Detailed information for compound 792507

Basic information

Technical information
  • TDR Targets ID: 792507
  • Name: 3-[5-chloro-4-[(5-chloro-2-methoxyphenyl)amin o]-6-oxopyridazin-1-yl]adamantane-1-carboxyli c acid
  • MW: 464.342 | Formula: C22H23Cl2N3O4
  • H donors: 2 H acceptors: 3 LogP: 4.06 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1Nc1cnn(c(=O)c1Cl)C12CC3CC(C1)CC(C2)(C3)C(=O)O)Cl
  • InChi: 1S/C22H23Cl2N3O4/c1-31-17-3-2-14(23)5-15(17)26-16-10-25-27(19(28)18(16)24)22-8-12-4-13(9-22)7-21(6-12,11-22)20(29)30/h2-3,5,10,12-13,26H,4,6-9,11H2,1H3,(H,29,30)
  • InChiKey: RMLPEIHTNVVMEV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[5-chloro-4-[(5-chloro-2-methoxy-phenyl)amino]-6-oxo-pyridazin-1-yl]adamantane-1-carboxylic acid
  • 3-[5-chloro-4-[(5-chloro-2-methoxyphenyl)amino]-6-oxo-1-pyridazinyl]-1-adamantanecarboxylic acid
  • 3-[5-chloro-4-[(5-chloro-2-methoxy-phenyl)amino]-6-keto-pyridazin-1-yl]adamantane-1-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0407 0.0407
Plasmodium falciparum heterochromatin protein 1 0.0013 0.0046 0.0408
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0046 0.0156
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0044 0.0044
Trypanosoma brucei hypothetical protein, conserved 0.0241 0.2999 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.061 0.176
Echinococcus granulosus geminin 0.0192 0.2364 0.2364
Echinococcus granulosus cathepsin L 0.001 0.0006 0.0006
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0111 0.0674
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0063
Schistosoma mansoni cpg binding protein 0.0033 0.03 0.03
Schistosoma mansoni cpg binding protein 0.0034 0.0324 0.0324
Mycobacterium ulcerans lipase LipD 0.0041 0.0407 0.1541
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0125 0.0245
Schistosoma mansoni cpg binding protein 0.0034 0.0324 0.0324
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0111 0.0111
Echinococcus multilocularis muscleblind protein 0.0169 0.207 0.207
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0125 0.0398
Echinococcus granulosus citrate lyase subunit beta protein 0.0028 0.0239 0.0239
Leishmania major cathepsin L-like protease 0.0019 0.0125 0.0048
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0075 0.0847 0.0847
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0046 0.0408
Schistosoma mansoni hypothetical protein 0.0039 0.0379 0.0379
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0013 0.0046 0.0046
Onchocerca volvulus 0.0031 0.0275 0.0696
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0046 0.0128
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0326 0.0326
Echinococcus granulosus ferritin 0.001 0.0004 0.0004
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0066 0.0734 0.2432
Leishmania major hypothetical protein, conserved 0.0241 0.2999 1
Echinococcus multilocularis dnaJ subfamily B 0.0464 0.5878 0.5878
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0815 0.2703
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0815 0.2703
Leishmania major cathepsin L-like protease 0.0019 0.0125 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0815 0.2703
Toxoplasma gondii ABC1 family protein 0.0041 0.0407 0.3771
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0125 0.0361
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0028 0.0239 0.0897
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0111 0.1055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0125 0.0361
Brugia malayi Cathepsin L-like precursor 0.0019 0.0125 0.0356
Onchocerca volvulus 0.0033 0.03 0.0774
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0013 0.0046 0.0408
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0028 0.0239 0.0723
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0087 0.1003 1
Brugia malayi Pre-SET motif family protein 0.0237 0.2941 0.8783
Loa Loa (eye worm) hypothetical protein 0.0035 0.0326 0.0905
Schistosoma mansoni hypothetical protein 0.0013 0.0046 0.0046
Mycobacterium ulcerans beta-lactamase 0.0041 0.0407 0.1541
Loa Loa (eye worm) hypothetical protein 0.0169 0.207 0.6155
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0075 0.0847 0.0847
Schistosoma mansoni apoferritin-2 0.001 0.0004 0.0004
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0125 0.0298
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0075 0.0847 0.255
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0326 0.0326
Schistosoma mansoni hypothetical protein 0.0055 0.0587 0.0587
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0142 0.0412
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0125 0.0361
Brugia malayi beta-lactamase family protein 0.0041 0.0407 0.1202
Brugia malayi Pre-SET motif family protein 0.0035 0.0326 0.0959
Echinococcus multilocularis cathepsin L 0.001 0.0006 0.0006
Brugia malayi CHD4 protein 0.0015 0.0071 0.0194
Brugia malayi isocitrate dehydrogenase 0.0018 0.0111 0.0315
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0125 0.0361
