TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 543.652 | Formula: C36H33NO4
H donors: 1 H acceptors: 3 LogP: 6.27 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: O=C(N1C[C@@H]2[C@@](C1)(C(=O)O)[C@@H]1CC[C@@]2(c2ccccc2)c2c1cccc2)Cc1ccccc1OCc1ccccc1
InChi: 1S/C36H33NO4/c38-33(21-26-13-7-10-18-31(26)41-23-25-11-3-1-4-12-25)37-22-32-35(27-14-5-2-6-15-27)20-19-30(36(32,24-37)34(39)40)28-16-8-9-17-29(28)35/h1-18,30,32H,19-24H2,(H,39,40)/t30-,32+,35-,36+/m1/s1
InChiKey: MIYGFNUNHXJSNN-FZLNFISESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tubulin alpha chain	0.0882	0.7499	0.7496
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0035	0.0148	0.0138
Brugia malayi	Cathepsin L-like precursor	0.0019	0.001	0.001
Plasmodium falciparum	alpha tubulin 1	0.0882	0.7499	0.7496
Schistosoma mansoni	hypothetical protein	0.0189	0.1481	0.1472
Schistosoma mansoni	tubulin subunit beta	0.0302	0.2463	0.2455
Leishmania major	beta tubulin	0.117	1	1
Loa Loa (eye worm)	hypothetical protein	0.0188	0.1473	0.1464
Echinococcus granulosus	Tubulin alpha 1 chain	0.0882	0.7499	0.7496
Toxoplasma gondii	beta tubulin	0.117	1	1
Trypanosoma brucei	beta tubulin	0.117	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0067	0.0425	0.0415
Echinococcus granulosus	Tubulin beta 2C chain	0.117	1	1
Loa Loa (eye worm)	alpha-tubulin	0.0882	0.7499	0.7496
Trypanosoma brucei	alpha tubulin	0.0882	0.7499	0.7477
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.048	0.0397
Trypanosoma brucei	beta tubulin	0.117	1	1
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.117	1	1
Echinococcus granulosus	tubulin alpha chain	0.0882	0.7499	0.7496
Brugia malayi	bHLH-PAS transcription factor	0.0041	0.0202	0.0202
Trichomonas vaginalis	tubulin gamma chain, putative	0.0302	0.2463	0.2455
Echinococcus granulosus	tubulin alpha chain	0.0882	0.7499	0.7496
Leishmania major	alpha tubulin	0.0882	0.7499	0.7496
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0679	0.574	0.5735
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0086	0.0076
Brugia malayi	Tubulin alpha chain	0.0882	0.7499	0.7499
Toxoplasma gondii	isocitrate dehydrogenase	0.0035	0.0148	0.0138
Plasmodium falciparum	tubulin beta chain	0.117	1	1
Entamoeba histolytica	tubulin alpha chain, putative	0.0882	0.7499	0.7496
Trypanosoma brucei	alpha tubulin	0.0882	0.7499	0.7477
Trypanosoma brucei	beta tubulin	0.117	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.048	0.0397
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.001	0.001
Leishmania major	alpha tubulin	0.0882	0.7499	0.7496
Trichomonas vaginalis	tubulin alpha chain, putative	0.0356	0.2937	0.293
Leishmania major	beta tubulin	0.117	1	1
Trypanosoma cruzi	alpha tubulin, putative	0.0882	0.7499	0.7496
Trichomonas vaginalis	tubulin gamma chain, putative	0.117	1	1
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0035	0.0148	0.0138
Plasmodium vivax	tubulin alpha chain, putative	0.0882	0.7499	0.7496
Echinococcus granulosus	Tubulin alpha 1 chain	0.0882	0.7499	0.7496
Leishmania major	cathepsin L-like protease	0.0073	0.048	0.047
Echinococcus granulosus	tubulin alpha 3 chain	0.0882	0.7499	0.7496
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.048	0.047
Leishmania major	alpha tubulin	0.0882	0.7499	0.7496
Echinococcus granulosus	tubulin alpha 1C chain	0.0882	0.7499	0.7496
Trichomonas vaginalis	tubulin beta chain, putative	0.117	1	1
Echinococcus multilocularis	tubulin subunit TubB	0.0882	0.7499	0.7496
