Detailed information for compound 822517

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 488.661 | Formula: C26H37FN4O2S
  • H donors: 1 H acceptors: 3 LogP: 3.89 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSCCC(=O)N(C(C1CCN(CC1)C(=O)c1n[nH]c(c1)CC(C)C)Cc1ccc(cc1)F)C
  • InChi: 1S/C26H37FN4O2S/c1-18(2)15-22-17-23(29-28-22)26(33)31-12-9-20(10-13-31)24(30(3)25(32)11-14-34-4)16-19-5-7-21(27)8-6-19/h5-8,17-18,20,24H,9-16H2,1-4H3,(H,28,29)
  • InChiKey: PDCGPXICPYDTSR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.053 0.053
Loa Loa (eye worm) hypothetical protein 0.0031 0.0067 0.0282
Brugia malayi hypothetical protein 0.023 0.1296 0.5461
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0022 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0038 0.0161
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0031 0.0067 0.0282
Brugia malayi von Willebrand factor type A domain containing protein 0.0031 0.0067 0.0282
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0161
Brugia malayi Zona pellucida-like domain containing protein 0.0031 0.0067 0.0282
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0055 0.0202
Toxoplasma gondii kringle domain-containing protein 0.0023 0.002 0.0199
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.0038 0.0038
Schistosoma mansoni lamin 0.0054 0.0213 0.0497
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.01 0.1895
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0038 0.0161
Loa Loa (eye worm) cytochrome P450 family protein 0.0068 0.0295 0.1243
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.053 1
Brugia malayi hypothetical protein 0.0036 0.01 0.0422
Schistosoma mansoni thyroid hormone receptor 0.0152 0.0812 0.1891
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0055 0.8204
Echinococcus granulosus pikachurin 0.0048 0.0177 0.0177
Entamoeba histolytica hypothetical protein 0.0031 0.0067 0.1261
Echinococcus granulosus nAChR subunit 0.0022 0.0013 0.0013
Entamoeba histolytica elongation factor-2 kinase, putative 0.0031 0.0067 0.1261
Onchocerca volvulus 0.0031 0.0067 0.0199
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.0038 0.0038
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0022 0.0013 0.0013
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0023 0.002 0.0844
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1296 0.1296
Echinococcus granulosus neurogenic locus notch protein 0.0048 0.0177 0.0177
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0183 0.1005 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.01 0.01
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0022 0.0013 0.003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Echinococcus multilocularis glycine receptor subunit beta 0.0022 0.0013 0.0013
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0055 0.0202
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.004 0.004
Schistosoma mansoni thyroid hormone receptor 0.0152 0.0812 0.1891
Brugia malayi von Willebrand factor type A domain containing protein 0.0031 0.0067 0.0282
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0031 0.0067 0.0282
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.002 0.0377
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0031 0.0067 0.0067
Schistosoma mansoni cell polarity protein 0.0048 0.0177 0.0412
Loa Loa (eye worm) CUTiclin-Like family member 0.0031 0.0067 0.0282
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0031 0.0067 0.0282
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0237 0.0551
Echinococcus granulosus intermediate filament protein 0.0054 0.0213 0.0213
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0405 0.2373 1
Brugia malayi Cache domain containing protein 0.0331 0.1917 0.8078
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0223 0.0223
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0067 0.0282
Entamoeba histolytica hypothetical protein, conserved 0.0031 0.0067 0.1261
Brugia malayi intermediate filament protein 0.0054 0.0213 0.0899
Plasmodium vivax thrombospondin-related anonymous protein 0.0031 0.0067 0.2826
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0143
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0055 0.8204
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0022 0.0013 0.0055
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.01 0.037
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0022 0.0013 0.003
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.01 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0038 0.0161
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0055 0.0175
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0183 0.0426
Brugia malayi follicle stimulating hormone receptor 0.0228 0.1281 0.5398
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.01 0.0233
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0038 0.0161
Echinococcus multilocularis pikachurin 0.0048 0.0177 0.0177
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0161
Brugia malayi von Willebrand factor type A domain containing protein 0.0031 0.0067 0.0282
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0022 0.0013 0.0013
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.053 1
Brugia malayi Cation transporter family protein 0.0022 0.0013 0.0055
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0237 0.0237
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0022 0.0013 0.0055