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0212 0.2623 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0407 0.1202
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0028 0.0239 0.07
Schistosoma mansoni hypothetical protein 0.0018 0.0111 0.0111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0815 0.2703
Echinococcus granulosus dnaJ subfamily B 0.0464 0.5878 0.5878
Echinococcus multilocularis muscleblind protein 1 0.0169 0.207 0.207
Plasmodium vivax vivapain-2 0.0019 0.0125 0.1194
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0125 0.0361
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0026 0.0026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0125 0.0361
Echinococcus multilocularis lamin 0.0031 0.0275 0.0275
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0111 0.0351
Toxoplasma gondii cathepsin CPL 0.0019 0.0125 0.0819
Echinococcus multilocularis musashi 0.0031 0.0275 0.0275
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0125 0.1194
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0615 0.2034
Onchocerca volvulus 0.0041 0.0407 0.1096
Schistosoma mansoni ferritin 0.001 0.0004 0.0004
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0028 0.0239 0.0897
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0098 0.028
Loa Loa (eye worm) hypothetical protein 0.0041 0.0407 0.1149
Entamoeba histolytica hypothetical protein 0.0013 0.0046 0.0156
Brugia malayi Cathepsin L-like precursor 0.0019 0.0125 0.0356
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0142 0.0412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0125 0.0361
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0046 0.0046
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0407 0.1202
Schistosoma mansoni intermediate filament proteins 0.0031 0.0275 0.0275
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0111 0.0111
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0587 0.1738
Onchocerca volvulus 0.0019 0.0125 0.0245
Brugia malayi Cathepsin L-like precursor 0.0019 0.0125 0.0356
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0212 0.2623 0.7797
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0407 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0125 0.0361
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0065 0.0725 0.2402
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0063
Brugia malayi MH2 domain containing protein 0.0135 0.163 0.4861
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0112
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0239 0.0778
Mycobacterium tuberculosis Conserved protein 0.0028 0.0239 0.0723
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0407 0.1242
Echinococcus multilocularis microtubule associated protein 2 0.0782 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.163 0.483
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0013 0.0046 0.0046
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.03 0.0827
Loa Loa (eye worm) hypothetical protein 0.0041 0.0407 0.1149
Entamoeba histolytica hypothetical protein 0.0013 0.0046 0.0156
Loa Loa (eye worm) hypothetical protein 0.0031 0.0275 0.075
Onchocerca volvulus 0.0041 0.0407 0.1096
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0046 0.0122
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0847 0.2812
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0013 0.0046 0.0408
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0111 0.0111
Schistosoma mansoni ferritin light chain 0.001 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0046 0.0128
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.001 0.0004 0.5
Chlamydia trachomatis endonuclease IV 0.0087 0.1003 0.5
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0006 0.0006
Onchocerca volvulus 0.0031 0.0275 0.0696
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0815 0.2703
Echinococcus multilocularis chromobox protein 2 0.0013 0.0046 0.0046
Schistosoma mansoni chromobox protein 0.0013 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0006 0.0006
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0046 0.0408
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0111 0.033
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0111 0.0257
Echinococcus granulosus muscleblind protein 0.0169 0.207 0.207
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0063
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0212 0.2623 0.7818
Onchocerca volvulus 0.0269 0.3362 1
Brugia malayi cathepsin L-like precursor 0.0013 0.0044 0.0113
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0239 0.0442
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0087 0.1003 0.3077
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0407 0.1541
Onchocerca volvulus 0.0055 0.0587 0.1636
Leishmania major cathepsin L-like protease 0.0072 0.0815 0.2437
Leishmania major cathepsin L-like protease 0.0072 0.0815 0.2437
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0407 0.1341
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0013 0.0046 0.0009
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0125 0.0245
