Detailed information for compound 757431

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 476.521 | Formula: C27H28N2O6
  • H donors: 1 H acceptors: 4 LogP: 3.33 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCN1C(=O)C(=C(C21C(=O)N(c1c2cccc1)CCC)C(=O)c1ccc2c(c1)CC(O2)C)O
  • InChi: 1S/C27H28N2O6/c1-4-11-28-20-8-6-5-7-19(20)27(26(28)33)22(24(31)25(32)29(27)12-13-34-3)23(30)17-9-10-21-18(15-17)14-16(2)35-21/h5-10,15-16,31H,4,11-14H2,1-3H3
  • InChiKey: RVABEXCSNZTDNQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0074 0.0249 0.0536
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0248 0.1194 0.1194
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0418 0.2114 0.2114
Schistosoma mansoni hypothetical protein 0.0418 0.2114 0.2109
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0632 0.327 0.3266
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0249 0.0576
Toxoplasma gondii ABC1 family protein 0.0074 0.0249 0.0789
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0348 0.1734 0.5613
Schistosoma mansoni carbonic anhydrase-related 0.0095 0.0365 0.036
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0263 0.0836
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0216 0.102 0.3106
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0632 0.327 0.3266
Giardia lamblia Hypothetical protein 0.012 0.0497 0.1504
Trichomonas vaginalis PIKK family atypical protein kinase 0.0314 0.1551 0.3511
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.012 0.0497 0.0497
Schistosoma mansoni hypothetical protein 0.0346 0.1725 0.172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0403 0.2033 0.4638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0147 0.0645 0.1392
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0604 0.3122 0.7216
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0604 0.3122 0.7216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.1847 0.4203
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0418 0.2114 0.4551
Schistosoma mansoni microtubule-associated protein tau 0.0673 0.3492 0.3488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0632 0.327 0.7529
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0088 0.0324 0.3792
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.012 0.0497 0.5858
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.073 0.2891
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0263 0.0257
Brugia malayi Bromodomain containing protein 0.0036 0.0046 0.0046
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0184 0.0844 0.2723
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0497 0.1046
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0174 0.0793 0.1833
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.012 0.0497 0.0491
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0057 0.0051
Leishmania major hypothetical protein, unknown function 0.012 0.0497 0.1149
Trichomonas vaginalis conserved hypothetical protein 0.0348 0.1734 0.3938
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0121 0.0115
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0314 0.1551 0.1546
Loa Loa (eye worm) hypothetical protein 0.0195 0.0903 0.1945
Echinococcus granulosus carbonic anhydrase 0.0095 0.0365 0.036
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0249 0.0249
Echinococcus multilocularis carbonic anhydrase 0.0095 0.0365 0.036
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0418 0.2114 0.2109
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0249 0.0466
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0533 0.2735 0.8057
Onchocerca volvulus 0.012 0.0497 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0249 0.0243
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1874 1 1
Loa Loa (eye worm) hypothetical protein 0.0428 0.2168 0.4668
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0275 0.0269
Toxoplasma gondii target of rapamycin (TOR), putative 0.0597 0.3084 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0184 0.0844 0.1818
Trichomonas vaginalis PIKK family atypical protein kinase 0.0577 0.2974 0.6837
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0598 0.309 0.912
Loa Loa (eye worm) RNA binding protein 0.0065 0.0204 0.0439
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.012 0.0497 0.0497
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0505 0.2582 0.5921
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.012 0.0497 0.0491
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.1084 0.1079
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0314 0.1551 0.1546
Mycobacterium leprae conserved hypothetical protein 0.012 0.0497 1
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.012 0.0497 0.5858
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0497 0.1046
Onchocerca volvulus 0.012 0.0497 1
Entamoeba histolytica hypothetical protein 0.0556 0.2861 0.8432
Echinococcus granulosus GPCR family 2 0.0079 0.0275 0.0269
Loa Loa (eye worm) hypothetical protein 0.0074 0.0249 0.0536
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0249 0.0847
Loa Loa (eye worm) phosphatidylinositol 3 0.012 0.0497 0.107
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0314 0.1551 0.1551
