Detailed information for compound 815199

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 506.656 | Formula: C29H34N2O4S
  • H donors: 0 H acceptors: 1 LogP: 5.09 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccccc1C(=O)N1CCOc2c(C1)cc(cc2OCC1CCCN(C1)C)c1ccc(s1)C
  • InChi: 1S/C29H34N2O4S/c1-20-10-11-27(36-20)22-15-23-18-31(29(32)24-8-4-5-9-25(24)33-3)13-14-34-28(23)26(16-22)35-19-21-7-6-12-30(2)17-21/h4-5,8-11,15-16,21H,6-7,12-14,17-19H2,1-3H3
  • InChiKey: NIDMXKANZRWMFV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0332 0.1256
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0347 0.1137
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0017 0.0066 0.0105
Trichomonas vaginalis ran, putative 0.0021 0.0117 0.0297
Onchocerca volvulus 0.0017 0.0066 0.0171
Brugia malayi PHD-finger family protein 0.003 0.0252 0.0729
Brugia malayi Bromodomain containing protein 0.0088 0.1046 0.3021
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0573 0.0559
Schistosoma mansoni zinc finger protein 0.0024 0.0168 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.027 0.074
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0242 0.0469
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0512 0.1025
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0072 0.0058
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0372 0.1234
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0066 0.0189
Trypanosoma cruzi ISWI complex protein 0.0018 0.0078 0.0049
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.0347 0.9321
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0017 0.0066 0.0105
Trypanosoma cruzi ribonuclease H1, putative 0.0197 0.2546 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0372 0.0735
Schistosoma mansoni ap endonuclease 0.0039 0.0372 0.0358
Trypanosoma brucei hypothetical protein, conserved 0.0214 0.2776 0.2728
Schistosoma mansoni DNA polymerase eta 0.0062 0.0685 0.0672
Onchocerca volvulus 0.0029 0.0227 0.0712
Brugia malayi Bromodomain containing protein 0.0044 0.0442 0.1277
Echinococcus multilocularis dna polymerase eta 0.0062 0.0685 0.1381
Schistosoma mansoni hypothetical protein 0.0024 0.0162 0.0148
Trypanosoma cruzi DNA polymerase eta, putative 0.0062 0.0685 0.2499
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0037 0.0347 0.0966
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0103 0.0258
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.0215 0.0201
Echinococcus multilocularis dna polymerase kappa 0.0037 0.0347 0.0685
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0372 0.1191
Brugia malayi hypothetical protein 0.0017 0.0066 0.0189
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0347 0.0284
Trichomonas vaginalis chromobox protein, putative 0.008 0.093 0.2654
Toxoplasma gondii exonuclease III APE 0.0039 0.0372 0.1412
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0066 0.0189
Loa Loa (eye worm) hypothetical protein 0.0082 0.0956 0.2411
Onchocerca volvulus 0.0054 0.0573 0.1868
Entamoeba histolytica hypothetical protein 0.0023 0.0146 0.3671
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0117 0.0211
Brugia malayi Associated with TFs and helicases family protein 0.0013 0.0014 0.0042
Trypanosoma brucei unspecified product 0.0214 0.2776 0.2728
Trichomonas vaginalis reverse transcriptases, putative 0.0017 0.0066 0.0148
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0017 0.0066 0.0105
Trypanosoma brucei ribonuclease H1 0.0197 0.2546 0.2497
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0103 0.0258
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0066 0.0189
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0372 0.1036
Schistosoma mansoni hypothetical protein 0.0017 0.0066 0.0051
Brugia malayi Zinc knuckle family protein 0.0017 0.0066 0.0189
Schistosoma mansoni bromodomain containing protein 0.0075 0.086 0.0847
Brugia malayi Heterochromatin protein 1 0.008 0.093 0.2685
Onchocerca volvulus 0.0013 0.0014 0.000000055796
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0531 0.0468
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0372 0.0915
Giardia lamblia DINP protein human, muc B family 0.0037 0.0347 0.1137
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0531 0.1498
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0531 0.1063
Echinococcus granulosus Chromobox protein 3 0.0013 0.0014 0.000000034329
Echinococcus granulosus KRAB A domain containing protein 0.0017 0.0066 0.0105
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0531 0.1063
Brugia malayi Importin beta-1 subunit 0.0028 0.0218 0.0629
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0347 0.0284
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0066 0.0189
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0017 0.0066 0.0171
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0103 0.0258
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0531 0.1836
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0103 0.0258
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0017 0.0066 0.0105
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0115 0.0258
Echinococcus granulosus dna polymerase kappa 0.0037 0.0347 0.0685
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0372 0.1036
Brugia malayi Protein cec-1. 0.0013 0.0014 0.0042
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.0347 0.0853
