Detailed information for compound 806575

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 373.446 | Formula: C20H27N3O4
  • H donors: 2 H acceptors: 3 LogP: 3.06 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(n1cc(C(=O)NCc2ccco2)c(=O)c(c1)C(=O)NCC(C)C)C
  • InChi: 1S/C20H27N3O4/c1-5-14(4)23-11-16(19(25)21-9-13(2)3)18(24)17(12-23)20(26)22-10-15-7-6-8-27-15/h6-8,11-14H,5,9-10H2,1-4H3,(H,21,25)(H,22,26)
  • InChiKey: SJFGCZPJFMBXHB-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0186 0.0529
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0122 0.0348
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0248 0.0703
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0122 0.0635
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0039 0.0122 0.317
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0123 0.035
Trypanosoma brucei polo-like protein kinase 0.0092 0.0444 0.3667
Schistosoma mansoni hypothetical protein 0.0044 0.0151 0.043
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0058 0.0084
Brugia malayi Cathepsin L-like precursor 0.0039 0.0123 0.035
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.004 0.0543
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0039 0.0122 0.0596
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0058 0.0313
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0058 0.0084
Loa Loa (eye worm) hypothetical protein 0.0048 0.0179 0.0508
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0362 0.2954
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0362 0.0955
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0186 0.1429
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0058 0.0313
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0122 0.0348
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0039 0.0122 0.0635
Schistosoma mansoni hypothetical protein 0.0044 0.0151 0.043
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.006 0.0332
Plasmodium falciparum glutathione reductase 0.0029 0.0058 0.1495
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0245 0.0696
Schistosoma mansoni kinase 0.0047 0.017 0.0482
Onchocerca volvulus 0.0029 0.006 0.0467
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0362 0.2143
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0362 0.1028
Entamoeba histolytica hypothetical protein 0.0035 0.0096 0.0468
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0039 0.0123 0.035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0362 0.2954
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.006 0.017
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0053 0.0209 0.0595
Echinococcus granulosus cathepsin L cysteine protease 0.0078 0.0362 0.1028
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.004 0.0543
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0362 0.211
Loa Loa (eye worm) hypothetical protein 0.0029 0.006 0.017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0362 0.2954
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0058 0.0013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0058 0.0084
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.1608 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0092 0.0261
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0245 0.194
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0058 0.1495
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0022 0.0561
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0028 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0039 0.0122 0.0596
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0444 0.1261
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0058 0.0313
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0248 0.1962
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0212 0.1173 0.3333
Echinococcus granulosus expressed conserved protein 0.01 0.0492 0.1397
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.1112 0.3159
Schistosoma mansoni cathepsin F (C01 family) 0.0039 0.0122 0.0348
Loa Loa (eye worm) hypothetical protein 0.0596 0.3519 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0039 0.0122 0.317
Brugia malayi Bromodomain containing protein 0.0028 0.0056 0.0158
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0092 0.0261
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.008 0.0372 0.0372
Echinococcus granulosus cathepsin l cysteine peptidase 0.0078 0.0362 0.1028
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0078 0.0362 0.1028
Leishmania major cysteine peptidase A (CPA) 0.0078 0.0362 0.2954
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0056 0.0296
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0022 0.3738
Plasmodium vivax serine-repeat antigen (SERA) 0.0039 0.0122 0.317
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0162 0.0849
Onchocerca volvulus 0.0026 0.004 0.0308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0362 0.211
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0161 0.0843
Brugia malayi Pre-SET motif family protein 0.0029 0.006 0.017
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0058 0.0164
Giardia lamblia Hypothetical protein 0.0039 0.0122 0.0429
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0039 0.0122 0.317
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0273 0.0273
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0444 0.0444
