TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 265.35 | Formula: C18H19NO
H donors: 1 H acceptors: 1 LogP: 3.5 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCc2c3C1Cc1cc(C)c(cc1c3ccc2)O
InChi: 1S/C18H19NO/c1-11-8-13-9-16-18-12(6-7-19(16)2)4-3-5-14(18)15(13)10-17(11)20/h3-5,8,10,16,20H,6-7,9H2,1-2H3
InChiKey: DUXOVUQQTZHZHF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	cell division protein FtsZ	0.0314	0.246	1
Entamoeba histolytica	hypothetical protein	0.0083	0.0534	0.0534
Trypanosoma brucei	epsilon tubulin	0.0747	0.6078	0.6042
Leishmania major	beta tubulin	0.1217	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.1217	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0314	0.246	0.246
Brugia malayi	hypothetical protein	0.0019	0.0001	0.0001
Schistosoma mansoni	tubulin subunit gamma	0.0748	0.6086	0.6086
Trichomonas vaginalis	tubulin, putative	0.0377	0.299	0.299
Trichomonas vaginalis	tubulin gamma chain, putative	0.0748	0.6086	0.6086
Toxoplasma gondii	alpha-tubulin I, putative	0.0917	0.7498	0.7498
Echinococcus multilocularis	tubulin subunit beta	0.1217	1	1
Leishmania major	gamma-tubulin	0.0748	0.6086	0.6086
Loa Loa (eye worm)	BEN-1 protein	0.1217	1	1
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0314	0.246	1
Onchocerca volvulus		0.0042	0.0186	0.0633
Echinococcus granulosus	beta tubulin	0.1217	1	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0917	0.7498	0.7498
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0917	0.7498	0.7498
Leishmania major	beta tubulin	0.1217	1	1
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0037	0.0144	0.0144
Loa Loa (eye worm)	tubulin alpha 2	0.0603	0.4876	0.4876
Echinococcus multilocularis	Tubulin beta 2C chain	0.1217	1	1
Giardia lamblia	Beta tubulin	0.1217	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0371	0.2934	0.2934
Leishmania major	cathepsin L-like protease	0.0074	0.0454	0.0454
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.009	0.009
Toxoplasma gondii	tubulin, putative	0.0063	0.0361	0.0361
Echinococcus multilocularis	tubulin epsilon chain	0.0747	0.6078	0.6078
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0037	0.0144	0.0144
Echinococcus multilocularis	tubulin alpha chain	0.0917	0.7498	0.7498
Trichomonas vaginalis	tubulin, putative	0.1217	1	1
Loa Loa (eye worm)	BEN-1 protein	0.1217	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.009	0.009
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.0091	0.0091
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0917	0.7498	0.7498
Loa Loa (eye worm)	alpha-tubulin	0.0917	0.7498	0.7498
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0454	0.0367
Schistosoma mansoni	transcription factor LCR-F1	0.0083	0.0534	0.0534
Brugia malayi	bHLH-PAS transcription factor	0.0042	0.0186	0.0186
Brugia malayi	Isocitrate dehydrogenase	0.0037	0.0144	0.0144
Trypanosoma cruzi	zeta tubulin, putative	0.097	0.794	0.794
Leishmania major	beta tubulin	0.1217	1	1
Brugia malayi	Tubulin gamma chain	0.0748	0.6086	0.6086
Echinococcus granulosus	tubulin alpha chain	0.0917	0.7498	0.7498
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0454	0.0367
Leishmania major	beta tubulin	0.1217	1	1
Leishmania major	alpha tubulin	0.0917	0.7498	0.7498
Leishmania major	alpha tubulin	0.0917	0.7498	0.7498
Echinococcus multilocularis	tubulin alpha chain	0.0917	0.7498	0.7498
Echinococcus multilocularis	tubulin alpha chain	0.0917	0.7498	0.7498
Leishmania major	alpha tubulin	0.0917	0.7498	0.7498
