Detailed information for compound 801721

Basic information

Technical information
  • TDR Targets ID: 801721
  • Name: 1-[5-[4-(4-acetylphenyl)piperazine-1-carbonyl ]-2,4-dimethyl-1H-pyrrol-3-yl]ethanone
  • MW: 367.442 | Formula: C21H25N3O3
  • H donors: 1 H acceptors: 3 LogP: 2.05 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)c1ccc(cc1)N1CCN(CC1)C(=O)c1[nH]c(c(c1C)C(=O)C)C
  • InChi: 1S/C21H25N3O3/c1-13-19(16(4)26)14(2)22-20(13)21(27)24-11-9-23(10-12-24)18-7-5-17(6-8-18)15(3)25/h5-8,22H,9-12H2,1-4H3
  • InChiKey: MSQCVSIVIZAVGQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[5-[[4-(4-acetylphenyl)-1-piperazinyl]-oxomethyl]-2,4-dimethyl-1H-pyrrol-3-yl]ethanone
  • 1-[5-[4-(4-ethanoylphenyl)piperazin-1-yl]carbonyl-2,4-dimethyl-1H-pyrrol-3-yl]ethanone
  • T5711553

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0165 0.0743
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0208 0.1637
Brugia malayi jmjC domain containing protein 0.0016 0.0047 0.0314
Onchocerca volvulus 0.0048 0.0221 0.2025
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0047 0.011
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0037 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0067 0.0363
Schistosoma mansoni cpg binding protein 0.0031 0.0128 0.0578
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.0712 0.3208
Brugia malayi CHE-14 protein 0.0041 0.0186 0.1459
Mycobacterium ulcerans UDP-N-acetylmuramyl tripeptide synthase 0.0181 0.0945 0.0911
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0056 0.0131
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0067 0.0363
Leishmania major DNA polymerase eta, putative 0.0045 0.0208 0.1883
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0487 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0237 0.1873
Brugia malayi jmjC domain containing protein 0.0016 0.0047 0.0314
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0067 0.0363
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0047 0.011
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0047 0.011
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0221 0.0184
Loa Loa (eye worm) hypothetical protein 0.0036 0.0155 0.1197
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0047 0.0144
Schistosoma mansoni hypothetical protein 0.0166 0.0866 0.39
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0067 0.0303
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0037 0.023
Schistosoma mansoni hypothetical protein 0.0047 0.0218 0.0983
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0047 0.0213
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0218 0.1722
Loa Loa (eye worm) hypothetical protein 0.0036 0.0155 0.1197
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0119 0.0902
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0067 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0221 0.1743
Loa Loa (eye worm) hypothetical protein 0.0038 0.0165 0.1278
Trypanosoma cruzi folylpolyglutamate synthetase 0.0181 0.0945 1
Echinococcus granulosus dna polymerase eta 0.0045 0.0208 0.0937
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0165 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0119 0.0907
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0155 0.13
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0067 0.003
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0186 0.0434
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0144 0.0118
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0047 0.0113
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0037 0.0011
Mycobacterium ulcerans UDP-N-acetylmuramate--L-alanine ligase 0.1068 0.5774 0.5758
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0165 0.0743
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0067 0.0363
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0165 0.2845
Mycobacterium ulcerans UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 0.0545 0.2927 0.2901
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0067 0.0363
Onchocerca volvulus Putative folylpolyglutamate synthase 0.0181 0.0945 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0067 0.0474
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0037 0.023
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0186 0.0839
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0796 0.4293 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0067 0.0333
Echinococcus multilocularis dna polymerase kappa 0.002 0.0067 0.0157
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0037 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0297 0.1338
Plasmodium falciparum dihydrofolate synthase/folylpolyglutamate synthase 0.0181 0.0945 1
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0186 0.0839
Onchocerca volvulus 0.0047 0.0218 0.1997
Loa Loa (eye worm) hypothetical protein 0.0232 0.1224 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0221 0.0184
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylmuramyl tripeptide synthase 0.0545 0.2927 0.2189
Brugia malayi jmjC domain containing protein 0.0016 0.0047 0.0314
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0487 0.2191
Leishmania major DNA polymerase kappa, putative 0.002 0.0067 0.0333
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0067 0.0363
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0105
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0067 0.0303
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0208 0.1883
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0221 0.0184
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0067 0.0363
Echinococcus multilocularis expressed conserved protein 0.0091 0.0455 0.1059
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0045 0.0296
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0221 0.4088
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0295 0.2346
Schistosoma mansoni survival motor neuron protein 0.0047 0.0218 0.0983
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0067 0.0157
Schistosoma mansoni patched 1 0.0041 0.0186 0.0839
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0037 0.0086
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0037 0.0225
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0105
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0067 0.0333
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0045 0.0291
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0144 0.0118
Loa Loa (eye worm) hypothetical protein 0.0041 0.0186 0.1455
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0067 0.0363
