Detailed information for compound 784355

Basic information

Technical information
  • TDR Targets ID: 784355
  • Name: 7-nitro-2,1,3-benzoxadiazol-6-amine
  • MW: 180.121 | Formula: C6H4N4O3
  • H donors: 1 H acceptors: 4 LogP: 0.88 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1c(N)ccc2c1non2
  • InChi: 1S/C6H4N4O3/c7-3-1-2-4-5(9-13-8-4)6(3)10(11)12/h1-2H,7H2
  • InChiKey: REYOCEWWSNTXIK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4-nitrobenzofurazan-5-yl)amine
  • 4-Nitro-2,1,3-benzoxadiazol-5-amine
  • Benzofurazan-5-amine, 4-nitro-
  • MLS000728227
  • SMR000306920
  • EU-0085504
  • ZERO/001431
  • ZINC04016552

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Protein Rev Starlite/ChEMBL No references
Homo sapiens kelch-like ECH-associated protein 1 No references
Caenorhabditis elegans Protein GLD-1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 No references
Human herpesvirus 8 ORF 73 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens tumor susceptibility 101 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania infantum calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Entamoeba histolytica CXXC-rich protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis Kelch repeat type 1 Get druggable targets OG5_134673 All targets in OG5_134673
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi tumor suppressor. Get druggable targets OG5_170288 All targets in OG5_170288
Trypanosoma cruzi calpain cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus fibrillin 1 Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis microtubule associated protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus kelch ECH associated protein 1 Get druggable targets OG5_134673 All targets in OG5_134673
Schistosoma japonicum IPR013091,EGF calcium-binding;IPR013111,EGF, extracellular;IPR001881,EGF-like calcium-binding;IPR006210,EGF;IPR000152,Aspartic a Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica hypothetical protein, conserved Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis DNA double-strand break repair Rad50 ATPase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma brucei gambiense calpain-like cysteine peptidase, putative,antigen, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Giardia lamblia High cysteine membrane protein Group 1 Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei variant surface glycoprotein (VSG), putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania infantum calpain-like cysteine peptidase Get druggable targets OG5_130635 All targets in OG5_130635
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis kelch ECH associated protein 1 Get druggable targets OG5_134673 All targets in OG5_134673
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania infantum cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum IPR006209,EGF-like;IPR013091,EGF calcium-binding;IPR001881,EGF-like calcium-binding;IPR006210,EGF;IPR000152,Aspartic acid and as Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis Involucrin, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus tumor susceptibility gene 101 protein Get druggable targets OG5_128950 All targets in OG5_128950
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania infantum surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma brucei gambiense Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus granulosus kelch ECH associated protein 1 like Get druggable targets OG5_134673 All targets in OG5_134673
Mycobacterium leprae Probable UDP-galactopyranose mutase Glf (UDP-galp mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) Get druggable targets OG5_139595 All targets in OG5_139595
Giardia lamblia High cysteine membrane protein TMK-like Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Schistosoma mansoni tsg101-related Get druggable targets OG5_128950 All targets in OG5_128950
Leishmania donovani calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma congolense cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma brucei hypothetical protein Get druggable targets OG5_130635 All targets in OG5_130635
Loa Loa (eye worm) TK/FER protein kinase Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni notch Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus microtubule associated protein Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum Tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) Get druggable targets OG5_139595 All targets in OG5_139595
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis kelch ECH associated protein 1 Get druggable targets OG5_134673 All targets in OG5_134673
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum Neurogenic locus notch protein homolog precursor, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus coiled coil domain containing protein 41 Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma congolense calpain, putative Get druggable targets OG5_130635 All targets in OG5_130635
Entamoeba histolytica pro protein convertase subtilisin/kexinType 5 precursor, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Onchocerca volvulus Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis fibrillin 1 Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Echinococcus granulosus kelch ECH associated protein 1 like Get druggable targets OG5_134673 All targets in OG5_134673
