TDR Targets

Basic information

Technical information

TDR Targets ID: 805707
Name: [4-[2-[(4-acetamidophenyl)amino]-1,3-thiazol- 4-yl]phenyl] acetate
MW: 367.422 | Formula: C19H17N3O3S
H donors: 2 H acceptors: 3 LogP: 3.42 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)Nc1ccc(cc1)Nc1scc(n1)c1ccc(cc1)OC(=O)C
InChi: 1S/C19H17N3O3S/c1-12(23)20-15-5-7-16(8-6-15)21-19-22-18(11-26-19)14-3-9-17(10-4-14)25-13(2)24/h3-11H,1-2H3,(H,20,23)(H,21,22)
InChiKey: WZGZGDXGENBKFA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[4-[2-[(4-acetamidophenyl)amino]thiazol-4-yl]phenyl] acetate
acetic acid [4-[2-[(4-acetamidophenyl)amino]-4-thiazolyl]phenyl] ester
acetic acid [4-[2-[(4-acetamidophenyl)amino]thiazol-4-yl]phenyl] ester
[4-[2-[(4-acetamidophenyl)amino]-1,3-thiazol-4-yl]phenyl] ethanoate
ZINC00813373
Acetic acid 4-[2-(4-acetylamino-phenylamino)-thiazol-4-yl]-phenyl ester
BAS 08769708
A3432/0145653