Echinococcus multilocularis carbonic anhydrase 0.0095 0.0365 0.036
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0121 0.0302
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0249 0.0847
Mycobacterium ulcerans hypothetical protein 0.0074 0.0249 0.3411
Loa Loa (eye worm) hypothetical protein 0.0074 0.0249 0.0536
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0249 0.0249
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0275 0.0275
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0136 0.0136
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0363 0.0357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0543 0.2788 0.6402
Toxoplasma gondii exonuclease III APE 0.0037 0.005 0.0141
Schistosoma mansoni carbonic anhydrase 0.0095 0.0365 0.036
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0418 0.2114 0.2114
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0556 0.2861 0.8432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0376 0.1885 0.4291
Loa Loa (eye worm) hypothetical protein 0.012 0.0497 0.107
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0332 0.1646 0.4788
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0095 0.0365 0.0365
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.0641 0.1481
Schistosoma mansoni cpg binding protein 0.0061 0.0181 0.0175
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0632 0.327 0.3266
Trichomonas vaginalis PIKK family atypical protein kinase 0.057 0.2936 0.6749
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0095 0.0365 0.0365
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0249 0.0847
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0275 0.0275
Entamoeba histolytica hypothetical protein 0.0109 0.0441 0.1175
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.012 0.0497 0.1149
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0263 0.3792
Mycobacterium ulcerans hypothetical protein 0.0163 0.073 1
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0249 0.0847
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0418 0.2114 0.2109
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0653 0.3383 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.028 0.1367 0.1367
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0249 0.3411
Trichomonas vaginalis bromodomain-containing protein, putative 0.0088 0.0324 0.0641
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0543 0.2788 0.6444
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0204 0.0439
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0057 0.0123
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0408 0.2059 0.629
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0632 0.327 0.327
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0632 0.327 0.327
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0248 0.1194 0.257
Onchocerca volvulus 0.0058 0.0163 0.319
Schistosoma mansoni hypothetical protein 0.0079 0.0275 0.0269
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0228 0.1086 0.1081
Schistosoma mansoni hypothetical protein 0.0346 0.1725 0.172
Leishmania major mitochondrial DNA polymerase beta 0.0309 0.1522 0.3517
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.3084 0.7095
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1748 0.9316 0.9315
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0204 0.0204
Loa Loa (eye worm) acetyltransferase 0.0298 0.1463 0.3151
Brugia malayi Calcitonin receptor-like protein seb-1 0.0248 0.1194 0.1194
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.028 0.1367 0.1367
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0249 0.0243
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0184 0.0844 0.0839
Loa Loa (eye worm) phosphatidylinositol 3 0.012 0.0497 0.107
Echinococcus granulosus microtubule associated protein 2 0.0673 0.3492 0.3488
Brugia malayi TAR-binding protein 0.0065 0.0204 0.0204
Schistosoma mansoni hypothetical protein 0.0228 0.1086 0.1081
Loa Loa (eye worm) hypothetical protein 0.0095 0.0365 0.0787
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0982 0.5167 0.5164
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0039 0.0033
Onchocerca volvulus 0.0074 0.0249 0.4949
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0263 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0441 0.0435
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0204 0.0439
Trichomonas vaginalis PIKK family atypical protein kinase 0.041 0.2067 0.4718
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.005 0.005
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0088 0.0324 0.1033
Trichomonas vaginalis PIKK family atypical protein kinase 0.057 0.2936 0.6749
Leishmania major phosphatidylinositol 3-kinase, putative 0.0184 0.0844 0.1951
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0204 0.0198
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0184 0.0844 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0184 0.0844 0.1858
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.2404 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.012 0.0497 0.0497
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0275 0.0269
Schistosoma mansoni hypothetical protein 0.0095 0.0365 0.036