Leishmania major cathepsin L-like protease 0.0019 0.0125 0.0048
Toxoplasma gondii endonuclease IV APN 0.0087 0.1003 1
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0212 0.2623 1
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0111 0.0315
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0275 0.0805
Echinococcus granulosus neuropeptide receptor A26 0.0524 0.6661 0.6661
Echinococcus multilocularis cysteine protease 0.0019 0.0125 0.0125
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0015 0.0071 0.0071
Schistosoma mansoni chromobox protein 0.0013 0.0046 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0125 0.0361
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0023 0.0175 0.0395
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.163 0.483
Schistosoma mansoni hypothetical protein 0.0192 0.2364 0.2364
Onchocerca volvulus 0.0019 0.0125 0.0245
Schistosoma mansoni chromobox protein 0.0013 0.0046 0.0046
Leishmania major cathepsin L-like protease 0.0019 0.0125 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0815 0.2703
Onchocerca volvulus 0.0019 0.0125 0.0245
Loa Loa (eye worm) helicase 0.0013 0.0046 0.0063
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0175 0.1713
Schistosoma mansoni lamin 0.0031 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0018 0.0111 0.0256
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0015 0.0071 0.0071
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0023 0.0175 0.0506
Schistosoma mansoni ferritin 0.001 0.0004 0.0004
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0815 0.2703
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0046 0.0128
Echinococcus granulosus cathepsin l1 0.0013 0.0044 0.0044
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0087 0.1003 0.2943
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0111 0.0351
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0407 0.1202
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0125 0.0125
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0065 0.0725 0.2147
Trichomonas vaginalis Heterochromatin protein, putative 0.0013 0.0046 0.0128
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0407 0.1242
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0407 0.1242
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0065 0.0725 0.2147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0125 0.0361
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0147 0.1777 0.5458
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0407 0.1202
Schistosoma mansoni ferritin light chain 0.001 0.0004 0.0004
Echinococcus granulosus survival motor neuron protein 1 0.0268 0.3347 0.3347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0125 0.0361
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0275 0.075
Onchocerca volvulus 0.0115 0.1365 0.398
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0102 0.1197 0.1197
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0125 0.0361
Schistosoma mansoni chromobox protein 0.0013 0.0046 0.0046
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.061 0.176
Trypanosoma cruzi hypothetical protein, conserved 0.0241 0.2999 1
Onchocerca volvulus 0.0047 0.0494 0.1355
Echinococcus multilocularis survival motor neuron protein 1 0.0268 0.3347 0.3347
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0142 0.0412
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0326 0.0326
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0125 0.1194
Mycobacterium ulcerans hypothetical protein 0.0023 0.0175 0.0654
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.007 0.007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0326 0.0326
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0125 0.0361
Brugia malayi Protein cec-1. 0.0013 0.0046 0.0122
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0063
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0142 0.0412
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0815 0.2703
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0111 0.0351
Schistosoma mansoni hypothetical protein 0.0464 0.5878 0.5878
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0091 0.0259
Schistosoma mansoni microtubule-associated protein tau 0.0782 1 1
Echinococcus multilocularis chromobox protein 1 0.0013 0.0046 0.0046
Brugia malayi M-phase phosphoprotein, mpp8 0.0115 0.1365 0.4066
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0046 0.0128
Brugia malayi intermediate filament protein 0.0031 0.0275 0.0805
Echinococcus granulosus lamin 0.0031 0.0275 0.0275
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0075 0.0847 0.2474
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0075 0.0847 0.3216
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0125 0.0125
Onchocerca volvulus 0.0019 0.0125 0.0245
Loa Loa (eye worm) fibroinase 0.0019 0.0125 0.0298
Leishmania major cathepsin L-like protease 0.0072 0.0815 0.2437
Loa Loa (eye worm) beta-lactamase 0.0041 0.0407 0.1149
Echinococcus granulosus cysteine protease 0.001 0.0006 0.0006