Trichomonas vaginalis	tubulin alpha chain, putative	0.0356	0.2937	0.293
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0525	0.4405	0.4399
Echinococcus granulosus	Tubulin beta 2C chain	0.117	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.048	0.0397
Echinococcus multilocularis	tubulin alpha	0.0658	0.5557	0.5553
Leishmania major	alpha tubulin	0.0882	0.7499	0.7496
Loa Loa (eye worm)	tubulin beta-4 chain	0.117	1	1
Leishmania major	alpha tubulin	0.0882	0.7499	0.7496
Echinococcus granulosus	tubulin alpha chain	0.0882	0.7499	0.7496
Echinococcus multilocularis	Tubulin beta 2C chain	0.117	1	1
Plasmodium vivax	tubulin epsilon chain, putative	0.0718	0.608	0.6076
Echinococcus multilocularis	tubulin alpha 3 chain	0.0882	0.7499	0.7496
Loa Loa (eye worm)	alpha-tubulin	0.0882	0.7499	0.7496
Brugia malayi	Tubulin beta chain	0.0302	0.2463	0.2463
Trypanosoma cruzi	major cysteine proteinase, putative	0.0058	0.0344	0.0334
Schistosoma mansoni	single-minded	0.0056	0.0329	0.0319
Brugia malayi	isocitrate dehydrogenase	0.0035	0.0148	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0525	0.4405	0.4399
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0035	0.0148	0.0138
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0035	0.0148	0.0062
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0266	0.2156	0.2148
Trypanosoma cruzi	zeta tubulin, putative	0.0933	0.7941	0.7939
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0302	0.2463	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0086	0.0076
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0882	0.7499	0.7496
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.048	0.047
Brugia malayi	hypoxia-induced factor 1	0.0173	0.1346	0.1346
Echinococcus multilocularis	tubulin alpha chain	0.0882	0.7499	0.7496
Leishmania major	alpha tubulin	0.0882	0.7499	0.7496
Echinococcus granulosus	tubulin beta 1 chain	0.117	1	1
Leishmania major	beta tubulin	0.117	1	1
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0882	0.7499	0.7496
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.048	0.0397
Schistosoma mansoni	tubulin subunit beta	0.117	1	1
Echinococcus granulosus	beta tubulin	0.117	1	1
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0035	0.0148	0.0138
Echinococcus granulosus	beta tubulin	0.117	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0882	0.7499	0.7496
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0035	0.0148	0.0138
Giardia lamblia	Alpha-tubulin	0.0882	0.7499	0.6681
Echinococcus granulosus	peroxisome assembly protein 26	0.0882	0.7499	0.7496
Giardia lamblia	Alpha-tubulin	0.0882	0.7499	0.6681
Leishmania major	cathepsin L-like protease	0.0073	0.048	0.047
Loa Loa (eye worm)	hypothetical protein	0.058	0.4879	0.4874
Leishmania major	cathepsin L-like protease	0.0073	0.048	0.047
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0035	0.0148	0.0062
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.048	0.0397
Echinococcus multilocularis	tubulin delta chain	0.0302	0.2463	0.2455
Trichomonas vaginalis	tubulin beta chain, putative	0.0882	0.7499	0.7496
Leishmania major	alpha tubulin	0.0882	0.7499	0.7496
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.048	0.0397
Schistosoma mansoni	tubulin subunit beta	0.117	1	1
Leishmania major	delta tubulin, putative	0.0679	0.574	0.5735
Brugia malayi	Cathepsin L-like precursor	0.0019	0.001	0.001
Trichomonas vaginalis	tubulin, putative	0.0356	0.2937	0.293