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.028 0.1367 0.308
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0079 0.0275 0.0269
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0363 0.0357
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0249 0.0466
Trichomonas vaginalis esterase, putative 0.0074 0.0249 0.0466
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0641 0.1481
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0249 0.0847
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.1847 0.4203
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0184 0.0844 0.2384
Entamoeba histolytica hypothetical protein 0.012 0.0497 0.1342
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0121 0.0115
Loa Loa (eye worm) hypothetical protein 0.0095 0.0365 0.0787
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0249 0.0466
Echinococcus multilocularis carbonic anhydrase 0.0095 0.0365 0.036
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0263 0.3071
Loa Loa (eye worm) hypothetical protein 0.005 0.0118 0.0254
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0168 0.0361
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0275 0.0269
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0228 0.1084 0.1079
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.012 0.0497 0.1149
Trypanosoma brucei carbonic anhydrase-like protein 0.0418 0.2114 0.4885
Schistosoma mansoni cpg binding protein 0.0061 0.0181 0.0175
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0263 0.3608
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0309 0.1522 0.3517
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.4327 1
Leishmania major phosphatidylinositol kinase, putative 0.012 0.0497 0.1149
Brugia malayi jmjC domain containing protein 0.0095 0.0363 0.0363
Trichomonas vaginalis PIKK family atypical protein kinase 0.057 0.2936 0.6748
Brugia malayi jmjC domain containing protein 0.0038 0.0057 0.0057
Brugia malayi beta-lactamase family protein 0.0074 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0314 0.1551 0.334
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.0483 0.1548
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.028 0.1367 0.3159
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1874 1 1
Toxoplasma gondii hypothetical protein 0.0095 0.0365 0.1168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0604 0.3121 0.7183
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0228 0.1084 0.1084
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.012 0.0497 0.0491
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.028 0.1367 0.3951
Trichomonas vaginalis PIKK family atypical protein kinase 0.057 0.2936 0.6749
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.012 0.0497 0.5858
Entamoeba histolytica hypothetical protein 0.012 0.0497 0.1342
Echinococcus multilocularis GPCR, family 2 0.0079 0.0275 0.0269
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0204 0.0198
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0653 0.3383 0.7794
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0249 0.3411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0543 0.2788 0.6402
Leishmania major carbonic anhydrase-like protein 0.0418 0.2114 0.4885
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0195 0.0903 0.0903
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0263 0.0257
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0084 0.0195
Entamoeba histolytica acetyltransferase, GNAT family 0.008 0.0284 0.0704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0598 0.309 0.7108
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.1522 0.1522
Echinococcus multilocularis dnaJ subfamily B 0.0418 0.2114 0.2109
Plasmodium falciparum histone acetyltransferase GCN5 0.008 0.0284 0.332
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0827 0.4327 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.1522 0.1522
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.1084 0.1079
Brugia malayi beta-lactamase 0.0074 0.0249 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0604 0.3121 0.7183
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0228 0.1084 0.1079
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0632 0.327 0.7558
Loa Loa (eye worm) hypothetical protein 0.0079 0.0275 0.0591
Echinococcus multilocularis Zinc finger, PHD finger 0.0184 0.0844 0.0839
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0653 0.3383 0.7794
Giardia lamblia Phosphatidylinositol 4-kinase 0.012 0.0497 0.1504
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0418 0.2114 0.2114
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0084 0.0084
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0263 0.0836
Schistosoma mansoni cpg binding protein 0.0058 0.0163 0.0157
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.012 0.0497 0.0497
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.012 0.0497 0.0491
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0163 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0632 0.327 0.7529
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0204 0.0198
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0249 0.0536
