Detailed information for compound 757470

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 490.548 | Formula: C28H30N2O6
  • H donors: 1 H acceptors: 4 LogP: 3.68 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN1c2ccccc2C2(C1=O)C(=C(C(=O)N2CCOC)O)C(=O)c1ccc2c(c1)CC(O2)C
  • InChi: 1S/C28H30N2O6/c1-4-5-12-29-21-9-7-6-8-20(21)28(27(29)34)23(25(32)26(33)30(28)13-14-35-3)24(31)18-10-11-22-19(16-18)15-17(2)36-22/h6-11,16-17,32H,4-5,12-15H2,1-3H3
  • InChiKey: UJKPPWYISRGIRB-UHFFFAOYSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0079 0.0275 0.0591
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0632 0.327 0.7558
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0228 0.1084 0.1079
Brugia malayi beta-lactamase 0.0074 0.0249 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0604 0.3121 0.7183
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.1084 0.1079
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.1522 0.1522
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0827 0.4327 1
Plasmodium falciparum histone acetyltransferase GCN5 0.008 0.0284 0.332
Echinococcus multilocularis dnaJ subfamily B 0.0418 0.2114 0.2109
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.1522 0.1522
Trichomonas vaginalis PIKK family atypical protein kinase 0.0598 0.309 0.7108
Entamoeba histolytica acetyltransferase, GNAT family 0.008 0.0284 0.0704
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0084 0.0195
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0263 0.0257
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0195 0.0903 0.0903
Leishmania major carbonic anhydrase-like protein 0.0418 0.2114 0.4885
Trichomonas vaginalis PIKK family atypical protein kinase 0.0543 0.2788 0.6402
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0249 0.3411
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0204 0.0198
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0653 0.3383 0.7794
Echinococcus multilocularis GPCR, family 2 0.0079 0.0275 0.0269
Entamoeba histolytica hypothetical protein 0.012 0.0497 0.1342
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.012 0.0497 0.5858
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0088 0.0324 0.1033
Schistosoma mansoni ap endonuclease 0.0037 0.005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0074 0.0249 0.0536
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0249 0.0847
Mycobacterium ulcerans lipase LipD 0.0074 0.0249 0.3411
Schistosoma mansoni phosphatidylinositol 4-kinase 0.012 0.0497 0.0491
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0982 0.5167 0.5164
Schistosoma mansoni hypothetical protein 0.0079 0.0275 0.0269
Brugia malayi PHD-finger family protein 0.0029 0.0006 0.0006
Loa Loa (eye worm) phosphatidylinositol 3 0.0827 0.4327 0.9315
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0095 0.0365 0.0365
Trichomonas vaginalis conserved hypothetical protein 0.0195 0.0903 0.1996
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.012 0.0497 0.0491
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0248 0.1194 0.257
Entamoeba histolytica hypothetical protein 0.0314 0.1551 0.4504
Echinococcus granulosus peregrin 0.0036 0.0046 0.004
Entamoeba histolytica protein kinase rad3, putative 0.0314 0.1551 0.4504
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0257 0.0251
Schistosoma mansoni hypothetical protein 0.017 0.0768 0.0763
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0249 0.0536
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0204 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0632 0.327 0.7529
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0163 0.035
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.012 0.0497 0.0497
Schistosoma mansoni cpg binding protein 0.0058 0.0163 0.0157
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0263 0.0836
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.012 0.0497 0.0491
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0084 0.0084
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0418 0.2114 0.2114
Giardia lamblia Phosphatidylinositol 4-kinase 0.012 0.0497 0.1504
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0653 0.3383 0.7794
Echinococcus multilocularis Zinc finger, PHD finger 0.0184 0.0844 0.0839
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0121 0.0115
Entamoeba histolytica hypothetical protein 0.012 0.0497 0.1342
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0184 0.0844 0.2384
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.1847 0.4203
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0641 0.1481
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0249 0.0847
Trichomonas vaginalis esterase, putative 0.0074 0.0249 0.0466
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0363 0.0357
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0249 0.0466
Schistosoma mansoni hypothetical protein 0.0079 0.0275 0.0269
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.005 0.005
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.028 0.1367 0.308
Schistosoma mansoni hypothetical protein 0.0095 0.0365 0.036
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0275 0.0269
