TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 324.44 | Formula: C19H20N2OS
H donors: 0 H acceptors: 1 LogP: 5.05 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCCOc1ccc(cc1)C=Nc1sc2c(c1C#N)CCCC2
InChi: 1S/C19H20N2OS/c1-2-11-22-15-9-7-14(8-10-15)13-21-19-17(12-20)16-5-3-4-6-18(16)23-19/h7-10,13H,2-6,11H2,1H3/b21-13+
InChiKey: GDIMANQHQSGLIP-FYJGNVAPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0301	0.365
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0095	0.0852	0.1424
Trypanosoma brucei	trypanothione reductase	0.0038	0.0159	0.1213
Trypanosoma cruzi	oligopeptidase b	0.0052	0.033	0.255
Loa Loa (eye worm)	hypothetical protein	0.0197	0.2087	0.4021
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0004	0.0007
Echinococcus granulosus	histone acetyltransferase MYST2	0.0095	0.0852	0.1424
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0046	0.2421
Echinococcus multilocularis	geminin	0.0164	0.1682	0.2818
Plasmodium vivax	JmjC domain containing protein	0.0038	0.0161	1
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0046	0.2672
Brugia malayi	serine/threonine-protein kinase plk-2	0.0092	0.0819	0.1577
Echinococcus granulosus	acetylcholinesterase	0.0133	0.1305	0.2184
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0131	0.1282	0.1279
Trypanosoma brucei	prolyl endopeptidase	0.0131	0.1282	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0084	0.008
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0382	0.4322	0.432
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0009	0.0041
Echinococcus multilocularis	chromobox protein 1	0.008	0.0663	0.1107
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0084	0.0162
Echinococcus granulosus	acetylcholinesterase	0.0133	0.1305	0.2184
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0009	0.0041
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0135	0.1336	0.2574
Plasmodium vivax	thioredoxin reductase, putative	0.0038	0.0159	0.9831
Echinococcus multilocularis	survival motor neuron protein 1	0.0239	0.2591	0.4342
Schistosoma mansoni	hypothetical protein	0.0068	0.0529	0.0525
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0135	0.1336	0.2574
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1282	0.2469
Brugia malayi	prolyl oligopeptidase family protein	0.0131	0.1282	0.2469
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0052	0.033	0.1785
Brugia malayi	Sphingomyelin synthase-related 1	0.0025	0.0004	0.0007
Echinococcus multilocularis	acetylcholinesterase	0.0133	0.1305	0.2184
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0463	0.0892
Echinococcus granulosus	survival motor neuron protein 1	0.0239	0.2591	0.4342
Loa Loa (eye worm)	glutathione reductase	0.0038	0.0159	0.0306
Schistosoma mansoni	chromobox protein	0.0207	0.2202	0.22
Onchocerca volvulus	Alhambra homolog	0.0029	0.0046	0.0081
Echinococcus granulosus	GPCR family 2	0.0032	0.0084	0.0135
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0413	0.0796
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0436	0.0725
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.0912	0.1757
Loa Loa (eye worm)	hypothetical protein	0.012	0.115	0.2216
Schistosoma mansoni	hypothetical protein	0.0029	0.0046	0.0042
Brugia malayi	Liprin-alpha 2	0.0025	0.0004	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0004	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0028	0.0299
Brugia malayi	hypothetical protein	0.0025	0.0009	0.0017
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0038	0.016	0.0263
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0052	0.033	0.255
Schistosoma mansoni	serine/threonine protein kinase	0.0092	0.0819	0.0815
Mycobacterium tuberculosis	Probable reductase	0.0086	0.0745	0.6127
Loa Loa (eye worm)	calpain family protein 1	0.0044	0.0236	0.0455
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0254	0.3074
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0046	0.0088
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0084	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0084	0.0162
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0084	0.0162
Echinococcus granulosus	tumor suppressor p53 binding protein 1	0.0325	0.3631	0.6089
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0095	0.0852	0.1424
Loa Loa (eye worm)	hypothetical protein	0.003	0.0063	0.0122
Brugia malayi	hypothetical protein	0.0025	0.0004	0.0007
Echinococcus granulosus	chromobox protein 1	0.008	0.0663	0.1107
Schistosoma mansoni	sex comb on midleg homolog	0.0264	0.2892	0.2889
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0436	1
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0454	0.5191	1
Toxoplasma gondii	prolyl endopeptidase	0.0131	0.1282	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0004	0.0007
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0382	0.4322	0.725
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0046	0.0042
