Detailed information for compound 826715

Basic information

Technical information
  • TDR Targets ID: 826715
  • Name: 1-(2-cyclohexylethyl)-2-(methoxymethyl)benzim idazole
  • MW: 272.385 | Formula: C17H24N2O
  • H donors: 0 H acceptors: 1 LogP: 4.16 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCc1nc2c(n1CCC1CCCCC1)cccc2
  • InChi: 1S/C17H24N2O/c1-20-13-17-18-15-9-5-6-10-16(15)19(17)12-11-14-7-3-2-4-8-14/h5-6,9-10,14H,2-4,7-8,11-13H2,1H3
  • InChiKey: MTIVMTVWCZMBAN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • T5443212

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi protein unc-22 0.0042 0.0004 0.0012
Echinococcus granulosus serine:threonine protein kinase PLK1 0.1574 0.2966 0.4244
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0046 0.0011 0.0036
Trypanosoma brucei aurora B kinase 0.0617 0.1114 0.2804
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0042 0.0004 0.0012
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.005 0.0018 0.0015
Loa Loa (eye worm) hypothetical protein 0.0158 0.0228 0.0769
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.005 0.0018 0.0021
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.1574 0.2966 1
Echinococcus multilocularis tyrosine protein kinase otk 0.0046 0.0011 0.001
Schistosoma mansoni cell adhesion molecule 0.0046 0.0011 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.1574 0.2966 1
Giardia lamblia Kinase, PLK 0.1574 0.2966 1
Schistosoma mansoni cell adhesion molecule 0.0241 0.0388 0.0385
Brugia malayi Immunoglobulin I-set domain containing protein 0.1287 0.2411 0.8128
Schistosoma mansoni cell adhesion molecule 0.005 0.0018 0.0015
Trypanosoma brucei polo-like protein kinase 0.1574 0.2966 1
Brugia malayi serine/threonine protein kinase 6 0.0617 0.1114 0.3757
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0036
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.013 0.0173 0.0242
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.1574 0.2966 0.4244
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0215 0.0337 0.0477
Echinococcus multilocularis 0.0244 0.0393 0.0558
Trichomonas vaginalis CAMK family protein kinase 0.1574 0.2966 1
Brugia malayi serine/threonine-protein kinase plk-2 0.1574 0.2966 1
Echinococcus multilocularis contactin neuroglian septate junction protein 0.005 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0036
Onchocerca volvulus 0.1027 0.1909 0.6433
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0004 0.0012
Echinococcus granulosus lachesin 0.0046 0.0011 0.001
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0046 0.0011 0.0036
Brugia malayi Cytochrome P450 family protein 0.0244 0.0393 0.1324
Loa Loa (eye worm) hypothetical protein 0.005 0.0018 0.0062
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1287 0.2411 0.8128
Plasmodium falciparum serine/threonine protein kinase, putative 0.0617 0.1114 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0402 0.0699 0.2358
Loa Loa (eye worm) AUR protein kinase 0.0617 0.1114 0.3757
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0244 0.0393 0.5
Mycobacterium leprae putative cytochrome p450 0.0244 0.0393 0.5
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0244 0.0393 0.5
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0065 0.0047 0.0159
Loa Loa (eye worm) cytochrome P450 0.0244 0.0393 0.1324
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0244 0.0393 0.5
Brugia malayi serine/threonine kinase 12 0.0617 0.1114 0.3757
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0046 0.0011 0.001
Brugia malayi Prion-like- 0.0046 0.0011 0.0036
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0244 0.0393 0.5
Echinococcus granulosus roundabout 2 0.005 0.0018 0.0021
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.1574 0.2966 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0037
Brugia malayi hypothetical protein 0.0347 0.0593 0.1999
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0244 0.0393 0.5
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0215 0.0337 0.0333
Echinococcus multilocularis hemicentin 1 0.0046 0.0011 0.001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0011 0.0036
Brugia malayi Cytochrome P450 family protein 0.0402 0.0699 0.2358
Loa Loa (eye worm) TK/ROR protein kinase 0.0045 0.0009 0.0031