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.012 0.0497 0.0497
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0184 0.0844 0.1858
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.2404 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0184 0.0844 1
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0204 0.0198
Leishmania major phosphatidylinositol 3-kinase, putative 0.0184 0.0844 0.1951
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0088 0.0324 0.1033
Trichomonas vaginalis PIKK family atypical protein kinase 0.057 0.2936 0.6749
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.005 0.005
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0204 0.0439
Trichomonas vaginalis PIKK family atypical protein kinase 0.041 0.2067 0.4718
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0441 0.0435
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0263 0.5
Onchocerca volvulus 0.0074 0.0249 0.4949
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0982 0.5167 0.5164
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0039 0.0033
Loa Loa (eye worm) hypothetical protein 0.0095 0.0365 0.0787
Schistosoma mansoni hypothetical protein 0.0228 0.1086 0.1081
Trichomonas vaginalis PIKK family atypical protein kinase 0.057 0.2936 0.6749
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.028 0.1367 0.3951
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.012 0.0497 0.0491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0604 0.3121 0.7183
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0228 0.1084 0.1084
Toxoplasma gondii hypothetical protein 0.0095 0.0365 0.1168
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1874 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.028 0.1367 0.3159
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.0483 0.1548
Brugia malayi beta-lactamase family protein 0.0074 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0314 0.1551 0.334
Brugia malayi jmjC domain containing protein 0.0038 0.0057 0.0057
Brugia malayi jmjC domain containing protein 0.0095 0.0363 0.0363
Leishmania major phosphatidylinositol kinase, putative 0.012 0.0497 0.1149
Trichomonas vaginalis PIKK family atypical protein kinase 0.057 0.2936 0.6748
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.4327 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0309 0.1522 0.3517
Schistosoma mansoni cpg binding protein 0.0061 0.0181 0.0175
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0263 0.3608
Trypanosoma brucei carbonic anhydrase-like protein 0.0418 0.2114 0.4885
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.012 0.0497 0.1149
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0275 0.0269
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0228 0.1084 0.1079
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0168 0.0361
Loa Loa (eye worm) hypothetical protein 0.005 0.0118 0.0254
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0263 0.3071
Echinococcus multilocularis carbonic anhydrase 0.0095 0.0365 0.036
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0249 0.0466
Loa Loa (eye worm) hypothetical protein 0.0095 0.0365 0.0787
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.012 0.0497 0.1149
Entamoeba histolytica hypothetical protein 0.0109 0.0441 0.1175
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0275 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.057 0.2936 0.6749
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0249 0.0847
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0095 0.0365 0.0365
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0632 0.327 0.3266
Schistosoma mansoni cpg binding protein 0.0061 0.0181 0.0175
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.0641 0.1481
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0095 0.0365 0.0365
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0332 0.1646 0.4788
Loa Loa (eye worm) hypothetical protein 0.012 0.0497 0.107
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0556 0.2861 0.8432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0376 0.1885 0.4291
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0418 0.2114 0.2114
Schistosoma mansoni carbonic anhydrase 0.0095 0.0365 0.036
Toxoplasma gondii exonuclease III APE 0.0037 0.005 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0543 0.2788 0.6402
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0363 0.0357
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0136 0.0136
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0275 0.0275
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0074 0.0249 0.0536
Mycobacterium ulcerans hypothetical protein 0.0074 0.0249 0.3411
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0249 0.0847
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0121 0.0302
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0314 0.1551 0.1551
Echinococcus multilocularis carbonic anhydrase 0.0095 0.0365 0.036
Brugia malayi TAR-binding protein 0.0065 0.0204 0.0204
Echinococcus granulosus microtubule associated protein 2 0.0673 0.3492 0.3488
Loa Loa (eye worm) phosphatidylinositol 3 0.012 0.0497 0.107
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0184 0.0844 0.0839
