Detailed information for compound 795454

Basic information

Technical information
  • TDR Targets ID: 795454
  • Name: 2-[[2-(2,1,3-benzothiadiazol-7-ylsulfonyl)ace tyl]amino]benzoic acid
  • MW: 377.395 | Formula: C15H11N3O5S2
  • H donors: 2 H acceptors: 7 LogP: 2.01 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CS(=O)(=O)c1cccc2c1nsn2)Nc1ccccc1C(=O)O
  • InChi: 1S/C15H11N3O5S2/c19-13(16-10-5-2-1-4-9(10)15(20)21)8-25(22,23)12-7-3-6-11-14(12)18-24-17-11/h1-7H,8H2,(H,16,19)(H,20,21)
  • InChiKey: XSELAJMJYCJTNW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[2-(2,1,3-benzothiadiazol-7-ylsulfonyl)-1-oxoethyl]amino]benzoic acid
  • 2-[(2-piazthiol-4-ylsulfonylacetyl)amino]benzoic acid
  • 2-[2-(2,1,3-benzothiadiazol-7-ylsulfonyl)ethanoylamino]benzoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae conserved hypothetical protein 0.0037 0.1172 1
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0553 0.0553
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1534 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.3451 0.3451
Echinococcus multilocularis cpg binding protein 0.0029 0.0907 0.567
Echinococcus granulosus cpg binding protein 0.0029 0.0907 0.567
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0011 0.0236 0.001
Trypanosoma brucei hypothetical protein, conserved 0.0011 0.0236 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.4273 0.4273
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.1172 0.1226
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Loa Loa (eye worm) CYP4Cod1 0.002 0.0553 0.0553
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0236 0.001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.0236 0.0052
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0011 0.0236 0.001
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0011 0.0236 0.1038
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.0236 0.0152
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.1172 0.1157
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0135 0.0346
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0532 0.3086
Loa Loa (eye worm) PDE1B protein 0.0011 0.0236 0.0236
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0236 0.0174
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0532 0.0373
Brugia malayi MH2 domain containing protein 0.0122 0.4273 0.4273
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0553 0.0553
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.1172 0.1096
Toxoplasma gondii exonuclease III APE 0.0019 0.0532 0.1991
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0236 0.0174
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.0236 0.0174
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0532 0.0312
Schistosoma mansoni smad1 5 8 and 0.0008 0.0135 0.0051
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0011 0.0236 0.001
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0011 0.0236 0.001
Loa Loa (eye worm) hypothetical protein 0.0099 0.3451 0.3451
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0532 0.3169
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0011 0.0236 0.1038
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.1172 0.1116
Schistosoma mansoni cpg binding protein 0.0028 0.0849 0.077
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.0236 0.0052
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0147 0.0147
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0849 0.0849
Loa Loa (eye worm) hypothetical protein 0.0011 0.0236 0.0236
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.0236 0.0052
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.0236 0.0152
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0977 0.6158
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Loa Loa (eye worm) hypothetical protein 0.0037 0.1172 0.1172
Echinococcus multilocularis 0.0011 0.0228 0.0983
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.0236 0.0152
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0011 0.0236 0.001
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.1172 0.1157
Brugia malayi cytochrome P450 0.0011 0.0228 0.0228
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.0236 0.0052
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0011 0.0236 0.0174
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0011 0.0236 0.1038
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0147 0.0428
Loa Loa (eye worm) cytochrome P450 0.0011 0.0228 0.0228
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.0236 0.0052
Leishmania major cytochrome p450-like protein 0.002 0.0553 0.0423
Onchocerca volvulus 0.0037 0.1172 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.1172 0.1157
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.0236 0.0152
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0011 0.0236 0.1038
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.1172 0.1157
Loa Loa (eye worm) hypothetical protein 0.0037 0.1172 0.1172
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0532 0.0532
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0553 0.0423
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0011 0.0236 0.1038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1534 0.1461
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0236 0.0174
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.0236 0.0174
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.1172 0.1157
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.1172 0.1157
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Schistosoma mansoni ap endonuclease 0.0019 0.0532 0.0451
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0532 0.5
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0011 0.0236 0.1038
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Echinococcus multilocularis Smad4 0.0008 0.0135 0.0346
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0532 0.5
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0532 0.3086
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0228 0.0983
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0532 0.0396