Trichomonas vaginalis	conserved hypothetical protein	0.0314	0.246	0.246
Brugia malayi	hypoxia-induced factor 1	0.0174	0.1291	0.1291
Echinococcus granulosus	tubulin alpha 1C chain	0.0917	0.7498	0.7498
Echinococcus granulosus	tubulin subunit TubB	0.0917	0.7498	0.7498
Leishmania major	beta tubulin	0.1217	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.0917	0.7498	0.7498
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0603	0.4876	0.4876
Leishmania major	zeta tubulin, putative	0.097	0.794	0.794
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.0454	0.0454
Leishmania major	delta tubulin, putative	0.0706	0.5738	0.5738
Echinococcus granulosus	tubulin alpha chain	0.0917	0.7498	0.7498
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0037	0.0144	0.0144
Trypanosoma brucei	zeta tubulin, putative	0.097	0.794	0.7921
Echinococcus multilocularis	peroxisome assembly protein 26	0.0917	0.7498	0.7498
Schistosoma mansoni	alpha tubulin	0.0917	0.7498	0.7498
Trypanosoma cruzi	beta tubulin, putative	0.1217	1	1
Entamoeba histolytica	hypothetical protein	0.0083	0.0534	0.0534
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0314	0.246	0.5
Brugia malayi	Tubulin alpha-2 chain	0.0917	0.7498	0.7498
Brugia malayi	Cytochrome P450 family protein	0.003	0.0091	0.0091
Plasmodium falciparum	tubulin gamma chain	0.0748	0.6086	0.6086
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.1217	1	1
Schistosoma mansoni	tubulin subunit beta	0.1217	1	1
Toxoplasma gondii	beta-1 tubulin, putative	0.1217	1	1
Brugia malayi	Tubulin alpha chain	0.0314	0.246	0.246
Echinococcus granulosus	Tubulin beta 2C chain	0.1217	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0314	0.246	0.246
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.0454	0.0454
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0684	0.5555	0.5555
Echinococcus granulosus	tubulin subunit beta	0.1217	1	1
Plasmodium vivax	tubulin alpha chain, putative	0.0917	0.7498	0.7498
Trypanosoma cruzi	epsilon tubulin, putative	0.0747	0.6078	0.6078
Echinococcus multilocularis	beta tubulin	0.1217	1	1
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.009	0.009
Onchocerca volvulus		0.0371	0.2934	1
Loa Loa (eye worm)	alpha-tubulin	0.0917	0.7498	0.7498
Echinococcus granulosus	alpha tubulin	0.0917	0.7498	0.7498
Leishmania major	beta tubulin	0.1217	1	1
Plasmodium falciparum	tubulin epsilon chain, putative	0.0747	0.6078	0.6078
Loa Loa (eye worm)	hypothetical protein	0.0603	0.4876	0.4876
Plasmodium vivax	tubulin gamma chain, putative	0.0748	0.6086	0.6086
Echinococcus multilocularis	transfer RNA-Lys	0.0042	0.0186	0.0186
Schistosoma mansoni	hypothetical protein	0.019	0.1421	0.1421
Trypanosoma brucei	epsilon tubulin	0.0684	0.5555	0.5515
Leishmania major	beta tubulin	0.1217	1	1
Trypanosoma brucei	epsilon tubulin	0.0747	0.6078	0.6042
Trichomonas vaginalis	tubulin beta chain, putative	0.1217	1	1
Trypanosoma brucei	zeta tubulin	0.097	0.794	0.7921
Leishmania major	hypothetical protein, conserved	0.003	0.009	0.009
Leishmania major	beta tubulin	0.1217	1	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.1217	1	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0083	0.0534	0.0534
Leishmania major	alpha tubulin	0.0917	0.7498	0.7498
Trichomonas vaginalis	tubulin alpha chain, putative	0.0684	0.5555	0.5555
Brugia malayi	Tubulin alpha chain	0.0917	0.7498	0.7498
Schistosoma mansoni	aryl hydrocarbon receptor	0.0056	0.0308	0.0308
Trypanosoma cruzi	alpha tubulin, putative	0.0917	0.7498	0.7498
Echinococcus granulosus	tubulin alpha 3 chain	0.0917	0.7498	0.7498