Schistosoma mansoni hypothetical protein 0.017 0.0768 0.0763
Echinococcus granulosus peregrin 0.0036 0.0046 0.004
Entamoeba histolytica protein kinase rad3, putative 0.0314 0.1551 0.4504
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0257 0.0251
Loa Loa (eye worm) hypothetical protein 0.0248 0.1194 0.257
Entamoeba histolytica hypothetical protein 0.0314 0.1551 0.4504
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.005 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0195 0.0903 0.1996
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.012 0.0497 0.0491
Loa Loa (eye worm) phosphatidylinositol 3 0.0827 0.4327 0.9315
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0095 0.0365 0.0365
Brugia malayi PHD-finger family protein 0.0029 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0079 0.0275 0.0269
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0982 0.5167 0.5164
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0249 0.0847
Mycobacterium ulcerans lipase LipD 0.0074 0.0249 0.3411
Schistosoma mansoni phosphatidylinositol 4-kinase 0.012 0.0497 0.0491
Loa Loa (eye worm) hypothetical protein 0.0074 0.0249 0.0536
Schistosoma mansoni ap endonuclease 0.0037 0.005 0.0044
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0088 0.0324 0.1033
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.012 0.0497 0.0491
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.028 0.1367 0.1362
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0653 0.3383 0.3383
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0263 0.0257
Mycobacterium tuberculosis Conserved protein 0.0074 0.0249 0.0847
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0184 0.0844 0.0839
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.012 0.0497 0.0497
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0441 0.0435
Schistosoma mansoni carbonic anhydrase-related 0.0095 0.0365 0.036
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0057 0.0051
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0184 0.0844 0.1858
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.012 0.0497 0.1595
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.012 0.0497 0.1342
Echinococcus granulosus geminin 0.0346 0.1725 0.172
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0298 0.1463 0.1458
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0184 0.0844 0.0844
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0428 0.2168 0.2168
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0184 0.0844 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0653 0.3383 0.3383
Echinococcus granulosus carbonic anhydrase II 0.0418 0.2114 0.2109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.3084 0.7095
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.012 0.0497 0.5858
Toxoplasma gondii FATC domain-containing protein 0.0314 0.1551 0.5019
Loa Loa (eye worm) hypothetical protein 0.0284 0.1388 0.2988
Loa Loa (eye worm) phosphatidylinositol kinase 0.012 0.0497 0.107
Entamoeba histolytica hypothetical protein 0.0109 0.0441 0.1175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.3084 0.7095
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0204 0.0198
Giardia lamblia GTOR 0.0632 0.327 1
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0228 0.1086 0.1081
Trichomonas vaginalis PIKK family atypical protein kinase 0.057 0.2936 0.6748
Mycobacterium ulcerans beta-lactamase 0.0074 0.0249 0.3411
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.3084 0.7095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0632 0.327 0.7529
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0514 0.0508
Echinococcus multilocularis microtubule associated protein 2 0.0673 0.3492 0.3488
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0314 0.1551 0.1551
Brugia malayi RNA binding protein 0.0065 0.0204 0.0204
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.005 0.0679
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0121 0.0302
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0249 0.0243
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0314 0.1551 0.1551
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0249 0.0243
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0095 0.0365 0.0787
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0314 0.1551 0.3585
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0161 0.0719 0.0719
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0095 0.0365 0.0365
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1874 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.012 0.0497 0.1046
Brugia malayi CXXC zinc finger family protein 0.0058 0.0163 0.0163
Entamoeba histolytica hypothetical protein 0.012 0.0497 0.1342
Echinococcus granulosus jumonji domain containing protein 0.004 0.0068 0.0061
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.012 0.0497 0.0491
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0173 0.0373
Onchocerca volvulus 0.0074 0.0249 0.4949
Echinococcus granulosus tar DNA binding protein 0.0065 0.0204 0.0198
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1874 1 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0249 0.0536
