogenic locus protein delta	0.1034	0.2987	0.298
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Schistosoma mansoni	notch	0.1034	0.2987	0.2987
Echinococcus multilocularis	lamin dm0	0.0027	0.005	0.004
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.002	0.0029	0.002
Trichomonas vaginalis	glucosylceramidase, putative	0.0258	0.0724	0.9645
Schistosoma mansoni	hypothetical protein	0.1034	0.2987	0.2987
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	0.0135	0.0126
Brugia malayi	Animal haem peroxidase family protein	0.344	1	1
Schistosoma mansoni	cell polarity protein	0.1034	0.2987	0.2987
Onchocerca volvulus		0.344	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0465	0.6055
Onchocerca volvulus		0.1034	0.2987	0.2952
Echinococcus granulosus	lamin	0.0027	0.005	0.004
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0465	0.6055
Brugia malayi	EGF-like domain containing protein	0.1034	0.2987	0.2978
Echinococcus granulosus	neurogenic locus notch protein	0.1034	0.2987	0.298
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Schistosoma mansoni	hypothetical protein	0.1034	0.2987	0.2987
Schistosoma mansoni	DNA helicase recq5	0.002	0.0029	0.0029
Schistosoma mansoni	notch	0.1034	0.2987	0.2987
Schistosoma mansoni	hypothetical protein	0.1034	0.2987	0.2987
Brugia malayi	EGF-like domain containing protein	0.1034	0.2987	0.2978
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0258	0.0724	0.0711
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.081	0.2334	0.2326
Schistosoma mansoni	peroxidasin	0.344	1	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.005	0.0049
Echinococcus multilocularis	notch	0.1034	0.2987	0.298
Onchocerca volvulus	Peroxidasin homolog	0.344	1	1
Loa Loa (eye worm)	hypothetical protein	0.344	1	1
Loa Loa (eye worm)	hypothetical protein	0.344	1	1
Echinococcus multilocularis	peroxidasin	0.344	1	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.005	0.0036
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0465	0.6055
Echinococcus granulosus	c-Jun N-terminal kinases	0.023	0.0643	0.0634
Treponema pallidum	ATP-dependent DNA helicase	0.001	0.0001	0.5
Schistosoma mansoni	notch	0.1034	0.2987	0.2987
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0029	0.0016
Schistosoma mansoni	hypothetical protein	0.1034	0.2987	0.2987
Schistosoma mansoni	DNA helicase recq1	0.002	0.0029	0.0029
Echinococcus granulosus	protein jagged 1	0.1034	0.2987	0.298
Echinococcus granulosus	neurogenic locus protein delta	0.1034	0.2987	0.298
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.002	0.0029	0.002
Onchocerca volvulus		0.0096	0.0251	0.0202
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.002	0.0029	0.5
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Loa Loa (eye worm)	hypothetical protein	0.0469	0.1338	0.1337
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Onchocerca volvulus	Peroxidase homolog	0.344	1	1
Loa Loa (eye worm)	glutaminase	0.0267	0.075	0.0749
Brugia malayi	GCC2 and GCC3 family protein	0.1034	0.2987	0.2978
Schistosoma mansoni	survival motor neuron protein	0.0096	0.0251	0.0251
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0122	0.0327	0.312
Echinococcus multilocularis	bloom syndrome protein	0.002	0.0029	0.002
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.002	0.0029	0.002
Loa Loa (eye worm)	hypothetical protein	0.015	0.041	0.0409
Echinococcus granulosus	bloom syndrome protein	0.002	0.0029	0.002
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0258	0.0724	0.0723
Schistosoma mansoni	aldehyde dehydrogenase	0.0122	0.0327	0.0327
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0014	0.0013
Entamoeba histolytica	hypothetical protein	0.0036	0.0077	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0122	0.0327	0.1094
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0029	0.0098
Echinococcus multilocularis	protein jagged 2	0.1034	0.2987	0.298
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0056	0.0135	0.0122
Echinococcus multilocularis	slit 2 protein	0.1034	0.2987	0.298
Brugia malayi	Animal haem peroxidase family protein	0.344	1	1
Loa Loa (eye worm)	hypothetical protein	0.344	1	1