Trichomonas vaginalis	tubulin epsilon chain, putative	0.1217	1	1
Brugia malayi	Tubulin alpha-2 chain	0.0917	0.7498	0.7498
Leishmania major	alpha tubulin	0.0917	0.7498	0.7498
Echinococcus granulosus	tubulin epsilon chain	0.0747	0.6078	0.6078
Trichomonas vaginalis	tubulin beta chain, putative	0.0917	0.7498	0.7498
Leishmania major	beta tubulin	0.1217	1	1
Trypanosoma brucei	tubulin delta chain	0.0706	0.5738	0.5699
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0037	0.0144	0.0144
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0917	0.7498	0.7498
Plasmodium vivax	delta tubulin, putative	0.0314	0.246	0.246
Trypanosoma cruzi	tubulin delta chain	0.0706	0.5738	0.5738
Brugia malayi	isocitrate dehydrogenase	0.0037	0.0144	0.0144
Giardia lamblia	Gamma tubulin	0.0748	0.6086	0.4809
Leishmania major	beta tubulin	0.1217	1	1
Echinococcus multilocularis	geminin	0.019	0.1421	0.1421
Echinococcus multilocularis	tubulin alpha chain	0.0917	0.7498	0.7498
Loa Loa (eye worm)	tubulin gamma chain	0.0748	0.6086	0.6086
Brugia malayi	hypothetical protein	0.0083	0.0534	0.0534
Trypanosoma brucei	tubulin gamma chain	0.0748	0.6086	0.605
Entamoeba histolytica	tubulin family protein	0.1217	1	1
Entamoeba histolytica	tubulin gamma chain	0.0748	0.6086	0.6086
Loa Loa (eye worm)	beta-tubulin	0.1217	1	1
Entamoeba histolytica	hypothetical protein	0.0083	0.0534	0.0534
Trichomonas vaginalis	tubulin, putative	0.0371	0.2934	0.2934
Schistosoma mansoni	tubulin subunit alpha	0.0917	0.7498	0.7498
Schistosoma mansoni	tubulin subunit beta	0.1217	1	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0917	0.7498	0.7498
Leishmania major	beta tubulin	0.1217	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0917	0.7498	0.7498
Schistosoma mansoni	single-minded	0.0056	0.0308	0.0308
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0037	0.0144	0.0144
Brugia malayi	Tubulin beta chain	0.0371	0.2934	0.2934
Trichomonas vaginalis	tubulin gamma chain, putative	0.1217	1	1
Leishmania major	epsilon tubulin, putative	0.0747	0.6078	0.6078
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0917	0.7498	0.7498
Trichomonas vaginalis	tubulin alpha chain, putative	0.0371	0.2934	0.2934
Echinococcus multilocularis	beta tubulin	0.1217	1	1
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0037	0.0144	0.0054
Echinococcus multilocularis	tubulin alpha	0.0684	0.5555	0.5555
Toxoplasma gondii	beta-tubulin, putative	0.1217	1	1
Echinococcus granulosus	tubulin gamma 1 chain	0.0748	0.6086	0.6086
Leishmania major	alpha tubulin	0.0917	0.7498	0.7498
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0376	0.2983	0.2983
Echinococcus granulosus	geminin	0.019	0.1421	0.1421
Trypanosoma cruzi	epsilon tubulin, putative	0.0747	0.6078	0.6078
Entamoeba histolytica	tubulin alpha-1 chain	0.0917	0.7498	0.7498
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0917	0.7498	0.7498
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.009	0.009
Trypanosoma brucei	beta tubulin	0.1217	1	1
Schistosoma mansoni	tubulin subunit beta	0.0314	0.246	0.246
Trypanosoma brucei	beta tubulin	0.1217	1	1
Mycobacterium leprae	cell division protein FtsZ	0.0314	0.246	0.5
Echinococcus granulosus	tubulin alpha 1C chain	0.0917	0.7498	0.7498
Giardia lamblia	Beta tubulin	0.1217	1	1
Trypanosoma cruzi	tubulin gamma chain	0.0748	0.6086	0.6086
Echinococcus multilocularis	tubulin delta chain	0.0314	0.246	0.246
Schistosoma mansoni	tubulin subunit beta	0.1217	1	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0083	0.0534	0.0534
