Detailed information for compound 823431

Basic information

Technical information
  • TDR Targets ID: 823431
  • Name: 2-[2-(4-methoxyphenyl)-4-oxopyrazolo[1,5-d][1 ,2,4]triazin-5-yl]-N-[(2-methylphenyl)methyl] acetamide
  • MW: 403.434 | Formula: C22H21N5O3
  • H donors: 1 H acceptors: 3 LogP: 2.8 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1nn2c(c1)c(=O)n(nc2)CC(=O)NCc1ccccc1C
  • InChi: 1S/C22H21N5O3/c1-15-5-3-4-6-17(15)12-23-21(28)13-26-22(29)20-11-19(25-27(20)14-24-26)16-7-9-18(30-2)10-8-16/h3-11,14H,12-13H2,1-2H3,(H,23,28)
  • InChiKey: ONBJRBXEVPXJAK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[2-(4-methoxyphenyl)-4-oxo-pyrazolo[1,5-d][1,2,4]triazin-5-yl]-N-[(2-methylphenyl)methyl]acetamide
  • 2-[2-(4-methoxyphenyl)-4-oxo-5-pyrazolo[1,5-d][1,2,4]triazinyl]-N-[(2-methylphenyl)methyl]acetamide
  • 2-[4-keto-2-(4-methoxyphenyl)pyrazolo[1,5-d][1,2,4]triazin-5-yl]-N-(2-methylbenzyl)acetamide
  • 2-[2-(4-methoxyphenyl)-4-oxo-pyrazolo[1,5-d][1,2,4]triazin-5-yl]-N-[(2-methylphenyl)methyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0004 0.0004
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0201 0.0201
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0547 1
Onchocerca volvulus 0.0229 0.1121 0.1026
Leishmania major trypanothione reductase 0.0046 0.0191 0.0206
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0488 0.8922
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.004 0.7101
Toxoplasma gondii exonuclease III APE 0.0019 0.0054 0.0905
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0056 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0106 0.0106
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.004 0.0043
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.098 0.098
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.004 0.0672
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.004 0.0355
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0011 0.0016 0.0146
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0011 0.0016 0.0146
Schistosoma mansoni DNA helicase recq1 0.0009 0.0004 0.0004
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.1979 1 1
Echinococcus granulosus vesicular acetylcholine transporter 0.1979 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0106 0.0106
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0056 0.0056
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.0488 0.8922
Onchocerca volvulus 0.0048 0.0201 0.0096
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0056 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0004 0.0004
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.004 0.2081
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0011 0.0016 0.0018
Schistosoma mansoni hypothetical protein 0.0331 0.1638 0.1638
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0056 0.006
Trypanosoma brucei unspecified product 0.0013 0.0026 0.0028
Brugia malayi Protein arginine N-methyltransferase 0.0011 0.0016 0.0016
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0106 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0026 0.0028
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.004 0.0043
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0056 0.0056
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.1979 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0045 0.0045
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0004 0.006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.004 0.0043
Plasmodium vivax SET domain protein, putative 0.0029 0.0106 0.5532
Trypanosoma brucei C-8 sterol isomerase, putative 0.1842 0.9306 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0056 0.006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0054 0.0058
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0011 0.0016 0.0018
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0056 0.006
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.0017 0.0147
Echinococcus multilocularis geminin 0.0331 0.1638 0.1638
Echinococcus multilocularis dna polymerase eta 0.0019 0.0056 0.0056
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0004 0.006
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0054 1
Schistosoma mansoni ap endonuclease 0.0019 0.0054 0.0054
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0547 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0054 0.0054
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0106 0.0106
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0056 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0004 0.0004
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0054 0.0054
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.004 0.0043
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.004 0.0043
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0066 0.0591
Trypanosoma brucei unspecified product 0.0019 0.0056 0.006
Brugia malayi follicle stimulating hormone receptor 0.0231 0.113 0.113
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0053 0.2786
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0056 0.05
Schistosoma mansoni hypothetical protein 0.0048 0.0201 0.0201
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0054 0.9531
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.004 0.0043
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0547 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0056 0.0056
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0106 0.1787
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0054 0.2802
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0056 0.0056
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.004 0.004
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.004 0.0043
Echinococcus granulosus dna polymerase kappa 0.0019 0.0056 0.0056
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0016
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.004 0.5
Brugia malayi glutathione reductase 0.0046 0.0191 0.0191
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.004 0.004
Brugia malayi Thioredoxin reductase 0.0046 0.0191 0.0191
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0125 0.0592 0.0592
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0011 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0056 0.0056
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.004 0.0043
Entamoeba histolytica recQ family helicase, putative 0.0011 0.0017 0.0044
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0106 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0056 0.006
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.004 0.0355
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1842 0.9306 0.9306
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0054 0.938
Loa Loa (eye worm) Carm1-pending protein 0.0125 0.0592 0.0592
Plasmodium vivax glutathione reductase, putative 0.0046 0.0191 1
Plasmodium falciparum thioredoxin reductase 0.0016 0.004 0.2081
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0056 0.1024
Plasmodium falciparum glutathione reductase 0.0016 0.004 0.2081
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0056 0.006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.004 0.0043
Schistosoma mansoni DNA helicase recq5 0.0009 0.0004 0.0004
Echinococcus granulosus dna polymerase eta 0.0019 0.0056 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0056 0.006
Plasmodium falciparum thioredoxin reductase 0.0046 0.0191 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0054 0.0478
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0056 0.006
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0004
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0066 0.0066
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.004 0.7101
Brugia malayi Pre-SET motif family protein 0.0029 0.0106 0.0106
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.004 0.7101
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0054 0.9561
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0056 0.006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0056 0.006