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0048 0.0177 0.0746
Toxoplasma gondii microneme protein MIC2 0.0031 0.0067 0.0665
Loa Loa (eye worm) hypothetical protein 0.0031 0.0067 0.0282
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0022 0.0013 0.0013
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.01 0.01
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.053 0.1951
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0022 0.0013 0.0055
Loa Loa (eye worm) CUTiclin family member 0.0031 0.0067 0.0282
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0055 0.1035
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1645 1 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.01 0.1895
Echinococcus granulosus leukotriene A 4 hydrolase 0.0223 0.1251 0.1251
Brugia malayi ecdysteroid receptor 0.0026 0.0038 0.0161
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0034 0.0639
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0038 0.0161
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.0038 0.0161
Brugia malayi Pre-SET motif family protein 0.0405 0.2373 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0152 0.0812 0.0812
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0055 0.0202
Brugia malayi Cation transporter family protein 0.0022 0.0013 0.0055
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0213 0.0899
Brugia malayi von Willebrand factor type A domain containing protein 0.0031 0.0067 0.0282
Onchocerca volvulus 0.0049 0.0183 0.0628
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0038 0.0038
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.0038 0.0038
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0031 0.0067 0.0282
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0161
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0034 0.0639
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0022 0.0013 0.0055
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0031 0.0067 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.01 0.1895
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.0038 0.0089
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0022 0.0013 0.0055
Schistosoma mansoni aldehyde dehydrogenase 0.0183 0.1005 0.234
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0022 0.0013 0.0013
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0031 0.0067 0.2826
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0748 0.4482 0.4482
Onchocerca volvulus 0.0026 0.0038 0.0093
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.0038 0.0038
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.053 0.1951
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0022 0.0013 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0038 0.0161
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.053 0.1689
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0038 0.0038
Mycobacterium ulcerans aldehyde dehydrogenase 0.0183 0.1005 1
Echinococcus granulosus glycine receptor subunit beta 0.0022 0.0013 0.0013
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0055 0.5459
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0022 0.0013 0.0055
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.0038 0.0038
Echinococcus granulosus glycine receptor subunit beta 0.0022 0.0013 0.0013
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0055 0.0202
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0031 0.0067 0.0665
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0034 0.0337
Loa Loa (eye worm) ACC-1 protein 0.0022 0.0013 0.0055
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0055 0.0202
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0213 0.0899
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.0038 0.0038
Echinococcus multilocularis musashi 0.0054 0.0213 0.0213
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.053 0.1951
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0022 0.0013 0.0055
Schistosoma mansoni hypothetical protein 0.0023 0.002 0.0046
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0022 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0031 0.0067 0.2826
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0022 0.0013 0.003
Schistosoma mansoni intermediate filament proteins 0.0054 0.0213 0.0497
Brugia malayi Zona pellucida-like domain containing protein 0.0031 0.0067 0.0282
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.053 0.1235
Mycobacterium ulcerans aldehyde dehydrogenase 0.0183 0.1005 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Schistosoma mansoni serine-rich repeat protein 0.0386 0.2256 0.5254
Brugia malayi Kringle domain containing protein 0.0023 0.002 0.0084
Loa Loa (eye worm) TK/ROR protein kinase 0.0023 0.002 0.0084
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0022 0.0013 0.0013
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.0653 0.0653
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.01 0.01
Echinococcus multilocularis lamin 0.0054 0.0213 0.0213
Echinococcus granulosus lamin dm0 0.0054 0.0213 0.0213
Echinococcus granulosus slit 2 protein 0.0048 0.0177 0.0177
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0168 0.0708
Loa Loa (eye worm) ACC-1 protein 0.0022 0.0013 0.0055
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0038 0.0089
Loa Loa (eye worm) hypothetical protein 0.0031 0.0067 0.0282