Leishmania major	beta tubulin	0.1217	1	1
Leishmania major	beta tubulin	0.1217	1	1
Brugia malayi	hypothetical protein	0.003	0.009	0.009
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0454	0.0367
Loa Loa (eye worm)	tubulin beta-2A chain	0.1217	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0917	0.7498	0.7498
Leishmania major	beta tubulin	0.1217	1	1
Trypanosoma brucei	beta tubulin	0.0684	0.5555	0.5515
Leishmania major	cathepsin L-like protease	0.0074	0.0454	0.0454
Leishmania major	alpha tubulin	0.0917	0.7498	0.7498
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0037	0.0144	0.0144
Schistosoma mansoni	hypothetical protein	0.0083	0.0534	0.0534
Brugia malayi	hypothetical protein	0.0189	0.1413	0.1413
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.009	0.009
Plasmodium falciparum	tubulin delta chain, putative	0.0314	0.246	0.246
Trypanosoma brucei	beta tubulin	0.1217	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0268	0.2073	0.2073
Trypanosoma brucei	alpha tubulin, putative	0.0371	0.2934	0.287
Trypanosoma brucei	alpha tubulin	0.0917	0.7498	0.7475
Brugia malayi	Tubulin beta chain	0.0314	0.246	0.246
Leishmania major	beta tubulin	0.1217	1	1
Echinococcus granulosus	tubulin beta 4A class IVa	0.1217	1	1
Echinococcus granulosus	tubulin delta chain	0.0314	0.246	0.246
Entamoeba histolytica	tubulin family protein	0.1217	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.1217	1	1
Plasmodium falciparum	tubulin beta chain	0.1217	1	1
Echinococcus granulosus	beta tubulin	0.1217	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0371	0.2934	0.2934
Giardia lamblia	Alpha-tubulin	0.0917	0.7498	0.6681
Loa Loa (eye worm)	hypothetical protein	0.0546	0.4402	0.4402
Trichomonas vaginalis	tubulin gamma chain, putative	0.0747	0.6078	0.6078
Echinococcus granulosus	tubulin alpha chain	0.0917	0.7498	0.7498
Loa Loa (eye worm)	tubulin alpha 2	0.0603	0.4876	0.4876
Entamoeba histolytica	hypothetical protein	0.0083	0.0534	0.0534
Toxoplasma gondii	isocitrate dehydrogenase	0.0037	0.0144	0.0144
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0454	0.0367
Schistosoma mansoni	alpha tubulin	0.0917	0.7498	0.7498
Echinococcus granulosus	tubulin alpha chain	0.0917	0.7498	0.7498
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0037	0.0144	0.0144
Echinococcus granulosus	Tubulin beta 2C chain	0.1217	1	1
Brugia malayi	tubulin alpha-2 chain	0.0917	0.7498	0.7498
Echinococcus multilocularis	tubulin alpha 1C chain	0.0917	0.7498	0.7498
Leishmania major	cathepsin L-like protease	0.0074	0.0454	0.0454
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0037	0.0144	0.0054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0454	0.0367
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0603	0.4876	0.4876
Trypanosoma cruzi	tubulin delta chain	0.0706	0.5738	0.5738
Plasmodium falciparum	alpha tubulin 2	0.0917	0.7498	0.7498
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0454	0.0367
Trichomonas vaginalis	tubulin beta chain, putative	0.0917	0.7498	0.7498
Schistosoma mansoni	tubulin subunit beta	0.1217	1	1
Schistosoma mansoni	tubulin subunit delta	0.0314	0.246	0.246
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0314	0.246	0.246
Echinococcus multilocularis	tubulin alpha chain	0.0917	0.7498	0.7498
Echinococcus multilocularis	tubulin gamma 1 chain	0.0748	0.6086	0.6086
Loa Loa (eye worm)	hypothetical protein	0.0917	0.7498	0.7498
Echinococcus multilocularis	hypothetical protein	0.0917	0.7498	0.7498
Loa Loa (eye worm)	tubulin alpha 2	0.0233	0.1781	0.1781