Leishmania major	beta tubulin	0.117	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0718	0.608	0.6076
Echinococcus granulosus	tubulin alpha 1C chain	0.0882	0.7499	0.7496
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0525	0.4405	0.4399
Echinococcus granulosus	tubulin alpha chain	0.0882	0.7499	0.7496
Schistosoma mansoni	transcription factor LCR-F1	0.008	0.0538	0.0528
Loa Loa (eye worm)	tubulin alpha 2	0.058	0.4879	0.4874
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0035	0.0148	0.0138
Entamoeba histolytica	tubulin family protein	0.117	1	1
Toxoplasma gondii	beta-1 tubulin, putative	0.117	1	1
Echinococcus granulosus	tubulin alpha chain	0.0882	0.7499	0.7496
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0362	0.2986	0.2979
Mycobacterium leprae	cell division protein FtsZ	0.0302	0.2463	0.5
Schistosoma mansoni	alpha tubulin	0.0882	0.7499	0.7496
Brugia malayi	Cell division protein ftsZ	0.0302	0.2463	0.2463
Trypanosoma brucei	alpha tubulin	0.0882	0.7499	0.7477
Loa Loa (eye worm)	hypothetical protein	0.0882	0.7499	0.7496
Echinococcus multilocularis	tubulin gamma 1 chain	0.0719	0.6088	0.6084
Brugia malayi	tubulin alpha-2 chain	0.0882	0.7499	0.7499
Leishmania major	epsilon tubulin, putative	0.0718	0.608	0.6076
Loa Loa (eye worm)	tubulin alpha 2	0.0224	0.1785	0.1776
Brugia malayi	Tubulin alpha-2 chain	0.0882	0.7499	0.7499
Leishmania major	beta tubulin	0.117	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0356	0.2937	0.293
Loa Loa (eye worm)	BEN-1 protein	0.117	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.117	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.048	0.0397
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0086	0.0076
Echinococcus multilocularis	Tubulin beta 2C chain	0.117	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0086	0.0076
Treponema pallidum	cell division protein FtsZ	0.0302	0.2463	0.5
Echinococcus granulosus	tubulin beta 4A class IVa	0.117	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0302	0.2463	0.2455
Echinococcus granulosus	alpha tubulin	0.0882	0.7499	0.7496
Giardia lamblia	Beta tubulin	0.117	1	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.008	0.0538	0.0528
Loa Loa (eye worm)	tubulin beta chain	0.0302	0.2463	0.2455
Loa Loa (eye worm)	tubulin beta chain	0.117	1	1
Plasmodium falciparum	tubulin gamma chain	0.0719	0.6088	0.6084
Echinococcus multilocularis	beta tubulin	0.117	1	1
Brugia malayi	Tubulin alpha chain	0.0302	0.2463	0.2463
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.0086	0.0076
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0882	0.7499	0.7496
Trichomonas vaginalis	tubulin alpha chain, putative	0.0356	0.2937	0.293
Brugia malayi	follicle stimulating hormone receptor	0.0266	0.2156	0.2156
Mycobacterium ulcerans	cell division protein FtsZ	0.0302	0.2463	1
Trichomonas vaginalis	tubulin, putative	0.117	1	1
Giardia lamblia	Beta tubulin	0.117	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0302	0.2463	0.2455
Echinococcus multilocularis	Tubulin beta 2C chain	0.117	1	1
Leishmania major	beta tubulin	0.117	1	1
Plasmodium vivax	tubulin beta chain, putative	0.117	1	1
Echinococcus granulosus	tubulin subunit TubB	0.0882	0.7499	0.7496
Echinococcus granulosus	Tubulin beta 2C chain	0.117	1	1
Leishmania major	beta tubulin	0.117	1	1
Echinococcus granulosus	tubulin alpha	0.0658	0.5557	0.5553
Echinococcus multilocularis	hypothetical protein	0.0882	0.7499	0.7496