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0531 0.1498
Leishmania major ribonuclease H1, putative 0.0197 0.2546 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0066 0.0189
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0117 0.0262
Trypanosoma brucei DNA polymerase eta, putative 0.0062 0.0685 0.0624
Echinococcus multilocularis chromobox protein 1 0.008 0.093 0.1883
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0218 0.0153
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0372 0.1234
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0242 0.0228
Trypanosoma brucei protein kinase, putative 0.0051 0.0531 0.0468
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0372 0.0308
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0512 0.0499
Trypanosoma brucei ISWI complex protein 0.0018 0.0078 0.0012
Schistosoma mansoni chromobox protein 0.008 0.093 0.0916
Echinococcus granulosus ribonuclease H1 0.0197 0.2546 0.5209
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0017 0.0066 0.0148
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0017 0.0067 0.0053
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.0347 0.9208
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0332 0.1075
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0189 0.0124
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.0215 0.0412
Brugia malayi Zinc knuckle family protein 0.0017 0.0066 0.0189
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0066 0.0189
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0037 0.0347 0.1093
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0037 0.0347 0.9208
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0227 0.0545
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0017 0.0066 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0347 0.0284
Leishmania major DNA polymerase kappa, putative 0.0037 0.0347 0.1093
Loa Loa (eye worm) hypothetical protein 0.0049 0.0512 0.1275
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.027 0.074
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0587 0.1178
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0146 0.038
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0372 1
Echinococcus multilocularis cpg binding protein 0.0032 0.028 0.0546
Schistosoma mansoni chromobox protein 0.008 0.093 0.0916
Brugia malayi RNase H family protein 0.0197 0.2546 0.7353
Echinococcus granulosus snurportin 1 0.0297 0.392 0.8036
Trypanosoma cruzi ISWI complex protein 0.0018 0.0078 0.0049
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0117 0.0211
Brugia malayi RNA, U transporter 1 0.0079 0.0923 0.2667
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0495 0.1608
Echinococcus multilocularis tumor protein p63 0.0367 0.4875 1
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0347 0.0284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0587 0.0573
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0347 0.1137
Leishmania major importin beta-1 subunit, putative 0.0023 0.0146 0.0275
Echinococcus granulosus chromobox protein 1 0.008 0.093 0.1883
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0162 0.0379
Brugia malayi reverse transcriptase 0.0017 0.0066 0.0189
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0531 0.1063
Trypanosoma brucei unspecified product 0.0037 0.0347 0.0284
Echinococcus multilocularis Chromobox protein 3 0.0013 0.0014 0.000000034329
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0106 0.0188
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0066 0.0189
Trypanosoma brucei RNA helicase, putative 0.074 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0587 0.1178
Echinococcus multilocularis RNA directed DNA polymerase 0.0017 0.0066 0.0105
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0531 0.1498
Schistosoma mansoni cpg binding protein 0.0032 0.028 0.0266
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0017 0.0066 0.0105
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0106 0.0188
Schistosoma mansoni phosphoglucomutase 0.0197 0.2546 0.2535
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0062 0.0138
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0066 0.0189
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0531 0.1876
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.0347 0.0685
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0405 0.0803
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0017 0.0067 0.0108
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0372 1
Schistosoma mansoni ap endonuclease 0.0039 0.0372 0.0358
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.0347 0.0685
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0242 0.09
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0449 0.1259
Loa Loa (eye worm) glutaminase 2 0.0264 0.3463 0.8829
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0017 0.0066 0.0105
Brugia malayi hypothetical protein 0.0017 0.0066 0.0189
Entamoeba histolytica Ran family GTPase 0.0021 0.0117 0.2869
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0066 0.0189
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0347 0.0284
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0146 0.038
Brugia malayi reverse transcriptase 0.0017 0.0066 0.0189
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0106 0.0091
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0421 0.0407
