TDR Targets

Basic information

Technical information

TDR Targets ID: 827629
Name: (3-amino-7-methoxypyrazolo[5,4-b]quinolin-1-y l)-(3-fluorophenyl)methanone
MW: 336.32 | Formula: C18H13FN4O2
H donors: 1 H acceptors: 3 LogP: 3.21 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)nc1c(c2)c(nn1C(=O)c1cccc(c1)F)N
InChi: 1S/C18H13FN4O2/c1-25-13-6-5-10-8-14-16(20)22-23(17(14)21-15(10)9-13)18(24)11-3-2-4-12(19)7-11/h2-9H,1H3,(H2,20,22)
InChiKey: CXHZJRFIQCUFSQ-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

(3-amino-7-methoxy-pyrazolo[5,4-b]quinolin-1-yl)-(3-fluorophenyl)methanone
(3-amino-7-methoxy-1-pyrazolo[5,4-b]quinolinyl)-(3-fluorophenyl)methanone
1-(3-fluorobenzoyl)-7-methoxy-1H-pyrazolo[3,4-b]quinolin-3-amine
MLS000731294
SMR000309569

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	protein tyrosine phosphatase, non-receptor type 11	Starlite/ChEMBL	No references
Homo sapiens	dual specificity phosphatase 3	Starlite/ChEMBL	No references
Homo sapiens	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	Starlite/ChEMBL	No references
Homo sapiens	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Homo sapiens	huntingtin	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Theileria parva	nuclear LIM interactor-interacting factor 1, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Trichomonas vaginalis	dullard protein, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Candida albicans	Plasma membrane Sodium Response 1	Get druggable targets OG5_127075	All targets in OG5_127075
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_130331	All targets in OG5_130331
Trypanosoma congolense	TFIIF-stimulated CTD phosphatase, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus granulosus	CTD small phosphatase protein like	Get druggable targets OG5_127075	All targets in OG5_127075
Neospora caninum	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Schistosoma japonicum	ko:K01090 protein phosphatase [EC3.1.3.16], putative	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium berghei	NLI interacting factor-like phosphatase	Get druggable targets OG5_127075	All targets in OG5_127075
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Trichomonas vaginalis	dullard protein, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus granulosus	Carboxy terminal domain RNA polymerase II	Get druggable targets OG5_127075	All targets in OG5_127075
Toxoplasma gondii	Dullard family phosphatase domain-containing protein	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium falciparum	NLI interacting factor-like phosphatase, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Schistosoma japonicum	ko:K07293 protein tyrosine phosphatase, non-receptor type 11, putative	Get druggable targets OG5_130331	All targets in OG5_130331
Plasmodium yoelii	NLI interacting factor, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Trichomonas vaginalis	dullard protein, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Giardia lamblia	Nuclear LIM interactor-interacting factor 1	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium vivax	NLI interacting factor-like phosphatase, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Leishmania donovani	dullard-like phosphatase domain containing protein, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium knowlesi	NLI interacting factor-like phosphatase, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	Get druggable targets OG5_127075	All targets in OG5_127075
Leishmania infantum	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Trypanosoma brucei	Mitochondrial import inner membrane translocase subunit TIM50	Get druggable targets OG5_127075	All targets in OG5_127075
Trypanosoma brucei gambiense	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Entamoeba histolytica	NLI interacting factor-like phosphatase domain-containing protein	Get druggable targets OG5_127075	All targets in OG5_127075
Entamoeba histolytica	dual specificity protein phosphatase, putative	Get druggable targets OG5_134995	All targets in OG5_134995
Loa Loa (eye worm)	protein-tyrosine phosphatase	Get druggable targets OG5_130331	All targets in OG5_130331
Brugia malayi	Protein-tyrosine phosphatase containing protein	Get druggable targets OG5_130331	All targets in OG5_130331
Brugia malayi	Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1	Get druggable targets OG5_127075	All targets in OG5_127075
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	Get druggable targets OG5_127075	All targets in OG5_127075
Schistosoma japonicum	IPR000242,Tyrosine specific protein phosphatase,domain-containing	Get druggable targets OG5_130331	All targets in OG5_130331
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_130331	All targets in OG5_130331
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_130331	All targets in OG5_130331
Onchocerca volvulus	Huntingtin homolog	Get druggable targets OG5_132837	All targets in OG5_132837
Echinococcus multilocularis		Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_130331	All targets in OG5_130331
Plasmodium vivax	NLI interacting factor-like phosphatase, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Schistosoma japonicum	CTD small phosphatase-like protein, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium yoelii	NLI interacting factor, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	Get druggable targets OG5_134995	All targets in OG5_134995
Leishmania major	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Plasmodium berghei	NLI interacting factor-like phosphatase	Get druggable targets OG5_127075	All targets in OG5_127075
Leishmania mexicana	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Trypanosoma congolense	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Onchocerca volvulus	Huntingtin homolog	Get druggable targets OG5_132837	All targets in OG5_132837
