Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | protein kinase, putative | 0.066 | 0.104 | 0.2488 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.012 | 0.013 | 0.0186 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0055 | 0.0021 | 0.0022 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0051 | 0.0015 | 0.0032 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0462 | 0.0707 | 0.2364 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.0332 | 0.1098 |
Schistosoma mansoni | septate junction protein | 0.0051 | 0.0015 | 0.0015 |
Echinococcus granulosus | neuroglian | 0.0264 | 0.0374 | 0.0528 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.1806 | 0.2971 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1806 | 0.2971 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0016 | 0.0033 |
Leishmania major | cytochrome p450-like protein | 0.0462 | 0.0707 | 0.1191 |
Echinococcus granulosus | tyrosine protein kinase otk | 0.0051 | 0.0015 | 0.0014 |
Trypanosoma brucei | polo-like protein kinase | 0.1806 | 0.2971 | 1 |
Brugia malayi | Peroxidasin | 0.0052 | 0.0016 | 0.0033 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0051 | 0.0015 | 0.0032 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.066 | 0.104 | 0.3488 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.028 | 0.04 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase transmembrane receptor | 0.0049 | 0.0012 | 0.0017 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.028 | 0.04 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.028 | 0.04 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 0.0418 | 0.139 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.1072 | 0.1734 | 0.5829 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1806 | 0.2971 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0055 | 0.0021 | 0.003 |
Schistosoma mansoni | cell adhesion molecule | 0.0051 | 0.0015 | 0.0015 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.028 | 0.04 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0055 | 0.0021 | 0.0021 |
Trypanosoma brucei | aurora B kinase | 0.066 | 0.104 | 0.2488 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0015 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.0337 | 0.1117 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0021 | 0.0052 |
Schistosoma mansoni | nephrin | 0.0268 | 0.038 | 0.038 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.066 | 0.104 | 0.1489 |
Toxoplasma gondii | aurora kinase | 0.066 | 0.104 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.028 | 0.04 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0055 | 0.0021 | 0.0052 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.066 | 0.104 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0015 | 0.0032 |
Echinococcus granulosus | Serine:threonine protein kinase PLK4 | 0.4189 | 0.6986 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0052 | 0.0016 | 0.0023 |
Schistosoma mansoni | tyrosine kinase | 0.0075 | 0.0055 | 0.0055 |
Echinococcus granulosus | roundabout 2 | 0.0055 | 0.0021 | 0.0022 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.1806 | 0.2971 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.028 | 0.04 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.028 | 0.04 | 0.5 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0051 | 0.0015 | 0.0032 |
Schistosoma mansoni | titin | 0.0046 | 0.0006 | 0.0006 |
Brugia malayi | serine/threonine protein kinase 6 | 0.066 | 0.104 | 0.3488 |
Echinococcus granulosus | contactin | 0.0055 | 0.0021 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0015 | 0.0032 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.1806 | 0.2971 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0462 | 0.0707 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.0337 | 0.1117 |
Echinococcus granulosus | Immunoglobulin | 0.0239 | 0.0331 | 0.0466 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0072 | 0.005 | 0.0147 |
Schistosoma mansoni | protein kinase | 0.066 | 0.104 | 0.104 |
Schistosoma mansoni | cytochrome P450 | 0.028 | 0.04 | 0.04 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.028 | 0.04 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.066 | 0.104 | 0.3488 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.028 | 0.04 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.066 | 0.104 | 0.104 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 0.0418 | 0.139 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.028 | 0.04 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase transmembrane receptor | 0.0049 | 0.0012 | 0.0008 |
Brugia malayi | Cytochrome P450 family protein | 0.028 | 0.04 | 0.1331 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1806 | 0.2971 | 1 |
Schistosoma mansoni | hypothetical protein | 0.028 | 0.04 | 0.04 |
Brugia malayi | hypothetical protein | 0.0242 | 0.0337 | 0.1117 |
Giardia lamblia | Kinase, PLK | 0.1806 | 0.2971 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0462 | 0.0707 | 0.1191 |
Trypanosoma cruzi | aurora B kinase, putative | 0.066 | 0.104 | 0.2488 |
Schistosoma mansoni | cell adhesion molecule | 0.0055 | 0.0021 | 0.0021 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.028 | 0.04 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.028 | 0.04 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.028 | 0.04 | 0.5 |
Brugia malayi | serine/threonine kinase 12 | 0.066 | 0.104 | 0.3488 |
Echinococcus multilocularis | hemicentin 1 | 0.0051 | 0.0015 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.0337 | 0.1117 |
Echinococcus granulosus | peroxidasin | 0.0052 | 0.0016 | 0.0014 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.028 | 0.04 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0015 | 0.0032 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1806 | 0.2971 | 1 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0055 | 0.0021 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.0235 | 0.0772 |
Schistosoma mansoni | septate junction protein | 0.0051 | 0.0015 | 0.0015 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0462 | 0.0707 | 0.1191 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.1806 | 0.2971 | 1 |
Echinococcus multilocularis | aurora kinase A | 0.066 | 0.104 | 0.1489 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0051 | 0.0015 | 0.0032 |
Echinococcus granulosus | hemicentin 1 | 0.0051 | 0.0015 | 0.0014 |
Echinococcus granulosus | defective proboscis extension response | 0.0239 | 0.0331 | 0.0466 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0265 | 0.0375 | 0.0529 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.028 | 0.04 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase otk | 0.0051 | 0.0015 | 0.0022 |