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.048	0.0397
Brugia malayi	hypothetical protein	0.0188	0.1473	0.1473
Entamoeba histolytica	hypothetical protein	0.008	0.0538	0.0528
Brugia malayi	Cathepsin L-like precursor	0.0019	0.001	0.001
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0035	0.0148	0.0138
Trichomonas vaginalis	tubulin, putative	0.0356	0.2937	0.293
Entamoeba histolytica	hypothetical protein	0.008	0.0538	0.0528
Schistosoma mansoni	tubulin subunit alpha	0.0882	0.7499	0.7496
Echinococcus granulosus	Tubulin beta 2C chain	0.117	1	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0882	0.7499	0.7496
Schistosoma mansoni	tubulin subunit alpha	0.0882	0.7499	0.7496
Echinococcus multilocularis	Tubulin beta 2C chain	0.117	1	1
Leishmania major	beta tubulin	0.117	1	1
Trypanosoma brucei	tubulin gamma chain	0.0719	0.6088	0.6054
Entamoeba histolytica	hypothetical protein	0.008	0.0538	0.0528
Plasmodium vivax	tubulin gamma chain, putative	0.0719	0.6088	0.6084
Brugia malayi	tubulin alpha chain - mouse	0.0882	0.7499	0.7499
Echinococcus granulosus	geminin	0.0189	0.1481	0.1472
Brugia malayi	beta-tubulin, identical	0.117	1	1
Trypanosoma cruzi	tubulin gamma chain	0.0719	0.6088	0.6084
Giardia lamblia	Gamma tubulin	0.0719	0.6088	0.4809
Echinococcus multilocularis	Tubulin beta 2C chain	0.117	1	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0035	0.0148	0.0138
Trypanosoma brucei	epsilon tubulin	0.0658	0.5557	0.5519
Trichomonas vaginalis	tubulin epsilon chain, putative	0.117	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0356	0.2937	0.293
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0882	0.7499	0.7496
Brugia malayi	Tubulin gamma chain	0.0719	0.6088	0.6088
Toxoplasma gondii	beta-tubulin, putative	0.117	1	1
Echinococcus multilocularis	geminin	0.0189	0.1481	0.1472
Giardia lamblia	Epsilon tubulin	0.0362	0.2986	0.0694
Plasmodium vivax	tubulin alpha chain, putative	0.0882	0.7499	0.7496
Echinococcus granulosus	Tubulin alpha 1 chain	0.0882	0.7499	0.7496
Trypanosoma brucei	epsilon tubulin	0.0718	0.608	0.6046
Schistosoma mansoni	aryl hydrocarbon receptor	0.0056	0.0329	0.0319
Brugia malayi	Isocitrate dehydrogenase	0.0035	0.0148	0.0148
Echinococcus multilocularis	beta tubulin	0.117	1	1
Onchocerca volvulus		0.0356	0.2937	1
Schistosoma mansoni	tubulin subunit epsilon	0.0718	0.608	0.6076
Trichomonas vaginalis	tubulin beta chain, putative	0.0882	0.7499	0.7496
Schistosoma mansoni	hypothetical protein	0.0189	0.1481	0.1472
Echinococcus multilocularis	transfer RNA-Lys	0.0041	0.0202	0.0193
Echinococcus granulosus	tubulin gamma 1 chain	0.0719	0.6088	0.6084
Leishmania major	beta tubulin	0.117	1	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0658	0.5557	0.5553
Trypanosoma cruzi	beta tubulin, putative	0.117	1	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0718	0.608	0.6076
Loa Loa (eye worm)	beta-tubulin	0.117	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0073	0.048	0.047
Trichomonas vaginalis	tubulin alpha chain, putative	0.0658	0.5557	0.5553
Leishmania major	alpha tubulin	0.0882	0.7499	0.7496
Brugia malayi	Tubulin beta chain	0.0356	0.2937	0.2937
Giardia lamblia	Beta tubulin	0.117	1	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.0104	0.0094
Brugia malayi	Tubulin alpha-2 chain	0.0882	0.7499	0.7499
Plasmodium falciparum	tubulin epsilon chain, putative	0.0718	0.608	0.6076
Leishmania major	beta tubulin	0.117	1	1
