Detailed information for compound 765058

Basic information

Technical information
  • TDR Targets ID: 765058
  • Name: (5Z)-2-furan-2-yl-5-[(4-methoxyphenyl)methyli dene]-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-on e
  • MW: 329.374 | Formula: C16H15N3O3S
  • H donors: 0 H acceptors: 3 LogP: 3.39 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C=C1SC2N(C1=O)NC(N2)c1ccco1
  • InChi: 1S/C16H11N3O3S/c1-21-11-6-4-10(5-7-11)9-13-15(20)19-16(23-13)17-14(18-19)12-3-2-8-22-12/h2-9H,1H3/b13-9-
  • InChiKey: XVJVHOIZEWIBHX-LCYFTJDESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-furan-2-yl-5-[(4-methoxyphenyl)methylidene]-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-one
  • (5Z)-2-(2-furyl)-5-[(4-methoxyphenyl)methylene]thiazolo[2,3-e][1,2,4]triazol-6-one
  • 2-(2-furyl)-5-[(4-methoxyphenyl)methylene]thiazolo[2,3-e][1,2,4]triazol-6-one
  • 2-(2-furyl)-5-[(4-methoxyphenyl)methylene]-6-thiazolo[2,3-e][1,2,4]triazolone
  • (5Z)-2-(2-furyl)-5-[(4-methoxyphenyl)methylene]-6-thiazolo[2,3-e][1,2,4]triazolone
  • 2-(2-furyl)-5-(4-methoxybenzylidene)thiazolo[2,3-e][1,2,4]triazol-6-one
  • (5Z)-2-(2-furyl)-5-(4-methoxybenzylidene)thiazolo[2,3-e][1,2,4]triazol-6-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0082 0.0154 0.0153
Schistosoma mansoni hypothetical protein 0.0264 0.0608 0.0608
Onchocerca volvulus 0.0747 0.1814 0.1813
Echinococcus granulosus GPCR family 2 0.0082 0.0154 0.0154
Brugia malayi hypothetical protein 0.0074 0.0132 0.0131
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0259 0.0595 1
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0112 0.0228 0.0228
Echinococcus multilocularis tumor protein p63 0.1027 0.2514 0.2514
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0049 0.0184
Toxoplasma gondii ABC1 family protein 0.0041 0.0049 0.1598
Leishmania major hypothetical protein, conserved 0.0041 0.0049 0.0009
Entamoeba histolytica hypothetical protein 0.0074 0.0132 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0308 0.393
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0049 0.0048
Mycobacterium leprae Probable lipase LipE 0.0041 0.0049 0.1768
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0049 0.018
Brugia malayi PHD-finger family protein 0.0026 0.0014 0.0013
Toxoplasma gondii hypothetical protein 0.0049 0.0071 0.2941
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0023 0.0037
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0075 0.0324
Schistosoma mansoni sodium-bile acid cotransporter related 0.1631 0.4024 0.4024
Onchocerca volvulus 0.0041 0.0049 0.0048
Entamoeba histolytica hypothetical protein 0.0074 0.0132 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0051 0.0075 0.039
Loa Loa (eye worm) hypothetical protein 0.0041 0.0049 0.0048
Entamoeba histolytica hypothetical protein 0.0074 0.0132 1
Brugia malayi TAR-binding protein 0.0192 0.0427 0.0426
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0058 0.0092 0.0786
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0001 0.0001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0132 0.0132
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0427 0.0427
Brugia malayi beta-lactamase 0.0041 0.0049 0.0048
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0049 0.1598
Echinococcus granulosus tumor protein p63 0.1027 0.2514 0.2514
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0079 0.045
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0049 0.0049
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0051 0.0075 0.0073
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0082 0.0154 0.0154
Schistosoma mansoni hypothetical protein 0.0031 0.0025 0.0025
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0154 0.0153
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0047 0.0045
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0049 0.0184
Loa Loa (eye worm) hypothetical protein 0.0178 0.0393 0.0392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0033 0.0093
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0043 0.0043
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0088 0.0168 0.0168
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0051 0.0075 0.1044
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0075 0.3224
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0049 0.0049
Brugia malayi Pre-SET motif family protein 0.0094 0.0183 0.0182
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0055 0.0769
Loa Loa (eye worm) hypothetical protein 0.0041 0.0049 0.0048
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0001 0.0001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0055 0.0096
Schistosoma mansoni jumonji domain containing protein 0.008 0.0149 0.0149
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0088 0.0168 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0008 0.0103
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0051 0.0075 0.0074
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0094 0.0183 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0049 0.0048
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0008 0.0008
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0308 0.393
Trypanosoma brucei target of rapamycin kinase 3, putative 0.004 0.0049 0.068
Loa Loa (eye worm) beta-lactamase 0.0041 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.026 0.0599 0.0597
Loa Loa (eye worm) hypothetical protein 0.0075 0.0135 0.0134
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0132 0.0132
Mycobacterium ulcerans hypothetical protein 0.016 0.0349 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0075 0.0324
Onchocerca volvulus Alhambra homolog 0.0031 0.0025 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0049 0.018
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0055 0.0055
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0058 0.0092 0.4744
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0025 0.0081
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0088 0.0168 0.5
Onchocerca volvulus 0.0094 0.0183 0.0182
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0025 0.0081
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0106 0.0106
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0001 0.0001
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.0168 0.9041
Schistosoma mansoni hypothetical protein 0.0074 0.0132 0.0132
