TDR Targets

Basic information

Technical information

TDR Targets ID: 797795
Name: ethyl 2-[5-[2-[(5-propan-2-yl-[1,2,4]triazino [5,6-b]indol-3-yl)sulfanyl]butanoylamino]-1,3 ,4-thiadiazol-2-yl]acetate
MW: 499.609 | Formula: C22H25N7O3S2
H donors: 1 H acceptors: 7 LogP: 3.38 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)Cc1nnc(s1)NC(=O)C(Sc1nnc2c(n1)n(C(C)C)c1c2cccc1)CC
InChi: 1S/C22H25N7O3S2/c1-5-15(20(31)24-22-27-25-16(34-22)11-17(30)32-6-2)33-21-23-19-18(26-28-21)13-9-7-8-10-14(13)29(19)12(3)4/h7-10,12,15H,5-6,11H2,1-4H3,(H,24,27,31)
InChiKey: GUAFVQQHNHWUMD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 2-[5-[2-[(5-isopropyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]butanoylamino]-1,3,4-thiadiazol-2-yl]acetate
2-[5-[[2-[(5-isopropyl-[1,2,4]triazino[5,6-b]indol-3-yl)thio]-1-oxobutyl]amino]-1,3,4-thiadiazol-2-yl]acetic acid ethyl ester
2-[5-[2-[(5-isopropyl-[1,2,4]triazino[5,6-b]indol-3-yl)thio]butanoylamino]-1,3,4-thiadiazol-2-yl]acetic acid ethyl ester
ethyl 2-[5-[2-[(5-propan-2-yl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]butanoylamino]-1,3,4-thiadiazol-2-yl]ethanoate
A2989/0125912