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0249 0.0243
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.028 0.1367 0.1367
Brugia malayi Calcitonin receptor-like protein seb-1 0.0248 0.1194 0.1194
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0204 0.0204
Loa Loa (eye worm) acetyltransferase 0.0298 0.1463 0.3151
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1748 0.9316 0.9315
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.3084 0.7095
Leishmania major mitochondrial DNA polymerase beta 0.0309 0.1522 0.3517
Schistosoma mansoni hypothetical protein 0.0346 0.1725 0.172
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0228 0.1086 0.1081
Schistosoma mansoni hypothetical protein 0.0079 0.0275 0.0269
Onchocerca volvulus 0.0058 0.0163 0.319
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0248 0.1194 0.257
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0408 0.2059 0.629
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0632 0.327 0.327
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0632 0.327 0.327
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0057 0.0123
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0204 0.0439
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0543 0.2788 0.6444
Trichomonas vaginalis bromodomain-containing protein, putative 0.0088 0.0324 0.0641
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0249 0.3411
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0418 0.2114 0.2109
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0653 0.3383 1
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0249 0.0847
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.028 0.1367 0.1367
Mycobacterium ulcerans hypothetical protein 0.0163 0.073 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0263 0.3792
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0314 0.1551 0.1546
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0121 0.0115
Leishmania major hypothetical protein, unknown function 0.012 0.0497 0.1149
Trichomonas vaginalis conserved hypothetical protein 0.0348 0.1734 0.3938
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0057 0.0051
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.012 0.0497 0.0491
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0174 0.0793 0.1833
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0497 0.1046
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0184 0.0844 0.2723
Brugia malayi Bromodomain containing protein 0.0036 0.0046 0.0046
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0263 0.0257
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.012 0.0497 0.5858
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0088 0.0324 0.3792
Trichomonas vaginalis PIKK family atypical protein kinase 0.0632 0.327 0.7529
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.073 0.2891
Schistosoma mansoni microtubule-associated protein tau 0.0673 0.3492 0.3488
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0418 0.2114 0.4551
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0604 0.3122 0.7216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.1847 0.4203
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0604 0.3122 0.7216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0147 0.0645 0.1392
Schistosoma mansoni hypothetical protein 0.0346 0.1725 0.172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0403 0.2033 0.4638
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.012 0.0497 0.0497
Trichomonas vaginalis PIKK family atypical protein kinase 0.0314 0.1551 0.3511
Giardia lamblia Hypothetical protein 0.012 0.0497 0.1504
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0216 0.102 0.3106
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0632 0.327 0.3266
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0263 0.0836
Schistosoma mansoni carbonic anhydrase-related 0.0095 0.0365 0.036
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0348 0.1734 0.5613
Toxoplasma gondii ABC1 family protein 0.0074 0.0249 0.0789
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0249 0.0576
Schistosoma mansoni hypothetical protein 0.0418 0.2114 0.2109
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0632 0.327 0.3266
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0248 0.1194 0.1194
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0418 0.2114 0.2114
Loa Loa (eye worm) hypothetical protein 0.0074 0.0249 0.0536
Loa Loa (eye worm) phosphatidylinositol 3 0.012 0.0497 0.107
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0249 0.0847
Echinococcus granulosus GPCR family 2 0.0079 0.0275 0.0269
Loa Loa (eye worm) hypothetical protein 0.0074 0.0249 0.0536
Entamoeba histolytica hypothetical protein 0.0556 0.2861 0.8432
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0497 0.1046
Onchocerca volvulus 0.012 0.0497 1
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.012 0.0497 0.5858
Mycobacterium leprae conserved hypothetical protein 0.012 0.0497 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0314 0.1551 0.1546
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.1084 0.1079
