Detailed information for compound 785025

Basic information

Technical information
  • TDR Targets ID: 785025
  • Name: tert-butyl 6-amino-8-(3-chlorophenyl)-5,7,7-t ricyano-1,3,8,8a-tetrahydroisoquinoline-2-car boxylate
  • MW: 435.906 | Formula: C23H22ClN5O2
  • H donors: 1 H acceptors: 4 LogP: 2.58 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(N)C(C(C2C1=CCN(C2)C(=O)OC(C)(C)C)c1cccc(c1)Cl)(C#N)C#N
  • InChi: 1S/C23H22ClN5O2/c1-22(2,3)31-21(30)29-8-7-16-17(10-25)20(28)23(12-26,13-27)19(18(16)11-29)14-5-4-6-15(24)9-14/h4-7,9,18-19H,8,11,28H2,1-3H3
  • InChiKey: JJHNKYUQHKBCLY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-amino-8-(3-chlorophenyl)-5,7,7-tricyano-1,3,8,8a-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester
  • ChemDiv1_025307
  • A0908/0042630
  • BAS 07416537
  • Oprea1_232032

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0121 0.0187
Brugia malayi Importin beta-1 subunit 0.003 0.0359 0.1712
Toxoplasma gondii exonuclease III APE 0.002 0.0121 0.0185
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.5251 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.646 1
Trichomonas vaginalis chromobox protein, putative 0.007 0.1279 0.198
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0201 0.3777
Schistosoma mansoni glucose transport protein 0.0105 0.2094 0.2932
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2094 0.2932
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.0565
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0357 0.05
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0201 0.0287
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0413 0.0639
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.0565
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0121 0.023
Brugia malayi Sugar transporter family protein 0.0105 0.2094 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.646 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0321 0.7143 1
Plasmodium vivax hexose transporter 0.0105 0.2094 0.2094
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0119 0.0227
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.188 0.2632
Brugia malayi Bromodomain containing protein 0.0031 0.0391 0.1867
Loa Loa (eye worm) hypothetical protein 0.0071 0.1304 0.1825
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0121 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0533 0.0746
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.646 1
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.7752
Trichomonas vaginalis ran, putative 0.0022 0.0173 0.0268
Plasmodium vivax importin-beta 2, putative 0.003 0.0359 0.0359
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0046 0.0064
Plasmodium falciparum hexose transporter 0.0105 0.2094 0.2094
Onchocerca volvulus 0.0038 0.0533 0.8386
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0336 0.0514
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.7752
Giardia lamblia Fructose-bisphosphate aldolase 0.0292 0.646 1
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0533 0.1015
Trypanosoma brucei glucose transporter 2A 0.0032 0.0413 0.7752
Brugia malayi Heterochromatin protein 1 0.007 0.1279 0.6108
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0413 0.7752
Toxoplasma gondii ABC1 family protein 0.0038 0.0533 0.0815
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0054 0.0076
Schistosoma mansoni jumonji domain containing protein 0.0076 0.1423 0.1992
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0566 0.8914
Echinococcus granulosus peregrin 0.0031 0.0391 0.0547
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.051 0.051
Schistosoma mansoni chromobox protein 0.007 0.1279 0.1791
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.646 1
Schistosoma mansoni chromobox protein 0.007 0.1279 0.1791
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0173 0.0243
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0226 0.035
Schistosoma mansoni transient receptor potential channel 0.0064 0.1152 0.1612
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.0565
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.051 0.9563
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.7752
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0388 0.0941
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.051 0.9563
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0533 0.0746
Echinococcus multilocularis peregrin 0.0031 0.0391 0.0547
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0479 0.067
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0301 0.0466
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2094 0.2932
Toxoplasma gondii protein kinase, putative 0.0295 0.6542 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0121 0.0187
Brugia malayi chromobox protein homolog 3 0.0039 0.0566 0.2705
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0121 0.2265
Echinococcus multilocularis importin subunit beta 1 0.003 0.0359 0.0502
Treponema pallidum fructose-bisphosphate aldolase 0.0292 0.646 1
Schistosoma mansoni ran 0.0022 0.0173 0.0243
Schistosoma mansoni hypothetical protein 0.0179 0.3832 0.5365
Entamoeba histolytica hypothetical protein 0.0024 0.0226 0.0166
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0201 0.0282
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0201 0.0312
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0173 0.0265
Loa Loa (eye worm) beta-lactamase 0.0038 0.0533 0.0746
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0523 0.0732
Echinococcus multilocularis transient receptor potential gamma protein 0.0097 0.1917 0.2683
Loa Loa (eye worm) hypothetical protein 0.0038 0.055 0.0771
Leishmania major hypothetical protein, conserved 0.0038 0.0533 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0119 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0413 0.0639
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0054 0.0076
Plasmodium falciparum phd finger protein, putative 0.0029 0.0336 0.0336
Trypanosoma cruzi ISWI complex protein 0.0015 0.0013 0.0253
Loa Loa (eye worm) hypothetical protein 0.0031 0.0388 0.0544
Echinococcus multilocularis zinc finger protein 0.002 0.0113 0.0158
Schistosoma mansoni hypothetical protein 0.0105 0.2094 0.2932
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.0565