Loa Loa (eye worm) heterochromatin protein 1 0.0013 0.0046 0.0063
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0054
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0028 0.0239 0.0897
Mycobacterium leprae Probable lipase LipE 0.0041 0.0407 0.4038
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0044 0.0145
Echinococcus granulosus cathepsin l1 0.0019 0.0125 0.0125
Echinococcus granulosus lamin dm0 0.0031 0.0275 0.0275
Mycobacterium ulcerans hypothetical protein 0.0028 0.0239 0.0897
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0087 0.1003 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0112
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0111 0.0314
Loa Loa (eye worm) hypothetical protein 0.0041 0.0407 0.1149
Mycobacterium ulcerans epimerase 0.0023 0.0175 0.0654
Loa Loa (eye worm) ctsf protein 0.0019 0.0125 0.0298
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0046 0.0128
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0006 0.0006
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0046 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0006 0.0006
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0212 0.2623 0.7797
Trichomonas vaginalis esterase, putative 0.0041 0.0407 0.1202
Brugia malayi Muscleblind-like protein 0.0169 0.207 0.6178
Schistosoma mansoni apoferritin-2 0.001 0.0004 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0125 0.0361
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0111 0.0256
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0046 0.0156
Loa Loa (eye worm) hypothetical protein 0.0115 0.1365 0.4031
Onchocerca volvulus 0.0019 0.0125 0.0245
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0407 0.1242
Onchocerca volvulus 0.0115 0.1365 0.398
Schistosoma mansoni ferritin 0.001 0.0004 0.0004
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0087 0.1003 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0046 0.0128
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0046 0.0128
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0407 0.4025
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0407 0.1202
Brugia malayi Cathepsin L-like precursor 0.0019 0.0125 0.0356
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0125 0.0125
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0212 0.2623 0.7797
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0075 0.0847 0.0847
Onchocerca volvulus 0.0019 0.0125 0.0245
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0212 0.2623 0.7797
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0125 0.0245
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0028 0.0239 0.0778
Loa Loa (eye worm) hypothetical protein 0.0019 0.0125 0.0298
Brugia malayi beta-lactamase 0.0041 0.0407 0.1202
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0261 0.3253 1
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0815 0.2703
Echinococcus multilocularis cysteine protease 0.0019 0.0125 0.0125
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0098 0.028
Echinococcus multilocularis geminin 0.0192 0.2364 0.2364
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0046 0.0122
Leishmania major cathepsin L-like protease 0.0019 0.0125 0.0048
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0125 0.0361
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0018 0.0111 0.0111
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0407 0.1242
Echinococcus granulosus cpg binding protein 0.0034 0.0324 0.0324
Echinococcus granulosus GPCR family 2 0.0018 0.0111 0.0111
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0125 0.0455
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0013 0.0046 0.0009
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0125 0.1194
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0237 0.2941 0.8776
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.061 0.1809
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.061 0.1809
Loa Loa (eye worm) hypothetical protein 0.003 0.0268 0.0728
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0006 0.0006
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0087 0.1003 0.2985
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0407 0.1202
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0326 0.0326
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0212 0.2623 0.7831
Echinococcus multilocularis ferritin 0.001 0.0004 0.0004
Mycobacterium ulcerans hypothetical protein 0.0028 0.0239 0.0897
Loa Loa (eye worm) CHromoDomain protein family member 0.0015 0.0071 0.0135
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0102 0.1197 0.1197
Echinococcus granulosus Chromo domain 0.0013 0.0046 0.0046
Loa Loa (eye worm) cysteine protease 0.0019 0.0125 0.0298
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.0725 0.2402
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0125 0.0455
Trypanosoma cruzi hypothetical protein, conserved 0.0241 0.2999 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0047 0.0494 0.0494