Leishmania braziliensis calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum ko:K01931 tumor suppressor protein 101 [EC:6.3.2.19], putative Get druggable targets OG5_128950 All targets in OG5_128950
Trypanosoma brucei calpain-like protein, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania major surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma brucei calpain-like cysteine peptidase, putative Get druggable targets OG5_130635 All targets in OG5_130635
Brugia malayi hypothetical protein Get druggable targets OG5_128950 All targets in OG5_128950
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei calpain, putative Get druggable targets OG5_130635 All targets in OG5_130635
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Loa Loa (eye worm) tumor suppressor Get druggable targets OG5_170288 All targets in OG5_170288
Leishmania mexicana calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134673 All targets in OG5_134673
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum Kelch-like ECH-associated protein 1, putative Get druggable targets OG5_134673 All targets in OG5_134673
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum ko:K10456 kelch-like protein 19, putative Get druggable targets OG5_134673 All targets in OG5_134673
Entamoeba histolytica tumor susceptibility gene 101 protein, putative Get druggable targets OG5_128950 All targets in OG5_128950
Leishmania infantum calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia High cysteine membrane protein TMK-like Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_126560 All targets in OG5_126560
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania braziliensis surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative Get druggable targets OG5_130635 All targets in OG5_130635
Mycobacterium ulcerans UDP-galactopyranose mutase Glf Get druggable targets OG5_139595 All targets in OG5_139595
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia High cysteine non-variant cyst protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis coiled coil domain containing protein 41 Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense calpain-like protein, putative Get druggable targets OG5_130635 All targets in OG5_130635
Leishmania braziliensis surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Giardia lamblia High cysteine membrane protein TMK-like Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania mexicana surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans weak similarity to S. cerevisiae STP22 putative ubiquitin receptor, and to mouse tumor susceiptibility protein TSG101 Get druggable targets OG5_128950 All targets in OG5_128950
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania infantum hypothetical protein, conserved Protein Rev   116 aa 95 aa 26.3 %
Brugia malayi Kelch motif family protein kelch-like ECH-associated protein 1 624 aa 565 aa 31.1 %
Leishmania donovani hypothetical protein, conserved Protein Rev   116 aa 95 aa 26.3 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0494 0.0855
Onchocerca volvulus 0.0037 0.0494 0.1394
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1616 0.3162
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.002 0.0038
Brugia malayi Muscleblind-like protein 0.018 0.2585 0.4597
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.002 0.0038
Entamoeba histolytica protein kinase, putative 0.0005 0.002 0.0038
Schistosoma mansoni hypothetical protein 0.0005 0.0021 0.013
Echinococcus multilocularis muscleblind protein 0.018 0.2585 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.1616 0.4563
Loa Loa (eye worm) hypothetical protein 0.0037 0.0494 0.0855
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.5106 1
Echinococcus granulosus prenylcysteine oxidase 0.0005 0.0021 0.0027
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0154 0.0734
Loa Loa (eye worm) hypothetical protein 0.0084 0.1176 0.2072
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0154 0.0734
Loa Loa (eye worm) hypothetical protein 0.0037 0.0494 0.0855
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0907 0.5599
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0494 0.0474
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0494 1
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.002 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0048 0.0089
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.002 0.0038
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.01 0.0334
Entamoeba histolytica hypothetical protein 0.0014 0.0154 0.0302
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.1616 0.8388
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1616 0.3162
Trypanosoma cruzi electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0005 0.0021 0.0036
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0494 0.3047
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1924 1
Echinococcus granulosus muscleblind protein 0.018 0.2585 1
Toxoplasma gondii ABC1 family protein 0.0037 0.0494 0.6157