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.012 0.0497 0.0491
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0505 0.2582 0.5921
Loa Loa (eye worm) RNA binding protein 0.0065 0.0204 0.0439
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.012 0.0497 0.0497
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0598 0.309 0.912
Trichomonas vaginalis PIKK family atypical protein kinase 0.0577 0.2974 0.6837
Toxoplasma gondii target of rapamycin (TOR), putative 0.0597 0.3084 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0184 0.0844 0.1818
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0275 0.0269
Loa Loa (eye worm) hypothetical protein 0.0428 0.2168 0.4668
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0249 0.0243
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1874 1 1
Onchocerca volvulus 0.012 0.0497 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0533 0.2735 0.8057
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0249 0.0466
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0418 0.2114 0.2109
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0249 0.0249
Echinococcus multilocularis carbonic anhydrase 0.0095 0.0365 0.036
Echinococcus granulosus carbonic anhydrase 0.0095 0.0365 0.036
Loa Loa (eye worm) hypothetical protein 0.0195 0.0903 0.1945
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0184 0.0844 0.2723
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0632 0.327 0.966
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0632 0.327 0.966
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.012 0.0497 0.1595
Loa Loa (eye worm) hypothetical protein 0.017 0.0768 0.1654
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0006 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0228 0.1086 0.2423
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0632 0.327 0.7558
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.028 0.1367 0.308
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0263 1
Loa Loa (eye worm) hypothetical protein 0.0284 0.1388 0.2988
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0095 0.0365 0.0365
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0184 0.0844 0.0839
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0249 0.0466
Echinococcus multilocularis geminin 0.0346 0.1725 0.172
Loa Loa (eye worm) phosphatidylinositol 3 0.0161 0.0719 0.1548
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.012 0.0497 0.0497
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0275 0.0591
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0184 0.0844 0.0844
Plasmodium falciparum phosphatidylinositol 4-kinase 0.012 0.0497 0.5858
Trichomonas vaginalis PIKK family atypical protein kinase 0.0369 0.1847 0.4203
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.005 0.0133
Mycobacterium tuberculosis Conserved hypothetical protein 0.012 0.0497 0.1901
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0827 0.4327 1
Brugia malayi beta-lactamase family protein 0.0074 0.0249 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.057 0.2936 0.6749
Leishmania major hypothetical protein, conserved 0.0074 0.0249 0.0576
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0204 0.0198
Schistosoma mansoni hypothetical protein 0.012 0.0497 0.0491
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0228 0.1084 0.1079
Loa Loa (eye worm) hypothetical protein 0.0348 0.1734 0.3733
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0184 0.0844 0.0839
Leishmania major phosphatidylinositol 3-kinase, putative 0.0543 0.2788 0.6444
Schistosoma mansoni hypothetical protein 0.0109 0.0441 0.0435
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0088 0.0324 0.0641
Trichomonas vaginalis PIKK family atypical protein kinase 0.057 0.2936 0.6748
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0184 0.0844 0.1951
Echinococcus multilocularis peregrin 0.0036 0.0046 0.004
Echinococcus granulosus dnaJ subfamily B 0.0418 0.2114 0.2109
Loa Loa (eye worm) phosphatidylinositol 3 0.0885 0.4644 1
Mycobacterium tuberculosis Conserved protein 0.0074 0.0249 0.0847
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0263 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.005 0.0115
Mycobacterium leprae Probable lipase LipE 0.0074 0.0249 0.341
Loa Loa (eye worm) phosphatidylinositol 3 0.012 0.0497 0.107
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0184 0.0844 0.1858
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.005 0.0044
Loa Loa (eye worm) hypothetical protein 0.0074 0.0249 0.0536
Schistosoma mansoni ap endonuclease 0.0037 0.005 0.0044
Brugia malayi latrophilin 2 splice variant baaae 0.017 0.0768 0.0768
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0632 0.327 0.7558
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0632 0.327 0.7558
Mycobacterium tuberculosis Conserved protein 0.0074 0.0249 0.0847
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.012 0.0497 0.0491
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0418 0.2114 0.2114
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0249 0.0466
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0314 0.1551 0.1551
Loa Loa (eye worm) phosphatidylinositol 3 0.012 0.0497 0.107