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0372 0.0735
Brugia malayi Pre-SET motif family protein 0.0203 0.2621 0.757
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0017 0.0066 0.0105
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0372 0.1234
Onchocerca volvulus 0.0035 0.0316 0.1009
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.063 0.2433
Toxoplasma gondii ribonuclease HI protein 0.0197 0.2546 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0587 0.0573
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0531 0.204
Schistosoma mansoni protein kinase 0.0017 0.0066 0.0051
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0372 1
Schistosoma mansoni glutaminase 0.0264 0.3463 0.3453
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0117 0.0207
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0066 0.0189
Echinococcus multilocularis snurportin 1 0.0297 0.392 0.8036
Echinococcus multilocularis zinc finger protein 0.0024 0.0168 0.0316
Onchocerca volvulus 0.0231 0.3005 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0804 0.1624
Loa Loa (eye worm) hypothetical protein 0.0062 0.0685 0.1718
Schistosoma mansoni cpg binding protein 0.0029 0.0227 0.0213
Loa Loa (eye worm) hypothetical protein 0.0035 0.0316 0.0773
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0347 0.0284
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0117 0.0207
Onchocerca volvulus Ribonuclease H1 homolog 0.0197 0.2546 0.8466
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0117 0.2869
Leishmania major DNA polymerase eta, putative 0.0036 0.0332 0.1031
Schistosoma mansoni ran 0.0021 0.0117 0.0103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0587 0.0573
Trichomonas vaginalis reverse transcriptases, putative 0.0017 0.0066 0.0148
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0347 0.0284
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0218 0.0153
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0066 0.0189
Trichomonas vaginalis ribonuclease H1, putative 0.0197 0.2546 0.7341
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0531 0.1876
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0146 0.038
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0117 0.0207
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0117 0.0338
Brugia malayi SET domain containing protein 0.0015 0.0038 0.0109
Trypanosoma brucei unspecified product 0.0026 0.0189 0.0124
Echinococcus granulosus dna polymerase eta 0.0062 0.0685 0.1381
Brugia malayi Valyl-tRNA synthetase 0.0013 0.0014 0.0042
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0189 0.0124
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0347 0.1137
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0117 0.2869
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0372 1
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0017 0.0066 0.0105
Trypanosoma brucei ingi protein (ORF1) 0.0214 0.2776 0.2728
Schistosoma mansoni zinc finger protein 0.0018 0.0078 0.0063
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0017 0.0066 0.0105
Brugia malayi hypothetical protein 0.0013 0.0014 0.0042
Echinococcus multilocularis ribonuclease H1 0.0197 0.2546 0.5209
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0017 0.0066 0.0105
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0531 0.1836
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0587 0.1178
Brugia malayi RNase H family protein 0.0197 0.2546 0.7353
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0495 0.1395
Plasmodium vivax importin-beta 2, putative 0.0028 0.0218 0.5696
Trypanosoma brucei ingi protein (ORF1) 0.0214 0.2776 0.2728
Schistosoma mansoni importin beta-1 0.0028 0.0218 0.0204
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0017 0.0067 0.0108
Brugia malayi reverse transcriptase 0.0017 0.0066 0.0189
Trichomonas vaginalis chromobox protein, putative 0.0048 0.0495 0.1395
Loa Loa (eye worm) hypothetical protein 0.0045 0.0449 0.1112
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0347 0.0284
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0405 0.0803
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0531 0.1876
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0449 0.1452
Trichomonas vaginalis glutaminase, putative 0.0264 0.3463 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0218 0.0521
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0037 0.0347 0.0334
Trypanosoma brucei unspecified product 0.0026 0.0189 0.0124
Plasmodium vivax SET domain protein, putative 0.003 0.0242 0.6376
Brugia malayi M-phase phosphoprotein, mpp8 0.0013 0.0014 0.0042
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0531 0.1876
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0066 0.0189
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0189 0.0124
Schistosoma mansoni cpg binding protein 0.0032 0.028 0.0266
Brugia malayi hypothetical protein 0.0017 0.0066 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0449 0.1259
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0146 0.0323
Loa Loa (eye worm) CHromoDomain protein family member 0.0017 0.0067 0.0135
Trypanosoma cruzi ribonuclease H1, putative 0.0197 0.2546 1
Brugia malayi CHD4 protein 0.0017 0.0067 0.0194
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0013 0.0014 0.0042
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0103 0.0258