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0025 0.0025
Entamoeba histolytica hypothetical protein 0.0074 0.0132 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0049 0.0184
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0091 0.0175 0.0175
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0427 0.0427
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0094 0.0183 0.0183
Schistosoma mansoni thyroid hormone receptor 0.0285 0.0661 0.0661
Brugia malayi latrophilin 2 splice variant baaae 0.0178 0.0393 0.0392
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0001 0.0001
Brugia malayi PHD-finger family protein 0.0031 0.0025 0.0024
Schistosoma mansoni thyroid hormone receptor 0.0285 0.0661 0.0661
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0001 0.0001
Echinococcus granulosus peregrin 0.0033 0.0032 0.0032
Echinococcus multilocularis sodium bile acid cotransporter 0.4022 1 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0055 0.0096
Schistosoma mansoni hypothetical protein 0.0023 0.0005 0.0005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0049 0.0048
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0045 0.0061 0.006
Loa Loa (eye worm) hypothetical protein 0.0053 0.008 0.0079
Giardia lamblia GTOR 0.0051 0.0075 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0042 0.0144
Brugia malayi jmjC domain containing protein 0.0101 0.0201 0.0199
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0001 0.0001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0154 0.0154
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0264 0.0608 0.0608
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0049 0.0049
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0055 0.0096
Loa Loa (eye worm) hypothetical protein 0.0043 0.0056 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0042 0.0144
Loa Loa (eye worm) hypothetical protein 0.015 0.0324 0.0323
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0049 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0049 0.018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0042 0.0144
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0075 0.3566
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.0349 0.5486
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0304 0.0709 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0001 0.0001
Leishmania major mitochondrial DNA polymerase beta 0.0304 0.0709 1
Schistosoma mansoni sodium-bile acid cotransporter 0.2391 0.5924 0.5924
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0025 0.0025
Brugia malayi Bromodomain containing protein 0.004 0.0049 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0075 0.0324
Loa Loa (eye worm) hypothetical protein 0.0112 0.0228 0.0227
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0154 0.0153
Loa Loa (eye worm) hypothetical protein 0.0041 0.0049 0.0048
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0005 0.0005
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.0168 0.3964
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.0168 0.3964
Brugia malayi beta-lactamase family protein 0.0041 0.0049 0.0048
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0241 0.024
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0132 0.0132
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0075 0.0402
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0047 0.0047
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0049 0.0184
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0001 0.0001
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0001 0.0001
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0042 0.0042
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0107 0.0106
Echinococcus granulosus peptidase Clp S14 family 0.0058 0.0092 0.0092
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0082 0.0154 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0016 0.0001
Loa Loa (eye worm) hypothetical protein 0.0088 0.0168 0.0167
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.0168 0.5
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0049 0.1768
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0024 0.0041
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0047 0.0047
Leishmania major hypothetical protein, conserved 0.0051 0.0075 0.0402
Brugia malayi hypothetical protein 0.0051 0.0075 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0183 0.0183
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0106 0.0106
Echinococcus multilocularis GPCR, family 2 0.0082 0.0154 0.0154
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0049 0.0009
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0088 0.0168 0.0168
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0264 0.0608 0.0608
Brugia malayi Probable ClpP-like protease 0.0088 0.0168 0.0167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0042 0.0144
Onchocerca volvulus 0.015 0.0324 0.0323
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0051 0.0075 0.039
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0075 0.3224
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0088 0.0168 1
Schistosoma mansoni hypothetical protein 0.0082 0.0154 0.0154
Plasmodium falciparum phd finger protein, putative 0.0031 0.0025 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.003 0.0077
Loa Loa (eye worm) hypothetical protein 0.0041 0.0049 0.0048
Schistosoma mansoni cellular tumor antigen P53 0.015 0.0324 0.0324
Brugia malayi Bromodomain containing protein 0.0033 0.0032 0.003
Echinococcus granulosus sodium bile acid cotransporter 0.4022 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0042 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0049 0.018
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0656 0.1588 0.1587
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0025 0.0025
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.0308 0.4342
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0094 0.0183 0.0183
Brugia malayi Bromodomain containing protein 0.0079 0.0146 0.0145
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0051 0.0075 0.0075
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0001 0.0001
Loa Loa (eye worm) TAR-binding protein 0.0192 0.0427 0.0426
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0024 0.0041
Brugia malayi RNA recognition motif domain containing protein 0.0192 0.0427 0.0426