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1924 1
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.002 0.0038
Trichomonas vaginalis DNA double-strand break repair Rad50 ATPase, putative 0.0004 0.0014 0.0024
Entamoeba histolytica hypothetical protein 0.0005 0.002 0.0038
Mycobacterium ulcerans beta-lactamase 0.0037 0.0494 0.0474
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0494 0.0474
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0014 0.0027
Giardia lamblia Kinase, PLK 0.0114 0.1616 0.3145
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1924 1
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0007 0.0048 0.0345
Brugia malayi tumor suppressor. 0.0388 0.5623 1
Entamoeba histolytica hypothetical protein 0.0004 0.0014 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0048 0.0089
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.5106 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5106 1
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0494 0.1918
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0494 0.0963
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0014 0.0027
Entamoeba histolytica cysteine surface protein, putative 0.0004 0.0014 0.0027
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0135 0.1924 1
Entamoeba histolytica cysteine surface protein, putative 0.0004 0.0014 0.0027
Schistosoma mansoni amine oxidase 0.0005 0.0021 0.013
Loa Loa (eye worm) hypothetical protein 0.0037 0.0494 0.0855
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.041 0.154
Onchocerca volvulus 0.0032 0.041 0.1158
Loa Loa (eye worm) beta-lactamase 0.0037 0.0494 0.0855
Loa Loa (eye worm) hypothetical protein 0.018 0.2585 0.4583
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0154 0.0734
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0584 0.2216
Loa Loa (eye worm) hypothetical protein 0.0182 0.2615 0.4637
Entamoeba histolytica hypothetical protein 0.0043 0.0584 0.1143
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.002 0.0038
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0154 0.0734
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1616 0.3162
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.3428 0.3414
Schistosoma mansoni tsg101-related 0.0057 0.0784 0.4837
Brugia malayi Protein kinase domain containing protein 0.0004 0.0014 0.0025
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.1616 0.623
Loa Loa (eye worm) hypothetical protein 0.0005 0.0021 0.0012
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0014 0.0027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5106 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0494 0.0855
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0048 0.0089
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0154 0.0734
Entamoeba histolytica CXXC-rich protein 0.0004 0.0014 0.0027
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.002 0.0038
Trichomonas vaginalis esterase, putative 0.0037 0.0494 0.0963
Trypanosoma cruzi electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0005 0.0021 0.0036
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.041 0.154
Brugia malayi hypothetical protein 0.0084 0.1176 0.2092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5106 1
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0027 0.0342 0.1058
Echinococcus granulosus hypothetical protein 0.0033 0.0429 0.1614
Brugia malayi Temporarily assigned gene name protein 44 0.0033 0.0429 0.0763
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0048 0.0089
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.2468 0.2452
Echinococcus multilocularis muscleblind protein 1 0.018 0.2585 1
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.002 0.0038
Brugia malayi beta-lactamase family protein 0.0037 0.0494 0.0878
Loa Loa (eye worm) hypothetical protein 0.0033 0.0429 0.074
Schistosoma mansoni hypothetical protein 0.0033 0.0429 0.2649
Loa Loa (eye worm) hypothetical protein 0.0037 0.0494 0.0855
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0494 0.0474
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0014 0.0024
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0887 0.5475
Entamoeba histolytica hypothetical protein 0.0014 0.0154 0.0302
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.1616 0.2855
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0057 0.0784 0.1534
Mycobacterium ulcerans lipase LipD 0.0037 0.0494 0.0474
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1616 0.3162
Schistosoma mansoni notch 0.0004 0.0014 0.0087
Brugia malayi hypothetical protein 0.0033 0.0429 0.0763
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0014 0.0027
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.1616 0.623
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0494 0.0474
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.002 0.0038
Schistosoma mansoni myst-related protein 0.0004 0 0.0002
Plasmodium vivax SET domain protein, putative 0.0032 0.041 0.8232
Echinococcus granulosus protoporphyrinogen oxidase 0.0005 0.0021 0.0027
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0907 0.3474
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0494 0.3047