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.0038 0.0093
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0055 0.0546
Onchocerca volvulus 0.0031 0.0067 0.0199
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0022 0.0013 0.003
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0362 0.2105 0.4901
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0055 0.0202
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0022 0.0013 0.0055
Onchocerca volvulus 0.0461 0.2717 1
Brugia malayi Protein kinase domain containing protein 0.0023 0.002 0.0084
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Schistosoma mansoni lamin 0.0054 0.0213 0.0497
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0055 0.0546
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0022 0.0013 0.0055
Brugia malayi Cytochrome P450 family protein 0.0068 0.0295 0.1243
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0022 0.0013 0.0055
Schistosoma mansoni hypothetical protein 0.0031 0.0067 0.0156
Onchocerca volvulus 0.0031 0.0067 0.0199
Schistosoma mansoni nAChR subunit 0.0022 0.0013 0.003
Loa Loa (eye worm) phosphofructokinase 0.0106 0.053 0.2234
Echinococcus granulosus voltage dependent calcium channel subunit 0.0748 0.4482 0.4482
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.0038 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0038 0.0161
Brugia malayi phosphofructokinase 0.0106 0.053 0.2234
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.0038 0.0089
Treponema pallidum 76K protein 0.0031 0.0067 0.0213
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0034 0.0639
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.0038 0.0089
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.053 0.1951
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0022 0.0013 0.0013
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0022 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0036 0.01 0.1888
Echinococcus multilocularis neurogenic locus notch protein 0.0048 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0053 0.0207 0.0873
Echinococcus granulosus tumor protein p63 0.0338 0.1957 0.1957
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0161
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.01 0.01
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0213 0.0899
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0038 0.0161
Brugia malayi hypothetical protein 0.0119 0.0608 0.2563
Loa Loa (eye worm) hypothetical protein 0.0048 0.0177 0.0746
Schistosoma mansoni slit 0.0048 0.0177 0.0412
Loa Loa (eye worm) hypothetical protein 0.0331 0.1917 0.8078
Loa Loa (eye worm) hypothetical protein 0.0026 0.004 0.017
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0022 0.0013 0.0013
Entamoeba histolytica hypothetical protein, conserved 0.0031 0.0067 0.1261
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.053 0.2234
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.053 0.1235
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.01 0.01
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.01 0.1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.053 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.0038 0.0038
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0223 0.1251 0.1251
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.0038 0.0093
Brugia malayi hypothetical protein 0.0103 0.051 0.2149
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0038 0.0161
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.0038 0.0038
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0223 0.1251 0.2914
Echinococcus multilocularis tumor protein p63 0.0338 0.1957 0.1957
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.01 0.01
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0038 0.0161
Brugia malayi von Willebrand factor type A domain containing protein 0.0031 0.0067 0.0282
Brugia malayi Pre-SET motif family protein 0.0058 0.0237 0.0997
Plasmodium falciparum thrombospondin-related anonymous protein 0.0031 0.0067 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0067 0.0282
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0022 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0036 0.01 0.0423
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Onchocerca volvulus 0.0054 0.0213 0.074
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.01 0.037
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0055 0.0546
Brugia malayi steroid hormone receptor 0.0026 0.0038 0.0161
Schistosoma mansoni hypothetical protein 0.0031 0.0067 0.0156
Brugia malayi hypothetical protein 0.0031 0.0067 0.0282
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.053 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0022 0.0013 0.0013
Echinococcus granulosus tissue type plasminogen activator 0.0023 0.002 0.002
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0038 0.0161
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0022 0.0013 0.0055
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.01 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0038 0.0161
Brugia malayi 6-phosphofructokinase 0.0106 0.053 0.2234
Schistosoma mansoni nAChR subunit 0.0022 0.0013 0.003
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.053 0.5276
Brugia malayi nuclear hormone receptor 0.0026 0.0038 0.0161
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.0653 0.0653
