Detailed information for compound 787355

Basic information

Technical information
  • TDR Targets ID: 787355
  • Name: N-(2-chloro-4-methylphenyl)-1-(cyclopropaneca rbonyl)-2,3-dihydroindole-5-sulfonamide
  • MW: 390.884 | Formula: C19H19ClN2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.29 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)Cl)NS(=O)(=O)c1ccc2c(c1)CCN2C(=O)C1CC1
  • InChi: 1S/C19H19ClN2O3S/c1-12-2-6-17(16(20)10-12)21-26(24,25)15-5-7-18-14(11-15)8-9-22(18)19(23)13-3-4-13/h2,5-7,10-11,13,21H,3-4,8-9H2,1H3
  • InChiKey: AJFZZCNHCXETKU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-chloro-4-methyl-phenyl)-1-(cyclopropanecarbonyl)indoline-5-sulfonamide
  • N-(2-chloro-4-methylphenyl)-1-(cyclopropyl-oxomethyl)-5-indolinesulfonamide
  • N-(2-chloro-4-methyl-phenyl)-1-cyclopropylcarbonyl-2,3-dihydroindole-5-sulfonamide
  • EU-0025782

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0227 0.0239
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.004 0.0276 0.0093
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.1066 0.1041
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.0695 0.0563
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0227 0.0038
Toxoplasma gondii ABC1 family protein 0.0036 0.0227 0.2984
Mycobacterium ulcerans acyl-CoA synthetase 0.0081 0.0754 0.0728
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.006 0.0035
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.0695 0.0563
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.006 0.0035
Loa Loa (eye worm) oxidoreductase 0.0076 0.0695 0.0669
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0149 0.1812
Loa Loa (eye worm) hypothetical protein 0.0076 0.0695 0.0669
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0227 0.02
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0053 0.0426 0.0261
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0076 0.0695 0.0754
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0081 0.0754 0.0818
Mycobacterium tuberculosis Probable thioesterase TesA 0.0041 0.0293 0.0312
Schistosoma mansoni hypothetical protein 0.0031 0.0177 0.0162
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0081 0.0754 0.0818
Loa Loa (eye worm) hypothetical protein 0.0076 0.0695 0.0669
Mycobacterium ulcerans beta-lactamase 0.0036 0.0227 0.02
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0076 0.0695 0.0725
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.006 0.031
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.006 0.031
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.005 0.039 0.0419
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0149 0.1165
Schistosoma mansoni hypothetical protein 0.0068 0.0604 0.0626
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.006 0.031
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0053 0.0426 0.0458
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0122 0.1238 0.135
Loa Loa (eye worm) hypothetical protein 0.0036 0.0227 0.02
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0695 0.0669
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.1066 0.1127
Entamoeba histolytica acyl-coA synthetase, putative 0.0076 0.0695 0.6429
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.006 0.006
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0081 0.0754 0.0754
Loa Loa (eye worm) hypothetical protein 0.0031 0.0177 0.015
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.005 0.039 0.0419
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0972 0.0972
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0177 0.0162
Loa Loa (eye worm) hypothetical protein 0.0021 0.006 0.0032
Giardia lamblia DINP protein human, muc B family 0.0021 0.006 0.2663
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0924 0.0973
Schistosoma mansoni hypothetical protein 0.0665 0.7608 0.8231
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.005 0.039 0.0221
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.004 0.0276 0.0249
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0076 0.0695 0.0669
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.006 0.031
Schistosoma mansoni hypothetical protein 0.0665 0.7608 0.8231
Leishmania major DNA polymerase kappa, putative 0.0021 0.006 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0695 0.0669
Echinococcus granulosus muscleblind protein 0.0145 0.1507 0.1607
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.1066 0.1127
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0076 0.0695 0.6429
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0972 0.0947
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.006 0.0056
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0105 0.0084
Mycobacterium ulcerans Type I modular polyketide synthase 0.005 0.039 0.0363
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.005 0.039 0.0221
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0227 0.0239
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0032 0.0186 0.2371
Loa Loa (eye worm) acyl carrier protein 0.0023 0.0076 0.0049
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0048 0.0372 0.0399
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0076 0.0695 0.0725
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0053 0.0426 0.0458
Loa Loa (eye worm) hypothetical protein 0.0025 0.0105 0.0077
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0076 0.0695 1
Leishmania major acetyl-CoA synthetase, putative 0.0076 0.0695 0.0735
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.1066 0.1127
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0076 0.0695 0.0669
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0227 0.0216
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0074 0.0677 0.0734
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0076 0.0695 0.0754
Echinococcus multilocularis geminin 0.0665 0.7608 0.8231