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0517	0.5961	1
Brugia malayi	bicaudal-C	0.0025	0.0004	0.0007
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0038	0.0165	0.0271
Loa Loa (eye worm)	jmjC domain-containing protein	0.017	0.1763	0.3397
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0436	0.3358
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0135	0.1336	0.2236
Loa Loa (eye worm)	hypothetical protein	0.0454	0.5191	1
Echinococcus granulosus	sterol O acyltransferase 1	0.0219	0.2346	0.3931
Schistosoma mansoni	hypothetical protein	0.0164	0.1682	0.1679
Echinococcus multilocularis	lysine specific demethylase 5A	0.0111	0.1049	0.1755
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0135	0.1336	0.2236
Brugia malayi	mbt repeat family protein	0.0454	0.5191	1
Echinococcus granulosus	geminin	0.0164	0.1682	0.2818
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0136	0.0133
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0122	0.1183	0.1979
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0066	0.0502	0.0837
Loa Loa (eye worm)	thioredoxin reductase	0.0038	0.0159	0.0306
Echinococcus granulosus	calpain A	0.0066	0.0502	0.0837
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0046	0.0071
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0084	0.0135
Trichomonas vaginalis	chromobox protein, putative	0.0052	0.0336	0.408
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.0912	0.1757
Onchocerca volvulus		0.003	0.0063	0.0115
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0096	0.0862	0.7345
Loa Loa (eye worm)	hypothetical protein	0.012	0.115	0.2216
Plasmodium falciparum	glutathione reductase	0.0038	0.0159	0.9825
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0086	0.0745	0.6127
Schistosoma mansoni	hypothetical protein	0.0032	0.0084	0.008
Mycobacterium tuberculosis	Probable oxidoreductase	0.0096	0.0862	0.7345
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0119	0.1136	0.1901
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0529	0.1019
Brugia malayi	calpain family protein 1	0.0063	0.0463	0.0892
Echinococcus multilocularis	chromobox protein 2	0.0207	0.2202	0.3691
Onchocerca volvulus	Huntingtin homolog	0.012	0.115	0.2211
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0133	0.1305	0.1302
Brugia malayi	jmjC domain containing protein	0.0119	0.1136	0.2188
Brugia malayi	Thioredoxin reductase	0.0038	0.0159	0.0306
Toxoplasma gondii	PLU-1 family protein	0.0044	0.0228	0.173
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0092	0.0819	0.636
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0092	0.0819	0.1368
Schistosoma mansoni	jumonji domain containing protein	0.0099	0.0904	0.09
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0066	0.0502	0.0499
Brugia malayi	hypothetical protein	0.012	0.115	0.2216
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0095	0.0852	0.0848
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0135	0.1336	0.2236
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0046	0.0296
Brugia malayi	Shank2E	0.0025	0.0004	0.0007
Loa Loa (eye worm)	heterochromatin protein 1	0.008	0.0663	0.1278
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0028	0.0299
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0819	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0084	0.0162
Schistosoma mansoni	hypothetical protein	0.0164	0.1682	0.1679
Schistosoma mansoni	hypothetical protein	0.0032	0.0084	0.008
Brugia malayi	Carboxylesterase family protein	0.0133	0.1305	0.2514
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0127	0.1236	0.1233
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0038	0.016	0.0157
Echinococcus granulosus	SAM and MBT domain containing protein	0.0382	0.4322	0.725
Schistosoma mansoni	sex comb on midleg homolog	0.0264	0.2892	0.2889
Echinococcus granulosus	histone acetyltransferase myst3	0.004	0.019	0.0313
Loa Loa (eye worm)	acetylcholinesterase 1	0.0133	0.1305	0.2514
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0052	0.033	0.2519
Toxoplasma gondii	thioredoxin reductase	0.0038	0.0159	0.1183
Plasmodium vivax	glutathione reductase, putative	0.0038	0.0159	0.9831
Echinococcus multilocularis	polycomb protein SCMH1	0.0264	0.2892	0.4848
Echinococcus granulosus	chromobox protein 1	0.008	0.0663	0.1107
Brugia malayi	coiled-coil like protein 1	0.0025	0.0004	0.0007
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0254	0.3074
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0066	0.0502	0.0499
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0086	0.0745	0.6127
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0127	0.1236	0.1233
Trichomonas vaginalis	chromobox protein, putative	0.008	0.0663	0.8095
Brugia malayi	chromobox protein homolog 3	0.005	0.0301	0.058
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0046	0.0071
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.0912	0.1757