Brugia malayi	Cathepsin L-like precursor	0.0019	0.001	0.001
Toxoplasma gondii	alpha-tubulin I, putative	0.0882	0.7499	0.7496
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.058	0.4879	0.4874
Trypanosoma cruzi	epsilon tubulin, putative	0.0718	0.608	0.6076
Brugia malayi	alpha-tubulin	0.0882	0.7499	0.7499
Trichomonas vaginalis	tubulin beta chain, putative	0.0882	0.7499	0.7496
Trypanosoma brucei	epsilon tubulin	0.0718	0.608	0.6046
Leishmania major	beta tubulin	0.117	1	1
Trypanosoma cruzi	tubulin delta chain	0.0679	0.574	0.5735
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0302	0.2463	0.5
Leishmania major	alpha tubulin	0.0882	0.7499	0.7496
Toxoplasma gondii	isocitrate dehydrogenase	0.0035	0.0148	0.0138
Trypanosoma cruzi	tubulin delta chain	0.0679	0.574	0.5735
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0035	0.0148	0.0138
Trypanosoma cruzi	zeta tubulin, putative	0.0933	0.7941	0.7939
Loa Loa (eye worm)	tubulin beta-2A chain	0.117	1	1
Echinococcus multilocularis	tubulin subunit beta	0.117	1	1
Brugia malayi	hypothetical protein	0.0028	0.0086	0.0086
Leishmania major	alpha tubulin	0.0882	0.7499	0.7496
Brugia malayi	PAS domain containing protein	0.0056	0.0329	0.0329
Trichomonas vaginalis	tubulin beta chain, putative	0.0882	0.7499	0.7496
Trypanosoma brucei	beta tubulin	0.0658	0.5557	0.5519
Trypanosoma brucei	alpha tubulin	0.0882	0.7499	0.7477
Entamoeba histolytica	hypothetical protein	0.008	0.0538	0.0528
Loa Loa (eye worm)	tubulin alpha chain	0.0882	0.7499	0.7496
Echinococcus granulosus	Tubulin beta 2C chain	0.117	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0882	0.7499	0.7496
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0302	0.2463	0.2455
Leishmania major	alpha tubulin	0.0882	0.7499	0.7496
Echinococcus multilocularis	tubulin alpha 1C chain	0.0882	0.7499	0.7496
Trichomonas vaginalis	tubulin beta chain, putative	0.0882	0.7499	0.7496
Echinococcus multilocularis	tubulin alpha chain	0.0882	0.7499	0.7496
Entamoeba histolytica	tubulin alpha-1 chain	0.0882	0.7499	0.7496
Schistosoma mansoni	tubulin subunit beta	0.117	1	1
Loa Loa (eye worm)	tubulin alpha 2	0.058	0.4879	0.4874
Schistosoma mansoni	alpha tubulin	0.0882	0.7499	0.7496
Schistosoma mansoni	alpha tubulin	0.0882	0.7499	0.7496
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0173	0.1346	0.1338
Trypanosoma brucei	tubulin delta chain	0.0679	0.574	0.5703
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.048	0.047
Leishmania major	zeta tubulin, putative	0.0933	0.7941	0.7939
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0035	0.0148	0.0138
Echinococcus multilocularis	tubulin alpha 1C chain	0.0882	0.7499	0.7496
Leishmania major	gamma-tubulin	0.0719	0.6088	0.6084
Trichomonas vaginalis	tubulin alpha chain, putative	0.117	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0882	0.7499	0.7496
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.048	0.0397
Echinococcus multilocularis	tubulin alpha chain	0.0882	0.7499	0.7496
Brugia malayi	Cathepsin L-like precursor	0.0019	0.001	0.001
Leishmania major	beta tubulin	0.117	1	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0086	0.0076
Schistosoma mansoni	tubulin subunit beta	0.117	1	1
Leishmania major	beta tubulin	0.117	1	1
Trypanosoma brucei	beta tubulin	0.117	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0719	0.6088	0.6084
Echinococcus granulosus	tubulin delta chain	0.0302	0.2463	0.2455
Schistosoma mansoni	tubulin subunit delta	0.0302	0.2463	0.2455