Echinococcus multilocularis GPCR, family 2 0.0031 0.0177 0.0162
Schistosoma mansoni hypothetical protein 0.0048 0.0367 0.0368
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0695 0.0669
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1066 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0053 0.0426 0.0261
Echinococcus granulosus geminin 0.0665 0.7608 0.8231
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0695 0.0669
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.006 0.031
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.005 0.039 0.0419
Schistosoma mansoni survival motor neuron protein 0.0048 0.0367 0.0368
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0149 0.1165
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.006 0.031
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.0695 0.6429
Loa Loa (eye worm) fatty acid synthase 0.0049 0.0382 0.0356
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0227 0.0239
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0227 0.02
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.006 0.0032
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0076 0.0695 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0149 0.1812
Echinococcus multilocularis muscleblind protein 0.0145 0.1507 0.1607
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0041 0.0284 0.0302
Schistosoma mansoni DNA polymerase eta 0.0021 0.006 0.0035
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0227 0.0239
Loa Loa (eye worm) phosphofructokinase 0.0107 0.1066 0.1041
Toxoplasma gondii type I fatty acid synthase, putative 0.0063 0.0549 0.7814
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0065 0.0572 0.0619
Loa Loa (eye worm) hypothetical protein 0.0233 0.2543 0.2522
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0227 0.1919
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0794 0.9114 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0076 0.0695 0.0725
Loa Loa (eye worm) beta-lactamase 0.0036 0.0227 0.02
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1066 1
Echinococcus granulosus dna polymerase eta 0.0021 0.006 0.0035
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0695 0.0695
Echinococcus multilocularis dna polymerase eta 0.0021 0.006 0.0035
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0149 0.1165
Onchocerca volvulus 0.0162 0.1706 1
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.002 0.0044 0.0039
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0177 0.0162
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0076 0.0695 0.0563
Mycobacterium ulcerans polyketide synthase 0.0053 0.0426 0.0399
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0695 0.0669
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0924 0.0973
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0076 0.0695 0.0669
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0924 0.0973
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0367 0.0367
Brugia malayi hypothetical protein 0.0025 0.0105 0.0105
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0149 0.1812
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0227 0.0216
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0149 0.1165
Trichomonas vaginalis antibiotic synthetase, putative 0.0076 0.0695 0.6429
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0695 0.0695
Trichomonas vaginalis antibiotic synthetase, putative 0.0076 0.0695 0.6429
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0105 0.1155
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0053 0.0426 0.0399
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.006 0.031
Mycobacterium tuberculosis Conserved protein 0.0036 0.0227 0.0239
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0076 0.0695 0.0725
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0149 0.1812
Trichomonas vaginalis esterase, putative 0.0036 0.0227 0.1919
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0227 0.0227
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0076 0.0695 0.0754
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0076 0.0695 0.0754
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0604 0.0604
Mycobacterium tuberculosis Conserved protein 0.0036 0.0227 0.0239
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0081 0.0754 0.0728
Loa Loa (eye worm) hypothetical protein 0.0094 0.0908 0.0883
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0227 0.1919
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0081 0.0754 0.0818
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.006 0.031
Mycobacterium ulcerans thioesterase 0.0041 0.0293 0.0266
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0105 0.1155
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.1066 0.1127
Echinococcus granulosus dna polymerase kappa 0.0021 0.006 0.0035
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0081 0.0754 0.0728
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0695 0.0669
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0227 0.0216
Mycobacterium ulcerans acetyl-CoA synthetase 0.0076 0.0695 0.0669
Loa Loa (eye worm) hypothetical protein 0.0145 0.1507 0.1484
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.006 0.031
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0227 0.0216
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0149 0.1165
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0074 0.0677 0.0734
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0869 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0177 0.015
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0094 0.091 0.091
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.1066 0.1161
Brugia malayi Muscleblind-like protein 0.0145 0.1507 0.1507