Brugia malayi Cytochrome P450 family protein 0.0059 0.0168 0.0168
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.005 0.005
Leishmania major phosphatidylinositol kinase related protein, putative 0.012 0.0497 0.1149
Schistosoma mansoni fkbp-rapamycin associated protein 0.0314 0.1551 0.1546
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.3084 0.7095
Entamoeba histolytica hypothetical protein 0.0109 0.0441 0.1175
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0982 0.5167 0.5164
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.005 0.0107
Loa Loa (eye worm) hypothetical protein 0.0095 0.0365 0.0787
Loa Loa (eye worm) phosphatidylinositol 3 0.0632 0.327 0.704
Leishmania major phosphatidylinositol 4-kinase, putative 0.012 0.0497 0.1149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.1084 0.1079
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0641 0.0641
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.028 0.1367 0.308
Brugia malayi hypothetical protein 0.0109 0.0441 0.0441
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0263 0.3608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0577 0.2974 0.6837
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0184 0.0844 0.0844
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.028 0.1367 0.3951
Loa Loa (eye worm) beta-lactamase 0.0074 0.0249 0.0536
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0184 0.0844 0.2384
Plasmodium falciparum carbonic anhydrase 0.0095 0.0365 0.4288
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0428 0.2168 0.2163
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.012 0.0497 0.1595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.3084 0.7095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0314 0.1551 0.3511
Trypanosoma cruzi target of rapamycin kinase 3 0.0604 0.3122 0.3122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0543 0.2788 0.6402
Brugia malayi FAT domain containing protein 0.0228 0.1086 0.1086
Loa Loa (eye worm) hypothetical protein 0.0224 0.1064 0.2291
Loa Loa (eye worm) hypothetical protein 0.0228 0.1086 0.2338
Echinococcus multilocularis serine protein kinase ATM 0.0314 0.1551 0.1546
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1874 1 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0298 0.1463 0.1458
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0084 0.0084
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0263 0.3071
Echinococcus multilocularis cpg binding protein 0.0061 0.0181 0.0175
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0653 0.3383 0.7794
Echinococcus granulosus histone acetyltransferase KAT2B 0.029 0.1418 0.1413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0604 0.3121 0.7183
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0314 0.1551 0.1546
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.012 0.0497 0.0497
Echinococcus multilocularis 0.012 0.0497 0.0491
Onchocerca volvulus 0.0074 0.0249 0.4949
Loa Loa (eye worm) hypothetical protein 0.0029 0.0006 0.0013
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0084 0.0084
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0441 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0195 0.0903 0.1996
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0068 0.0061
Echinococcus granulosus histone acetyltransferase KAT2B 0.0088 0.0324 0.0318
Trichomonas vaginalis PIKK family atypical protein kinase 0.0604 0.3121 0.7183
Echinococcus granulosus carbonic anhydrase 0.0095 0.0365 0.036
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0653 0.3383 0.3383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0604 0.3121 0.7183
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0184 0.0844 0.1951
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.012 0.0497 0.0491
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0184 0.0844 0.0839
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0275 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.3084 0.7095
Giardia lamblia Histone acetyltransferase GCN5 0.008 0.0284 0.0853
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0428 0.2168 0.2163
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0632 0.327 0.327
Echinococcus multilocularis carbonic anhydrase II 0.0418 0.2114 0.2109
Brugia malayi acetyltransferase, GNAT family protein 0.0298 0.1463 0.1463
Schistosoma mansoni hypothetical protein 0.0079 0.0275 0.0269
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0375 0.1882 0.435
Brugia malayi Probable ClpP-like protease 0.0076 0.0263 0.0263
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0505 0.2582 0.5921
Toxoplasma gondii hypothetical protein 0.005 0.0119 0.0367
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0249 0.0249
Plasmodium vivax hypothetical protein 0.012 0.0497 0.5858
Echinococcus granulosus serine protein kinase ATM 0.0314 0.1551 0.1546
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.005 0.0115
Loa Loa (eye worm) phosphatidylinositol 3 0.012 0.0497 0.107
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0314 0.1551 0.1551
Schistosoma mansoni carbonic anhydrase-related 0.0095 0.0365 0.036
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.012 0.0497 0.0497