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0035	0.0035
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0029	0.0037
Echinococcus multilocularis	mitogen activated protein kinase	0.0062	0.0639	0.0639
Plasmodium vivax	hypothetical protein, conserved	0.0108	0.1218	1
Echinococcus multilocularis	serotonin transporter	0.0636	0.7797	0.7797
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0636	0.7797	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0636	0.7797	1
Onchocerca volvulus		0.0027	0.021	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0016	0.007	0.009
Onchocerca volvulus		0.0108	0.1218	0.1562
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0631	0.0809
Schistosoma mansoni	sodium/chloride dependent transporter	0.0108	0.1218	0.1562
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.0156	0.5
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0495	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1218	0.1562
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0429	0.0429
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0108	0.1218	0.1562
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0108	0.1218	0.1562
Onchocerca volvulus		0.0027	0.021	0.0269
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0108	0.1218	0.1562
Echinococcus multilocularis	vesicular acetylcholine transporter	0.0244	0.2909	0.2909
Onchocerca volvulus		0.0108	0.1218	0.1562
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0631	0.0809
Schistosoma mansoni	ap endonuclease	0.0023	0.0156	0.02
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.0244	0.2909	0.373
Echinococcus granulosus	lamin	0.0027	0.021	0.0269
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0108	0.1218	1
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0045	0.0429	0.6712
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0631	0.0809
Echinococcus granulosus	sodium and chloride dependent glycine	0.0108	0.1218	0.1562
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0561	0.0719
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.0639	0.082
Schistosoma mansoni	eyes absent homolog	0.0106	0.1198	0.1537
Brugia malayi	vesicular acetylcholine transporter unc-17	0.0244	0.2909	0.373
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0639	1
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1198	0.1537
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0298	0.0383
Schistosoma mansoni	hypothetical protein	0.0036	0.0322	0.0413
Schistosoma mansoni	sodium/chloride dependent transporter	0.0636	0.7797	1
Trypanosoma brucei	protein kinase, putative	0.0062	0.0639	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0156	0.02
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0108	0.1218	0.1562
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.0156	0.363
Echinococcus multilocularis	lamin	0.0027	0.021	0.021
Toxoplasma gondii	hypothetical protein	0.0108	0.1218	1
Brugia malayi	hypothetical protein	0.0036	0.0322	0.0413
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0045	0.0429	0.6712
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0429	0.6712
Echinococcus granulosus	serotonin transporter	0.0636	0.7797	1
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0429	0.6712
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0639	0.1945
Brugia malayi	glutaminase DH11.1	0.0274	0.3287	0.4215
Mycobacterium leprae	Probable metal cation-transporting P-type ATPase C CtpC	0.001	0	0.5
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.007	0.007
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0495	0.0635
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0108	0.1218	0.1218
Schistosoma mansoni	hypothetical protein	0.0034	0.0298	0.0383
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0322	0.0413
Echinococcus multilocularis	GPCR, family 2	0.0016	0.007	0.007
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0631	0.0631
Loa Loa (eye worm)	hypothetical protein	0.0237	0.2826	0.3624
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.0156	0.02
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1218	0.1562
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0561	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1218	0.1562
Schistosoma mansoni	hypothetical protein	0.0016	0.007	0.009
Entamoeba histolytica	hypothetical protein	0.0036	0.0322	0.7507
Echinococcus multilocularis	survival motor neuron protein 1	0.0237	0.2826	0.2826
Giardia lamblia	Kinase, CMGC MAPK	0.0062	0.0639	1
Loa Loa (eye worm)	hypothetical protein	0.0636	0.7797	1
Entamoeba histolytica	hypothetical protein	0.0036	0.0322	0.7507
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0108	0.1218	0.1562
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0561	0.0561
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0045	0.0429	1
Plasmodium falciparum	amino acid transporter, putative	0.0108	0.1218	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0062	0.0639	0.0639
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0108	0.1218	0.1562
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0045	0.0429	0.055
Echinococcus granulosus	mitogen activated protein kinase 3	0.0062	0.0639	0.082
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.021	0.0269
Schistosoma mansoni	lamin	0.0027	0.021	0.0269
Brugia malayi	hypothetical protein	0.0106	0.1198	0.1537
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0639	1
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0108	0.1218	0.1562
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0631	0.192
Schistosoma mansoni	lamin	0.0027	0.021	0.0269
Plasmodium falciparum	transporter, putative	0.0108	0.1218	1
Echinococcus granulosus	ubiquitin specific protease 41	0.0045	0.0429	0.055
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0429	0.055
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0631	0.5182
Plasmodium vivax	amine transporter, putative	0.0108	0.1218	1
Echinococcus granulosus	intermediate filament protein	0.0027	0.021	0.0269
Loa Loa (eye worm)	glutaminase 2	0.0274	0.3287	0.4215
Onchocerca volvulus		0.0048	0.0475	0.0609
Toxoplasma gondii	hypothetical protein	0.0108	0.1218	1
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0639	0.1945
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0631	0.9872
Loa Loa (eye worm)	hypothetical protein	0.0027	0.021	0.0269
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0156	0.0474
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0053	0.0068
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0561	0.0561
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0429	0.1306
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.021	0.0269
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0561	0.0719
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0631	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0156	0.2436
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0639	0.1945
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0108	0.1218	0.1218
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0156	0.1279
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0429	0.0429
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0062	0.0639	1
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0108	0.1218	0.1562