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0149 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0227 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0227 0.02
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.006 0.031
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0924 0.0924
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0111 0.0111
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.005 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0028 0.0135 0.0107
Mycobacterium leprae Polyketide synthase Pks13 0.0074 0.0677 0.0543
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0076 0.0695 0.0725
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0695 0.0695
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.006 0.0056
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0227 0.1919
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.1066 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0081 0.0754 0.6994
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0149 0.1165
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0076 0.0695 0.0735
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0695 0.0669
Brugia malayi 6-phosphofructokinase 0.0107 0.1066 0.1066
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0036 0.0226 0.0239
Mycobacterium ulcerans Type I modular polyketide synthase 0.005 0.039 0.0363
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.1066 0.0978
Mycobacterium ulcerans hypothetical protein 0.0036 0.0227 0.02
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0227 0.2984
Loa Loa (eye worm) hypothetical protein 0.0036 0.0227 0.02
Echinococcus granulosus long chain fatty acid transport protein 4 0.0804 0.9237 1
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.2543 0.2731
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0227 0.1919
Plasmodium vivax acetyl-CoA synthetase, putative 0.0076 0.0695 1
Onchocerca volvulus 0.0076 0.0695 0.3165
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0028 0.5
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0076 0.0695 0.0669
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0081 0.0754 0.0628
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.006 0.031
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0105 0.0084
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.006 0.0032
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.1066 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0149 0.1812
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0076 0.0695 0.0754
Onchocerca volvulus 0.0048 0.0367 0.0946
Echinococcus granulosus GPCR family 2 0.0031 0.0177 0.0162
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0695 0.0695
Onchocerca volvulus Fatty acid synthase homolog 0.0089 0.0856 0.4255
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.1066 0.1127
Echinococcus multilocularis dna polymerase kappa 0.0021 0.006 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0695 0.0669
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0041 0.0293 0.0112
Brugia malayi hypothetical protein 0.0233 0.2543 0.2543
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0695 0.0695
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0149 0.5
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.006 0.031
Onchocerca volvulus 0.0076 0.0695 0.3165
Trypanosoma brucei unspecified product 0.0021 0.006 0.031
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0076 0.0695 1
Mycobacterium ulcerans polyketide synthase Pks9 0.0033 0.0193 0.0166
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.0695 0.0563
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.006 0.031
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0081 0.0754 0.0818
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0695 0.0735
Loa Loa (eye worm) hypothetical protein 0.0036 0.0227 0.02
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.006 0.0035
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0076 0.0695 0.6429
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.006 0.0035
Onchocerca volvulus 0.0081 0.0754 0.3562
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.006 0.031
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0177 0.0177
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0036 0.0226 0.2969
Mycobacterium ulcerans Type I modular polyketide synthase 0.005 0.039 0.0363
Loa Loa (eye worm) hypothetical protein 0.0036 0.0227 0.02
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0076 0.0695 0.6429
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0081 0.0754 0.0728
Onchocerca volvulus 0.0122 0.1238 0.6834
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0227 0.02
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.1066 0.1041
Toxoplasma gondii propionate-CoA ligase 0.0076 0.0695 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0076 0.0695 0.0754
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0695 0.0735
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0695 0.0669
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.006 0.0035
Loa Loa (eye worm) hypothetical protein 0.0076 0.0695 0.0669
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0028 0.0028
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.004 0.0276 0.0249
Mycobacterium ulcerans hypothetical protein 0.0076 0.0695 0.0669
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0227 0.1919
Schistosoma mansoni acetyl-CoA synthetase 0.0076 0.0695 0.0725
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0105 0.1155
Brugia malayi beta-lactamase family protein 0.0036 0.0227 0.0227
Leishmania major DNA polymerase eta, putative 0.0021 0.006 0.0035
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.006 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0695 0.0669
Mycobacterium ulcerans polyketide synthase 0.005 0.039 0.0363
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0076 0.0695 0.0695