Entamoeba histolytica hypothetical protein 0.0109 0.0441 0.1175
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.005 0.0519
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0057 0.0051
Loa Loa (eye worm) hypothetical protein 0.0076 0.0263 0.0567
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0228 0.1084 0.1079
Leishmania major hypothetical protein, conserved 0.012 0.0497 0.1149
Echinococcus granulosus carbonic anhydrase 0.0095 0.0365 0.036
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0228 0.1084 0.2334
Plasmodium vivax hypothetical protein, conserved 0.012 0.0497 0.5858
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.005 0.0519
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0329 0.1633 0.1633
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.012 0.0497 0.1046
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0249 0.341
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0249 0.0847
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0263 0.5
Echinococcus granulosus cpg binding protein 0.0061 0.0181 0.0175
Loa Loa (eye worm) carbonic anhydrase 3 0.0418 0.2114 0.4551
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0249 0.2899
Trichomonas vaginalis PIKK family atypical protein kinase 0.0543 0.2788 0.6402
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0204 0.0198
Schistosoma mansoni hypothetical protein 0.012 0.0497 0.0491
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0204 0.0198
Leishmania major hypothetical protein, conserved 0.0074 0.0249 0.0576
Trichomonas vaginalis PIKK family atypical protein kinase 0.057 0.2936 0.6749
Brugia malayi beta-lactamase family protein 0.0074 0.0249 0.0249
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0827 0.4327 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.012 0.0497 0.1901
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.005 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.1847 0.4203
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0184 0.0844 0.0844
Plasmodium falciparum phosphatidylinositol 4-kinase 0.012 0.0497 0.5858
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0275 0.0591
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.012 0.0497 0.0497
Loa Loa (eye worm) phosphatidylinositol 3 0.0161 0.0719 0.1548
Echinococcus multilocularis geminin 0.0346 0.1725 0.172
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0249 0.0466
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0095 0.0365 0.0365
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0184 0.0844 0.0839
Loa Loa (eye worm) hypothetical protein 0.0284 0.1388 0.2988
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.028 0.1367 0.308
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0263 1
Trichomonas vaginalis conserved hypothetical protein 0.0228 0.1086 0.2423
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0632 0.327 0.7558
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0006 0.0013
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.012 0.0497 0.1595
Loa Loa (eye worm) hypothetical protein 0.017 0.0768 0.1654
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0632 0.327 0.966
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0632 0.327 0.966
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0184 0.0844 0.2723
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0249 0.0466
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0418 0.2114 0.2114
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.012 0.0497 0.0491
Mycobacterium tuberculosis Conserved protein 0.0074 0.0249 0.0847
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0632 0.327 0.7558
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0632 0.327 0.7558
Brugia malayi latrophilin 2 splice variant baaae 0.017 0.0768 0.0768
Schistosoma mansoni ap endonuclease 0.0037 0.005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0074 0.0249 0.0536
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.005 0.0044
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0184 0.0844 0.1858
Mycobacterium leprae Probable lipase LipE 0.0074 0.0249 0.341
Loa Loa (eye worm) phosphatidylinositol 3 0.012 0.0497 0.107
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.005 0.0115
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0263 1
Mycobacterium tuberculosis Conserved protein 0.0074 0.0249 0.0847
Loa Loa (eye worm) phosphatidylinositol 3 0.0885 0.4644 1
Echinococcus granulosus dnaJ subfamily B 0.0418 0.2114 0.2109
Echinococcus multilocularis peregrin 0.0036 0.0046 0.004
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0184 0.0844 0.1951
Schistosoma mansoni hypothetical protein 0.0109 0.0441 0.0435
Trichomonas vaginalis PIKK family atypical protein kinase 0.057 0.2936 0.6748
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0088 0.0324 0.0641
Leishmania major phosphatidylinositol 3-kinase, putative 0.0543 0.2788 0.6444
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0184 0.0844 0.0839
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0228 0.1084 0.1079
Loa Loa (eye worm) hypothetical protein 0.0348 0.1734 0.3733

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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