Giardia lamblia Hypothetical protein 0.0039 0.0122 0.0429
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0022 0.0296
Plasmodium vivax glutathione reductase, putative 0.0082 0.0386 1
Plasmodium vivax vivapain-3 0.0078 0.0362 0.9372
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0039 0.0122 0.0429
Entamoeba histolytica cysteine protease, putative 0.0078 0.0362 0.2143
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0096 0.0096
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0039 0.0122 0.0635
Giardia lamblia Cysteine protease 0.0039 0.0122 0.0429
Mycobacterium tuberculosis Probable reductase 0.0188 0.1029 0.8895
Plasmodium falciparum cysteine proteinase falcipain 3 0.0078 0.0362 0.9372
Brugia malayi Niemann-Pick C1 protein precursor 0.0106 0.0531 0.1509
Echinococcus multilocularis protein dispatched 1 0.0052 0.0201 0.0201
Leishmania major cathepsin L-like protease 0.0078 0.0362 0.2954
Trypanosoma cruzi trypanothione reductase, putative 0.0082 0.0386 0.1025
Brugia malayi fibroinase precursor 0.0039 0.0122 0.0348
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.008 0.0372 0.1058
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0245 0.0696
Toxoplasma gondii cathepsin CPC2 0.0039 0.0122 0.0875
Brugia malayi cathepsin F-like cysteine proteinase 0.0039 0.0122 0.0348
Schistosoma mansoni cathepsin F (C01 family) 0.0078 0.0362 0.1028
Onchocerca volvulus 0.0078 0.0362 0.2822
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0039 0.0122 0.317
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0102 0.0464
Entamoeba histolytica cysteine protease, putative 0.0078 0.0362 0.2143
Entamoeba histolytica cysteine protease, putative 0.0039 0.0122 0.0635
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0039 0.0122 0.317
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0122 0.0596
Schistosoma mansoni hypothetical protein 0.0035 0.0096 0.0273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0362 0.211
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0057 0.023 0.0578
Plasmodium vivax vivapain-2 0.0078 0.0362 0.9372
Entamoeba histolytica cysteine protease, putative 0.0078 0.0362 0.2143
Brugia malayi fructose-1,6-bisphosphatase 0.0153 0.0815 0.2315
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0058 0.1495
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0186 0.0999
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0162 0.0849
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0122 0.0596
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0161 0.0161
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0079 0.0503
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.006 0.017
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0102 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0039 0.0122 0.0596
Schistosoma mansoni hypothetical protein 0.008 0.0372 0.1058
Onchocerca volvulus 0.0039 0.0122 0.0955
Schistosoma mansoni cathepsin F (C01 family) 0.0078 0.0362 0.1028
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0186 0.0999
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1608 1
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0057 0.023 0.1809
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0444 0.119
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.004 0.0341
Trypanosoma brucei hypothetical protein, conserved 0.0206 0.1139 0.9706
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0058 0.0313
Brugia malayi Cathepsin L-like precursor 0.0078 0.0362 0.1028
Plasmodium vivax thioredoxin reductase, putative 0.0082 0.0386 1
Brugia malayi Cathepsin L-like precursor 0.0078 0.0362 0.1028
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0122 0.0348
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0596 0.3519 1
Echinococcus granulosus tar DNA binding protein 0.013 0.0674 0.1915
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0058 0.0084
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0186 0.0529
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0186 0.0186
Brugia malayi Cathepsin L-like precursor 0.0039 0.0122 0.0348
Loa Loa (eye worm) hypothetical protein 0.0026 0.004 0.0112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0362 0.2954
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0056 0.0158
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0186 0.0452
Giardia lamblia Cathepsin B precursor 0.0039 0.0122 0.0429
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0102 0.0464
Giardia lamblia Cathepsin B precursor 0.0212 0.1173 0.7195
Schistosoma mansoni cathepsin S (C01 family) 0.0039 0.0122 0.0348
Echinococcus granulosus peregrin 0.0028 0.0056 0.0158
Entamoeba histolytica cysteine protease, putative 0.0039 0.0122 0.0635
Plasmodium falciparum serine repeat antigen 7 0.0039 0.0122 0.317
Treponema pallidum NADH oxidase 0.0029 0.0058 0.0227
Plasmodium falciparum serine repeat antigen 8 0.0039 0.0122 0.317
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0362 0.0955
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0122 0.0348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0362 0.211
Plasmodium falciparum acyl-CoA synthetase 0.0019 0 0.0003
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0348
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0245 0.3372
Plasmodium vivax vivapain-2 0.0078 0.0362 0.9372
Onchocerca volvulus 0.0078 0.0362 0.2822