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	aspartyl protease	0.0255	0.0977	0.1017
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0255	0.0977	0.0847
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0085	0.0225	0.0085
Treponema pallidum	alginate O-acetylation protein (algI)	0.0085	0.0225	0.5
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.0085	0.0225	0.0193
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0255	0.0977	1
Onchocerca volvulus		0.0255	0.0977	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0761	0.322	0.3123
Trypanosoma brucei	proteasome beta 6 subunit	0.0113	0.0349	0.4422
Brugia malayi	hypothetical protein	0.0255	0.0977	1
Mycobacterium ulcerans	proteasome PrcB	0.0148	0.0506	0.5
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0225	0.0609
Brugia malayi	Proteasome A-type and B-type family protein	0.0148	0.0506	0.518
Loa Loa (eye worm)	MBOAT family protein	0.0085	0.0225	0.0609
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0085	0.0225	0.0193
Plasmodium falciparum	plasmepsin VII	0.0255	0.0977	0.2511
Plasmodium vivax	aspartyl proteinase, putative	0.0761	0.322	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0255	0.0977	0.0847
Brugia malayi	Pepsin A precursor	0.0255	0.0977	1
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0255	0.0977	0.0847
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0085	0.0225	0.0609
Leishmania major	proteasome beta 5 subunit, putative	0.0148	0.0506	1
Brugia malayi	MBOAT family protein	0.0085	0.0225	0.2304
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0225	0.0609
Toxoplasma gondii	proteasome subunit beta type, putative	0.0148	0.0506	0.038
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0148	0.0506	0.5
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0085	0.0225	0.0193
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0255	0.0977	0.0847
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0085	0.0225	0.0193
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0255	0.0977	0.0847
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0085	0.0225	0.0193
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0113	0.0349	0.0415
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0085	0.0225	0.0193
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0085	0.0225	0.0609
Plasmodium vivax	plasmepsin V, putative	0.0255	0.0977	0.2511
Brugia malayi	MBOAT family protein	0.0085	0.0225	0.2304
Plasmodium falciparum	proteasome subunit beta type-5	0.0148	0.0506	0.0939
Toxoplasma gondii	aspartyl protease ASP3	0.058	0.2416	0.2963
Plasmodium falciparum	plasmepsin X	0.058	0.2416	0.7315
Plasmodium vivax	aspartyl protease, putative	0.0255	0.0977	0.2511
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0113	0.0349	0.0415
Toxoplasma gondii	eukaryotic aspartyl protease superfamily protein	0.0255	0.0977	0.1017
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0085	0.0225	0.0085
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0113	0.0349	0.0415
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0113	0.0349	0.048
Loa Loa (eye worm)	hhat protein	0.0085	0.0225	0.0609
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0761	0.322	0.7124
Loa Loa (eye worm)	MBOAT family protein	0.0085	0.0225	0.0609
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0255	0.0977	0.2643
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0148	0.0506	0.0939
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0085	0.0225	0.0193
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0085	0.0225	0.0193
Plasmodium vivax	aspartyl protease, putative	0.058	0.2416	0.7315
Loa Loa (eye worm)	hypothetical protein	0.0255	0.0977	0.2643
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0255	0.0977	0.0847
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0085	0.0225	0.0193
Schistosoma mansoni	zinc finger protein	0.0085	0.0225	0.0085
Plasmodium falciparum	plasmepsin VI	0.0761	0.322	1
Loa Loa (eye worm)	MBOAT family protein	0.0085	0.0225	0.0609
Schistosoma mansoni	memapsin-2 (A01 family)	0.1494	0.6467	0.6416
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1042	0.4463	1
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0148	0.0506	0.0939
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0113	0.0349	0.4422
Schistosoma mansoni	cathepsin D (A01 family)	0.2292	1	1
Plasmodium falciparum	plasmepsin II	0.0761	0.322	1
Toxoplasma gondii	1,3-beta-glucan synthase component protein	0.1755	0.7619	1
Plasmodium vivax	plasmepsin IV, putative	0.0761	0.322	1
Loa Loa (eye worm)	hhat protein	0.0085	0.0225	0.0609
Brugia malayi	proteasome subunit beta type 1	0.0113	0.0349	0.3576
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0113	0.0349	0.048
Plasmodium falciparum	plasmepsin III	0.0255	0.0977	0.2511
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0225	0.0609
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0148	0.0506	1
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0148	0.0506	1
Onchocerca volvulus		0.0085	0.0225	0.2304
Loa Loa (eye worm)	hypothetical protein	0.0255	0.0977	0.2643
Loa Loa (eye worm)	aspartyl protease 6	0.0255	0.0977	0.2643
Echinococcus multilocularis	sterol O acyltransferase 1	0.0869	0.3697	0.8227
Plasmodium falciparum	plasmepsin I	0.0761	0.322	1
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0761	0.322	0.405
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0085	0.0225	0.0193
Echinococcus granulosus	proteasome prosome macropain	0.0148	0.0506	0.0843
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0113	0.0349	0.0945
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0761	0.322	1
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0085	0.0225	0.0193
Plasmodium vivax	aspartyl protease, putative	0.058	0.2416	0.7315
Brugia malayi	MBOAT family protein	0.0085	0.0225	0.2304
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0255	0.0977	0.0847
Brugia malayi	MBOAT family protein	0.0085	0.0225	0.2304
Brugia malayi	hypothetical protein	0.0255	0.0977	1
Schistosoma mansoni	hypothetical protein	0.0085	0.0225	0.0085
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0761	0.322	0.7124
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0113	0.0349	0.4422
Brugia malayi	Hhat protein	0.0085	0.0225	0.2304
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0148	0.0506	0.0843
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0085	0.0225	0.0193
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0148	0.0506	0.1369
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0085	0.0225	0.0085
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0113	0.0349	0.0211
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0761	0.322	0.8711
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0113	0.0349	0.4422
Loa Loa (eye worm)	hypothetical protein	0.0761	0.322	0.8711
Plasmodium falciparum	plasmepsin V	0.0255	0.0977	0.2511
Brugia malayi	MBOAT family protein	0.0085	0.0225	0.2304
Brugia malayi	aspartic protease BmAsp-2, identical	0.0255	0.0977	1
Echinococcus granulosus	sterol O acyltransferase 1	0.0869	0.3697	0.8227
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0113	0.0349	0.0168
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0085	0.0225	0.0193
Plasmodium falciparum	plasmepsin IX	0.058	0.2416	0.7315
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0085	0.0225	0.0193
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0113	0.0349	0.4422
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0148	0.0506	0.037
Plasmodium vivax	aspartyl proteinase, putative	0.0255	0.0977	0.2511
Plasmodium falciparum	plasmepsin VIII, putative	0.0255	0.0977	0.2511
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0148	0.0506	0.5
Brugia malayi	diacylglycerol acyltransferase	0.0085	0.0225	0.2304
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0085	0.0225	0.0085
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0148	0.0506	1
Toxoplasma gondii	aspartyl protease ASP1	0.0761	0.322	0.405
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0255	0.0977	0.0847
Brugia malayi	aspartic protease BmAsp-1, identical	0.0255	0.0977	1
Loa Loa (eye worm)	hypothetical protein	0.0784	0.3321	0.8983
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0085	0.0225	0.0193
Echinococcus granulosus	tm gpcr rhodopsin	0.1042	0.4463	1
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.0085	0.0225	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0869	0.3697	1
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0085	0.0225	0.0085
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0148	0.0506	1
Schistosoma mansoni	sterol O-acyltransferase 1	0.0869	0.3697	0.3606
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0085	0.0225	0.0085
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0148	0.0506	1
Plasmodium falciparum	plasmepsin IV	0.0761	0.322	1
Onchocerca volvulus		0.0255	0.0977	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 805707