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.005 0.0115
Echinococcus granulosus serine protein kinase ATM 0.0314 0.1551 0.1546
Plasmodium vivax hypothetical protein 0.012 0.0497 0.5858
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0249 0.0249
Toxoplasma gondii hypothetical protein 0.005 0.0119 0.0367
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0505 0.2582 0.5921
Schistosoma mansoni hypothetical protein 0.0079 0.0275 0.0269
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0375 0.1882 0.435
Brugia malayi Probable ClpP-like protease 0.0076 0.0263 0.0263
Brugia malayi acetyltransferase, GNAT family protein 0.0298 0.1463 0.1463
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0632 0.327 0.327
Echinococcus multilocularis carbonic anhydrase II 0.0418 0.2114 0.2109
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0428 0.2168 0.2163
Giardia lamblia Histone acetyltransferase GCN5 0.008 0.0284 0.0853
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.3084 0.7095
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0275 0.0269
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0184 0.0844 0.0839
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.012 0.0497 0.0491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0604 0.3121 0.7183
Echinococcus granulosus carbonic anhydrase 0.0095 0.0365 0.036
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0653 0.3383 0.3383
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0184 0.0844 0.1951
Trichomonas vaginalis PIKK family atypical protein kinase 0.0195 0.0903 0.1996
Trichomonas vaginalis PIKK family atypical protein kinase 0.0604 0.3121 0.7183
Echinococcus granulosus histone acetyltransferase KAT2B 0.0088 0.0324 0.0318
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0068 0.0061
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0204 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0543 0.2788 0.6402
Loa Loa (eye worm) carbonic anhydrase 3 0.0418 0.2114 0.4551
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0249 0.2899
Echinococcus granulosus cpg binding protein 0.0061 0.0181 0.0175
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0263 0.5
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0249 0.0847
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0249 0.341
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.012 0.0497 0.1046
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.005 0.0519
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0329 0.1633 0.1633
Plasmodium vivax hypothetical protein, conserved 0.012 0.0497 0.5858
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0228 0.1084 0.2334
Echinococcus granulosus carbonic anhydrase 0.0095 0.0365 0.036
Leishmania major hypothetical protein, conserved 0.012 0.0497 0.1149
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0228 0.1084 0.1079
Loa Loa (eye worm) hypothetical protein 0.0076 0.0263 0.0567
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0057 0.0051
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.005 0.0519
Entamoeba histolytica hypothetical protein 0.0109 0.0441 0.1175
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.012 0.0497 0.0497
Schistosoma mansoni carbonic anhydrase-related 0.0095 0.0365 0.036
Loa Loa (eye worm) beta-lactamase 0.0074 0.0249 0.0536
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.028 0.1367 0.3951
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0184 0.0844 0.0844
Trichomonas vaginalis PIKK family atypical protein kinase 0.0577 0.2974 0.6837
Brugia malayi hypothetical protein 0.0109 0.0441 0.0441
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0263 0.3608
Leishmania major phosphatidylinositol 4-kinase, putative 0.012 0.0497 0.1149
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.1084 0.1079
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.028 0.1367 0.308
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0641 0.0641
Loa Loa (eye worm) phosphatidylinositol 3 0.0632 0.327 0.704
Loa Loa (eye worm) hypothetical protein 0.0095 0.0365 0.0787
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.005 0.0107
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0982 0.5167 0.5164
Entamoeba histolytica hypothetical protein 0.0109 0.0441 0.1175
Schistosoma mansoni fkbp-rapamycin associated protein 0.0314 0.1551 0.1546
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.3084 0.7095
Leishmania major phosphatidylinositol kinase related protein, putative 0.012 0.0497 0.1149
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.005 0.005
Brugia malayi Cytochrome P450 family protein 0.0059 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0074 0.0249 0.0536
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1874 1 1
Echinococcus granulosus tar DNA binding protein 0.0065 0.0204 0.0198
Onchocerca volvulus 0.0074 0.0249 0.4949
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0173 0.0373
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.012 0.0497 0.0491
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0441 0.0435
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0029 0.0006 0.0013
Onchocerca volvulus 0.0074 0.0249 0.4949