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0018 0.0018
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0056 0.0056
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.004 0.2081
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0056 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0106 0.0106
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0054 0.0058
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.1143 0.1143
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0056 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0056 0.006
Echinococcus granulosus methyltransferase protein 5 0.0011 0.0016 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0056 0.006
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0054 0.0478
Schistosoma mansoni hypothetical protein 0.0331 0.1638 0.1638
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0488 0.8922
Echinococcus granulosus geminin 0.0331 0.1638 0.1638
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.004 0.0043
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0056 0.006
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0011 0.0016 0.0018
Brugia malayi Pre-SET motif family protein 0.0201 0.098 0.098
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0054 0.0979
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.004 0.0043
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0044 0.0044
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.01 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0056 0.006
Toxoplasma gondii bicoid-interacting protein BIN3 0.0011 0.0016 0.0276
Echinococcus granulosus bloom syndrome protein 0.0021 0.0066 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0026 0.0028
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0191 0.3495
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.004 0.0672
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0017 0.0018
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0004 0.0004
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.004 0.004
Brugia malayi hypothetical protein 0.0011 0.0016 0.0016
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0011 0.0016 0.0018
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.1143 0.1143
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0054 0.2802
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0011 0.0016 0.0018
Schistosoma mansoni hypothetical protein 0.0011 0.0016 0.0016
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0017 0.0018
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0017 0.0018
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0011 0.0016 0.0018
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0066 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0026 0.0028
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0547 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0011 0.0016 0.0146
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.004 0.0043
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.004 0.6904
Mycobacterium tuberculosis Probable reductase 0.0104 0.0488 0.8922
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0106
Leishmania major DNA polymerase kappa, putative 0.0019 0.0056 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0056 0.006
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0004 0.0186
Schistosoma mansoni DNA polymerase eta 0.0019 0.0056 0.0056
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0125 0.0592 0.0592
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.004 0.2081
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0054 0.0058
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0004 0.0004
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0191 0.0206
Trypanosoma brucei unspecified product 0.0013 0.0026 0.0028
Loa Loa (eye worm) RecQ helicase 0.0021 0.0066 0.0066
Schistosoma mansoni vesicular acetylcholine transporter 0.1979 1 1
Leishmania major arginine N-methyltransferase, type I 0.0011 0.0016 0.0018
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.004 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0056 0.006
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.004 0.004
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0004 0.0004
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0054 0.0054
Brugia malayi Carm1-pending protein 0.0125 0.0592 0.0592
Echinococcus multilocularis vesicular acetylcholine transporter 0.1979 1 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.004 0.0043
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0031 0.0521
Trypanosoma brucei trypanothione reductase 0.0046 0.0191 0.0206
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0056 0.0056
Leishmania major DNA polymerase eta, putative 0.0019 0.0056 0.006
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0011 0.0016 0.0276
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.004 0.2081
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.004 0.0043
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0191 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0056 0.006
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0191 1
Echinococcus granulosus protein arginine N methyltransferase 7 0.0011 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0941 0.4736 0.4736
Plasmodium falciparum glutathione reductase 0.0046 0.0191 1
Schistosoma mansoni ap endonuclease 0.0019 0.0054 0.0054
Toxoplasma gondii thioredoxin reductase 0.0046 0.0191 0.3231
Onchocerca volvulus 0.0113 0.0535 0.0434
Loa Loa (eye worm) hypothetical protein 0.1842 0.9306 0.9306
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0011 0.0016 0.0018
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0011 0.0016 0.0018
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0056 0.05
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0191 0.0191
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1842 0.9306 1
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0011 0.0016 0.0016
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.004 0.0727
Schistosoma mansoni protein arginine n-methyltransferase 0.0125 0.0592 0.0592
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0066 0.0591
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0004 0.0004
Trichomonas vaginalis set domain proteins, putative 0.0229 0.1121 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0018 0.0018
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0054 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0056 0.006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.004 0.0043
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0191 0.0191
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0056 0.1024
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0125 0.0592 1
Brugia malayi hypothetical protein 0.0233 0.1143 0.1143
Loa Loa (eye worm) hypothetical protein 0.0233 0.1143 0.1143
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0011 0.0016 0.0018
Leishmania major C-8 sterol isomerase-like protein 0.1842 0.9306 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0054 0.0058
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0056 0.0056
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0056 0.006
Schistosoma mansoni survival motor neuron protein 0.0048 0.0201 0.0201
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0488 0.8922
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0032 0.1656
Loa Loa (eye worm) glutathione reductase 0.0046 0.0191 0.0191
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0056 0.006
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0488 0.8922
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.004 0.0043
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.113 0.113
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0488 0.8922
Giardia lamblia DINP protein human, muc B family 0.0019 0.0056 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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