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0122 0.0348
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0188 0.1029 0.8895
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0028 0.0387
Brugia malayi Cathepsin L-like precursor 0.0078 0.0362 0.1028
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0273 0.0776
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0039 0.0122 0.0596
Trypanosoma cruzi cysteine proteinase, putative 0.0078 0.0362 0.0955
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0058 0.1495
Brugia malayi AMP-binding enzyme family protein 0.0026 0.004 0.0112
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0444 0.263
Toxoplasma gondii cathepsin CPL 0.0078 0.0362 0.2954
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0209 0.1157 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0362 0.211
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.004 0.0341
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0444 0.119
Echinococcus multilocularis Niemann Pick C1 protein 0.0152 0.0809 0.0809
Brugia malayi Pre-SET motif family protein 0.0201 0.1112 0.3159
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0444 0.3463
Toxoplasma gondii fructose-bisphospatase II 0.0153 0.0815 0.689
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0058 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0122 0.0596
Plasmodium falciparum thioredoxin reductase 0.0082 0.0386 1
Trypanosoma cruzi cysteine peptidase, putative 0.0039 0.0123 0.0272
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0273 0.2185
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0039 0.0122 0.317
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0153 0.0815 0.2315
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0186 0.0999
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0362 0.2954
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0058 0.4509
Entamoeba histolytica cysteine protease, putative 0.0078 0.0362 0.2143
Echinococcus multilocularis protein patched 0.0046 0.0161 0.0161
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0092 0.0092
Onchocerca volvulus Cathepsin F homolog 0.0078 0.0362 0.2822
Trypanosoma brucei trypanothione reductase 0.0082 0.0386 0.3164
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0082 0.0386 0.3334
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0348
Entamoeba histolytica cysteine proteinase 1, putative 0.0078 0.0362 0.2143
Giardia lamblia Cathepsin L-like protease 0.0039 0.0122 0.0429
Onchocerca volvulus Cathepsin L homolog 0.0078 0.0362 0.2822
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0058 0.0187
Schistosoma mansoni cathepsin s 0.0039 0.0123 0.035
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0444 0.1261
Giardia lamblia Cathepsin L precursor 0.0039 0.0122 0.0429
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1608 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0212 0.1173 1
Entamoeba histolytica cysteine protease, putative 0.0039 0.0122 0.0635
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0362 0.211
Loa Loa (eye worm) hypothetical protein 0.0106 0.0531 0.1509
Onchocerca volvulus 0.0078 0.0362 0.2822
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.006 0.006
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0011 0.0033
Leishmania major cathepsin L-like protease 0.0078 0.0362 0.2954
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0362 0.211
Onchocerca volvulus 0.008 0.0374 0.2921
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0362 0.1028
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0123 0.0123
Plasmodium falciparum serine repeat antigen 3 0.0039 0.0122 0.317
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0022 0.0186
Onchocerca volvulus 0.0078 0.0362 0.2822
Loa Loa (eye worm) apoptosis regulator protein 0.008 0.0372 0.1058
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0186 0.1429
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0186 0.0186
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0596 0.3519 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0273 0.2185
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.006 0.017
Echinococcus granulosus cathepsin l1 0.0039 0.0122 0.0348
Brugia malayi cathepsin B-like cysteine proteinase 0.0596 0.3519 1
Loa Loa (eye worm) ctsf protein 0.0078 0.0362 0.1028
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0058 0.1495
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0362 0.211
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0122 0.0348
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.004 0.0543
Trypanosoma cruzi cruzipain precursor, putative 0.0078 0.0362 0.0955
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0058 0.0058
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0186 0.0529
Plasmodium falciparum serine repeat antigen 4 0.0039 0.0122 0.317
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0212 0.1173 0.3279
Leishmania major cathepsin L-like protease 0.0078 0.0362 0.2954
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0028 0.0387
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.1608 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0058 0.0084
Echinococcus granulosus L aminoadipate semialdehyde 0.008 0.0374 0.1064
Loa Loa (eye worm) glutathione reductase 0.0082 0.0386 0.1097
Giardia lamblia Cathepsin L precursor 0.0039 0.0122 0.0429
