Detailed information for compound 765058

Basic information

Technical information
  • TDR Targets ID: 765058
  • Name: (5Z)-2-furan-2-yl-5-[(4-methoxyphenyl)methyli dene]-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-on e
  • MW: 329.374 | Formula: C16H15N3O3S
  • H donors: 0 H acceptors: 3 LogP: 3.39 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C=C1SC2N(C1=O)NC(N2)c1ccco1
  • InChi: 1S/C16H11N3O3S/c1-21-11-6-4-10(5-7-11)9-13-15(20)19-16(23-13)17-14(18-19)12-3-2-8-22-12/h2-9H,1H3/b13-9-
  • InChiKey: XVJVHOIZEWIBHX-LCYFTJDESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-furan-2-yl-5-[(4-methoxyphenyl)methylidene]-[1,3]thiazolo[2,3-e][1,2,4]triazol-6-one
  • (5Z)-2-(2-furyl)-5-[(4-methoxyphenyl)methylene]thiazolo[2,3-e][1,2,4]triazol-6-one
  • 2-(2-furyl)-5-[(4-methoxyphenyl)methylene]thiazolo[2,3-e][1,2,4]triazol-6-one
  • 2-(2-furyl)-5-[(4-methoxyphenyl)methylene]-6-thiazolo[2,3-e][1,2,4]triazolone
  • (5Z)-2-(2-furyl)-5-[(4-methoxyphenyl)methylene]-6-thiazolo[2,3-e][1,2,4]triazolone
  • 2-(2-furyl)-5-(4-methoxybenzylidene)thiazolo[2,3-e][1,2,4]triazol-6-one
  • (5Z)-2-(2-furyl)-5-(4-methoxybenzylidene)thiazolo[2,3-e][1,2,4]triazol-6-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Calcitonin receptor-like protein seb-1 0.026 0.0599 0.0597
Schistosoma mansoni hypothetical protein 0.0178 0.0393 0.0393
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0049 0.0184
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.0168 0.3964
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0016 0.0001
Schistosoma mansoni hypothetical protein 0.0023 0.0005 0.0005
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0001 0.0001
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0264 0.0608 0.0608
Entamoeba histolytica hypothetical protein 0.0074 0.0132 1
Loa Loa (eye worm) hypothetical protein 0.015 0.0324 0.0323
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0132 0.0132
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0049 0.0009
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0094 0.0183 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0112 0.0228 0.0228
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0049 0.018
Brugia malayi latrophilin 2 splice variant baaae 0.0178 0.0393 0.0392
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0055 0.0096
Echinococcus granulosus sodium bile acid cotransporter 0.4022 1 1
Schistosoma mansoni coup transcription factor 0.0021 0.0001 0.0001
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0025 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0049 0.018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0075 0.0324
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0049 0.0184
Loa Loa (eye worm) hypothetical protein 0.0031 0.0025 0.0024
Loa Loa (eye worm) pigment dispersing factor receptor c 0.026 0.0599 0.0597
Loa Loa (eye worm) hypothetical protein 0.4022 1 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0304 0.0709 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.004 0.0049 0.068
Schistosoma mansoni hypothetical protein 0.0082 0.0154 0.0154
Loa Loa (eye worm) beta-lactamase 0.0041 0.0049 0.0048
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0112 0.0228 0.0228
Schistosoma mansoni cellular tumor antigen P53 0.015 0.0324 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0056 0.0221
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.0168 0.5
Brugia malayi Bromodomain containing protein 0.0033 0.0032 0.003
Mycobacterium leprae Probable lipase LipE 0.0041 0.0049 0.1768
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0001 0.0001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0154 0.0153
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0264 0.0608 0.0608
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0001 0.0001
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0001 0.0001
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0043 0.0043
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0008 0.0103
Echinococcus multilocularis sodium bile acid cotransporter 0.4022 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0259 0.0595 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0047 0.0047
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0075 0.0402
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0055 0.0096
Brugia malayi Probable ClpP-like protease 0.0088 0.0168 0.0167
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0308 0.393
Echinococcus granulosus tumor protein p63 0.1027 0.2514 0.2514
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0088 0.0168 0.0168
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.026 0.0599 0.0597
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0025 0.0081
Schistosoma mansoni thyroid hormone receptor 0.0285 0.0661 0.0661
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0024 0.0041
Brugia malayi RNA binding protein 0.0192 0.0427 0.0426
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.0168 0.3964
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0132 0.0132
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0049 0.0049
Onchocerca volvulus 0.0747 0.1814 0.1813
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0079 0.045
Echinococcus multilocularis GPCR, family 2 0.0082 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0041 0.0049 0.0048
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0008 0.0008
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0005 0.0005
Onchocerca volvulus 0.4022 1 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0201 0.0201
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0051 0.0075 0.039
Echinococcus granulosus sodium bile acid cotransporter 0.4022 1 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0088 0.0168 0.9041
Schistosoma mansoni peptidase Clp (S14 family) 0.0088 0.0168 0.0168
Brugia malayi Pre-SET motif family protein 0.0094 0.0183 0.0182
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0091 0.0175 0.0175
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0074 0.0132 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0001 0.0001
Brugia malayi hypothetical protein 0.0051 0.0075 0.0074
Brugia malayi beta-lactamase 0.0041 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0075 0.0135 0.0134
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0047 0.0045
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0656 0.1588 0.1587