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0135	0.1336	0.2236
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0135	0.1336	0.1333
Loa Loa (eye worm)	MH2 domain-containing protein	0.0121	0.116	0.2234
Echinococcus multilocularis	calpain family protein 1, d	0.0044	0.0236	0.039
Schistosoma mansoni	hypothetical protein	0.0036	0.0136	0.0133
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0819	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0119	0.1136	0.1901
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0092	0.0819	0.1368
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0092	0.0819	0.1577
Loa Loa (eye worm)	tnks protein	0.0025	0.0004	0.0007
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.0819	0.6375
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0436	0.3354
Schistosoma mansoni	hypothetical protein	0.0032	0.0084	0.008
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0131	0.1282	1
Brugia malayi	MH2 domain containing protein	0.0121	0.116	0.2234
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0084	0.0135
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0041	0.0201	0.1513
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0136	0.0223
Mycobacterium tuberculosis	Probable dehydrogenase	0.0086	0.0745	0.6127
Trypanosoma cruzi	prolyl endopeptidase	0.0131	0.1282	1
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0038	0.0161	1
Echinococcus multilocularis	chromobox protein 1	0.008	0.0663	0.1107
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0086	0.0745	0.781
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0052	0.033	0.255
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0009	0.0331
Brugia malayi	hypothetical protein	0.0025	0.0004	0.0007
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0063	0.0463	0.046
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0436	1
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0517	0.5961	1
Brugia malayi	PHD-finger family protein	0.0029	0.0046	0.0088
Brugia malayi	hypothetical protein	0.0239	0.2591	0.4991
Trypanosoma cruzi	trypanothione reductase, putative	0.0038	0.0159	0.1213
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0004	0.0007
Loa Loa (eye worm)	AIDA-1b	0.0025	0.0004	0.0007
Brugia malayi	hypothetical protein	0.0036	0.0136	0.0263
Echinococcus multilocularis	prolyl endopeptidase	0.0131	0.1282	0.2146
Brugia malayi	Carboxylesterase family protein	0.0133	0.1305	0.2514
Loa Loa (eye worm)	hypothetical protein	0.0219	0.2346	0.4519
Schistosoma mansoni	hypothetical protein	0.0325	0.3631	0.3628
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0084	0.0135
Schistosoma mansoni	chromobox protein	0.008	0.0663	0.066
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0181	0.0298
Echinococcus granulosus	polycomb protein SCMH1	0.0264	0.2892	0.4848
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0004	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0239	0.2591	0.4991
Echinococcus multilocularis	acetylcholinesterase	0.0133	0.1305	0.2184
Brugia malayi	Heterochromatin protein 1	0.008	0.0663	0.1278
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0236	0.0455
Leishmania major	trypanothione reductase	0.0038	0.0159	0.1177
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.005	0.0301	0.0573
Schistosoma mansoni	sterol O-acyltransferase 1	0.0219	0.2346	0.2343
Schistosoma mansoni	survival motor neuron protein	0.0049	0.029	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1305	0.2514
Loa Loa (eye worm)	CHromoDomain protein family member	0.0038	0.016	0.0309
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0436	0.0432
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0436	0.0725
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0096	0.0862	0.7345
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0004	0.0007
Trypanosoma brucei	polo-like protein kinase	0.0092	0.0819	0.6375
Loa Loa (eye worm)	toll and interleukin 1 receptor domain-containing protein isoform f	0.0025	0.0004	0.0007
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0038	0.016	0.0263
Brugia malayi	sterile alpha and TIR motif containing protein 1 isoform a	0.0025	0.0004	0.0007
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0009	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0009	0.0017
Brugia malayi	CHD4 protein	0.0038	0.016	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0374	0.072
Trypanosoma cruzi	polo-like protein kinase, putative	0.0092	0.0819	0.6375
Brugia malayi	calpain family protein 1	0.0063	0.0463	0.0892
Mycobacterium tuberculosis	Probable peptidase	0.0052	0.033	0.1785
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0117	0.1116	1
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0131	0.1282	0.2464
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0046	0.0088
Loa Loa (eye worm)	hypothetical protein	0.01	0.0912	0.1757
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0095	0.0852	0.1424