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0022 0.0561
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0058 0.0187
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0362 0.2143
Plasmodium vivax unspecified product 0.0039 0.0123 0.3188
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0109 0.0109
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0273 0.0776
Onchocerca volvulus Cathepsin L homolog 0.0039 0.0122 0.0955
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0362 0.2954
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.0447 0.1271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0362 0.211
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0348
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.0447 0.0447
Echinococcus multilocularis cathepsin L cysteine protease 0.0078 0.0362 0.0362
Brugia malayi cathepsin L-like precursor 0.0039 0.0122 0.0348
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0362 0.2954
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0092 0.0261
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.1608 1
Entamoeba histolytica cysteine protease, putative 0.0078 0.0362 0.2143
Onchocerca volvulus 0.0078 0.0362 0.2822
Echinococcus granulosus cathepsin l1 0.0078 0.0362 0.1028
Entamoeba histolytica cysteine protease, putative 0.0039 0.0122 0.0635
Leishmania major cathepsin L-like protease 0.0078 0.0362 0.2954
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0186 0.0452
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0058 0.0313
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0078 0.0362 0.9372
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0102 0.021
Mycobacterium tuberculosis Probable oxidoreductase 0.0209 0.1157 1
Entamoeba histolytica cysteine protease, putative 0.0039 0.0122 0.0635
Brugia malayi jmjC domain containing protein 0.0034 0.0092 0.0261
Entamoeba histolytica cysteine protease, putative 0.0078 0.0362 0.2143
Trypanosoma cruzi cysteine proteinase, putative 0.0078 0.0362 0.0955
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0273 0.0702
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0444 0.263
Giardia lamblia Cathepsin B precursor 0.0039 0.0122 0.0429
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0186 0.1429
Echinococcus granulosus cathepsin L cysteine proteinase 0.0078 0.0362 0.1028
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0078 0.0362 0.1028
Entamoeba histolytica cysteine protease, putative 0.0078 0.0362 0.2143
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0078 0.0362 0.0362
Echinococcus multilocularis cathepsin L 0.0078 0.0362 0.0362
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0056 0.0158
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0186 0.084
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0248 0.0703
Trypanosoma brucei protein kinase, putative 0.005 0.0186 0.1429
Schistosoma mansoni hypothetical protein 0.0028 0.0056 0.0158
Entamoeba histolytica cysteine protease, putative 0.0078 0.0362 0.2143
Echinococcus multilocularis cathepsin b 0.0596 0.3519 0.3519
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0096 0.0273
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0039 0.0122 0.0596
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.004 0.0157
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.0058 1
Leishmania major cathepsin L-like protease 0.0078 0.0362 0.2954
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0596 0.3519 1
Toxoplasma gondii thioredoxin reductase 0.0082 0.0386 0.3164
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0028 0.0243
Loa Loa (eye worm) hypothetical protein 0.008 0.0372 0.1058
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0153 0.0815 0.2253
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0348
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0444 0.266
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0273 0.1585
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0186 0.1429
Loa Loa (eye worm) hypothetical protein 0.0026 0.004 0.0112
Echinococcus multilocularis peregrin 0.0028 0.0056 0.0056
Giardia lamblia Encystation-specific protease 0.0039 0.0122 0.0429
Schistosoma mansoni tar DNA-binding protein 0.013 0.0674 0.1915
Brugia malayi PHD-finger family protein 0.0028 0.0056 0.0158
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0057 0.023 0.1809
Loa Loa (eye worm) hypothetical protein 0.0026 0.004 0.0112
Schistosoma mansoni patched 1 0.0046 0.0161 0.0459
Echinococcus multilocularis cathepsin b 0.0596 0.3519 0.3519
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0273 0.0776
Loa Loa (eye worm) hypothetical protein 0.0028 0.0056 0.0158
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0199 0.0567
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0058 0.0313
Schistosoma mansoni cathepsin B (C01 family) 0.0039 0.0122 0.0348
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.004 0.0155
Loa Loa (eye worm) hypothetical protein 0.0039 0.0123 0.035
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0058 0.0313
Schistosoma mansoni hypothetical protein 0.008 0.0372 0.1058
Mycobacterium ulcerans hypothetical protein 0.0026 0.004 0.0543
Trypanosoma brucei cysteine peptidase C (CPC) 0.0212 0.1173 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0039 0.0122 0.0348
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0348