Brugia malayi jmjC domain containing protein 0.0039 0.0047 0.0045
Loa Loa (eye worm) hypothetical protein 0.026 0.0599 0.0597
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0001 0.0001
Schistosoma mansoni thyroid hormone receptor 0.0285 0.0661 0.0661
Schistosoma mansoni hypothetical protein 0.0082 0.0154 0.0154
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0094 0.0183 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0024 0.0041
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0075 0.1055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0042 0.0144
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.0709 1
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0003 0.0002
Giardia lamblia GTOR 0.0051 0.0075 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0112 0.0228 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0033 0.0093
Brugia malayi hypothetical protein 0.0074 0.0132 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0042 0.0144
Onchocerca volvulus 0.0041 0.0049 0.0048
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0154 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0049 0.018
Entamoeba histolytica hypothetical protein 0.0074 0.0132 1
Echinococcus multilocularis tumor protein p63 0.1027 0.2514 0.2514
Loa Loa (eye worm) hypothetical protein 0.0041 0.0049 0.0048
Brugia malayi beta-lactamase family protein 0.0041 0.0049 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0042 0.0144
Entamoeba histolytica hypothetical protein 0.0074 0.0132 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0051 0.0075 0.0073
Brugia malayi Bromodomain containing protein 0.0079 0.0146 0.0145
Schistosoma mansoni hypothetical protein 0.0082 0.0154 0.0154
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0107 0.0106
Schistosoma mansoni sodium-bile acid cotransporter related 0.4022 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0043 0.0043
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0001 0.0001
Trichomonas vaginalis set domain proteins, putative 0.0747 0.1814 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0308 0.393
Schistosoma mansoni sodium-bile acid cotransporter 0.2391 0.5924 0.5924
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0094 0.0183 0.0183
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0051 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0088 0.0168 0.0167
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0001 0.0001
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0025 0.0081
Echinococcus multilocularis peptidase Clp (S14 family) 0.0058 0.0092 0.0092
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0049 0.1598
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.0709 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0001 0.0001
Brugia malayi jmjC domain containing protein 0.0101 0.0201 0.0199
Brugia malayi RNA recognition motif domain containing protein 0.0192 0.0427 0.0426
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0058 0.0092 0.0786
Schistosoma mansoni bromodomain containing protein 0.0067 0.0115 0.0115
Schistosoma mansoni hypothetical protein 0.0031 0.0025 0.0025
Brugia malayi hypothetical protein 0.0033 0.003 0.0029
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0025 0.0081
Brugia malayi Bromodomain containing protein 0.004 0.0049 0.0048
Echinococcus multilocularis thyroid hormone receptor alpha 0.0285 0.0661 0.0661
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0088 0.0168 0.0168
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0001 0.0001
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0025 0.0025
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0201 0.0201
Echinococcus multilocularis peregrin 0.0033 0.0032 0.0032
Toxoplasma gondii ABC1 family protein 0.0041 0.0049 0.1598
Trichomonas vaginalis esterase, putative 0.0041 0.0049 0.0184
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0055 0.0096
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0241 0.024
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0049 0.0049
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0049 0.0048
Loa Loa (eye worm) RNA binding protein 0.0192 0.0427 0.0426
Brugia malayi PHD-finger family protein 0.0031 0.0025 0.0024
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.0168 0.9041
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0001 0.0001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0001 0.0001
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.0168 0.5
Echinococcus multilocularis sodium bile acid cotransporter 0.4022 1 1
Plasmodium vivax SET domain protein, putative 0.0094 0.0183 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0008 0.0008
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0192 0.0427 0.0426
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0049 0.1768
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0178 0.0393 0.0392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0042 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0023 0.0037
Toxoplasma gondii hypothetical protein 0.0049 0.0071 0.2941
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0154 0.0153
Toxoplasma gondii target of rapamycin (TOR), putative 0.0038 0.0042 0.1143
Loa Loa (eye worm) hypothetical protein 0.0043 0.0056 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0016 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0024 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0049 0.0009
Schistosoma mansoni sodium-bile acid cotransporter related 0.1631 0.4024 0.4024
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0001 0.0001
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0001 0.0001
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0132 0.0132
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0055 0.0055
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0106 0.0106
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0075 0.3566
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0075 0.3224
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0058 0.0092 0.0786
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0075 0.3224
Brugia malayi beta-lactamase family protein 0.0041 0.0049 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0042 0.0144
Loa Loa (eye worm) hypothetical protein 0.0041 0.0049 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0049 0.018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0049 0.0049