Babesia bovis	Dullard-like phosphatase domain containing protein	Get druggable targets OG5_127075	All targets in OG5_127075
Leishmania braziliensis	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Candida albicans	Plasma membrane Sodium Response 1	Get druggable targets OG5_127075	All targets in OG5_127075
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Trypanosoma cruzi	hypothetical protein, conserved	Get druggable targets OG5_127075	All targets in OG5_127075
Brugia malayi	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Plasmodium knowlesi	NLI interacting factor-like phosphatase, putative	Get druggable targets OG5_127075	All targets in OG5_127075
Neospora caninum	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Cryptosporidium parvum	hypothetical protein	Get druggable targets OG5_127075	All targets in OG5_127075
Echinococcus multilocularis	Carboxy terminal domain RNA polymerase II	Get druggable targets OG5_127075	All targets in OG5_127075
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	Get druggable targets OG5_130331	All targets in OG5_130331

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	kinetoplastid-specific dual specificity phosphatase, putative	dual specificity phosphatase 3	185 aa	182 aa	25.3 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %
Trypanosoma brucei	TFIIF-stimulated CTD phosphatase, putative	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1	260 aa	263 aa	27.0 %
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0083	0.015
Onchocerca volvulus		0.0025	0.0261	0.0327
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0018	0.0165	0.0298
Onchocerca volvulus		0.0018	0.0165	0.015
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0261	0.0472
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0083	0.009
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0018	0.0165	0.0298
Schistosoma mansoni	hypothetical protein	0.0205	0.2857	0.517
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0064	0.0069
Brugia malayi	Serotonin receptor	0.0025	0.0261	0.0281
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0083	0.015
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0533	0.0965
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0083	0.009
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0018	0.0165	0.0298
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0025	0.0261	0.0472
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0025	0.0261	0.0472
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0083	0.009
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0165	0.0298
Brugia malayi	hypothetical protein	0.0018	0.0165	0.0178
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.0261	0.0281
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0018	0.0165	0.0046
Brugia malayi	follicle stimulating hormone receptor	0.0025	0.0261	0.0281
Brugia malayi	steroid hormone receptor	0.0012	0.0083	0.009
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0007	0.0014	0.0026
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0165	0.0178
Trichomonas vaginalis	pten, drome, putative	0.0018	0.0165	0.0151
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0007	0.0014	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.0261	0.0472
Brugia malayi	hypothetical protein	0.0025	0.0261	0.0281
Brugia malayi	ORL1-like opioid receptor	0.0025	0.0261	0.0281
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0083	0.015
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0261	0.0472
Echinococcus multilocularis	allatostatin A receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0261	0.0472
Schistosoma mansoni	histamine h1 receptor	0.0025	0.0261	0.0472
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0025	0.0261	0.0472
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0261	0.0472
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0261	0.0472
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0011	0.0064	0.0069
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0083	0.015
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0025	0.0261	0.0281
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0007	0.0014	0.0026
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0083	0.015
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0261	0.0472
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0153	0.212	0.3836
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0083	0.009
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0083	0.009
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0261	0.0472
Brugia malayi	hypothetical protein	0.0148	0.204	0.2202
Echinococcus granulosus	7TM GPCR rhodopsin	0.0025	0.0261	0.0472
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0025	0.0261	0.0472
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0261	0.0472
Schistosoma mansoni	amine GPCR	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0014	0.0016
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0018	0.0165	0.0178
Trichomonas vaginalis	dullard protein, putative	0.0015	0.0123	0.0109
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0038	0.045	0.0813
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Echinococcus granulosus	vesicular acetylcholine transporter	0.039	0.5527	1
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0018	0.0165	0.0042
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0261	0.0472
Entamoeba histolytica	hypothetical protein	0.0043	0.0533	0.0415
Brugia malayi	sulfakinin receptor protein	0.0025	0.0261	0.0281
Onchocerca volvulus		0.0018	0.0165	0.015
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0261	0.0472
Schistosoma mansoni	hypothetical protein	0.0015	0.012	0.0218
Brugia malayi	nuclear hormone receptor	0.0012	0.0083	0.009
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0261	0.0472