Leishmania major	beta tubulin	0.117	1	1
Trypanosoma brucei	zeta tubulin, putative	0.0933	0.7941	0.7923
Leishmania major	beta tubulin	0.117	1	1
Schistosoma mansoni	hypothetical protein	0.008	0.0538	0.0528
Plasmodium falciparum	alpha tubulin 2	0.0882	0.7499	0.7496
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0882	0.7499	0.7496
Trichomonas vaginalis	tubulin beta chain, putative	0.0882	0.7499	0.7496
Schistosoma mansoni	tubulin subunit alpha	0.0302	0.2463	0.2455
Echinococcus granulosus	single minded 2	0.0041	0.0202	0.0193
Plasmodium falciparum	tubulin delta chain, putative	0.0302	0.2463	0.2455
Schistosoma mansoni	tubulin subunit beta	0.117	1	1
Leishmania major	alpha tubulin	0.0882	0.7499	0.7496
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0882	0.7499	0.7496
Schistosoma mansoni	tubulin subunit beta	0.117	1	1
Leishmania major	beta tubulin	0.117	1	1
Entamoeba histolytica	tubulin family protein	0.117	1	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0035	0.0148	0.0138
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.058	0.4879	0.4874
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.008	0.0538	0.0528
Plasmodium vivax	delta tubulin, putative	0.0302	0.2463	0.2455
Echinococcus granulosus	tubulin epsilon chain	0.0718	0.608	0.6076
Leishmania major	beta tubulin	0.117	1	1
Trichomonas vaginalis	tubulin, putative	0.0363	0.2994	0.2986
Schistosoma mansoni	tubulin subunit gamma	0.0719	0.6088	0.6084
Brugia malayi	Cathepsin L-like precursor	0.0019	0.001	0.001
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0302	0.2463	0.2455
Echinococcus multilocularis	tubulin beta 1 chain	0.117	1	1
Loa Loa (eye worm)	tubulin gamma chain	0.0719	0.6088	0.6084
Leishmania major	beta tubulin	0.117	1	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.117	1	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0882	0.7499	0.7496
Entamoeba histolytica	tubulin gamma chain	0.0719	0.6088	0.6084
Leishmania major	hypothetical protein, conserved	0.0028	0.0086	0.0076
Toxoplasma gondii	alpha tubulin TUBA1	0.0882	0.7499	0.7496
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.048	0.0397
Loa Loa (eye worm)	tubulin alpha chain	0.0882	0.7499	0.7496
Brugia malayi	hypothetical protein	0.008	0.0538	0.0538
Trypanosoma brucei	zeta tubulin	0.0933	0.7941	0.7923
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0035	0.0148	0.0138
Onchocerca volvulus		0.0041	0.0202	0.0657
Brugia malayi	Cytochrome P450 family protein	0.003	0.0104	0.0104
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.048	0.0397
Trypanosoma brucei	alpha tubulin, putative	0.0356	0.2937	0.2876
Toxoplasma gondii	tubulin, putative	0.006	0.0366	0.0356
Echinococcus multilocularis	isocitrate dehydrogenase	0.0035	0.0148	0.0138
Echinococcus multilocularis	tubulin epsilon chain	0.0718	0.608	0.6076
Toxoplasma gondii	LsmAD domain-containing protein	0.0028	0.0086	0.0076
Loa Loa (eye worm)	BEN-1 protein	0.117	1	1
Echinococcus multilocularis	peroxisome assembly protein 26	0.0882	0.7499	0.7496
Echinococcus granulosus	tubulin subunit beta	0.117	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 30 uM	Binding affinity of the compound against Ras protein	ChEMBL.	10794697
Ki (binding)	= 32 uM	Inhibition of farnesyltransferase by Ras/SPA assay	ChEMBL.	10794697
Ki (binding)	= 32 uM	Inhibition of farnesyltransferase by Ras/SPA assay	ChEMBL.	10794697

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 76245