Schistosoma mansoni hypothetical protein 0.0022 0.0003 0.0003
Echinococcus granulosus tar DNA binding protein 0.0192 0.0427 0.0427
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0154 0.0153
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0001 0.0001
Echinococcus multilocularis tar DNA binding protein 0.0192 0.0427 0.0427
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0001 0.0001
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0094 0.0183 0.0183
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0051 0.0075 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.003 0.0077
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0001 0.0001
Echinococcus granulosus sodium bile acid cotransporter 0.4022 1 1
Echinococcus multilocularis sodium bile acid cotransporter 0.4022 1 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0055 0.0769
Onchocerca volvulus 0.015 0.0324 0.0323
Onchocerca volvulus Alhambra homolog 0.0031 0.0025 0.0024
Schistosoma mansoni jumonji domain containing protein 0.008 0.0149 0.0149
Echinococcus granulosus peregrin 0.0033 0.0032 0.0032
Onchocerca volvulus 0.0094 0.0183 0.0182
Loa Loa (eye worm) phosphatidylinositol 3 0.0051 0.0075 0.0073
Loa Loa (eye worm) hypothetical protein 0.0041 0.0049 0.0048
Brugia malayi TAR-binding protein 0.0192 0.0427 0.0426
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0427 0.0427
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0051 0.0075 0.1044
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0049 0.0184
Onchocerca volvulus 0.0041 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0041 0.0049 0.0048
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0154 0.0154
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.0168 0.9041
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0049 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0049 0.018
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0051 0.0075 0.039
Loa Loa (eye worm) hypothetical protein 0.0082 0.0154 0.0153
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0088 0.0168 1
Echinococcus granulosus peptidase Clp S14 family 0.0058 0.0092 0.0092
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0154 0.0154
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0075 0.0324
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0001 0.0001
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0001 0.0001
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.0308 0.4342
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.0349 0.5486
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0042 0.0042
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0025 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0427 0.0427
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0088 0.0168 0.5
Brugia malayi Pre-SET motif family protein 0.0656 0.1588 0.1587
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0001 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0427 0.0427
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0008 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0049 0.0184
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0051 0.0075 0.1044
Leishmania major hypothetical protein, conserved 0.0041 0.0049 0.0009
Schistosoma mansoni hypothetical protein 0.0082 0.0154 0.0154
Mycobacterium ulcerans hypothetical protein 0.016 0.0349 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0058 0.0092 0.4744
Loa Loa (eye worm) TAR-binding protein 0.0192 0.0427 0.0426
Loa Loa (eye worm) hypothetical protein 0.0045 0.0061 0.006
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0088 0.0168 1
Plasmodium falciparum phd finger protein, putative 0.0031 0.0025 0.009
Brugia malayi MH2 domain containing protein 0.0117 0.0241 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0016 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0023 0.0037
Echinococcus granulosus GPCR family 2 0.0082 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0051 0.0075 0.0074
Leishmania major hypothetical protein, conserved 0.0051 0.0075 0.0402
Brugia malayi PHD-finger family protein 0.0026 0.0014 0.0013
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0001 0.0001
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0001 0.0001
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0005 0.0005
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0075 0.3566
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0051 0.0075 0.039
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0049 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0042 0.0144
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0154 0.0154
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0049 0.0689
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0427 0.0427
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0025 0.0025
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0001 0.0001
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0049 0.0049
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0088 0.0168 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0075 0.0402
Loa Loa (eye worm) hypothetical protein 0.0041 0.005 0.0048
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0053 0.008 0.0079
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0055 0.0055
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0041 0.0049 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0075 0.0324
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0074 0.0132 0.0132
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0241 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0016 0.0001
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0051 0.0075 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0042 0.0144
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0112 0.0228 0.0228
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0264 0.0608 0.0608
Onchocerca volvulus 0.0041 0.0049 0.0048
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0112 0.0228 0.0228
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0106 0.0106
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0051 0.0075 0.0075
Leishmania major mitochondrial DNA polymerase beta 0.0304 0.0709 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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