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Brugia malayi	hypothetical protein	0.0025	0.0261	0.0281
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0025	0.0261	0.0472
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0035	0.0414	0.04
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0165	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0018	0.0165	0.0298
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0649	0.9266	1
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0261	0.0472
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0083	0.009
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0011	0.0064	0.0116
Brugia malayi	hypothetical protein	0.0025	0.0261	0.0281
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0083	0.015
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0018	0.0165	0.0042
Brugia malayi	AKH receptor	0.0025	0.0261	0.0281
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0038	0.045	0.0813
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0083	0.009
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0083	0.009
Onchocerca volvulus		0.0025	0.0261	0.0327
Onchocerca volvulus		0.0025	0.0261	0.0327
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0015	0.0123	0.0109
Echinococcus granulosus	geminin	0.0205	0.2857	0.517
Echinococcus multilocularis	fmrfamide receptor	0.0025	0.0261	0.0472
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0083	0.015
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0083	0.015
Onchocerca volvulus		0.0018	0.0165	0.015
Onchocerca volvulus		0.0018	0.0165	0.015
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0025	0.0261	0.0472
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0018	0.0165	0.0298
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0025	0.0261	0.0472
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0261	0.0472
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0025	0.0261	0.0472
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0083	0.009
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0153	0.212	0.3836
Onchocerca volvulus		0.0025	0.0261	0.0327
Brugia malayi	Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1	0.0015	0.0123	0.0133
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0165	0.0178
Echinococcus multilocularis	voltage gated potassium channel	0.0011	0.0064	0.0116
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0018	0.0165	0.0298
Onchocerca volvulus		0.0025	0.0261	0.0327
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0018	0.0165	0.0298
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0083	0.015
Echinococcus granulosus	Carboxy terminal domain RNA polymerase II	0.0015	0.0123	0.0223
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0018	0.0165	0.0298
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0018	0.0165	0.0298
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0165	0.0298
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0018	0.0165	0.0298
Echinococcus multilocularis	neuropeptides capa receptor	0.0025	0.0261	0.0472
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0018	0.0165	0.0298
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0007	0.0014	0.0026
Onchocerca volvulus		0.0025	0.0261	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Brugia malayi	putative neuropeptide receptor	0.0025	0.0261	0.0281
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0018	0.0165	0.0046
Brugia malayi	neuropeptide F receptor	0.0025	0.0261	0.0281
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0007	0.0014	0.0026
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0165	0.0178
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0083	0.009
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0165	0.0298
Brugia malayi	Serotonin receptor	0.0025	0.0261	0.0281
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.0261	0.0281
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.0261	0.0472
Echinococcus granulosus	neuropeptide receptor	0.0025	0.0261	0.0472
Onchocerca volvulus		0.0018	0.0165	0.015
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0261	0.0472
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0083	0.009
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0025	0.0261	0.0472
Onchocerca volvulus		0.0025	0.0261	0.0327
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0007	0.0014	0.0026
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0018	0.0165	0.0178
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0083	0.015
Brugia malayi	neuropeptide F receptor	0.0025	0.0261	0.0281
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0007	0.0014	0.0026
Brugia malayi	hypothetical protein	0.0018	0.0165	0.0178
Echinococcus granulosus	neuropeptide FF receptor 2	0.0025	0.0261	0.0472
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0083	0.015
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0165	0.0298
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0165	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0123	0.0133
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0153	0.212	0.2288
Brugia malayi	hypothetical protein	0.0018	0.0165	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Echinococcus multilocularis	serotonin receptor	0.0025	0.0261	0.0472
Echinococcus granulosus	hypothetical protein	0.0025	0.0261	0.0472
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0165	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Echinococcus multilocularis	fmrfamide receptor	0.0025	0.0261	0.0472
Schistosoma mansoni	protein tyrosine phosphatase	0.0018	0.0165	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0083	0.009
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0261	0.0472
Schistosoma mansoni	hypothetical protein	0.0205	0.2857	0.517
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0261	0.0472
Echinococcus multilocularis	G protein coupled receptor 139	0.0025	0.0261	0.0472