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0531 0.1063
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0347 0.0284
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0017 0.0066 0.0105
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0804 0.1624
Loa Loa (eye worm) hypothetical protein 0.0054 0.0573 0.143
Brugia malayi glutaminase DH11.1 0.0264 0.3463 1
Brugia malayi RNase H family protein 0.0197 0.2546 0.7353
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2621 0.6674
Schistosoma mansoni ran 0.0021 0.0117 0.0103
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0103 0.0258
Echinococcus granulosus zinc finger protein 0.0024 0.0168 0.0316
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0017 0.0066 0.0105
Schistosoma mansoni phosphoglucomutase 0.0197 0.2546 0.2535
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0218 0.0804
Trichomonas vaginalis DNA polymerase eta, putative 0.0037 0.0347 0.0966
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.392 1
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0017 0.0066 0.0105
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0066 0.0189
Onchocerca volvulus 0.0017 0.0066 0.0171
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.0347 0.1004
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0347 0.0284
Loa Loa (eye worm) hypothetical protein 0.0047 0.0481 0.1194
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0531 0.1323
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0531 0.0517
Echinococcus granulosus tumor protein p63 0.0367 0.4875 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0587 0.1695
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0587 0.1178
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.0685 0.198
Mycobacterium ulcerans glutaminase 0.0264 0.3463 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0103 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0347 0.0284
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0062 0.0138
Brugia malayi chromobox protein homolog 3 0.0045 0.0449 0.1296
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0372 0.0078
Trichomonas vaginalis set domain proteins, putative 0.0231 0.3005 0.8672
Brugia malayi Pre-SET motif family protein 0.003 0.0242 0.07
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.0056 0.0119
Loa Loa (eye worm) hypothetical protein 0.0051 0.0533 0.1329
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0106 0.0091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0512 0.0499
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.0347 0.0284
Schistosoma mansoni hypothetical protein 0.0297 0.392 0.3911
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0372 0.1074
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0218 0.0419
Brugia malayi hypothetical protein 0.0017 0.0066 0.0189
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0117 0.0052
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0219 0.0421
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0587 0.1466
Echinococcus multilocularis chromobox protein 1 0.008 0.093 0.1883
Onchocerca volvulus 0.0043 0.0421 0.1361
Plasmodium falciparum importin beta, putative 0.0028 0.0218 0.5696
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0682 0.0668
Echinococcus granulosus importin subunit beta 1 0.0028 0.0218 0.0419
Echinococcus granulosus chromobox protein 1 0.008 0.093 0.1883
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.0347 0.1137
Giardia lamblia Ribonuclease H 0.0197 0.2546 1
Schistosoma mansoni hypothetical protein 0.0018 0.0078 0.0063
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0017 0.0066 0.0105
Loa Loa (eye worm) hypothetical protein 0.0044 0.0443 0.1098
Brugia malayi CXXC zinc finger family protein 0.0029 0.0227 0.0657
Echinococcus granulosus RNA directed DNA polymerase 0.0017 0.0066 0.0105
Trichomonas vaginalis chromobox protein, putative 0.008 0.093 0.2654
Schistosoma mansoni phosphoglucomutase 0.0197 0.2546 0.2535
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0103 0.0258
Brugia malayi MAP kinase sur-1 0.0051 0.0531 0.1533
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0117 0.0405
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0531 0.1876
Echinococcus granulosus cpg binding protein 0.0032 0.028 0.0546
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0017 0.0066 0.0051
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0347 0.0284
Schistosoma mansoni hypothetical protein 0.0017 0.0066 0.0051
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0531 0.1498
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0197 0.2546 1
Loa Loa (eye worm) heterochromatin protein 1 0.008 0.093 0.2343
Leishmania major DNA polymerase eta, putative 0.0062 0.0685 0.2462
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0214 0.2776 0.2728
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.0347 0.0334
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.0215 0.0412
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0512 0.1025
Loa Loa (eye worm) glutaminase 0.0264 0.3463 0.8829
Treponema pallidum ribonuclease H (rnhA) 0.0197 0.2546 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0017 0.0066 0.0189
Leishmania major GTP-binding protein, putative 0.0021 0.0117 0.0159

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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