Plasmodium vivax	tubulin epsilon chain, putative	0.0747	0.6078	0.6078
Trichomonas vaginalis	tubulin alpha chain, putative	0.0371	0.2934	0.2934
Trichomonas vaginalis	tubulin beta chain, putative	0.0917	0.7498	0.7498
Leishmania major	beta tubulin	0.1217	1	1
Brugia malayi	beta-tubulin, identical	0.1217	1	1
Echinococcus multilocularis	isocitrate dehydrogenase	0.0037	0.0144	0.0144
Giardia lamblia	Epsilon tubulin	0.0376	0.2983	0.0694
Toxoplasma gondii	alpha tubulin TUBA1	0.0917	0.7498	0.7498
Plasmodium vivax	tubulin beta chain, putative	0.1217	1	1
Schistosoma mansoni	alpha tubulin	0.0917	0.7498	0.7498
Brugia malayi	Cell division protein ftsZ	0.0314	0.246	0.246
Giardia lamblia	Alpha-tubulin	0.0917	0.7498	0.6681
Plasmodium vivax	tubulin alpha chain, putative	0.0917	0.7498	0.7498
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0546	0.4402	0.4402
Giardia lamblia	Beta tubulin	0.1217	1	1
Entamoeba histolytica	tubulin alpha chain, putative	0.0917	0.7498	0.7498
Trichomonas vaginalis	tubulin, putative	0.0371	0.2934	0.2934
Loa Loa (eye worm)	tubulin beta-1 chain	0.1217	1	1
Leishmania major	alpha tubulin	0.0917	0.7498	0.7498
Loa Loa (eye worm)	tubulin beta chain	0.1217	1	1
Echinococcus granulosus	tubulin alpha	0.0684	0.5555	0.5555
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0917	0.7498	0.7498
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0454	0.0367
Schistosoma mansoni	tubulin subunit epsilon	0.0747	0.6078	0.6078
Echinococcus granulosus	tubulin beta 1 chain	0.1217	1	1
Echinococcus granulosus	tubulin alpha chain	0.0917	0.7498	0.7498
Trichomonas vaginalis	tubulin beta chain, putative	0.0917	0.7498	0.7498
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0454	0.0367
Echinococcus granulosus	Tubulin alpha 1 chain	0.0917	0.7498	0.7498
Schistosoma mansoni	tubulin subunit alpha	0.0917	0.7498	0.7498
Trypanosoma cruzi	cruzipain precursor, putative	0.0074	0.0454	0.0454
Trichomonas vaginalis	tubulin gamma chain, putative	0.0314	0.246	0.246
Trypanosoma cruzi	zeta tubulin, putative	0.097	0.794	0.794
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0174	0.1291	0.1291
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0454	0.0367
Echinococcus multilocularis	tubulin alpha 3 chain	0.0917	0.7498	0.7498
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.009	0.009
Trichomonas vaginalis	tubulin epsilon chain, putative	0.1217	1	1
Trypanosoma brucei	alpha tubulin	0.0917	0.7498	0.7475
Plasmodium falciparum	alpha tubulin 1	0.0917	0.7498	0.7498
Trichomonas vaginalis	tubulin alpha chain, putative	0.1217	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0454	0.0367
Echinococcus granulosus	Tubulin beta 2C chain	0.1217	1	1
Brugia malayi	alpha-tubulin	0.0917	0.7498	0.7498
Echinococcus multilocularis	Tubulin beta 2C chain	0.1217	1	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0058	0.0322	0.0322
Brugia malayi	tubulin alpha chain - mouse	0.0917	0.7498	0.7498
Trichomonas vaginalis	conserved hypothetical protein	0.0314	0.246	0.246
Echinococcus multilocularis	tubulin alpha 1C chain	0.0917	0.7498	0.7498
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0546	0.4402	0.4402
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0037	0.0144	0.0144
Brugia malayi	PAS domain containing protein	0.0056	0.0308	0.0308
Toxoplasma gondii	isocitrate dehydrogenase	0.0037	0.0144	0.0144
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0037	0.0144	0.0144
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0268	0.2073	0.2073