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Echinococcus granulosus	somatostatin receptor	0.0025	0.0261	0.0472
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0018	0.0165	0.0298
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Onchocerca volvulus		0.0018	0.0165	0.015
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0015	0.0123	0.0109
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0533	0.0965
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0025	0.0261	0.0281
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0083	0.015
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0261	0.0472
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0083	0.015
Onchocerca volvulus		0.0018	0.0165	0.015
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0018	0.0165	0.0298
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0083	0.009
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0649	0.9266	1
Onchocerca volvulus		0.0018	0.0165	0.015
Onchocerca volvulus		0.0025	0.0261	0.0327
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0018	0.0165	0.0298
Onchocerca volvulus		0.0025	0.0261	0.0327
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Echinococcus multilocularis	somatostatin receptor	0.0025	0.0261	0.0472
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0261	0.0472
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0018	0.0165	0.0298
Echinococcus granulosus	voltage gated potassium channel	0.0011	0.0064	0.0116
Giardia lamblia	Protein tyrosine phosphatase	0.0018	0.0165	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0083	0.009
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0025	0.0261	0.0281
Echinococcus multilocularis	sex peptide receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0018	0.0165	0.0178
Trichomonas vaginalis	dullard protein, putative	0.0015	0.0123	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0083	0.015
Schistosoma mansoni	adenoreceptor	0.0025	0.0261	0.0472
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0025	0.0261	0.0472
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0083	0.015
Echinococcus multilocularis	neuropeptide receptor	0.0025	0.0261	0.0472
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Schistosoma mansoni	protein tyrosine phosphatase	0.0018	0.0165	0.0298
Onchocerca volvulus		0.0018	0.0165	0.015
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Onchocerca volvulus		0.0018	0.0165	0.015
Schistosoma mansoni	amine GPCR	0.0025	0.0261	0.0472
Schistosoma mansoni	growth hormone secretagogue receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0038	0.045	0.0485
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0018	0.0165	0.0178
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0083	0.015
Echinococcus multilocularis	neuropeptide Y receptor	0.0025	0.0261	0.0472
Schistosoma mansoni	voltage-gated potassium channel	0.0041	0.0499	0.0904
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0018	0.0165	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0153	0.212	0.2288
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0038	0.045	0.0485
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0007	0.0014	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0148	0.204	0.2202
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Brugia malayi	Dopamine receptor protein 1	0.0025	0.0261	0.0281
Brugia malayi	RE15519p	0.0025	0.0261	0.0281
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0649	0.9266	1
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0018	0.0165	0.0298
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0261	0.0472
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Schistosoma mansoni	amine GPCR	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0378	0.0408
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0165	0.0298
Echinococcus granulosus	CTD small phosphatase protein like	0.0015	0.0123	0.0223
Schistosoma mansoni	hypothetical protein	0.0025	0.0261	0.0472
Onchocerca volvulus		0.0018	0.0165	0.015
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0083	0.009
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0018	0.0165	0.0298
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0025	0.0261	0.0472
Schistosoma mansoni	amine GPCR	0.0025	0.0261	0.0472
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0018	0.0165	0.0298
Schistosoma mansoni	hypothetical protein	0.0025	0.0261	0.0472
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0261	0.0472
Schistosoma mansoni	opsin-like receptor	0.0025	0.0261	0.0472
Brugia malayi	larval opioid receptor	0.0025	0.0261	0.0281
Onchocerca volvulus		0.0025	0.0261	0.0327
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0018	0.0165	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0083	0.015
Echinococcus granulosus	serotonin receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0165	0.0298
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Schistosoma mansoni	hypothetical protein	0.0025	0.0261	0.0472
Onchocerca volvulus		0.0025	0.0261	0.0327
Echinococcus granulosus	dro:myosuppressin receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Onchocerca volvulus		0.0018	0.0165	0.015
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0007	0.0014	0.0016
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0007	0.0014	0.0016
Onchocerca volvulus		0.0025	0.0261	0.0327
Brugia malayi	GnHR receptor homolog	0.0025	0.0261	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0083	0.009
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0025	0.0261	0.0281
Echinococcus granulosus	hyperpolarization activated cyclic	0.0007	0.0014	0.0026
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0083	0.015
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0261	0.0472
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0015	0.0123	0.0109