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0029	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.001	0.0008
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Loa Loa (eye worm)	animal heme peroxidase	0.344	1	1
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Toxoplasma gondii	EGF family domain-containing protein	0.1034	0.2987	1
Brugia malayi	EGF-like domain containing protein	0.1034	0.2987	0.2978
Brugia malayi	Calcium binding EGF domain containing protein	0.1034	0.2987	0.2978
Onchocerca volvulus	Glucosylceramidase homolog	0.0169	0.0465	0.0418
Entamoeba histolytica	hypothetical protein	0.0036	0.0077	1
Brugia malayi	Animal haem peroxidase family protein	0.344	1	1
Loa Loa (eye worm)	hypothetical protein	0.344	1	1
Onchocerca volvulus	Chorion peroxidase homolog	0.344	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0178	0.0492	0.6424
Loa Loa (eye worm)	hypothetical protein	0.344	1	1
Loa Loa (eye worm)	hypothetical protein	0.344	1	1
Echinococcus granulosus	protein jagged 2	0.1034	0.2987	0.298
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Brugia malayi	Muscle positioning protein 4	0.1034	0.2987	0.2978
Echinococcus multilocularis	fat cadherin tumor suppressor	0.1034	0.2987	0.298
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0029	0.5
Brugia malayi	EGF-like domain containing protein	0.1034	0.2987	0.2978
Echinococcus granulosus	peroxidasin	0.344	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0258	0.0724	0.9645
Onchocerca volvulus		0.1034	0.2987	0.2952
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.1034	0.2987	0.2952
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0077	0.0077
Loa Loa (eye worm)	CMGC/MAPK/JNK protein kinase	0.023	0.0643	0.0642
Loa Loa (eye worm)	hypothetical protein	0.002	0.0029	0.0028
Schistosoma mansoni	serine/threonine protein kinase	0.023	0.0643	0.0643
Entamoeba histolytica	hypothetical protein	0.0036	0.0077	1
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0029	0.0016
Loa Loa (eye worm)	hypothetical protein	0.344	1	1
Loa Loa (eye worm)	hypothetical protein	0.344	1	1
Onchocerca volvulus		0.1034	0.2987	0.2952
Brugia malayi	hypothetical protein	0.0469	0.1338	0.1327
Brugia malayi	Calcium binding EGF domain containing protein	0.1034	0.2987	0.2978
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Loa Loa (eye worm)	hypothetical protein	0.344	1	1
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0056	0.0135	0.3559
Schistosoma mansoni	slit	0.1034	0.2987	0.2987
Onchocerca volvulus		0.1034	0.2987	0.2952
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Schistosoma mansoni	septate junction protein	0.1034	0.2987	0.2987
Echinococcus granulosus	neural cadherin	0.1034	0.2987	0.298
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0122	0.0327	0.312
Schistosoma mansoni	glutaminase	0.0267	0.075	0.075
Echinococcus multilocularis	neurogenic locus notch protein	0.1034	0.2987	0.298
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0465	0.6055
Brugia malayi	glutaminase DH11.1	0.0267	0.075	0.0737
Echinococcus granulosus	neurogenic locus notch protein	0.1034	0.2987	0.298
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0122	0.0327	1
Schistosoma mansoni	lamin	0.0027	0.005	0.005
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0122	0.0327	0.0318
Loa Loa (eye worm)	animal heme peroxidase	0.344	1	1
Schistosoma mansoni	hypothetical protein	0.1034	0.2987	0.2987
Loa Loa (eye worm)	animal heme peroxidase	0.344	1	1
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Echinococcus multilocularis	c Jun NH2 terminal kinase	0.023	0.0643	0.0634
Brugia malayi	Blistered cuticle protein 3	0.344	1	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0457	0.1305	0.1304
Loa Loa (eye worm)	hypothetical protein	0.344	1	1
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.0029	0.5
Brugia malayi	Cadherin domain containing protein	0.1034	0.2987	0.2978
Echinococcus multilocularis	neurogenic locus protein delta	0.1034	0.2987	0.298
Schistosoma mansoni	hypothetical protein	0.1034	0.2987	0.2987
Brugia malayi	Bloom's syndrome protein homolog	0.002	0.0029	0.0016
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.002	0.0029	0.0028