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.002 0.0038
Entamoeba histolytica protein kinase, putative 0.0005 0.002 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0048 0.0089
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0907 0.5599
Entamoeba histolytica hypothetical protein 0.0004 0.0014 0.0027
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1924 1
Schistosoma mansoni tsg101-related 0.007 0.0971 0.5992
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0154 0.0299
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0014 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0494 0.2511
Entamoeba histolytica hypothetical protein 0.0004 0.0014 0.0027
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0494 0.0474
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0048 0.0089
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1924 1
Echinococcus multilocularis Kelch repeat type 1 0.0114 0.162 0.6248
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0789 1
Schistosoma mansoni tsg101-related 0.007 0.0971 0.5992
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0494 0.0474
Onchocerca volvulus 0.0182 0.2615 0.7386
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1924 1
Trypanosoma brucei polo-like protein kinase 0.0114 0.1616 0.826
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5106 1
Entamoeba histolytica protein kinase, putative 0.0005 0.002 0.0038
Brugia malayi beta-lactamase 0.0037 0.0494 0.0878
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.002 0.0038
Echinococcus multilocularis kelch ECH associated protein 1 0.0114 0.1616 0.623
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1616 0.3162
Onchocerca volvulus 0.0005 0.0021 0.006
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0084 0.1176 0.452
Loa Loa (eye worm) hypothetical protein 0.0032 0.041 0.0706
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0384 0.1439
Entamoeba histolytica hypothetical protein 0.0043 0.0584 0.1143
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0005 0.0021 1
Entamoeba histolytica protein kinase, putative 0.0004 0.0014 0.0027
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0154 0.0734
Leishmania major electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0005 0.0021 0.0036
Mycobacterium leprae Probable lipase LipE 0.0037 0.0494 0.0474
Mycobacterium tuberculosis Conserved protein 0.0037 0.0494 0.0474
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0014 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0494 0.2511
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.002 0.0038
Entamoeba histolytica cysteine surface protein, putative 0.0004 0.0014 0.0027
Entamoeba histolytica pro protein convertase subtilisin/kexinType 5 precursor, putative 0.0004 0.0014 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0048 0.0089
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0048 0.0089
Entamoeba histolytica hypothetical protein, conserved 0.0004 0.0014 0.0027
Echinococcus multilocularis cpg binding protein 0.0031 0.0408 0.1533
Schistosoma mansoni cpg binding protein 0.0031 0.0408 0.252
Loa Loa (eye worm) hypothetical protein 0.0037 0.0494 0.0855
Loa Loa (eye worm) hypothetical protein 0.0005 0.0021 0.0012
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0383 0.0658
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0154 0.0734
Echinococcus granulosus kelch ECH associated protein 1 0.0114 0.1616 0.623
Brugia malayi Pre-SET motif family protein 0.0216 0.3106 0.5524
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.041 0.2531
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0907 0.5599
Entamoeba histolytica protein kinase, putative 0.0004 0.0014 0.0027
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0494 0.0474
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0154 0.0734
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.002 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0048 0.0089
Onchocerca volvulus 0.0005 0.0021 0.006
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.1616 0.2873
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0494 0.0474
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1924 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1616 0.8388
Trichomonas vaginalis helicase, putative 0.0007 0.0048 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.041 0.2531
Trichomonas vaginalis hypothetical protein 0.0041 0.0547 0.1067
Brugia malayi Pre-SET motif family protein 0.0032 0.041 0.0729
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0048 0.0089
Schistosoma mansoni hypothetical protein 0.0033 0.0429 0.2649
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0494 0.0474
Brugia malayi hypothetical protein 0.0043 0.0584 0.1038
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.3106 0.5512
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1924 1
Echinococcus granulosus cpg binding protein 0.0031 0.0408 0.1533
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.002 0.0038
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0014 0.0027
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0135 0.1924 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0048 0.0089