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0261	0.0472
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0025	0.0261	0.0327
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0025	0.0261	0.0472
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0153	0.212	0.3836
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0261	0.0472
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.0261	0.0281
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0025	0.0261	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0083	0.009
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0025	0.0261	0.0281
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0083	0.009
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Onchocerca volvulus		0.0018	0.0165	0.015
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0007	0.0014	0.0026
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0007	0.0014	0.0026
Schistosoma mansoni	myosin xvIII	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Leishmania major	tyrosine specific protein phosphatase, putative	0.0018	0.0165	0.0046
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0025	0.0261	0.0281
Brugia malayi	Dopamine receptor protein 2	0.0025	0.0261	0.0281
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0083	0.009
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Echinococcus multilocularis	orexin receptor type 2	0.0025	0.0261	0.0472
Schistosoma mansoni	neuropeptide F-like receptor	0.0025	0.0261	0.0472
Onchocerca volvulus		0.0018	0.0165	0.015
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0018	0.0165	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0083	0.015
Schistosoma mansoni	protein tyrosine phosphatase	0.0018	0.0165	0.0298
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0018	0.0165	0.0298
Brugia malayi	G-protein coupled receptor	0.0025	0.0261	0.0281
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0261	0.0472
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0083	0.015
Echinococcus granulosus	fmrfamide receptor	0.0025	0.0261	0.0472
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	0.07	1	1
Onchocerca volvulus		0.0025	0.0261	0.0327
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0025	0.0261	0.0281
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0083	0.009
Onchocerca volvulus		0.0018	0.0165	0.015
Brugia malayi	Protein-tyrosine phosphatase 1	0.0018	0.0165	0.0178
Echinococcus multilocularis	hypothetical protein	0.0018	0.0165	0.0298
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0533	0.0965
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0083	0.009
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0083	0.009
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Echinococcus multilocularis	vesicular acetylcholine transporter	0.039	0.5527	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0083	0.015
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0649	0.9266	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0025	0.0261	0.0472
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Brugia malayi	Dopamine receptor	0.0025	0.0261	0.0281
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0083	0.009
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0083	0.015
Schistosoma mansoni	hypothetical protein	0.0043	0.0533	0.0965
Brugia malayi	Protein-tyrosine phosphatase	0.0018	0.0165	0.0178
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0018	0.0165	0.0298
Brugia malayi	G-protein coupled receptor	0.0025	0.0261	0.0281
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0018	0.0165	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Brugia malayi	vesicular acetylcholine transporter unc-17	0.039	0.5527	0.5964
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0007	0.0014	0.0026
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0165	0.0178
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0261	0.0472
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0025	0.0261	0.0472
Onchocerca volvulus		0.0018	0.0165	0.015
Toxoplasma gondii	Dullard family phosphatase domain-containing protein	0.0015	0.0123	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0153	0.212	0.3836
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0018	0.0165	0.0298
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0261	0.0472
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Entamoeba histolytica	hypothetical protein	0.0043	0.0533	0.0415
Onchocerca volvulus		0.0025	0.0261	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0025	0.0261	0.0281
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0007	0.0014	0.0026
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0018	0.0165	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0018	0.0165	0.0298
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0083	0.009
Schistosoma mansoni	pcd6 interacting protein-related	0.0018	0.0165	0.0298
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.039	0.5527	0.5964
Echinococcus multilocularis		0.0015	0.0123	0.0223
Echinococcus granulosus	G protein coupled receptor 139	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Brugia malayi	hypothetical protein	0.0025	0.0261	0.0281
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0261	0.0472
Echinococcus multilocularis	neuropeptide receptor	0.0025	0.0261	0.0472
Schistosoma mansoni	vesicular acetylcholine transporter	0.039	0.5527	1
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0261	0.0472
Brugia malayi	hypothetical protein	0.0025	0.0261	0.0281
Brugia malayi	putative neuropeptide receptor NPR1	0.0025	0.0261	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Onchocerca volvulus		0.0025	0.0261	0.0327
Schistosoma mansoni	opsin-like receptor	0.0025	0.0261	0.0472
Entamoeba histolytica	hypothetical protein	0.0043	0.0533	0.0415
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0083	0.015