Entamoeba histolytica serine/threonine protein kinase, putative 0.1574 0.2966 1
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0617 0.1114 0.1591
Trypanosoma cruzi cytochrome P450, putative 0.0402 0.0699 0.1192
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0244 0.0393 0.5
Schistosoma mansoni septate junction protein 0.0046 0.0011 0.0007
Loa Loa (eye worm) hypothetical protein 0.0215 0.0337 0.1136
Echinococcus granulosus aurora kinase A 0.0617 0.1114 0.1591
Brugia malayi serine/threonine-protein kinase 6 0.0617 0.1114 0.3757
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0215 0.0337 0.0333
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0244 0.0393 0.5
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.013 0.0173 0.0242
Trichomonas vaginalis CAMK family protein kinase 0.1574 0.2966 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0244 0.0393 0.5
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.005 0.0018 0.0021
Schistosoma mansoni serine/threonine protein kinase 0.1574 0.2966 0.2964
Leishmania major protein kinase, putative 0.0617 0.1114 0.2804
Loa Loa (eye worm) hypothetical protein 0.0215 0.0337 0.1136
Loa Loa (eye worm) TK protein kinase 0.0153 0.0218 0.0736
Echinococcus multilocularis aurora kinase A 0.0617 0.1114 0.1591
Echinococcus granulosus defective proboscis extension response 0.0215 0.0337 0.0477
Echinococcus multilocularis roundabout 2 0.005 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0347 0.0593 0.1999
Schistosoma mansoni hypothetical protein 0.0244 0.0393 0.0389
Brugia malayi Cytochrome P450 family protein 0.0402 0.0699 0.2358
Schistosoma mansoni titin 0.0046 0.0011 0.0007
Schistosoma mansoni roundabout 0.0046 0.0011 0.0007
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.005 0.0018 0.0062
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0244 0.0393 0.5
Echinococcus granulosus neuroglian 0.005 0.0018 0.0021
Brugia malayi Fibronectin type III domain containing protein 0.0219 0.0345 0.1161
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0011 0.0036
Loa Loa (eye worm) CAMK protein kinase 0.0042 0.0004 0.0012
Brugia malayi Immunoglobulin I-set domain containing protein 0.0219 0.0345 0.1161
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.005 0.0018 0.0021
Trichomonas vaginalis CAMK family protein kinase 0.1574 0.2966 1
Trichomonas vaginalis CAMK family protein kinase 0.1574 0.2966 1
Schistosoma mansoni serine/threonine protein kinase 0.0617 0.1114 0.1111
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0046 0.0011 0.0007
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0244 0.0393 0.5
Schistosoma mansoni nephrin 0.005 0.0018 0.0015
Mycobacterium leprae Conserved hypothetical protein 0.0244 0.0393 0.5
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0617 0.1114 0.5
Echinococcus granulosus twitchin 0.0253 0.0411 0.0584
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0402 0.0699 1
Trypanosoma cruzi polo-like protein kinase, putative 0.1574 0.2966 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0244 0.0393 0.5
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0244 0.0393 0.5
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0244 0.0393 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0036
Echinococcus multilocularis lachesin 0.0046 0.0011 0.001
Brugia malayi cytochrome P450 0.0244 0.0393 0.1324
Brugia malayi Immunoglobulin I-set domain containing protein 0.0153 0.0218 0.0736
Echinococcus granulosus Immunoglobulin 0.0215 0.0337 0.0477
Loa Loa (eye worm) CYP4Cod1 0.0402 0.0699 0.2358
Echinococcus multilocularis neuroglian 0.005 0.0018 0.0021
Echinococcus multilocularis neuroglian 0.0238 0.0382 0.0543
Echinococcus granulosus roundabout 2 0.0265 0.0434 0.0616
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0011 0.0036
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0244 0.0393 0.5
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0244 0.0393 0.5
Schistosoma mansoni vesicular amine transporter 0.0215 0.0337 0.0333
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0617 0.1114 0.1591
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0011 0.0036
Echinococcus granulosus roundabout 2 0.005 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0261 0.0426 0.1437