Leishmania major importin beta-1 subunit, putative 0.0024 0.0226 0.424
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0121 0.0405
Brugia malayi beta-lactamase family protein 0.0038 0.0533 0.2545
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.7752
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0404 0.7573
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0054 0.0076
Echinococcus granulosus geminin 0.0179 0.3832 0.5365
Echinococcus granulosus chromobox protein 1 0.007 0.1279 0.1791
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0173 0.0243
Trypanosoma cruzi ISWI complex protein 0.0015 0.0013 0.0253
Loa Loa (eye worm) hypothetical protein 0.0053 0.0886 0.124
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0121 0.0169
Loa Loa (eye worm) hypothetical protein 0.0043 0.065 0.091
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0533 0.1445
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0566 0.0877
Loa Loa (eye worm) hypothetical protein 0.0017 0.0054 0.0076
Loa Loa (eye worm) hypothetical protein 0.0039 0.0566 0.0793
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.1152 0.1612
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0566 0.0877
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0533 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.2094 0.3201
Brugia malayi Bromodomain containing protein 0.0075 0.1403 0.67
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0201 0.0201
Entamoeba histolytica hypothetical protein 0.0023 0.0201 0.0127
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0046 0.022
Mycobacterium leprae Probable lipase LipE 0.0038 0.0533 0.1445
Brugia malayi PHD-finger family protein 0.0029 0.0336 0.1604
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0138 0.0193
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0533 0.2545
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0201 0.0282
Schistosoma mansoni importin beta-1 0.003 0.0359 0.0502
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0404 0.0404
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2094 0.2932
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0388 0.1855
Entamoeba histolytica Ran family GTPase 0.0022 0.0173 0.0083
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.0565
Leishmania major glucose transporter, lmgt2 0.0032 0.0413 0.7752
Mycobacterium tuberculosis Conserved protein 0.0038 0.0533 0.1015
Schistosoma mansoni glucose transport protein 0.0105 0.2094 0.2932
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0336 0.047
Loa Loa (eye worm) hypothetical protein 0.0031 0.037 0.0518
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0533 1
Brugia malayi RNA, U transporter 1 0.0086 0.1651 0.7885
Trichomonas vaginalis chromobox protein, putative 0.007 0.1279 0.198
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0413 0.0639
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0404 0.0404
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0359 0.0548
Schistosoma mansoni zinc finger protein 0.002 0.0113 0.0158
Loa Loa (eye worm) hypothetical protein 0.0036 0.0498 0.0697
Plasmodium falciparum proline--tRNA ligase 0.0037 0.051 0.051
Loa Loa (eye worm) hypothetical protein 0.0061 0.1076 0.1507
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.7752
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0533 0.1015
Onchocerca volvulus 0.0038 0.0533 0.8386
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2094 0.2932
Echinococcus multilocularis geminin 0.0179 0.3832 0.5365
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.0064
Schistosoma mansoni transient receptor potential channel 4 0.0097 0.1917 0.2683
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0404 0.0565
Brugia malayi jmjC domain containing protein 0.0095 0.188 0.8977
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0533 0.1015
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0182 0.0255
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.188 0.2632
Schistosoma mansoni protein kinase 0.0032 0.0404 0.0565
Loa Loa (eye worm) hypothetical protein 0.0033 0.0422 0.0591
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0336 0.047
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0226 0.035
Loa Loa (eye worm) hypothetical protein 0.0023 0.0201 0.0282
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0404 0.1927
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0533 0.1015
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0388 0.0544
Schistosoma mansoni hypothetical protein 0.0029 0.0336 0.047
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0404 0.0625
Loa Loa (eye worm) hypothetical protein 0.003 0.0359 0.0502
Schistosoma mansoni transient receptor potential channel 0.0097 0.1917 0.2683
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0388 0.0544
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0173 0.3254
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0046 0.0064
Mycobacterium ulcerans hypothetical protein 0.0038 0.0533 0.1788
Loa Loa (eye worm) hypothetical protein 0.0038 0.0533 0.0746
Brugia malayi Bromodomain containing protein 0.0038 0.0549 0.2621
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0173 0.0243
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0201 0.0312
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0388 0.0601
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0404 0.0404
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0533 0.0746
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0533 0.1788
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0533 0.0825
Loa Loa (eye worm) hypothetical protein 0.0041 0.0606 0.0848
Leishmania major glucose transporter, lmgt1 0.0032 0.0413 0.7752
Brugia malayi beta-lactamase family protein 0.0038 0.0533 0.2545
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0201 0.0282
Trypanosoma brucei ISWI complex protein 0.0015 0.0013 0.0253
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0533 0.1015
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0201 0.0675
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0404 0.0565
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.7752
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.7752
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0533 0.0825
Brugia malayi beta-lactamase 0.0038 0.0533 0.2545
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.051 0.9563