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0034 0.1432
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.01 0.037
Toxoplasma gondii aldehyde dehydrogenase 0.0183 0.1005 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0161
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.01 0.0234
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0 0.5
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.053 0.5276
Loa Loa (eye worm) abnormal epIthelia family member 0.0048 0.0177 0.0746
Onchocerca volvulus 0.0023 0.002 0.0026
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0022 0.0013 0.003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0183 0.1005 0.1005
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0718 0.4294 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0055 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0038 0.0161
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0022 0.0013 0.0013
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0055 0.2318
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0022 0.0013 0.0055
Trichomonas vaginalis set domain proteins, putative 0.0461 0.2717 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.01 0.01
Schistosoma mansoni hypothetical protein 0.0386 0.2256 0.5254
Schistosoma mansoni hypothetical protein 0.0036 0.01 0.0233
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0022 0.0013 0.0013
Echinococcus multilocularis glycine receptor subunit beta 0.0022 0.0013 0.0013
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0022 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0038 0.0161
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0022 0.0013 0.0013
Mycobacterium ulcerans aldehyde dehydrogenase 0.0183 0.1005 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0038 0.0038
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0022 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0038 0.0161
Entamoeba histolytica hypothetical protein 0.0036 0.01 0.1888
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0031 0.0067 0.0246
Schistosoma mansoni nAChR subunit 0.0022 0.0013 0.003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0161
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0022 0.0013 0.003
Brugia malayi von Willebrand factor type A domain containing protein 0.0031 0.0067 0.0282
Loa Loa (eye worm) hypothetical protein 0.0031 0.0067 0.0282
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.01 0.1895
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.1281 0.5398
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.053 0.5276
Echinococcus granulosus FTZ F1 alpha 0.0026 0.0038 0.0038
Brugia malayi laminin-like protein K08C7.3 precursor 0.0048 0.0177 0.0746
Loa Loa (eye worm) hypothetical protein 0.0048 0.0177 0.0746
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1296 0.1296
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0031 0.0067 0.2826
Onchocerca volvulus 0.0054 0.0213 0.074
Loa Loa (eye worm) hypothetical protein 0.0309 0.178 0.75
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.0038 0.0089
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Brugia malayi nuclear receptor NHR-88 0.0026 0.0038 0.0161
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.053 1
Schistosoma mansoni nAChR subunit 0.0022 0.0013 0.003
Entamoeba histolytica hypothetical protein 0.0036 0.01 0.1888
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.0038 0.0089
Echinococcus multilocularis expressed protein 0.0364 0.2115 0.2115
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0161
Leishmania major hypothetical protein, conserved 0.0023 0.002 0.0199
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0022 0.0013 0.0055
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0067 0.2826
Plasmodium falciparum cysteine repeat modular protein 1 0.0023 0.002 0.2986
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0237 0.0237
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.053 0.3139 1
Echinococcus multilocularis slit 2 protein 0.0048 0.0177 0.0177
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0038 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0038 0.0161
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0022 0.0013 0.0055
Onchocerca volvulus 0.0031 0.0067 0.0199
Echinococcus multilocularis nAChR subunit 0.0022 0.0013 0.0013
Brugia malayi von Willebrand Factor 0.0031 0.0067 0.0282
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0058 0.0244
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Onchocerca volvulus 0.0031 0.0067 0.0199
Loa Loa (eye worm) hypothetical protein 0.0031 0.0067 0.0282
Brugia malayi excitatory GABA receptor EXP-1A 0.0022 0.0013 0.0055
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0183 0.1005 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0022 0.0013 0.0055
Echinococcus granulosus glycine receptor subunit alpha 1 0.0022 0.0013 0.0013
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0223 0.1251 0.5274
Loa Loa (eye worm) LGC-31 protein 0.0022 0.0013 0.0055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Schistosoma mansoni coup transcription factor 0.0026 0.0038 0.0089
Entamoeba histolytica hypothetical protein 0.0036 0.01 0.1888
Loa Loa (eye worm) hypothetical protein 0.0031 0.0067 0.0282
Loa Loa (eye worm) hypothetical protein 0.0031 0.0067 0.0282
Schistosoma mansoni hypothetical protein 0.0047 0.0168 0.0391