Leishmania major hypothetical protein, conserved 0.0016 0.0047 0.0113
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0067 0.003
Brugia malayi hypothetical protein 0.0232 0.1224 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0067 0.0041
Schistosoma mansoni cpg binding protein 0.0031 0.0128 0.0578
Echinococcus multilocularis cpg binding protein 0.0031 0.0128 0.0299
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.0712 0.1659
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0119
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0221 0.1743
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0037 0.023
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylmuramate-alanine ligase 0.1068 0.5774 0.5333
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0309
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0056 0.0253
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0165 0.1409
Chlamydia trachomatis UDP-N-acetylmuramoylalanine--D-glutamate ligase 0.0545 0.2927 0.2816
Echinococcus granulosus dnaJ subfamily B 0.0415 0.222 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0037 0.023
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0165 0.0384
Echinococcus granulosus geminin 0.0166 0.0866 0.39
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylmuramyl pentapeptide synthase 0.1844 1 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0134 0.1073
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0037 0.0011
Echinococcus multilocularis dnaJ subfamily B 0.0415 0.222 0.5172
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0037 0.023
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0045 0.0019
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0225
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0047 0.0213
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0286 0.0665
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.1224 0.2851
Echinococcus multilocularis geminin 0.0166 0.0866 0.2017
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0286 0.1286
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0045 0.0088
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0165 0.1409
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0165 0.0384
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.001 0.0044
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0067 0.0333
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0144 0.0118
Schistosoma mansoni hypothetical protein 0.004 0.0178 0.0802
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0037 0.0031
Leishmania major DNA polymerase eta, putative 0.0032 0.0134 0.1073
Schistosoma mansoni hypothetical protein 0.004 0.0178 0.0802
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0047 0.0213
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0221 0.0195
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0047 0.0309
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0286 0.0665
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0165 0.0384
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0067 0.0363
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0047 0.0113
Trypanosoma brucei folylpolyglutamate synthase, putative 0.0181 0.0945 1
Echinococcus granulosus dna polymerase kappa 0.002 0.0067 0.0303
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0221 0.1743
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0045 0.0088
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0186 0.1455
Mycobacterium ulcerans hypothetical protein 0.0048 0.0221 0.0184
Echinococcus multilocularis protein patched 0.0041 0.0186 0.0434
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0165 0.1409
Schistosoma mansoni jumonji domain containing protein 0.006 0.0286 0.1286
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0067 0.0333
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0165 0.1283
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0047 0.0213
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0221 0.4088
Plasmodium vivax dihydrofolate synthase/folylpolyglutamate synthase, putative 0.0181 0.0945 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0165 0.1436
Chlamydia trachomatis UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase 0.0545 0.2927 0.2816
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0037 0.0167
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0067 0.0672
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0155 0.0129
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0208 0.1909
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0037 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0165 0.1409
Mycobacterium tuberculosis Possible ligase 0.0181 0.0945 0.0921
Brugia malayi jmjC domain containing protein 0.0016 0.0047 0.0314
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0045 0.0203
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0261 0.247
Loa Loa (eye worm) hypothetical protein 0.0097 0.0487 0.3927
Treponema pallidum UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (murE) 0.1068 0.5774 0.4025
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0047 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0067 0.0363
Mycobacterium leprae PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) 0.0545 0.2927 0.2901
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0045 0.0105
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0067 0.0479
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0495 0.2228
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0047 0.0309
Loa Loa (eye worm) hypothetical protein 0.0036 0.0155 0.1197
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0221 0.0184
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0221 0.0184
Loa Loa (eye worm) hypothetical protein 0.0045 0.0208 0.1633
Brugia malayi FolC bifunctional protein 0.0181 0.0945 0.7702
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0037 0.0167
Loa Loa (eye worm) hypothetical protein 0.0036 0.0155 0.1197
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0155 0.0118
Mycobacterium leprae possible ligase 0.0181 0.0945 0.0911
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0221 0.0195
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0487 0.3931
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0088
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0221 0.2025
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0067 0.0333
Schistosoma mansoni hypothetical protein 0.004 0.0178 0.0802
Echinococcus multilocularis dna polymerase eta 0.0045 0.0208 0.0484
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0045 0.0088