Trypanosoma brucei glucose transporter 1E 0.0032 0.0413 0.7752
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.646 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0886 0.124
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.1152 0.1612
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0201 0.3777
Echinococcus multilocularis chromobox protein 1 0.007 0.1279 0.1791
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0359 0.6728
Mycobacterium tuberculosis Conserved protein 0.0038 0.0533 0.1015
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0173 0.0173
Leishmania major GTP-binding protein, putative 0.0022 0.0173 0.3254
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0388 0.1855
Schistosoma mansoni glucose transport protein 0.0105 0.2094 0.2932
Loa Loa (eye worm) hypothetical protein 0.0036 0.0497 0.0696
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0404 0.0617
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.0639
Leishmania major hypothetical protein, conserved 0.0015 0.0013 0.0253
Mycobacterium tuberculosis Conserved protein 0.0038 0.0533 0.1015
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0357 0.05
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0523 0.0732
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.051 0.0779
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0173 0.3254
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0169 0.3595 0.3595
Leishmania major protein kinase, putative 0.0032 0.0404 0.7573
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.646 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.2981 0.5676
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0201 0.0675
Echinococcus multilocularis chromobox protein 1 0.007 0.1279 0.1791
Schistosoma mansoni hypothetical protein 0.0321 0.7143 1
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0602 0.0842
Entamoeba histolytica protein kinase, putative 0.0032 0.0404 0.0446
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0336 0.047
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.0064
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0054 0.0076
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0533 0.0746
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0404 0.0404
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0046 0.0064
Schistosoma mansoni hypothetical protein 0.0179 0.3832 0.5365
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.0064
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0201 0.0282
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0404 0.0404
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0533 0.1015
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.051 0.9563
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0201 0.3777
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.0565
Trichomonas vaginalis esterase, putative 0.0038 0.0533 0.0825
Schistosoma mansoni zinc finger protein 0.0015 0.0013 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0336 0.0336
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0494 0.0691
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0121 0.0169
Schistosoma mansoni transient receptor potential channel 0.0064 0.1152 0.1612
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0173 0.3254
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0121 0.0576
Echinococcus multilocularis snurportin 1 0.0321 0.7143 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0121 0.2265
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.1047 0.1466
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0121 0.2265
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2094 0.2932
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0388 0.0422
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0533 0.0533
Leishmania major glucose transporter, lmgt3 0.0032 0.0413 0.7752
Schistosoma mansoni ap endonuclease 0.002 0.0121 0.0169
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0336 0.047
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0301 0.0466
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0404 0.0404
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.1152 0.1612
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.646 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0046 0.0064
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0336 0.0514
Loa Loa (eye worm) hypothetical protein 0.0038 0.0533 0.0746
Schistosoma mansoni ap endonuclease 0.002 0.0121 0.0169
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0121 0.0121
Echinococcus granulosus snurportin 1 0.0321 0.7143 1
Brugia malayi Cam kinase protein 1 0.0032 0.0404 0.1927
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2094 0.2932
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.1047 0.1466
Loa Loa (eye worm) hypothetical protein 0.0097 0.1917 0.2683
Onchocerca volvulus 0.0038 0.0533 0.8386
Plasmodium falciparum importin beta, putative 0.003 0.0359 0.0359
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0046 0.022
Echinococcus granulosus chromobox protein 1 0.007 0.1279 0.1791
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0494 0.0691
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0635 0.0984
Trypanosoma cruzi hexose transporter, putative 0.0018 0.007 0.1322
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0359 0.6728
Brugia malayi PHD-finger family protein 0.0025 0.0237 0.1133
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.2094 0.3242
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0498 0.0697
Schistosoma mansoni protein kinase 0.0032 0.0404 0.0565
Schistosoma mansoni hypothetical protein 0.0017 0.0046 0.0064
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.051 0.9563
Echinococcus multilocularis General substrate transporter 0.009 0.1752 0.2452
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2094 0.2932
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0201 0.0201
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.2094 0.2932
Loa Loa (eye worm) hypothetical protein 0.0038 0.0533 0.0746
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0054 0.0076
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0533 0.1015
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0533 0.0825
Schistosoma mansoni hypothetical protein 0.0021 0.0138 0.0193