Echinococcus granulosus hemicentin 1 0.0046 0.0011 0.001
Echinococcus multilocularis roundabout 2 0.005 0.0018 0.0021
Echinococcus multilocularis hemicentin 1 0.0046 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0219 0.0345 0.1161
Loa Loa (eye worm) hypothetical protein 0.0219 0.0345 0.1161
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0036
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0244 0.0393 0.5
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.365 0.6984 1
Trypanosoma cruzi aurora B kinase, putative 0.0617 0.1114 0.2804
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0244 0.0393 0.5
Trypanosoma cruzi polo-like protein kinase, putative 0.1574 0.2966 1
Echinococcus granulosus tyrosine protein kinase otk 0.0046 0.0011 0.001
Brugia malayi Peroxidasin 0.0046 0.0011 0.0037
Schistosoma mansoni cell adhesion molecule 0.005 0.0018 0.0015
Leishmania major cytochrome p450-like protein 0.0402 0.0699 0.1192
Schistosoma mansoni cytochrome P450 0.0244 0.0393 0.0389
Loa Loa (eye worm) AUR protein kinase 0.0617 0.1114 0.3757
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0011 0.0036
Echinococcus multilocularis Immunoglobulin 0.0215 0.0337 0.0477
Brugia malayi Immunoglobulin I-set domain containing protein 0.005 0.0018 0.0062
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.005 0.0018 0.0021
Loa Loa (eye worm) cytochrome P450 family protein 0.0402 0.0699 0.2358
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.365 0.6984 1
Echinococcus multilocularis Immunoglobulin 0.0215 0.0337 0.0477
Brugia malayi Cytochrome P450 family protein 0.0973 0.1805 0.6084
Onchocerca volvulus Tyrosine kinase homolog 0.1073 0.1997 0.6729
Echinococcus multilocularis fibroblast growth factor receptor 4 0.013 0.0173 0.0242
Loa Loa (eye worm) hypothetical protein 0.0261 0.0426 0.1437
Loa Loa (eye worm) AUR protein kinase 0.0617 0.1114 0.3757
Onchocerca volvulus Serine\/threonine kinase homolog 0.1574 0.2966 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.005 0.0018 0.0062
Loa Loa (eye worm) hypothetical protein 0.0219 0.0345 0.1161
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0011 0.0036
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0045 0.0009 0.0008
Brugia malayi Immunoglobulin I-set domain containing protein 0.005 0.0018 0.0062
Schistosoma mansoni tyrosine kinase 0.013 0.0173 0.0169
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0244 0.0393 0.5
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0036
Echinococcus granulosus contactin 0.005 0.0018 0.0021
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0237 0.0381 0.054
Echinococcus granulosus neuroglian 0.0238 0.0382 0.0543
Echinococcus multilocularis roundabout 2 0.0265 0.0434 0.0616
Echinococcus granulosus cytochrome P450 2K1 0.0244 0.0393 0.0558
Toxoplasma gondii aurora kinase 0.0617 0.1114 1
Schistosoma mansoni tyrosine kinase 0.0068 0.0053 0.0049
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0046 0.0011 0.0024
Echinococcus granulosus peroxidasin 0.0046 0.0011 0.0011
Schistosoma mansoni protein kinase 0.0617 0.1114 0.1111
Schistosoma mansoni neuroglian 0.005 0.0018 0.0015
Loa Loa (eye worm) cytochrome P450 family protein 0.0973 0.1805 0.6084
Trichomonas vaginalis CAMK family protein kinase 0.1574 0.2966 1
Loa Loa (eye worm) hypothetical protein 0.0215 0.0337 0.1137
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0045 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0046 0.0011 0.0036
Schistosoma mansoni septate junction protein 0.0046 0.0011 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.1574 0.2966 1
Brugia malayi hypothetical protein 0.0219 0.0345 0.1161
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0244 0.0393 0.5
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0244 0.0393 0.5
Loa Loa (eye worm) hypothetical protein 0.0237 0.0381 0.1283
Echinococcus multilocularis peroxidasin 0.0046 0.0011 0.0011
Echinococcus granulosus fibroblast growth factor receptor 4 0.013 0.0173 0.0242
Schistosoma mansoni nephrin 0.0242 0.039 0.0387
Trypanosoma cruzi cytochrome P450, putative 0.0402 0.0699 0.1192
Trypanosoma brucei cytochrome P450, putative 0.0402 0.0699 0.1192

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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