TDR Targets

Basic information

Technical information

TDR Targets ID: 782440
Name: N-[2-(4-methoxyphenyl)-7-methylimidazo[3,2-a] pyridin-3-yl]-3-methylbutanamide
MW: 337.416 | Formula: C20H23N3O2
H donors: 1 H acceptors: 2 LogP: 4.53 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)c1nc2n(c1NC(=O)CC(C)C)ccc(c2)C
InChi: 1S/C20H23N3O2/c1-13(2)11-18(24)22-20-19(15-5-7-16(25-4)8-6-15)21-17-12-14(3)9-10-23(17)20/h5-10,12-13H,11H2,1-4H3,(H,22,24)
InChiKey: BFHXAZQICJMQJV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-(4-methoxyphenyl)-7-methyl-imidazo[3,2-a]pyridin-3-yl]-3-methyl-butanamide
N-[2-(4-methoxyphenyl)-7-methyl-3-imidazo[3,2-a]pyridinyl]-3-methylbutanamide
N-[2-(4-methoxyphenyl)-7-methyl-imidazo[3,2-a]pyridin-3-yl]-3-methyl-butyramide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.2126	0.2126
Trichomonas vaginalis	DNA helicase recq, putative	0.0014	0.0488	0.1768
Brugia malayi	Bloom's syndrome protein homolog	0.0026	0.1279	0.1279
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0153	0.9545	1
Echinococcus granulosus	zinc finger protein	0.0025	0.1217	0.1275
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0049	0.2763	0.2895
Schistosoma mansoni	apoferritin-2	0.0009	0.0181	0.0181
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0023	0.1073	0.3834
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0019	0.0788	0.0788
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0009	0.0181	0.5
Echinococcus multilocularis	expressed protein	0.0009	0.0181	0.0181
Brugia malayi	PHD-finger family protein	0.0031	0.1594	0.1594
Echinococcus multilocularis	zinc finger protein	0.0025	0.1217	0.1217
Echinococcus multilocularis	ferritin	0.0009	0.0181	0.0181
Schistosoma mansoni	apoferritin-2	0.0009	0.0181	0.0181
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.016	1	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0049	0.2763	1
Entamoeba histolytica	hypothetical protein	0.0039	0.2126	0.8821
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0282	0.0282
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.2126	0.2227
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0019	0.0788	0.0788
Trichomonas vaginalis	DNA helicase recq, putative	0.0026	0.1279	0.4629
Loa Loa (eye worm)	hypothetical protein	0.0132	0.8128	0.8128
Leishmania major	hypothetical protein, conserved	0.0017	0.0663	1
Schistosoma mansoni	ferritin	0.0009	0.0181	0.0181
Schistosoma mansoni	hypothetical protein	0.0017	0.0663	0.0663
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0019	0.0788	0.0788
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.1176	0.1176
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0011	0.0282	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0135	0.0135
Entamoeba histolytica	hypothetical protein	0.0039	0.2126	0.8821
Loa Loa (eye worm)	hypothetical protein	0.0077	0.4583	0.4583
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2714	0.2714
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0011	0.0282	0.0282
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0069	0.4055	0.4248
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0019	0.0788	0.0788
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0007	0.0036	0.0131
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0039	0.2123	0.2123
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0009	0.0181	0.5
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0007	0.0036	0.0131
Schistosoma mansoni	DNA helicase recq1	0.0011	0.0282	0.0282
Entamoeba histolytica	hypothetical protein	0.0039	0.2126	0.8821
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0017	0.0716	0.259
Treponema pallidum	bacterioferrin (TpF1)	0.0009	0.0181	0.5
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0282	0.1021
Trichomonas vaginalis	DNA helicase recq1, putative	0.0026	0.1279	0.4629
Schistosoma mansoni	bromodomain containing protein	0.0073	0.4308	0.4308
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0019	0.0788	0.0825
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0049	0.2763	1
Echinococcus granulosus	expressed protein	0.0009	0.0181	0.019
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0009	0.0181	0.5
Plasmodium falciparum	histone acetyltransferase GCN5	0.0043	0.2345	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0019	0.0788	0.0825
Schistosoma mansoni	ferritin light chain	0.0009	0.0181	0.0181
Schistosoma mansoni	hypothetical protein	0.0039	0.2126	0.2126
Echinococcus granulosus	ferritin	0.0009	0.0181	0.019
Brugia malayi	hypothetical protein	0.0039	0.2126	0.2126
Mycobacterium ulcerans	bacterioferritin BfrA	0.0009	0.0181	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0282	0.0282
Entamoeba histolytica	acetyltransferase, GNAT family	0.0043	0.2345	1
Schistosoma mansoni	ferritin	0.0009	0.0181	0.0181
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0069	0.4055	0.4055
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0009	0.0181	0.5
Loa Loa (eye worm)	RecQ helicase	0.0026	0.1279	0.1279
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.1041	0.1041
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0049	0.2763	1
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.1176	0.1232
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.1176	0.1176
Trichomonas vaginalis	ferritin, putative	0.0009	0.0181	0.0655
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0282	0.0282
Loa Loa (eye worm)	hypothetical protein	0.005	0.2849	0.2849
Brugia malayi	Bromodomain containing protein	0.0046	0.2541	0.2541
Entamoeba histolytica	hypothetical protein	0.0039	0.2126	0.8821
Loa Loa (eye worm)	hypothetical protein	0.0042	0.2295	0.2295
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.016	1	1
Trypanosoma brucei	ISWI complex protein	0.0017	0.0663	1
Loa Loa (eye worm)	bromodomain containing protein	0.0023	0.1082	0.1082
Schistosoma mansoni	blooms syndrome DNA helicase	0.0021	0.0922	0.0922
Schistosoma mansoni	ferritin light chain	0.0009	0.0181	0.0181
Schistosoma mansoni	zinc finger protein	0.0017	0.0663	0.0663
Echinococcus multilocularis	bloom syndrome protein	0.0026	0.1279	0.1279
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.2126	0.2126
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0049	0.2763	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0039	0.2123	0.2224
Schistosoma mansoni	zinc finger protein	0.0025	0.1217	0.1217
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0011	0.0282	0.0282
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0049	0.2763	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0282	0.1021
Schistosoma mansoni	hypothetical protein	0.0022	0.1041	0.1041
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0011	0.0282	0.0296
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0019	0.0788	0.0788
Schistosoma mansoni	ferritin	0.0009	0.0181	0.0181
Schistosoma mansoni	DNA helicase recq5	0.0011	0.0282	0.0282
Trypanosoma cruzi	ISWI complex protein	0.0017	0.0663	1
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0011	0.0282	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0788	0.0788
Brugia malayi	Bromodomain containing protein	0.0086	0.5137	0.5137
Schistosoma mansoni	ferritin	0.0009	0.0181	0.0181
Trypanosoma cruzi	ISWI complex protein	0.0017	0.0663	1
Loa Loa (eye worm)	acetyltransferase	0.016	1	1
Giardia lamblia	Histone acetyltransferase GCN5	0.0043	0.2345	1
Schistosoma mansoni	bromodomain containing protein	0.0009	0.0135	0.0135
Mycobacterium ulcerans	bacterioferritin BfrB	0.0009	0.0181	0.5
Echinococcus granulosus	bloom syndrome protein	0.0026	0.1279	0.134
Giardia lamblia	Sgs1 DNA helicase, putative	0.0011	0.0282	0.1204
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0019	0.0788	0.0788

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 782440