Echinococcus granulosus	prolyl endopeptidase	0.0131	0.1282	0.2146
Schistosoma mansoni	hypothetical protein	0.0049	0.029	0.0287
Giardia lamblia	PHD finger protein 15	0.0029	0.0046	0.0517
Echinococcus granulosus	carboxylesterase 5A	0.0133	0.1305	0.2184
Brugia malayi	cask-interacting protein 2	0.0025	0.0004	0.0007
Echinococcus multilocularis	histone acetyltransferase myst3	0.004	0.019	0.0313
Loa Loa (eye worm)	hypothetical protein	0.005	0.0301	0.058
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0052	0.033	0.255
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.029	0.0559
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0819	1
Onchocerca volvulus		0.0299	0.3324	0.6402
Trypanosoma brucei	oligopeptidase b	0.0052	0.033	0.255
Onchocerca volvulus		0.0044	0.0236	0.0448
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0046	0.0296
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0131	0.1282	0.1279
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0819	1
Brugia malayi	jmjC domain containing protein	0.017	0.1763	0.3397
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0095	0.0852	0.1641
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0096	0.0862	1
Loa Loa (eye worm)	mbt repeat family protein	0.0274	0.3022	0.5821
Echinococcus multilocularis	sterol O acyltransferase 1	0.0219	0.2346	0.3931
Brugia malayi	mbt repeat family protein	0.0274	0.3022	0.5821
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0086	0.0745	0.6127
Trypanosoma cruzi	oligopeptidase b	0.0052	0.033	0.255
Onchocerca volvulus		0.0049	0.029	0.0553
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0135	0.1336	0.1333
Trichomonas vaginalis	chromobox protein, putative	0.0052	0.0336	0.408
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0004	0.0007
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0092	0.0819	0.1571
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0086	0.0745	0.6127
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0135	0.1336	0.1333
Giardia lamblia	Kinase, PLK	0.0092	0.0819	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0436	0.2895
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0009	0.0006
Echinococcus multilocularis	calpain A	0.0066	0.0502	0.0837
Trichomonas vaginalis	conserved hypothetical protein	0.005	0.0301	0.365
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0819	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0084	0.0135
Loa Loa (eye worm)	calpain family protein 1	0.0063	0.0463	0.0892
Echinococcus multilocularis	tumor suppressor p53 binding protein 1	0.0325	0.3631	0.6089
Trichomonas vaginalis	chromobox protein, putative	0.008	0.0663	0.8095
Echinococcus multilocularis	peregrin	0.0029	0.0046	0.0071
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0436	1
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0122	0.1183	0.1979
Schistosoma mansoni	kinase	0.0047	0.0269	0.0265
Brugia malayi	latrophilin 2 splice variant baaae	0.0068	0.0529	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0463	0.0892
Onchocerca volvulus	Huntingtin homolog	0.012	0.115	0.2211
Echinococcus granulosus	thioredoxin glutathione reductase	0.0038	0.0165	0.0271
Plasmodium falciparum	thioredoxin reductase	0.0038	0.0159	0.9825
Schistosoma mansoni	phd finger protein	0.004	0.019	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0236	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1305	0.2514
Loa Loa (eye worm)	MBCTL1	0.0095	0.0852	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0004	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0852	0.1641
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0136	0.0223
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0066	0.0502	0.0837
Loa Loa (eye worm)	carboxylesterase	0.0133	0.1305	0.2514
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0092	0.0819	1
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0181	0.0298
Leishmania major	oligopeptidase b	0.0052	0.033	0.2519
Echinococcus granulosus	chromobox protein 2	0.0207	0.2202	0.3691
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0819	1
Echinococcus multilocularis	carboxylesterase 5A	0.0133	0.1305	0.2184
Echinococcus granulosus	lysine specific demethylase 5A	0.0127	0.1236	0.2068
Brugia malayi	Bromodomain containing protein	0.0029	0.0046	0.0088
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0052	0.033	0.255
Schistosoma mansoni	chromobox protein	0.008	0.0663	0.066
Echinococcus granulosus	peregrin	0.0029	0.0046	0.0071
Loa Loa (eye worm)	transcription factor SMAD2	0.0121	0.116	0.2234
Trichomonas vaginalis	CAMK family protein kinase	0.0092	0.0819	1
Brugia malayi	glutathione reductase	0.0038	0.0159	0.0306
Brugia malayi	AIDA-1b	0.0025	0.0004	0.0007
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0052	0.0336	0.0641
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0436	0.0432

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 795892