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0188 0.1029 0.8895
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0362 0.0955
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0122 0.0596
Plasmodium falciparum phd finger protein, putative 0.0028 0.0056 0.1443
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0153 0.0815 0.2253
Echinococcus multilocularis cysteine protease 0.0078 0.0362 0.0362
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0122 0.0596
Onchocerca volvulus 0.0078 0.0362 0.2822
Giardia lamblia Cathepsin B precursor 0.0039 0.0122 0.0429
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0039 0.0122 0.0596
Plasmodium vivax vivapain-1 0.0078 0.0362 0.9372
Leishmania major trypanothione reductase 0.0082 0.0386 0.3164
Entamoeba histolytica cysteine protease, putative 0.0078 0.0362 0.2143
Mycobacterium tuberculosis Conserved protein 0.0024 0.0028 0.0243
Echinococcus multilocularis cathepsin L cysteine protease 0.0078 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.0039 0.0123 0.035
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0039 0.0122 0.0596
Giardia lamblia Cathepsin B precursor 0.0212 0.1173 0.7195
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0212 0.1173 0.7244
Plasmodium falciparum glutathione reductase 0.0082 0.0386 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0039 0.0122 0.027
Entamoeba histolytica cysteine protease, putative 0.0078 0.0362 0.2143
Brugia malayi cathepsin L-like cysteine proteinase 0.0039 0.0122 0.0348
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0039 0.0123 0.035
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.004 0.0155
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0157 0.0843 0.2395
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0273 0.0702
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0153 0.0815 0.689
Toxoplasma gondii cathepsin B 0.0212 0.1173 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0108 0.0541 0.1537
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0039 0.0122 0.317
Plasmodium falciparum serine repeat antigen 1 0.0039 0.0122 0.317
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0053 0.0152
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0039 0.0122 0.317
Schistosoma mansoni hypothetical protein 0.0044 0.0151 0.043
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0039 0.0122 0.0429
Brugia malayi Cathepsin L-like precursor 0.0078 0.0362 0.1028
Brugia malayi MAP kinase sur-1 0.005 0.0186 0.0529
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0348
Entamoeba histolytica cysteine proteinase 2 0.0078 0.0362 0.2143
Mycobacterium tuberculosis Probable dehydrogenase 0.0188 0.1029 0.8895
Leishmania major cathepsin L-like protease 0.0078 0.0362 0.2954
Echinococcus multilocularis thioredoxin glutathione reductase 0.0083 0.0389 0.0389
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.004 0.0543
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0056 0.0056
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0039 0.0122 0.317
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0239 0.0679
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1608 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0362 0.211
Brugia malayi jmjC domain containing protein 0.0092 0.0447 0.1271
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0209 0.1157 1
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0028 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0362 0.2954
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0596 0.3519 1
Brugia malayi hypothetical protein 0.0035 0.0096 0.0273
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0058 0.0084
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0245 0.0696
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0122 0.0596
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.008 0.0374 0.1064
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0078 0.0362 0.9372
Entamoeba histolytica cysteine protease, putative 0.0078 0.0362 0.2143
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0039 0.0122 0.0348
Trichomonas vaginalis set domain proteins, putative 0.0229 0.1281 0.7931
Brugia malayi Thioredoxin reductase 0.0082 0.0386 0.1097
Entamoeba histolytica cysteine protease, putative 0.0078 0.0362 0.2143
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1608 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0245 0.0245
Brugia malayi cathepsin Z-like cysteine proteinase 0.0039 0.0122 0.0348
Plasmodium falciparum cysteine proteinase falcipain 1 0.0078 0.0362 0.9372
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0058 0.0793
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0209 0.1157 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0102 0.0289
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0362 0.211
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0039 0.0122 0.317
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0362 0.211
Brugia malayi TAR-binding protein 0.013 0.0674 0.1915
Loa Loa (eye worm) hypothetical protein 0.0078 0.0362 0.1028
Plasmodium vivax unspecified product 0.0039 0.0122 0.317
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.004 0.0113
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.004 0.0543
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0245 0.2116