Echinococcus multilocularis 0.012 0.0497 0.0491
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.012 0.0497 0.0497
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0314 0.1551 0.1546
Trichomonas vaginalis PIKK family atypical protein kinase 0.0604 0.3121 0.7183
Echinococcus granulosus histone acetyltransferase KAT2B 0.029 0.1418 0.1413
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0653 0.3383 0.7794
Echinococcus multilocularis cpg binding protein 0.0061 0.0181 0.0175
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0263 0.3071
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0084 0.0084
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0298 0.1463 0.1458
Echinococcus multilocularis serine protein kinase ATM 0.0314 0.1551 0.1546
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1874 1 1
Loa Loa (eye worm) hypothetical protein 0.0228 0.1086 0.2338
Loa Loa (eye worm) hypothetical protein 0.0224 0.1064 0.2291
Brugia malayi FAT domain containing protein 0.0228 0.1086 0.1086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0543 0.2788 0.6402
Trypanosoma cruzi target of rapamycin kinase 3 0.0604 0.3122 0.3122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0314 0.1551 0.3511
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.3084 0.7095
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.012 0.0497 0.1595
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0428 0.2168 0.2163
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0184 0.0844 0.2384
Plasmodium falciparum carbonic anhydrase 0.0095 0.0365 0.4288
Echinococcus granulosus carbonic anhydrase II 0.0418 0.2114 0.2109
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0653 0.3383 0.3383
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0184 0.0844 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0428 0.2168 0.2168
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0184 0.0844 0.0844
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0298 0.1463 0.1458
Echinococcus granulosus geminin 0.0346 0.1725 0.172
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.012 0.0497 0.1342
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.012 0.0497 0.1595
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0184 0.0844 0.1858
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0057 0.0051
Schistosoma mansoni carbonic anhydrase-related 0.0095 0.0365 0.036
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0441 0.0435
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.012 0.0497 0.0497
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0184 0.0844 0.0839
Mycobacterium tuberculosis Conserved protein 0.0074 0.0249 0.0847
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0263 0.0257
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0653 0.3383 0.3383
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.028 0.1367 0.1362
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.012 0.0497 0.0491
Entamoeba histolytica hypothetical protein 0.012 0.0497 0.1342
Echinococcus granulosus jumonji domain containing protein 0.004 0.0068 0.0061
Brugia malayi CXXC zinc finger family protein 0.0058 0.0163 0.0163
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.012 0.0497 0.1046
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1874 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0161 0.0719 0.0719
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0095 0.0365 0.0365
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0314 0.1551 0.3585
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0249 0.0243
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0095 0.0365 0.0787
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0314 0.1551 0.1551
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.005 0.0679
Brugia malayi RNA binding protein 0.0065 0.0204 0.0204
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0249 0.0243
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0121 0.0302
Echinococcus multilocularis microtubule associated protein 2 0.0673 0.3492 0.3488
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0314 0.1551 0.1551
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.0514 0.0508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0632 0.327 0.7529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.3084 0.7095
Mycobacterium ulcerans beta-lactamase 0.0074 0.0249 0.3411
Trichomonas vaginalis PIKK family atypical protein kinase 0.057 0.2936 0.6748
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0228 0.1086 0.1081
Giardia lamblia GTOR 0.0632 0.327 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0204 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.3084 0.7095
Entamoeba histolytica hypothetical protein 0.0109 0.0441 0.1175
Loa Loa (eye worm) phosphatidylinositol kinase 0.012 0.0497 0.107
Loa Loa (eye worm) hypothetical protein 0.0284 0.1388 0.2988
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.012 0.0497 0.5858
Trichomonas vaginalis PIKK family atypical protein kinase 0.0597 0.3084 0.7095
Toxoplasma gondii FATC domain-containing protein 0.0314 0.1551 0.5019

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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