Trichomonas vaginalis	tubulin beta chain, putative	0.0917	0.7498	0.7498
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1413	0.1413
Echinococcus multilocularis	tubulin beta 1 chain	0.1217	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0067	0.0401	0.0401
Schistosoma mansoni	tubulin subunit beta	0.1217	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.0917	0.7498	0.7498
Leishmania major	alpha tubulin	0.0917	0.7498	0.7498
Schistosoma mansoni	tubulin subunit beta	0.1217	1	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0037	0.0144	0.0144
Leishmania major	alpha tubulin	0.0917	0.7498	0.7498
Echinococcus granulosus	Tubulin beta 2C chain	0.1217	1	1
Loa Loa (eye worm)	tubulin beta chain	0.0314	0.246	0.246
Schistosoma mansoni	hypothetical protein	0.019	0.1421	0.1421
Leishmania major	alpha tubulin	0.0917	0.7498	0.7498
Echinococcus multilocularis	tubulin subunit TubB	0.0917	0.7498	0.7498
Trypanosoma brucei	beta tubulin	0.1217	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0917	0.7498	0.7498
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0037	0.0144	0.0144
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0074	0.0454	0.0367
Echinococcus granulosus	Tubulin beta 2C chain	0.1217	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0371	0.2934	0.2934
Toxoplasma gondii	beta tubulin	0.1217	1	1
Trypanosoma brucei	alpha tubulin	0.0917	0.7498	0.7475
Leishmania major	alpha tubulin	0.0917	0.7498	0.7498
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0037	0.0144	0.0144
Leishmania major	beta tubulin	0.1217	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0074	0.0454	0.0454
Echinococcus granulosus	Tubulin alpha 1 chain	0.0917	0.7498	0.7498
Echinococcus multilocularis	Tubulin beta 2C chain	0.1217	1	1
Echinococcus granulosus	single minded 2	0.0042	0.0186	0.0186
Leishmania major	beta tubulin	0.1217	1	1
Trypanosoma brucei	alpha tubulin	0.0917	0.7498	0.7475
Treponema pallidum	cell division protein FtsZ	0.0314	0.246	0.5
Echinococcus granulosus	peroxisome assembly protein 26	0.0917	0.7498	0.7498
Trichomonas vaginalis	tubulin beta chain, putative	0.0917	0.7498	0.7498
Loa Loa (eye worm)	hypothetical protein	0.003	0.009	0.009
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0706	0.5738	0.5738

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (binding)	uM	Ability to antagonize electrical induced contractile responses in Guinea pig ileum for 5-HT1A receptor. Inactive at dose level of 1.0 microM.	ChEMBL.	7783115
ED50 (binding)	uM	Ability to antagonize Acetylcholine induced contractile responses in Guinea pig ileum for 5-HT1A receptor. Inactive at dose level of 1.0 microM.	ChEMBL.	7783115
ED50 (binding)	uM	Ability to antagonize electrical induced contractile responses in Guinea pig ileum for 5-HT1A receptor; Inactive at dose level of 1.0 microM.	ChEMBL.	7783115
ED50 (binding)	0 uM	Ability to antagonize electrical induced contractile responses in Guinea pig ileum for 5-HT1A receptor; Inactive at dose level of 1.0 microM.	ChEMBL.	7783115
ED50 (binding)	0 uM	Ability to antagonize Acetylcholine induced contractile responses in Guinea pig ileum for 5-HT1A receptor. Inactive at dose level of 1.0 microM.	ChEMBL.	7783115
ED50 (binding)	0 uM	Ability to antagonize electrical induced contractile responses in Guinea pig ileum for 5-HT1A receptor. Inactive at dose level of 1.0 microM.	ChEMBL.	7783115

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL54454
PubChem: 10400647

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 80315