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0001 0.0001
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0075 0.0402
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0154 0.0154
Schistosoma mansoni hypothetical protein 0.0082 0.0154 0.0154
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.0168 0.5
Loa Loa (eye worm) RNA binding protein 0.0192 0.0427 0.0426
Schistosoma mansoni peptidase Clp (S14 family) 0.0088 0.0168 0.0168
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0075 0.1055
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0049 0.0689
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0005 0.0005
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0051 0.0075 0.0075
Plasmodium vivax SET domain protein, putative 0.0094 0.0183 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0051 0.0075 0.039
Onchocerca volvulus 0.0041 0.0049 0.0048
Trichomonas vaginalis set domain proteins, putative 0.0747 0.1814 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0051 0.0075 0.0073
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0001 0.0001
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0008 0.0008
Brugia malayi hypothetical protein 0.0033 0.003 0.0029
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0001 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0427 0.0427
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0001 0.0001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0154 0.0154
Brugia malayi Calcitonin receptor-like protein seb-1 0.026 0.0599 0.0597
Loa Loa (eye worm) hypothetical protein 0.0041 0.005 0.0048
Echinococcus multilocularis peregrin 0.0033 0.0032 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0049 0.0009
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0154 0.0153
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.0042 0.1143
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.0709 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0051 0.0075 0.0075
Brugia malayi beta-lactamase family protein 0.0041 0.0049 0.0048
Schistosoma mansoni hypothetical protein 0.0178 0.0393 0.0393
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0001 0.0001
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0201 0.0201
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.0709 1
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0427 0.0427
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0042 0.0144
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0051 0.0075 0.039
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0201 0.0201
Brugia malayi RNA binding protein 0.0192 0.0427 0.0426
Brugia malayi MH2 domain containing protein 0.0117 0.0241 0.024
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0001 0.0001
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0051 0.0075 0.1044
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0023 0.0037
Schistosoma mansoni sodium-bile acid cotransporter related 0.4022 1 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0025 0.0081
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0241 0.024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0112 0.0228 0.0228
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0112 0.0228 0.0228
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0058 0.0092 0.0786
Loa Loa (eye worm) hypothetical protein 0.0031 0.0025 0.0024
Onchocerca volvulus 0.0041 0.0049 0.0048
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0003 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0049 0.018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0016 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0042 0.0144
Echinococcus multilocularis peptidase Clp (S14 family) 0.0058 0.0092 0.0092
Schistosoma mansoni bromodomain containing protein 0.0067 0.0115 0.0115
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0049 0.0048
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0001 0.0001
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0001 0.0001
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0001 0.0001
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.0168 0.9041
Schistosoma mansoni hypothetical protein 0.0022 0.0003 0.0003
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0088 0.0168 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0056 0.0221
Trichomonas vaginalis esterase, putative 0.0041 0.0049 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0024 0.0041
Loa Loa (eye worm) pigment dispersing factor receptor c 0.026 0.0599 0.0597
Schistosoma mansoni coup transcription factor 0.0021 0.0001 0.0001
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0025 0.0024
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0088 0.0168 0.9041
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0427 0.0427
Echinococcus multilocularis sodium bile acid cotransporter 0.4022 1 1
Echinococcus multilocularis tar DNA binding protein 0.0192 0.0427 0.0427
Echinococcus granulosus tar DNA binding protein 0.0192 0.0427 0.0427
Echinococcus multilocularis thyroid hormone receptor alpha 0.0285 0.0661 0.0661
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0192 0.0427 0.0426
Echinococcus multilocularis sodium bile acid cotransporter 0.4022 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.026 0.0599 0.0597
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0055 0.0055
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0001 0.0001
Brugia malayi jmjC domain containing protein 0.0039 0.0047 0.0045
Echinococcus granulosus sodium bile acid cotransporter 0.4022 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0001 0.0001
Echinococcus granulosus histone lysine methyltransferase setb 0.0112 0.0228 0.0228
Echinococcus granulosus sodium bile acid cotransporter 0.4022 1 1
Onchocerca volvulus 0.4022 1 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0008 0.0008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0049 0.0049
Brugia malayi Pre-SET motif family protein 0.0656 0.1588 0.1587
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.4022 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0016 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0016 0.0001
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0075 0.3566

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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