Trichomonas vaginalis	dullard protein, putative	0.0015	0.0123	0.0109
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0165	0.0178
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0165	0.0178
Entamoeba histolytica	hypothetical protein	0.0043	0.0533	0.0415
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0165	0.0178
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0011	0.0064	0.0116
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0025	0.0261	0.0472
Onchocerca volvulus	Huntingtin homolog	0.0148	0.204	0.3595
Schistosoma mansoni	voltage-gated potassium channel	0.0007	0.0014	0.0026
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0165	0.0178
Brugia malayi	ecdysteroid receptor	0.0012	0.0083	0.009
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0018	0.0165	0.0298
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0025	0.0261	0.0472
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0083	0.015
Onchocerca volvulus		0.0018	0.0165	0.015
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.039	0.5527	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0083	0.015
Echinococcus multilocularis	g-protein coupled receptor	0.0025	0.0261	0.0472
Echinococcus multilocularis	neuropeptide receptor A26	0.0025	0.0261	0.0472
Plasmodium vivax	NLI interacting factor-like phosphatase, putative	0.0015	0.0123	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0261	0.0472
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0018	0.0165	0.0298
Onchocerca volvulus		0.0018	0.0165	0.015
Echinococcus granulosus	orexin receptor type 2	0.0025	0.0261	0.0472
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0018	0.0165	0.0298
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0025	0.0261	0.0281
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0083	0.009
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0018	0.0165	0.0298
Echinococcus multilocularis		0.0018	0.0165	0.0298
Brugia malayi	G protein-coupled receptor	0.0025	0.0261	0.0281
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.0261	0.0472
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0018	0.0165	0.0298
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0018	0.0165	0.0298
Plasmodium vivax	NLI interacting factor-like phosphatase, putative	0.0015	0.0123	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.0025	0.0261	0.0472
Plasmodium falciparum	NLI interacting factor-like phosphatase, putative	0.0015	0.0123	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0025	0.0261	0.0472
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0332	0.4691	0.5062
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0007	0.0014	0.0026
Schistosoma mansoni	voltage-gated potassium channel	0.0041	0.0499	0.0904
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Trichomonas vaginalis	nuclear lim interactor-interacting factor, putative	0.0015	0.0123	0.0109
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0018	0.0165	0.0298
Echinococcus granulosus	g-protein coupled receptor	0.0025	0.0261	0.0472
Echinococcus multilocularis	dro:myosuppressin receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0018	0.0165	0.0298
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0083	0.009
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.0261	0.0472
Brugia malayi	hypothetical protein	0.0018	0.0165	0.0178
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0025	0.0261	0.0472
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0018	0.0165	0.0298
Onchocerca volvulus		0.0018	0.0165	0.015
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0018	0.0165	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0083	0.009
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Onchocerca volvulus		0.0025	0.0261	0.0327
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0025	0.0261	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Echinococcus multilocularis	serotonin receptor	0.0025	0.0261	0.0472
Brugia malayi	hypothetical protein	0.0043	0.0533	0.0576
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0165	0.0298
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0083	0.009
Loa Loa (eye worm)	hypothetical protein	0.0148	0.204	0.2202
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0083	0.015
Brugia malayi	G protein-coupled receptor F59B2.13	0.0025	0.0261	0.0281
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0018	0.0165	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0261	0.0472
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0018	0.0165	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Brugia malayi	Melatonin receptor type 1A	0.0025	0.0261	0.0281
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0261	0.0472
Brugia malayi	Protein-tyrosine phosphatase	0.0018	0.0165	0.0178
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0018	0.0165	0.0298
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0083	0.009
Brugia malayi	hypothetical protein	0.0025	0.0261	0.0281
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0018	0.0165	0.0178
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0025	0.0261	0.0472
Onchocerca volvulus		0.0018	0.0165	0.015
Onchocerca volvulus		0.0018	0.0165	0.015
Echinococcus multilocularis	Carboxy terminal domain RNA polymerase II	0.0015	0.0123	0.0223
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0025	0.0261	0.0472
Echinococcus multilocularis	geminin	0.0205	0.2857	0.517
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0153	0.212	0.3836
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0025	0.0261	0.0472
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.0261	0.0281
Brugia malayi	hypothetical protein	0.0025	0.0261	0.0281
Onchocerca volvulus		0.0018	0.0165	0.015
Onchocerca volvulus		0.0025	0.0261	0.0327
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0015	0.0123	0.0223
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0083	0.015