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0631	0.192
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0561	0.0719
Brugia malayi	intermediate filament protein	0.0027	0.021	0.0269
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0156	0.2436
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.007	0.009
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0035	0.0045
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.007	0.009
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0029	0.0037
Mycobacterium ulcerans	glutaminase	0.0274	0.3287	1
Schistosoma mansoni	hypothetical protein	0.0016	0.007	0.009
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0429	0.1306
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.007	0.009
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0108	0.1218	0.1562
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0156	0.0474
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0108	0.1218	0.1562
Echinococcus granulosus	lamin dm0	0.0027	0.021	0.0269
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0108	0.1218	0.1562
Loa Loa (eye worm)	glutaminase	0.0274	0.3287	0.4215
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0062	0.0639	1
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0636	0.7797	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0495	0.0635
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0429	0.055
Echinococcus multilocularis	lamin dm0	0.0027	0.021	0.021
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0045	0.0429	0.055
Schistosoma mansoni	vesicular acetylcholine transporter	0.0244	0.2909	0.373
Schistosoma mansoni	hypothetical protein	0.0016	0.007	0.009
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0561	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0106	0.1198	0.1537
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.007	0.009
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0062	0.0639	0.082
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0108	0.1218	0.1562
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0156	0.2436
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.007	0.009
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1218	0.1562
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0156	0.02
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0156	0.2436
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0561	0.0719
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.021	0.0269
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.007	0.007
Loa Loa (eye worm)	norepinephrine transporter	0.0636	0.7797	1
Brugia malayi	hypothetical protein	0.0108	0.1218	0.1562
Loa Loa (eye worm)	serotonin transporter b	0.0636	0.7797	1
Echinococcus granulosus	survival motor neuron protein 1	0.0237	0.2826	0.3624
Schistosoma mansoni	intermediate filament proteins	0.0027	0.021	0.0269
Brugia malayi	MAP kinase sur-1	0.0062	0.0639	0.082
Entamoeba histolytica	hypothetical protein	0.0036	0.0322	0.7507
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0053	0.0068
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0156	0.1279
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0561	0.0719
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0108	0.1218	0.1562
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0108	0.1218	1
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0108	0.1218	0.1562
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0062	0.0639	1
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER ATPASE I CTPI	0.001	0	0.5
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0475	0.0609
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0108	0.1218	0.1218
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0475	0.0609
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0203	0.0261
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0108	0.1218	0.1218
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0035	0.0045
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0062	0.0639	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0156	0.02
Loa Loa (eye worm)	hypothetical protein	0.0636	0.7797	1
Echinococcus granulosus	GPCR family 2	0.0016	0.007	0.009
Onchocerca volvulus		0.0636	0.7797	1
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0108	0.1218	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.0109	0.1225	0.1571
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0322	0.0322
Schistosoma mansoni	hypothetical protein	0.0048	0.0475	0.0609
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0429	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1218	0.1562
Entamoeba histolytica	hypothetical protein	0.0036	0.0322	0.7507
Toxoplasma gondii	exonuclease III APE	0.0023	0.0156	0.1279
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0322	0.0413
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0108	0.1218	0.1562
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0298	0.0383
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0156	0.2436
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0062	0.0639	1
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0108	0.1218	1
Treponema pallidum	sodium- and chloride- dependent transporter	0.0636	0.7797	1
Schistosoma mansoni	hypothetical protein	0.0016	0.007	0.009
Onchocerca volvulus		0.0108	0.1218	0.1562
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0495	0.0635
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0108	0.1218	0.1562
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0108	0.1218	0.1218
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0062	0.0639	0.5249
Echinococcus multilocularis	ubiquitin specific protease 41	0.0045	0.0429	0.0429
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0631	0.192
Loa Loa (eye worm)	hypothetical protein	0.0636	0.7797	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0.0156	0.0474
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0108	0.1218	0.1562
Echinococcus granulosus	sodium and chloride dependent glycine	0.0108	0.1218	0.1562
Echinococcus multilocularis	musashi	0.0027	0.021	0.021
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0429	0.6712
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0108	0.1218	0.1562
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1218	0.1562
Echinococcus granulosus	mitogen activated protein kinase	0.0062	0.0639	0.082
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0108	0.1218	0.1562
Echinococcus granulosus	vesicular acetylcholine transporter	0.0244	0.2909	0.373
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.0244	0.2909	0.373
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0045	0.0429	0.055
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0639	0.1945
Schistosoma mansoni	ap endonuclease	0.0023	0.0156	0.02
Schistosoma mansoni	glutaminase	0.0274	0.3287	0.4215
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB	0.001	0	0.5
Trichomonas vaginalis	glutaminase, putative	0.0274	0.3287	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0429	0.055
Brugia malayi	hypothetical protein	0.0237	0.2826	0.3624
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1218	0.1562
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.0156	0.2468

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 797795