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0154 0.0734
Loa Loa (eye worm) lethal protein 721 0.0005 0.0021 0.0012
Schistosoma mansoni cpg binding protein 0.003 0.0383 0.2367
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.041 0.2531
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0494 0.1865
Echinococcus granulosus protein quaking 0.0033 0.0429 0.1614
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0084 0.1176 0.452
Trichomonas vaginalis set domain proteins, putative 0.0246 0.3541 0.6934
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5106 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0907 0.5599
Echinococcus granulosus tar DNA binding protein 0.0066 0.0907 0.3474
Entamoeba histolytica hypothetical protein 0.0014 0.0154 0.0302
Schistosoma mansoni kinase 0.0058 0.0796 0.4914
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.041 0.2531
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0154 0.0734
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0014 0.0024
Onchocerca volvulus 0.0037 0.0494 0.1394
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0048 0.0089
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.002 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0048 0.0089
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0494 0.1865
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0494 0.0963
Brugia malayi hypothetical protein 0.0182 0.2615 0.4651
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.002 0.0038
Entamoeba histolytica hypothetical protein 0.0043 0.0584 0.1143
Schistosoma mansoni hypothetical protein 0.0043 0.0584 0.3604
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.002 0.0038
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.002 0.0038
Loa Loa (eye worm) histone methyltransferase 0.001 0.01 0.0153
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1924 1
Leishmania major hypothetical protein, conserved 0.0037 0.0494 0.2511
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0027 0.0342 0.1714
Schistosoma mansoni cpg binding protein 0.0031 0.0408 0.252
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0494 0.0474
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.1616 0.3164
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0494 0.0878
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0074 0.0231
Mycobacterium tuberculosis UDP-galactopyranose mutase Glf (UDP-GALP mutase) (NAD+-flavin adenine dinucleotide-requiring enzyme) 0.0688 1 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0135 0.1924 1
Schistosoma mansoni myst-related protein 0.0004 0 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0494 0.0963
Loa Loa (eye worm) hypothetical protein 0.018 0.2585 0.4583
Entamoeba histolytica hypothetical protein 0.0004 0.0014 0.0027
Echinococcus multilocularis prenylcysteine oxidase 0.0005 0.0021 0.0027
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.002 0.0038
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0074 0.0231
Loa Loa (eye worm) RNA binding protein 0.0066 0.0907 0.1592
Trypanosoma brucei hypothetical protein 0.0135 0.1924 1
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.5106 0.5
Leishmania major hypothetical protein, conserved 0.0027 0.0342 0.1714
Entamoeba histolytica protein kinase, putative 0.0005 0.002 0.0038
Entamoeba histolytica hypothetical protein 0.0043 0.0584 0.1143
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0048 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0154 0.0299
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0014 0.0027
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.002 0.0038
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.01 0.0334
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0494 0.0963
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.2468 0.2452
Loa Loa (eye worm) tumor suppressor 0.0388 0.5623 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0154 0.0734
Entamoeba histolytica hypothetical protein 0.0005 0.002 0.0038
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.002 0.0038
Entamoeba histolytica tyrosine kinase, putative 0.0005 0.002 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1616 0.9973
Trypanosoma brucei calpain, putative 0.0135 0.1924 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0135 0.1924 1
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.002 0.0038
Trypanosoma cruzi UDP-galactopyranose mutase 0.0005 0.0021 0.0036
Onchocerca volvulus 0.0004 0.0014 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0048 0.0089
Entamoeba histolytica hypothetical protein 0.0014 0.0154 0.0302
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0014 0.0027
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0074 0.0231
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0907 0.1592
Entamoeba histolytica protein kinase, putative 0.0005 0.002 0.0038
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0074 0.0455
Brugia malayi RNA binding protein 0.0066 0.0907 0.1613
Schistosoma mansoni hypothetical protein 0.0114 0.162 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0154 0.0734
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0907 0.5599