Echinococcus multilocularis | roundabout 2 | 0.0055 | 0.0021 | 0.003 |
Echinococcus granulosus | lachesin | 0.0051 | 0.0015 | 0.0014 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0242 | 0.0337 | 0.1117 |
Schistosoma mansoni | titin | 0.0051 | 0.0015 | 0.0015 |
Schistosoma mansoni | nephrin | 0.0055 | 0.0021 | 0.0021 |
Echinococcus multilocularis | roundabout 2 | 0.0055 | 0.0021 | 0.003 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1806 | 0.2971 | 0.2971 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.028 | 0.04 | 0.0565 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.0331 | 0.1097 |
Echinococcus multilocularis | Immunoglobulin | 0.0239 | 0.0331 | 0.0474 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.028 | 0.04 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0051 | 0.0015 | 0.0032 |
Loa Loa (eye worm) | cytochrome P450 | 0.028 | 0.04 | 0.1331 |
Brugia malayi | Prion-like- | 0.0051 | 0.0015 | 0.0032 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0055 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0462 | 0.0707 | 0.2364 |
Mycobacterium leprae | putative cytochrome p450 | 0.028 | 0.04 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0051 | 0.0015 | 0.0032 |
Schistosoma mansoni | roundabout | 0.0051 | 0.0015 | 0.0015 |
Schistosoma mansoni | neuroglian | 0.0055 | 0.0021 | 0.0021 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.1806 | 0.2971 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.123 | 0.2001 | 0.673 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0046 | 0.0006 | 0.0006 |
Echinococcus multilocularis | Immunoglobulin | 0.0239 | 0.0331 | 0.0474 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.066 | 0.104 | 0.5 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.1806 | 0.2971 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.0375 | 0.1245 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.147 | 0.2405 | 0.809 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.1806 | 0.2971 | 0.4248 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.012 | 0.013 | 0.0186 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0051 | 0.0015 | 0.0032 |
Echinococcus granulosus | twitchin | 0.0281 | 0.0403 | 0.0568 |
Echinococcus multilocularis | neurotracting:lsamp:neurotrimin:obcam | 0.0051 | 0.0015 | 0.0022 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0239 | 0.0331 | 0.0331 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.1806 | 0.2971 | 0.4252 |
Echinococcus multilocularis | lachesin | 0.0051 | 0.0015 | 0.0022 |
Schistosoma mansoni | neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule | 0.0051 | 0.0015 | 0.0015 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.028 | 0.04 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0015 | 0.0032 |
Echinococcus granulosus | roundabout 2 | 0.0294 | 0.0424 | 0.0599 |
Loa Loa (eye worm) | AUR protein kinase | 0.066 | 0.104 | 0.3488 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.028 | 0.04 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.028 | 0.04 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0462 | 0.0707 | 0.2364 |
Echinococcus granulosus | roundabout 2 | 0.0055 | 0.0021 | 0.0022 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1806 | 0.2971 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.0239 | 0.0331 | 0.0331 |
Echinococcus granulosus | aurora kinase A | 0.066 | 0.104 | 0.1482 |
Onchocerca volvulus | 0.1181 | 0.1918 | 0.645 | |
Brugia malayi | Cytochrome P450 family protein | 0.1072 | 0.1734 | 0.5829 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0239 | 0.0331 | 0.0331 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.066 | 0.104 | 0.1482 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0049 | 0.0012 | 0.002 |
Brugia malayi | Cytochrome P450 family protein | 0.0462 | 0.0707 | 0.2364 |
Schistosoma mansoni | cell adhesion molecule | 0.0268 | 0.0381 | 0.0381 |
Brugia malayi | cytochrome P450 | 0.028 | 0.04 | 0.1331 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1806 | 0.2971 | 1 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0239 | 0.0331 | 0.0474 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0462 | 0.0707 | 0.1191 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.012 | 0.013 | 0.0178 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0055 | 0.0021 | 0.003 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0055 | 0.0021 | 0.003 |
Brugia malayi | hypothetical protein | 0.0308 | 0.0447 | 0.1489 |
Echinococcus granulosus | neuroglian | 0.0055 | 0.0021 | 0.0022 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.028 | 0.04 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0145 | 0.0173 | 0.0564 |
Schistosoma mansoni | tyrosine kinase | 0.012 | 0.013 | 0.013 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0055 | 0.0021 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0015 | 0.0032 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0055 | 0.0021 | 0.0052 |
Echinococcus multilocularis | neuroglian | 0.0055 | 0.0021 | 0.003 |
Echinococcus multilocularis | roundabout 2 | 0.0294 | 0.0424 | 0.0607 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 0.0331 | 0.1097 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0051 | 0.0015 | 0.0032 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.012 | 0.013 | 0.0178 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.1806 | 0.2971 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.0145 | 0.0173 | 0.0564 |
Brugia malayi | Cytochrome P450 family protein | 0.0462 | 0.0707 | 0.2364 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1806 | 0.2971 | 1 |
Echinococcus multilocularis | neuroglian | 0.0264 | 0.0374 | 0.0536 |
Loa Loa (eye worm) | AUR protein kinase | 0.066 | 0.104 | 0.3488 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0242 | 0.0337 | 0.1117 |
Echinococcus multilocularis | 0.028 | 0.04 | 0.0573 | |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0055 | 0.0021 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0308 | 0.0447 | 0.1489 |
Echinococcus multilocularis | Serine:threonine protein kinase PLK4 | 0.4189 | 0.6986 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.147 | 0.2405 | 0.809 |
Echinococcus multilocularis | titin | 0.0046 | 0.0006 | 0.0008 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.028 | 0.04 | 0.5 |
Echinococcus multilocularis | hemicentin 1 | 0.0051 | 0.0015 | 0.0022 |
Onchocerca volvulus | Basement membrane proteoglycan homolog | 0.0051 | 0.0015 | 0.0032 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.