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0111 0.0351
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0134
Schistosoma mansoni ferritin 0.001 0.0004 0.0004
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0102 0.1197 0.1197
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0125 0.0125
Mycobacterium tuberculosis Conserved protein 0.0041 0.0407 0.1242
Plasmodium vivax heterochromatin protein 1, putative 0.0013 0.0046 0.0408
Onchocerca volvulus 0.0212 0.2623 0.777
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0046 0.0128
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0063
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0175 0.0527
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0125 0.0361
Brugia malayi SET domain containing protein 0.0015 0.0072 0.0198
Echinococcus multilocularis neuropeptide s receptor 0.0524 0.6661 0.6661
Entamoeba histolytica hypothetical protein 0.0013 0.0046 0.0156
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0023 0.0175 0.0654
Echinococcus granulosus neuropeptide s receptor 0.0524 0.6661 0.6661
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0044 0.0119
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0026 0.0026
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0046 0.0128
Trichomonas vaginalis set domain proteins, putative 0.0269 0.3362 1
Schistosoma mansoni hypothetical protein 0.0018 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0041 0.0407 0.1149
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0091 0.0255
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0046 0.0156
Loa Loa (eye worm) hypothetical protein 0.0041 0.0407 0.1149
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0044 0.0119
Echinococcus granulosus chromobox protein 1 0.0013 0.0046 0.0046
Onchocerca volvulus 0.0019 0.0125 0.0245
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0407 0.1242
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0379 0.1117
Loa Loa (eye worm) hypothetical protein 0.0039 0.0379 0.1064
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.0044 0.0113
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0212 0.2623 0.7797
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0013 0.0046 0.0046
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0111 0.0314
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0789 0.0789
Echinococcus multilocularis lamin dm0 0.0031 0.0275 0.0275
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0111 0.0111
Leishmania major hypothetical protein, conserved 0.0041 0.0407 0.1026
Trichomonas vaginalis hypothetical protein 0.0013 0.0046 0.0128
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0407 0.1149
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0046 0.0128
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0407 0.1541
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0102 0.1197 0.1197
Brugia malayi Cathepsin L-like precursor 0.0013 0.0044 0.0113
Leishmania major hypothetical protein, conserved 0.0065 0.0725 0.2126
Mycobacterium ulcerans endonuclease IV 0.0087 0.1003 0.3818
Echinococcus granulosus chromobox protein 2 0.0013 0.0046 0.0046
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0024 0.0055
Mycobacterium tuberculosis Conserved protein 0.0041 0.0407 0.1242
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0015 0.0071 0.0071
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0111 0.1055
Echinococcus granulosus chromobox protein 1 0.0013 0.0046 0.0046
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0046 0.0046
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0268 0.3347 1
Mycobacterium ulcerans hypothetical protein 0.0041 0.0407 0.1541
Loa Loa (eye worm) hypothetical protein 0.0013 0.0044 0.0054
Echinococcus multilocularis citrate lyase subunit beta protein 0.0028 0.0239 0.0239
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0111 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0125 0.0361
Echinococcus granulosus intermediate filament protein 0.0031 0.0275 0.0275
Treponema pallidum bacterioferrin (TpF1) 0.001 0.0004 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0125 0.0361
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0125 0.0361
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.044 0.044
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0046 0.0128
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0326 0.0326
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0111 0.0111
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0111 0.0674
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0046 0.0128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0815 0.2703
Echinococcus multilocularis neuropeptide receptor A26 0.0524 0.6661 0.6661
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0212 0.2623 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0046 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0046 0.0128
Echinococcus multilocularis Chromo domain 0.0013 0.0046 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0407 0.1341