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0533 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0533 0.0746
Schistosoma mansoni hypothetical protein 0.0015 0.0013 0.0019
Echinococcus granulosus importin subunit beta 1 0.003 0.0359 0.0502
Echinococcus granulosus zinc finger protein 0.002 0.0113 0.0158
Loa Loa (eye worm) hypothetical protein 0.0031 0.0388 0.0544
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0388 0.0544
Schistosoma mansoni protein kinase 0.0032 0.0404 0.0565
Giardia lamblia PHD finger protein 15 0.0029 0.0336 0.052
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0134 0.0208
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0054 0.0076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.646 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0169 0.3595 0.5495
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.1841 0.2578
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.7752
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0404 0.0404
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.2981 1
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0404 0.0565
Plasmodium vivax CDK-related protein kinase 6, putative 0.0444 1 1
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0498 0.0697
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0226 0.424
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.646 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0388 0.0544
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.7752
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.7752
Entamoeba histolytica protein kinase, putative 0.0032 0.0404 0.0446
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0173 0.0268
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0173 0.0828
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.646 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0121 0.2265
Schistosoma mansoni bromodomain containing protein 0.0063 0.113 0.1582
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0635 0.0984
Onchocerca volvulus Alhambra homolog 0.0029 0.0336 0.5287
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0388 0.0601
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.1841 0.2578
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0054 0.0076
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0523 0.0732
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0201 0.5
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.1152 0.1612
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0201 0.0308
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0533 0.0746
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.0064
Plasmodium falciparum protein kinase 7 0.0295 0.6542 0.6542
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.7752
Brugia malayi jmjC domain containing protein 0.0037 0.0523 0.2498
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0523 0.0732
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0032 0.0404 0.0565
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.7752
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0121 0.0121
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0046 0.0064
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0404 0.0617
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0069 0.0096
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.2981 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0533 0.0746
Loa Loa (eye worm) hypothetical protein 0.0025 0.0251 0.0352
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0404 0.0617
Plasmodium falciparum mitogen-activated protein kinase 2 0.0169 0.3595 0.3595
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.0639
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0635 1
Echinococcus granulosus GPCR family 2 0.0017 0.0046 0.0064
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0498 0.2376
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.1059 0.1482
Trypanosoma cruzi hexose transporter 0.0032 0.0413 0.7752
Loa Loa (eye worm) hypothetical protein 0.0029 0.0336 0.047
Onchocerca volvulus 0.0031 0.037 0.5823
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0201 0.0961
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.0639
Mycobacterium ulcerans lipase LipD 0.0038 0.0533 0.1788
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0886 0.4229
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0886 0.4229
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0404 0.0404
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0602 0.0842
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.7752
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0497 0.2373
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.7752
Mycobacterium ulcerans beta-lactamase 0.0038 0.0533 0.1788
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.1279 0.1791
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0533 0.0746
Loa Loa (eye worm) hypothetical protein 0.005 0.0821 0.1149
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0182 0.0255
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0533 0.0825
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0054 0.0076
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0121 0.0187
Schistosoma mansoni ran 0.0022 0.0173 0.0243
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.0565
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0121 0.0169
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0404 0.0565
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0533 0.1788
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0413 0.0639
Echinococcus granulosus General substrate transporter 0.009 0.1752 0.2452
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0533 0.0825
Echinococcus multilocularis GPCR, family 2 0.0017 0.0046 0.0064
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0226 0.035
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0404 0.0404
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0182 0.0255
Loa Loa (eye worm) sugar transporter 0.0105 0.2094 0.2932
Schistosoma mansoni hypothetical protein 0.0036 0.0497 0.0696
Echinococcus granulosus transient receptor potential gamma protein 0.0097 0.1917 0.2683

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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