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0165	0.0178
Loa Loa (eye worm)	TYRA-2 protein	0.0025	0.0261	0.0281
Brugia malayi	hypothetical protein	0.0025	0.0261	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Brugia malayi	hypothetical protein	0.0018	0.0165	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0083	0.015
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0261	0.0472
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0018	0.0165	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0015	0.012	0.013
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Schistosoma mansoni	amine GPCR	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0018	0.0165	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Schistosoma mansoni	neuropeptide F-like receptor	0.0025	0.0261	0.0472
Schistosoma mansoni	neuropeptide f receptor 76f	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0018	0.0165	0.0298
Leishmania major	C-8 sterol isomerase-like protein	0.0649	0.9266	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0165	0.0178
Schistosoma mansoni	nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if)	0.0015	0.0123	0.0223
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0018	0.0165	0.0046
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0083	0.015
Onchocerca volvulus		0.0018	0.0165	0.015
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0261	0.0472
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0261	0.0472
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0261	0.0472
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0018	0.0165	0.0178
Echinococcus granulosus	neuropeptide s receptor	0.0025	0.0261	0.0472
Brugia malayi	hypothetical protein	0.0025	0.0261	0.0281
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0064	0.0116
Schistosoma mansoni	hypothetical protein	0.0025	0.0261	0.0472
Loa Loa (eye worm)	melatonin receptor type 1A	0.0025	0.0261	0.0281
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0083	0.009
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0083	0.015
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0018	0.0165	0.0178
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0018	0.0165	0.0298
Echinococcus granulosus	neuropeptide receptor A26	0.0025	0.0261	0.0472
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0035	0.0414	0.04
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0261	0.0472
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0007	0.0014	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0083	0.009
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0261	0.0472
Onchocerca volvulus	4.1 G protein, putative homolog	0.0018	0.0165	0.015
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0261	0.0472
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.0261	0.0472
Schistosoma mansoni	opsin-like receptor	0.0025	0.0261	0.0472
Echinococcus granulosus	neuropeptide receptor	0.0025	0.0261	0.0472
Onchocerca volvulus	Huntingtin homolog	0.0148	0.204	0.3595
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0025	0.0261	0.0327
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0018	0.0165	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Echinococcus granulosus	hyperpolarization activated cyclic	0.0007	0.0014	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Echinococcus multilocularis	neuropeptides capa receptor	0.0025	0.0261	0.0472
Echinococcus granulosus	sex peptide receptor	0.0025	0.0261	0.0472
Echinococcus granulosus	allatostatin A receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Brugia malayi	hypothetical protein	0.0025	0.0261	0.0281
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0018	0.0165	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0007	0.0014	0.0016
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0018	0.0165	0.0298
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0064	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0083	0.009
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0083	0.009
Schistosoma mansoni	coup transcription factor	0.0012	0.0083	0.015
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0018	0.0165	0.0298
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0018	0.0165	0.0046
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0165	0.0178
Echinococcus multilocularis	neuropeptide s receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.0261	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0261	0.0281

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 4.31 uM	PUBCHEM_BIOASSAY: Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	= 5.27 uM	PUBCHEM_BIOASSAY: Dose Response selectivity of inhibitors of Striatal-Enriched Phosphatase (STEP) in a SHP2 (PTPN11) Inhibition Assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	= 8.49 uM	PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493091, AID493120]	ChEMBL.	No reference
IC50 (functional)	= 16.9 uM	PUBCHEM_BIOASSAY: Dose response confirmation of uHTS small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	60.173 uM	PubChem BioAssay. Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the Lymphoid Phosphatase (PTPN22) Inhibition Assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	80 uM	PubChem BioAssay. Dose response orthogonal assay of uHTS small molecule inhibitors of Striatal-Enriched Phosphatase via a colorimetric intensity assay. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 1 um	PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ]	ChEMBL.	No reference
Potency (functional)	= 1 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 2.5119 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	2.5929 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	6.5131 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1430499
Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 827629