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0022 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0023 0.002 0.0084
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Loa Loa (eye worm) hypothetical protein 0.0031 0.0067 0.0282
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0034 0.5068
Echinococcus multilocularis lamin dm0 0.0054 0.0213 0.0213
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0031 0.0067 1
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.053 0.053
Echinococcus granulosus lamin 0.0054 0.0213 0.0213
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.01 0.0423
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0022 0.0013 0.0055
Brugia malayi 6-phosphofructokinase 0.0106 0.053 0.2234
Brugia malayi Cation transporter family protein 0.0022 0.0013 0.0055
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0022 0.0013 0.0055
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0144
Echinococcus granulosus glycine receptor subunit alpha 1 0.0022 0.0013 0.0013
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0022 0.0013 0.0055
Onchocerca volvulus 0.0031 0.0067 0.0199
Schistosoma mansoni laminin gamma-3 chain 0.0048 0.0177 0.0412
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0038 0.0161
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0144
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0038 0.0038
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.053 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.0038 0.0038
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.01 0.01
Onchocerca volvulus 0.0058 0.0237 0.0827
Onchocerca volvulus 0.0031 0.0067 0.0199
Loa Loa (eye worm) hypothetical protein 0.0058 0.0237 0.0997
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0038 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0237 0.0551
Schistosoma mansoni hypothetical protein 0.0126 0.0653 0.1521
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.0038 0.0038
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.0038 0.0093
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0055 0.2318
Loa Loa (eye worm) hypothetical protein 0.0048 0.0177 0.0746
Echinococcus granulosus glycine receptor subunit alpha 1 0.0022 0.0013 0.0013
Brugia malayi von Willebrand factor type A domain containing protein 0.0031 0.0067 0.0282
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0022 0.0013 0.0055
Leishmania major hypothetical protein, conserved 0.0025 0.0034 0.0337
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0183 0.1005 0.1005
Loa Loa (eye worm) hypothetical protein 0.0054 0.0213 0.0899
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0237 0.2355
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.0038 0.0089
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0055 0.0202
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0048 0.0177 0.0412
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.0237 0.0551
Loa Loa (eye worm) hypothetical protein 0.023 0.1296 0.5461
Onchocerca volvulus 0.0047 0.0168 0.0573
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.0038 0.0089
Schistosoma mansoni nAChR subunit 0.0022 0.0013 0.003
Echinococcus granulosus expressed protein 0.0364 0.2115 0.2115
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.053 0.2234
Schistosoma mansoni aldehyde dehydrogenase 0.0183 0.1005 0.234
Brugia malayi laminin alpha chain 0.0048 0.0177 0.0746
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0038 0.0161
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0022 0.0013 0.0055
Plasmodium vivax SET domain protein, putative 0.0058 0.0237 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0237 0.0551
Schistosoma mansoni nAChR subunit 0.0022 0.0013 0.003
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0038 0.0161
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0031 0.0067 0.0282
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0022 0.0013 0.0055
Loa Loa (eye worm) hypothetical protein 0.0049 0.0183 0.0771
Echinococcus multilocularis tissue type plasminogen activator 0.0023 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0038 0.0161
Loa Loa (eye worm) hypothetical protein 0.0031 0.0067 0.0282
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0038 0.0161
Brugia malayi von Willebrand factor type A domain containing protein 0.0031 0.0067 0.0282
Echinococcus granulosus collagen alpha 1VII chain 0.0031 0.0067 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0038 0.0161
Brugia malayi EGF-like domain containing protein 0.0048 0.0177 0.0746
Brugia malayi hypothetical protein 0.0025 0.0034 0.0143
Schistosoma mansoni survival motor neuron protein 0.0047 0.0168 0.0391
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0055
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0034 0.5068
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.0038 0.0089
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0058 0.0244
Schistosoma mansoni nAChR subunit 0.0022 0.0013 0.003
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0055 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0067 0.0282
Loa Loa (eye worm) hypothetical protein 0.0031 0.0067 0.0282
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0038 0.0161
Treponema pallidum hypothetical protein 0.0031 0.0067 0.0213

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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