Schistosoma mansoni hypothetical protein 0.0031 0.0977 0.09
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.1172 0.1116
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0011 0.0236 0.001
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.1172 0.1157
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0011 0.0236 0.1038
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0135 0.0135
Mycobacterium tuberculosis Conserved protein 0.0037 0.1172 0.1157
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1534 1
Brugia malayi beta-lactamase family protein 0.0037 0.1172 0.1172
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0011 0.0236 0.0152
Mycobacterium ulcerans glutaminase 0.0279 1 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0011 0.0236 0.0174
Loa Loa (eye worm) hypothetical protein 0.0009 0.0159 0.0159
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0011 0.0236 0.1038
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.1534 0.1534
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0532 0.0396
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.0236 0.0052
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.0236 0.0052
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0011 0.0236 0.001
Brugia malayi MH1 domain containing protein 0.0008 0.0135 0.0135
Echinococcus granulosus smad 0.0008 0.0135 0.0346
Leishmania major hypothetical protein, conserved 0.0037 0.1172 0.1226
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0011 0.0236 0.1038
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.0236 0.0052
Loa Loa (eye worm) hypothetical protein 0.0037 0.1172 0.1172
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1534 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0011 0.0236 0.001
Schistosoma mansoni Smad4 0.0008 0.0135 0.0051
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0937 0.0937
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0011 0.0236 0.0152
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0236 0.001
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0011 0.0236 0.1038
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1988 0.1919
Brugia malayi MH2 domain containing protein 0.0008 0.0135 0.0135
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0532 0.0396
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.1172 0.1172
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0236 0.0174
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.4273 0.4273
Schistosoma mansoni hypothetical protein 0.0068 0.2306 0.224
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0236 0.001
Mycobacterium ulcerans beta-lactamase 0.0037 0.1172 0.0966
Brugia malayi CXXC zinc finger family protein 0.0028 0.0849 0.0849
Mycobacterium tuberculosis Conserved protein 0.0037 0.1172 0.1157
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0977 0.6158
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0011 0.0236 0.001
Schistosoma mansoni hypothetical protein 0.0031 0.0977 0.09
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0011 0.0236 0.1038
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.0236 0.0052
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0135 0.0051
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0236 0.0174
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0532 0.0472
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0532 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0135 0.0051
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0011 0.0236 0.1038
Schistosoma mansoni smad 0.0008 0.0135 0.0051
Brugia malayi MH1 domain containing protein 0.0008 0.0135 0.0135
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.0236 0.0174
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0532 0.0532
Echinococcus granulosus GPCR family 2 0.0031 0.0977 0.6158
Brugia malayi Cytochrome P450 family protein 0.003 0.0937 0.0937
Schistosoma mansoni hypothetical protein 0.0031 0.0977 0.09
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0011 0.0236 0.0174
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.0236 0.0236
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0236 0.0174
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0011 0.0236 0.001
Schistosoma mansoni hypothetical protein 0.0011 0.0228 0.0144
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.0236 0.0052
Mycobacterium tuberculosis Conserved protein 0.0037 0.1172 0.1157
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0011 0.0236 0.1038
Brugia malayi Cytochrome P450 family protein 0.002 0.0553 0.0553
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0532 0.5
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0011 0.0236 0.0174
Loa Loa (eye worm) hypothetical protein 0.0011 0.0236 0.0236
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0011 0.0236 0.0152
Schistosoma mansoni hypothetical protein 0.0031 0.0977 0.09
Brugia malayi beta-lactamase 0.0037 0.1172 0.1172
Onchocerca volvulus 0.0037 0.1172 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1534 0.1461
Echinococcus multilocularis GPCR, family 2 0.0031 0.0977 0.6158
Schistosoma mansoni cytochrome P450 0.0011 0.0228 0.0144
Schistosoma mansoni cpg binding protein 0.0029 0.0907 0.0829
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0011 0.0236 0.0152
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.2306 0.2306
Leishmania major hypothetical protein, conserved 0.0222 0.7927 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.0236 0.0052
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0011 0.0236 0.1038
Toxoplasma gondii ABC1 family protein 0.0037 0.1172 0.6171
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0236 0.001
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.1172 0.75
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Trypanosoma brucei cytochrome P450, putative 0.002 0.0553 0.0423
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0011 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0037 0.1172 0.1172
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.1172 0.1172