Onchocerca volvulus		0.344	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0465	0.6055
Schistosoma mansoni	lamin	0.0027	0.005	0.005
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.001	0.0001	1
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	0.0135	0.0126
Echinococcus granulosus	muscleblind protein	0.015	0.041	0.0401
Loa Loa (eye worm)	blistered cuticle protein 3	0.344	1	1
Schistosoma mansoni	hypothetical protein	0.1034	0.2987	0.2987
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0001	0.0004
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0056	0.0135	0.0135
Brugia malayi	hypothetical protein	0.0036	0.0077	0.0064
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Schistosoma mansoni	notch	0.1034	0.2987	0.2987
Trichomonas vaginalis	glucosylceramidase, putative	0.0178	0.0492	0.6424
Brugia malayi	notch-like transmembrane receptor	0.1034	0.2987	0.2978
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Echinococcus granulosus	lamin dm0	0.0027	0.005	0.004
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0048	0.0047
Loa Loa (eye worm)	glutaminase 2	0.0267	0.075	0.0749
Trichomonas vaginalis	glucosylceramidase, putative	0.0258	0.0724	0.9645
Echinococcus granulosus	intermediate filament protein	0.0027	0.005	0.004
Loa Loa (eye worm)	hypothetical protein	0.001	0.0001	0.000000000023612
Loa Loa (eye worm)	animal heme peroxidase	0.344	1	1
Echinococcus multilocularis	protein jagged 1	0.1034	0.2987	0.298
Onchocerca volvulus	Peroxidasin homolog	0.344	1	1
Onchocerca volvulus	Neurogenic locus notch homolog	0.1034	0.2987	0.2952
Onchocerca volvulus	Peroxidase homolog	0.344	1	1
Loa Loa (eye worm)	hypothetical protein	0.015	0.041	0.0409
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.005	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0008	0.0007
Loa Loa (eye worm)	hypothetical protein	0.344	1	1
Onchocerca volvulus	Dual oxidase homolog	0.344	1	1
Loa Loa (eye worm)	hypothetical protein	0.344	1	1
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Echinococcus granulosus	protein jagged 2	0.1034	0.2987	0.298
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.1034	0.2987	0.2978
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0122	0.0327	0.0318
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0465	0.6055
Echinococcus multilocularis	muscleblind protein	0.015	0.041	0.0401
Schistosoma mansoni	peroxidasin	0.344	1	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0122	0.0327	0.312
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0122	0.0327	1
Giardia lamblia	High cysteine protein	0.1034	0.2987	1
Schistosoma mansoni	notch	0.1034	0.2987	0.2987
Trichomonas vaginalis	glucosylceramidase, putative	0.0169	0.0465	0.6055
Brugia malayi	Animal haem peroxidase family protein	0.344	1	1
Loa Loa (eye worm)	hypothetical protein	0.1034	0.2987	0.2986
Entamoeba histolytica	recQ family DNA helicase	0.001	0.0001	0.0143
Echinococcus multilocularis	lamin	0.0027	0.005	0.004
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.1034	0.2987	0.2987
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0029	0.0098
Onchocerca volvulus		0.344	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0258	0.0724	0.9645
Brugia malayi	Calcium binding EGF domain containing protein	0.1034	0.2987	0.2978
Brugia malayi	Muscleblind-like protein	0.015	0.041	0.0397
Brugia malayi	Stress-activated protein kinase jnk-1	0.023	0.0643	0.063
Echinococcus multilocularis	survival motor neuron protein 1	0.0469	0.1338	0.133
Brugia malayi	intermediate filament protein	0.0027	0.005	0.0036
Onchocerca volvulus	Putative cubilin	0.1034	0.2987	0.2952
Echinococcus multilocularis	musashi	0.0027	0.005	0.004
Schistosoma mansoni	notch	0.1034	0.2987	0.2987
Schistosoma mansoni	hypothetical protein	0.0036	0.0077	0.0077
Echinococcus multilocularis	neurogenic locus notch protein 4	0.1034	0.2987	0.298
Entamoeba histolytica	hypothetical protein	0.0036	0.0077	1
Echinococcus granulosus	delta-like protein 1	0.1034	0.2987	0.298
Echinococcus multilocularis	neural cadherin	0.1034	0.2987	0.298
Schistosoma mansoni	aldehyde dehydrogenase	0.0122	0.0327	0.0327

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 756336