Plasmodium falciparum serine repeat antigen 5 0.0039 0.0122 0.317
Toxoplasma gondii fructose-bisphospatase I 0.0057 0.023 0.1809
Brugia malayi RNA recognition motif domain containing protein 0.013 0.0674 0.1915
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0362 0.2143
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0153 0.0815 0.2315
Brugia malayi Papain family cysteine protease containing protein 0.0039 0.0122 0.0348
Schistosoma mansoni tar DNA-binding protein 0.013 0.0674 0.1915
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0444 0.3667
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0186 0.0452
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1608 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0362 0.211
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0058 0.0498
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0122 0.0596
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0039 0.0122 0.0348
Entamoeba histolytica cysteine protease, putative 0.0039 0.0122 0.0635
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0039 0.0122 0.317
Giardia lamblia Cathepsin L precursor 0.0039 0.0122 0.0429
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0362 0.211
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0028 0.0387
Giardia lamblia Kinase, PLK 0.0092 0.0444 0.25
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0362 0.2954
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0122 0.0596
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0362 0.211
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0079 0.068
Loa Loa (eye worm) TAR-binding protein 0.013 0.0674 0.1915
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.008 0.0372 0.0372
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0058 0.0164
Giardia lamblia Cysteine protease 0.0039 0.0122 0.0429
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0011 0.0033
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0039 0.0122 0.0348
Echinococcus multilocularis L aminoadipate semialdehyde 0.008 0.0374 0.0374
Brugia malayi CHE-14 protein 0.0046 0.0161 0.0459
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0078 0.0362 0.1028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0122 0.0596
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0248 0.0248
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0039 0.0122 0.0596
Schistosoma mansoni hypothetical protein 0.0044 0.0151 0.043
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0188 0.1029 0.8895
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.006 0.017
Onchocerca volvulus 0.0229 0.1281 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0039 0.0122 0.0348
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0039 0.0122 0.0429
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0444 0.263
Echinococcus multilocularis cathepsin L 0.0039 0.0122 0.0122
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0186 0.0999
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.004 0.0155
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0102 1
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0161 0.0459
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.004 0.0157
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0596 0.3519 1
Giardia lamblia Cathepsin L precursor 0.0039 0.0122 0.0429
Loa Loa (eye worm) inositol-1 0.0036 0.0102 0.0289
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0078 0.0362 0.0955
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0057 0.023 0.0578
Brugia malayi Inositol-1 0.0036 0.0102 0.0289
Giardia lamblia Cathepsin B precursor 0.0039 0.0122 0.0429
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.004 0.0113
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0362 0.211
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0102 0.0102
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0362 0.211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0362 0.2954
Toxoplasma gondii cathepsin CPC1 0.0039 0.0122 0.0875
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0248 0.2138
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0092 0.0261
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.008 0.0374 0.1064
Mycobacterium ulcerans hypothetical protein 0.0024 0.0028 0.0387
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.1139 0.3182
Schistosoma mansoni lipoxygenase 0.0053 0.0209 0.0595
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0039 0.0122 0.0348
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0248 0.1962
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0444 0.263
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0348
Echinococcus granulosus Niemann Pick C1 protein 0.0152 0.0809 0.2298
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0039 0.0122 0.0596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0362 0.211
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0362 0.2143
Echinococcus multilocularis Niemann Pick C1 protein 0.0106 0.0531 0.0531
Plasmodium falciparum thioredoxin reductase 0.0029 0.0058 0.1495
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0157 0.0843 0.0843
Entamoeba histolytica hypothetical protein 0.0035 0.0096 0.0468
Leishmania major hypothetical protein, conserved 0.0206 0.1139 0.9706
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.0726 0.6275