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0407 0.4038
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0046 0.0128
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0142 0.0412
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0301 0.0301
Echinococcus granulosus expressed protein 0.001 0.0004 0.0004
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0693 0.676
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0111 0.0111
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0046 0.0128
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0407 0.1341
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0125 0.0356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0125 0.0361
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0275 0.075
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0046 0.0128
Trichomonas vaginalis chromobox protein, putative 0.0013 0.0046 0.0128
Brugia malayi Cathepsin L-like precursor 0.0019 0.0125 0.0356
Schistosoma mansoni hypothetical protein 0.0018 0.0111 0.0111
Brugia malayi Heterochromatin protein 1 0.0013 0.0046 0.0122
Plasmodium vivax SET domain protein, putative 0.0035 0.0326 0.3213
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0815 0.2703
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0407 0.0407
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0046 0.0122
Entamoeba histolytica cysteine protease, putative 0.0019 0.0125 0.0455
Schistosoma mansoni survival motor neuron protein 0.0055 0.0587 0.0587
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0125 0.0361
Echinococcus multilocularis GPCR, family 2 0.0018 0.0111 0.0111
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0046 0.0046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0142 0.0412
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0142 0.0412
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0125 0.0361
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0125 0.0361
Echinococcus multilocularis cpg binding protein 0.0034 0.0324 0.0324
Brugia malayi CXXC zinc finger family protein 0.0033 0.03 0.0882
Brugia malayi beta-lactamase family protein 0.0041 0.0407 0.1202
Brugia malayi Cathepsin L-like precursor 0.0013 0.0044 0.0113
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0326 0.2924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0125 0.0361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0815 0.2703
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0407 0.0407
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0125 0.0125
Brugia malayi hypothetical protein 0.0115 0.1365 0.4066
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0407 0.1242
Echinococcus multilocularis expressed protein 0.001 0.0004 0.0004
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0125 0.0298
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0111 0.0111
Echinococcus granulosus Chromobox protein 3 0.0013 0.0046 0.0046
Schistosoma mansoni lamin 0.0031 0.0275 0.0275
Echinococcus multilocularis chromobox protein 1 0.0013 0.0046 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0046 0.0128
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0111 0.0111
Mycobacterium tuberculosis Conserved protein 0.0041 0.0407 0.1242
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0125 0.0048
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0142 0.0412
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0125 0.0125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0815 0.2703
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0125 0.0361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0815 0.2703
Loa Loa (eye worm) hypothetical protein 0.0169 0.207 0.6155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0815 0.2703
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0212 0.2623 0.7797
Onchocerca volvulus 0.0041 0.0407 0.1096
Brugia malayi Cathepsin L-like precursor 0.0019 0.0125 0.0356
Loa Loa (eye worm) hypothetical protein 0.0023 0.0175 0.0449
Echinococcus granulosus transcription factor Dp 1 0.0043 0.044 0.044
Schistosoma mansoni hypothetical protein 0.0192 0.2364 0.2364
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.0725 0.2402
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0075 0.0847 0.2519
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0847 0.2812
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0091 0.0197
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0075 0.0847 0.2812
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0212 0.2623 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.1365 0.4031
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0111 0.0111
Brugia malayi hypothetical protein 0.0268 0.3347 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0407 0.1149
Plasmodium vivax vivapain-2 0.0019 0.0125 0.1194
Brugia malayi chromobox protein homolog 3 0.0013 0.0046 0.0122
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0125 0.0125

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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