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Plasmodium vivax hypothetical protein, conserved 0.0037 0.1172 1
Brugia malayi Smad1 0.0008 0.0135 0.0135
Brugia malayi Cytochrome P450 family protein 0.002 0.0553 0.0553
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0977 0.0977
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0977 0.0977
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0977 0.6158
Loa Loa (eye worm) hypothetical protein 0.0037 0.1172 0.1172
Mycobacterium ulcerans lipase LipD 0.0037 0.1172 0.0966
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0532 0.0396
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.0236 0.0152
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0011 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0011 0.0236 0.0236
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.0236 0.0052
Brugia malayi MH2 domain containing protein 0.0008 0.0135 0.0135
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.0236 0.0236
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.3451 0.3451
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0236 0.001
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0011 0.0236 0.1038
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0553 0.0423
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0135 0.0346
Brugia malayi beta-lactamase family protein 0.0037 0.1172 0.1172
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.0236 0.0152
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1534 0.1461
Leishmania major hypothetical protein, conserved 0.0011 0.0236 0.001
Schistosoma mansoni cpg binding protein 0.0029 0.0907 0.0829
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0011 0.0236 0.001
Mycobacterium ulcerans hypothetical protein 0.0037 0.1172 0.0966
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0236 0.0174
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0011 0.0236 0.1038
Loa Loa (eye worm) hypothetical protein 0.0068 0.2306 0.2306
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0011 0.0236 0.001
Mycobacterium leprae Probable lipase LipE 0.0037 0.1172 1
Loa Loa (eye worm) Smad1 0.0008 0.0135 0.0135
Schistosoma mansoni smad1 5 8 and 0.0008 0.0135 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.1172 0.1226
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.1172 0.1226
Loa Loa (eye worm) hypothetical protein 0.0037 0.1172 0.1172
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1758 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0236 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0236 0.0174
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.1172 0.1116
Echinococcus multilocularis smad 0.0008 0.0135 0.0346
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.8388 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.0236 0.0052
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0236 0.0174
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0011 0.0236 0.0236
Schistosoma mansoni ap endonuclease 0.0019 0.0532 0.0451
Onchocerca volvulus 0.0037 0.1172 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.1172 0.0966
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.1172 0.0966
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.0236 0.0174
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0236 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0236 0.001
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.0236 0.0052
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0147 0.0428
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0135 0.0346
Echinococcus granulosus Smad4 0.0008 0.0135 0.0346
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0532 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0532 0.0472
Leishmania major cAMP-specific phosphodiesterase, putative 0.0011 0.0236 0.001
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.0236 0.0152
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0135 0.0346
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0977 0.0977
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0236 0.0174
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0977 0.6158
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.0236 0.0052
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1534 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0011 0.0236 0.0236
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.0236 0.0174
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.1172 0.1096
Loa Loa (eye worm) beta-lactamase 0.0037 0.1172 0.1172
Schistosoma mansoni glutaminase 0.0279 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0977 0.0977
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.0236 0.0052
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.0236 0.0052
Trichomonas vaginalis esterase, putative 0.0037 0.1172 0.1116
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.1534 0.1534
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.1172 0.1116
Loa Loa (eye worm) glutaminase 0.0279 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.1172 0.1116
Trichomonas vaginalis glutaminase, putative 0.0279 1 1
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0222 0.7927 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.1172 0.75
Loa Loa (eye worm) glutaminase 2 0.0279 1 1
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0143 0.0143
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0236 0.0174
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0135 0.0135
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.0236 0.0236
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0222 0.7927 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0553 0.0333
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0236 0.0174
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0011 0.0236 0.0052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.3451 0.3451
Brugia malayi Cytochrome P450 family protein 0.0011 0.0228 0.0228

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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