Plasmodium vivax unspecified product 0.0078 0.0362 0.9372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0362 0.2954
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0161 0.0459
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0362 0.0955
Toxoplasma gondii preprocathepsin c precursor, putative 0.0039 0.0122 0.0875
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0273 0.0776
Echinococcus granulosus thioredoxin glutathione reductase 0.0083 0.0389 0.1105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0058 0.0084
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0362 0.1028
Schistosoma mansoni tar DNA-binding protein 0.013 0.0674 0.1915
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0444 0.263
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0161 0.0459
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0078 0.0362 0.0362
Brugia malayi Cathepsin L-like precursor 0.0078 0.0362 0.1028
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0102 0.0464
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0022 0.0296
Giardia lamblia Cathepsin B precursor 0.0212 0.1173 0.7195
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0362 0.211
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0248 0.3408
Brugia malayi Cathepsin L-like cysteine proteinase 0.0039 0.0122 0.0348
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0102 0.0695
Loa Loa (eye worm) cysteine protease 0.0078 0.0362 0.1028
Echinococcus granulosus cathepsin L 0.0078 0.0362 0.1028
Echinococcus granulosus cathepsin L 0.0039 0.0122 0.0348
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0444 0.1261
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.1139 0.3182
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0078 0.0362 0.1028
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0122 0.0596
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0039 0.0122 0.317
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0153 0.0815 0.2315
Giardia lamblia Cathepsin L precursor 0.0039 0.0122 0.0429
Loa Loa (eye worm) hypothetical protein 0.0157 0.0843 0.2395
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0058 0.4509
Loa Loa (eye worm) fibroinase 0.0078 0.0362 0.1028
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0186 0.0529
Plasmodium falciparum serine repeat antigen 2 0.0039 0.0122 0.317
Loa Loa (eye worm) hypothetical protein 0.0046 0.0161 0.0459
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0058 0.0793
Brugia malayi cathepsin L precursor 0.0039 0.0122 0.0348
Giardia lamblia Cysteine protease 0.0039 0.0122 0.0429
Loa Loa (eye worm) hypothetical protein 0.0039 0.0123 0.035
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0362 0.211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0362 0.2954
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0362 0.2954
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0348
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0058 0.0313
Brugia malayi glutathione reductase 0.0082 0.0386 0.1097
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.008 0.0372 0.1058
Giardia lamblia Cathepsin L precursor 0.0039 0.0122 0.0429
Brugia malayi cathepsin Z-like cysteine proteinase 0.0039 0.0122 0.0348
Onchocerca volvulus Alhambra homolog 0.0028 0.0056 0.0435
Onchocerca volvulus 0.0039 0.0122 0.0955
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.004 0.0113
Plasmodium vivax SET domain protein, putative 0.0029 0.006 0.155
Loa Loa (eye worm) RNA binding protein 0.013 0.0674 0.1915
Brugia malayi RNA binding protein 0.013 0.0674 0.1915
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0058 0.0164
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0362 0.211
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0039 0.0122 0.027
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0362 0.2143
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0245 0.3372
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0039 0.0122 0.0348
Plasmodium vivax serine-repeat antigen (SERA) 0.0039 0.0122 0.317
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0157 0.0843 0.2395
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0096 0.0273
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0102 0.0695
Schistosoma mansoni tar DNA-binding protein 0.013 0.0674 0.1915
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0056 0.0296
Echinococcus granulosus cysteine protease 0.0078 0.0362 0.1028
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.008 0.0372 0.1058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0122 0.0596
Trypanosoma cruzi major cysteine proteinase, putative 0.0039 0.0122 0.027
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.0726 1
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0056 0.1443
Loa Loa (eye worm) hypothetical protein 0.008 0.0374 0.1064
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0039 0.0122 0.0429
Brugia malayi cathepsin F-like cysteine proteinase 0.0039 0.0123 0.035
Loa Loa (eye worm) hypothetical protein 0.0039 0.0122 0.0348
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0362 0.0955
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0248 0.0703
Loa Loa (eye worm) hypothetical protein 0.0056 0.0224 0.0636
Brugia malayi AMP-binding enzyme family protein 0.0026 0.004 0.0112
Leishmania major 0.0153 0.0815 0.689
Leishmania major cathepsin L-like protease 0.0078 0.0362 0.2954