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0098 0.0175
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1616 0.3162
Entamoeba histolytica hypothetical protein 0.0004 0.0014 0.0027
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1924 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.2468 0.2452
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.5106 1
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0907 0.1592
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0584 0.3604
Brugia malayi TAR-binding protein 0.0066 0.0907 0.1613
Mycobacterium ulcerans hypothetical protein 0.0037 0.0494 0.0474
Brugia malayi beta-lactamase family protein 0.0037 0.0494 0.0878
Onchocerca volvulus 0.0004 0.0014 0.004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5106 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0048 0.0089
Entamoeba histolytica hypothetical protein 0.0005 0.002 0.0038
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.041 0.5068
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.041 0.154
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0074 0.0231
Trichomonas vaginalis Involucrin, putative 0.0004 0.0014 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5106 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0048 0.0089
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0907 0.1613
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0014 0.0154 0.0734
Brugia malayi CXXC zinc finger family protein 0.003 0.0383 0.0682
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1616 0.3162
Mycobacterium ulcerans UDP-galactopyranose mutase Glf 0.0688 1 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0135 0.1924 1
Brugia malayi all-trans-13,14-dihydroretinol saturase 0.0005 0.0021 0.0038
Entamoeba histolytica protein kinase, putative 0.0005 0.002 0.0038
Echinococcus multilocularis kelch ECH associated protein 1 0.0114 0.1616 0.623
Entamoeba histolytica protein kinase domain containing protein 0.0005 0.002 0.0038
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1616 0.8388
Echinococcus multilocularis protein quaking 0.0033 0.0429 0.1614
Entamoeba histolytica cysteine surface protein, putative 0.0004 0.0014 0.0027
Entamoeba histolytica protein kinase, putative 0.0005 0.002 0.0038
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0494 0.0963
Mycobacterium tuberculosis Conserved protein 0.0037 0.0494 0.0474
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0774 0.1513
Onchocerca volvulus 0.0037 0.0494 0.1394
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.5106 1
Entamoeba histolytica tyrosine kinase, putative 0.0004 0.0014 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0774 0.1513
Trypanosoma brucei calpain-like protein, putative 0.0135 0.1924 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0028 0.0173
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0584 0.2216
Onchocerca volvulus 0.0246 0.3541 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0494 0.0474
Onchocerca volvulus 0.003 0.0383 0.1083
Echinococcus granulosus kelch ECH associated protein 1 like 0.0114 0.1616 0.623
Echinococcus granulosus kelch ECH associated protein 1 like 0.0114 0.1616 0.623
Entamoeba histolytica protein kinase, putative 0.0005 0.002 0.0038

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 7.95 uM PUBCHEM_BIOASSAY: Inhibitors of Mycobacterium tuberculosis UDP-galactopyranose mutase (UGM) enzyme Measured in Biochemical System Using Plate Reader - 2105-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504439] ChEMBL. No reference
AC50 (binding) = 7.99 uM PUBCHEM_BIOASSAY: Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504540] ChEMBL. No reference
AC50 (binding) = 8.033 uM PUBCHEM_BIOASSAY: C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504431] ChEMBL. No reference
IC50 (binding) = 0.24751 uM PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of GLD-1 protein - TGE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2280, AID2290, AID2459] ChEMBL. No reference
IC50 (binding) = 0.69035 um PUBCHEM_BIOASSAY: Counterscreen for inhibitors of gld-1: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of the HIV Rev protein-RRE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2290 (Summary (gld-1 inhibitors)), 2280 (Primary screen (gld-1 inhibitors in singlicate))] ChEMBL. No reference
Max_Activity_Concent (functional) 26 uM PubChem BioAssay. Thermal shift assay to identify compound binding to Kelch domain of Keap1 protein Measured in Biochemical System Using RT-PCR - 2119-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.2334 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.5659 uM PubChem BioAssay. qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.8876 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter. (Class of assay: confirmatory) [Related pubchem assays: 2281 (Summary of qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a), 463106 (LOPAC Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a)] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction: HTRF assay against cherry picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction: TR assay against cherry picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.