Leishmania major hypothetical protein, conserved 0.0025 0.0105 0.0085
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0149 0.1812
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0149 0.1812
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0177 0.0162
Mycobacterium ulcerans thioesterase TesA 0.0041 0.0293 0.0266
Mycobacterium tuberculosis Conserved protein 0.0036 0.0227 0.0239
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0227 0.1919
Toxoplasma gondii type I fatty acid synthase, putative 0.0035 0.0223 0.292
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.006 0.031
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.006 0.0032
Leishmania major hypothetical protein, conserved 0.0036 0.0227 0.0219
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0053 0.0426 0.0399
Brugia malayi AMP-binding enzyme family protein 0.0122 0.1238 0.1238
Schistosoma mansoni hypothetical protein 0.0031 0.0177 0.0162
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0081 0.0754 0.0728
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0177 0.0162
Mycobacterium ulcerans polyketide synthase Pks13 0.0074 0.0677 0.0651
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0076 0.0695 0.0669
Brugia malayi 6-phosphofructokinase 0.0107 0.1066 0.1066
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.006 0.0035
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0804 0.9237 1
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1066 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.1507 0.1484
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1066 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0604 0.0578
Mycobacterium leprae Probable lipase LipE 0.0036 0.0227 0.0038
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0028 0.0021
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0076 0.0695 0.0669
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1066 1
Brugia malayi phosphofructokinase 0.0107 0.1066 0.1066
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0804 0.9237 1
Mycobacterium leprae Probable polyketide synthase Pks1 0.0053 0.0426 0.0261
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.2543 0.2731
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0227 0.0239
Leishmania major fatty acid transporter protein-like protein 0.0794 0.9114 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0033 0.0193 0.0166
Loa Loa (eye worm) hypothetical protein 0.0076 0.0695 0.0669
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.006 0.0035
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0105 0.0743
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0076 0.0695 0.0754
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0149 0.1165
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.006 0.0035
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0227 0.0239
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0804 0.9237 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0149 0.1165
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0924 0.0973
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0794 0.9114 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0177 0.0177
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0869 1 1
Schistosoma mansoni hypothetical protein 0.0031 0.0177 0.0162
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.1066 1
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0028 0.0139 0.0143
Loa Loa (eye worm) hypothetical protein 0.0076 0.0695 0.0669
Schistosoma mansoni hypothetical protein 0.0031 0.0177 0.0162
Brugia malayi beta-lactamase 0.0036 0.0227 0.0227
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.006 0.006
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0048 0.0372 0.0399
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0076 0.0695 0.0669
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.006 0.031
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0122 0.1238 0.1214
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.005 0.039 0.0363
Brugia malayi beta-lactamase family protein 0.0036 0.0227 0.0227
Leishmania major acetyl-CoA synthetase, putative 0.0076 0.0695 0.0735
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1507 0.1607
Loa Loa (eye worm) hypothetical protein 0.0036 0.0227 0.02
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.1066 0.1143
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.1066 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.006 0.0035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0924 0.0973
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0149 0.1165
Loa Loa (eye worm) hypothetical protein 0.0099 0.0972 0.0947
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0053 0.0426 0.0458
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0149 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.1066 0.1041
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0227 0.0216
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.2478 0.2712
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0076 0.0695 0.0725
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0924 0.0973
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0972 0.0972
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0924 0.0898
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0924 0.0973
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0076 0.0695 0.0754
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0695 0.0735
Mycobacterium ulcerans lipase LipD 0.0036 0.0227 0.02
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0227 0.0239
Schistosoma mansoni FFA transport protein 0.0804 0.9237 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.006 0.031
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0105 0.1155

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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