Echinococcus multilocularis tar DNA binding protein 0.013 0.0674 0.0674
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0362 0.211
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.004 0.0543
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0106 0.0531 0.321
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1608 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0188 0.1029 0.8895
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0102 0.0695
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0444 0.263
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0078 0.0362 0.211
Entamoeba histolytica hypothetical protein 0.0039 0.0122 0.0635
Entamoeba histolytica cysteine protease, putative 0.0078 0.0362 0.2143
Loa Loa (eye worm) pip kinase 2 0.0157 0.0843 0.2395
Onchocerca volvulus 0.0078 0.0362 0.2822
Echinococcus granulosus Niemann Pick C1 protein 0.0106 0.0531 0.1509
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0188 0.1029 0.8874
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0039 0.0122 0.0348
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.0674 0.1915
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0122 0.0596
Brugia malayi Cathepsin L-like precursor 0.0039 0.0122 0.0348
Echinococcus granulosus cathepsin b 0.0596 0.3519 1
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0109 0.031
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0331 0.0941
Loa Loa (eye worm) cathepsin B 0.0212 0.1173 0.3333
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0362 0.211
Giardia lamblia Cathepsin L-like protease 0.0039 0.0122 0.0429
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0153 0.0815 0.0815
Loa Loa (eye worm) thioredoxin reductase 0.0082 0.0386 0.1097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1608 1
Giardia lamblia Cathepsin B precursor 0.0039 0.0122 0.0429
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0362 0.211
Plasmodium falciparum serine repeat antigen 9 0.0039 0.0122 0.317
Giardia lamblia Cysteine protease 0.0039 0.0122 0.0429
Schistosoma mansoni inositol monophosphatase 0.0036 0.0102 0.0289
Echinococcus multilocularis cysteine protease 0.0078 0.0362 0.0362
Echinococcus granulosus cathepsin b 0.0596 0.3519 1
Entamoeba histolytica hypothetical protein 0.0035 0.0096 0.0468
Plasmodium falciparum serine repeat antigen 6 0.0039 0.0122 0.317
Brugia malayi Pip kinase protein 2 0.0157 0.0843 0.2395
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0058 0.0313
Onchocerca volvulus Cathepsin L homolog 0.0078 0.0362 0.2822
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.008 0.0372 0.1058
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0444 0.1261
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0248 0.3408
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.006 0.017
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0102 0.021
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0102 0.1398
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.004 0.0543
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0078 0.0362 0.211
Schistosoma mansoni hypothetical protein 0.008 0.0372 0.1058
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0157 0.0843 0.2395
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.1608 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0102 0.0504
Trypanosoma cruzi cysteine protease, putative 0.0078 0.0362 0.0955
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0056 0.0158
Brugia malayi Cathepsin L-like precursor 0.0078 0.0362 0.1028
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0444 0.263
Schistosoma mansoni cathepsin C 0.0039 0.0122 0.0348
Trypanosoma cruzi cruzipain precursor, putative 0.0039 0.0123 0.0272
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0039 0.0122 0.317
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0053 0.0209 0.0209
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.006 0.006
Onchocerca volvulus 0.0157 0.0843 0.6577
Echinococcus multilocularis expressed conserved protein 0.01 0.0492 0.0492
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0186 0.0452
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0058 0.0084
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0058 0.0313
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0078 0.0362 0.1028
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0028 0.0057
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0362 0.2143
Brugia malayi AMP-binding enzyme family protein 0.0026 0.004 0.0112
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0058 0.0793
Entamoeba histolytica hypothetical protein 0.0035 0.0096 0.0468
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.0726 0.6204
Schistosoma mansoni tar DNA-binding protein 0.013 0.0674 0.1915
Leishmania major cathepsin L-like protease 0.0078 0.0362 0.2954
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0362 0.211
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0039 0.0122 0.0348
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.1608 1
Entamoeba histolytica cysteine protease, putative 0.0078 0.0362 0.2143
Mycobacterium ulcerans hypothetical protein 0.0024 0.0028 0.0387
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0248 0.3408
Schistosoma mansoni apoptosis regulator bax 0.008 0.0372 0.1058

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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