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0221 0.0184
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0221 0.0184
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0221 0.2025
Echinococcus granulosus phd:f box containing protein 0.0016 0.0047 0.0213
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0221 0.2025
Loa Loa (eye worm) hypothetical protein 0.0048 0.0221 0.1738
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0047 0.0113
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0165 0.1409
Loa Loa (eye worm) hypothetical protein 0.0048 0.0221 0.1738
Loa Loa (eye worm) hypothetical protein 0.0036 0.0155 0.1197
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0045 0.0119
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0155 0.13
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0067 0.0333
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0047 0.0213
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0037 0.0011
Leishmania major folylpolyglutamate synthetase 0.0181 0.0945 1
Echinococcus granulosus cpg binding protein 0.0031 0.0128 0.0578
Loa Loa (eye worm) FolC protein 0.0181 0.0945 0.7701
Echinococcus granulosus folylpolyglutamate synthase, mitochondrial 0.0181 0.0945 0.4255
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.1224 0.5513
Mycobacterium leprae ProbableUDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF 0.1844 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0221 0.4088
Treponema pallidum UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase (murF) 0.1844 1 1
Trypanosoma cruzi folylpolyglutamate synthase, putative 0.0181 0.0945 1
Toxoplasma gondii bifunctional protein FolC subfamily protein 0.0181 0.0945 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0045 0.0088
Chlamydia trachomatis bifunctional UDP-N-acetylmuramate-alanine ligase/D-alanine-D-alanine ligase 0.1068 0.5774 0.5708
Echinococcus multilocularis protein dispatched 1 0.0047 0.0218 0.0508
Brugia malayi isocitrate dehydrogenase 0.0016 0.0045 0.0296
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0203
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0165 0.0743
Schistosoma mansoni cpg binding protein 0.0029 0.0119 0.0537
Mycobacterium ulcerans folylpolyglutamate synthase protein FolC 0.0545 0.2927 0.2901
Mycobacterium tuberculosis Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF 0.1844 1 1
Brugia malayi jmjC domain containing protein 0.0061 0.0295 0.235
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0037 0.0031
Mycobacterium ulcerans UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanyl ligase MurF 0.1844 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0309
Treponema pallidum UDP-N-acetylmuramate--L-alanine ligase 0.1068 0.5774 0.4025
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0037 0.023
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0045 0.0088
Loa Loa (eye worm) hypothetical protein 0.0014 0.0037 0.0225
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0037 0.0011
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0045 0.0088
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0165 0.0743
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0186 0.1645
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0067 0.0303
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0047 0.0213
Trypanosoma brucei unspecified product 0.002 0.0067 0.0363
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0067 0.0363
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0037 0.0011
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0047 0.0309
Echinococcus multilocularis folylpolyglutamate synthase, mitochondrial 0.0181 0.0945 0.2201
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0037 0.0011
Plasmodium vivax JmjC domain containing protein 0.0016 0.0047 0.0113
Onchocerca volvulus 0.0029 0.0119 0.0906
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0134 0.1073
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0221 0.0184
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0221 0.0184
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0037 0.0011
Echinococcus granulosus expressed conserved protein 0.0091 0.0455 0.2048
Loa Loa (eye worm) oxidoreductase 0.0014 0.0037 0.0225
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0047 0.011
Echinococcus multilocularis folylpolyglutamate synthase, mitochondrial 0.0181 0.0945 0.2201
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0165 0.0743
Schistosoma mansoni hypothetical protein 0.0415 0.222 1
Brugia malayi jmjC domain containing protein 0.006 0.0286 0.2276
Trichomonas vaginalis dihydrofolate synthase/folylpolyglutamate synthase, putative 0.0181 0.0945 1
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0295 0.1327
Mycobacterium tuberculosis Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) 0.0545 0.2927 0.2908
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0144 0.0118
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0045 0.0105
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0037 0.0225
Schistosoma mansoni hypothetical protein 0.0166 0.0866 0.39
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0067 0.0363
Schistosoma mansoni hypothetical protein 0.004 0.0178 0.0802
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0487 0.1133
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0295 0.1327
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0295 0.1327
Mycobacterium ulcerans UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase 0.1068 0.5774 0.5758
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0047 0.0213
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0165 0.1409
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0309
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.001 0.0023
Schistosoma mansoni DNA polymerase eta 0.0045 0.0208 0.0937
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0037 0.0011
Echinococcus granulosus folylpolyglutamate synthase mitochondrial 0.0181 0.0945 0.4255
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0045 0.0105
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0047 0.0113
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0067 0.0333
Loa Loa (eye worm) hypothetical protein 0.0048 0.0221 0.1738
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0047 0.0213
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0067 0.0363
Schistosoma mansoni folylpolyglutamate synthase 0.0181 0.0945 0.4255

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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