Detailed information for compound 827991

Basic information

Technical information
  • TDR Targets ID: 827991
  • Name: 3-(3,4-dimethoxybenzoyl)-1-[(4-fluorophenyl)m ethyl]quinolin-4-one
  • MW: 417.429 | Formula: C25H20FNO4
  • H donors: 0 H acceptors: 2 LogP: 4.79 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)C(=O)c1cn(Cc2ccc(cc2)F)c2c(c1=O)cccc2
  • InChi: 1S/C25H20FNO4/c1-30-22-12-9-17(13-23(22)31-2)24(28)20-15-27(14-16-7-10-18(26)11-8-16)21-6-4-3-5-19(21)25(20)29/h3-13,15H,14H2,1-2H3
  • InChiKey: JRBRVUIFBYFQSY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[(3,4-dimethoxyphenyl)-oxomethyl]-1-[(4-fluorophenyl)methyl]-4-quinolinone
  • 3-(3,4-dimethoxybenzoyl)-1-(4-fluorobenzyl)-4-quinolone
  • 3-(3,4-dimethoxyphenyl)carbonyl-1-[(4-fluorophenyl)methyl]quinolin-4-one
  • ZINC02691634

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Echinococcus granulosus biogenic amine 5HT receptor 0.0059 0.0019 0.0027
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0286 0.0394 0.5
Echinococcus granulosus neuropeptide s receptor 0.0059 0.0019 0.0027
Echinococcus multilocularis hemicentin 1 0.0053 0.0009 0.0013
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0286 0.0394 0.5
Echinococcus granulosus roundabout 2 0.0301 0.0418 0.0599
Loa Loa (eye worm) cytochrome P450 family protein 0.0472 0.07 0.2361
Echinococcus multilocularis Immunoglobulin 0.0245 0.0326 0.0466
Onchocerca volvulus 0.0059 0.0019 0.0064
Brugia malayi GnHR receptor homolog 0.0059 0.0019 0.0064
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0286 0.0394 0.5
Echinococcus multilocularis neuropeptide FF receptor 2 0.0059 0.0019 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0019 0.0019
Echinococcus granulosus peptide allatostatin:somatostatin 0.0059 0.0019 0.0027
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0286 0.0394 0.5
Echinococcus granulosus g protein coupled receptor 0.0059 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0059 0.0019 0.0027
Schistosoma mansoni hypothetical protein 0.0059 0.0019 0.0019
Echinococcus granulosus neuropeptide FF receptor 2 0.0059 0.0019 0.0027
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0286 0.0394 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.0009 0.0032
Echinococcus granulosus tm gpcr rhodopsin 0.0059 0.0019 0.0027
Echinococcus granulosus orexin receptor type 2 0.0059 0.0019 0.0027
Trypanosoma cruzi cytochrome P450, putative 0.0472 0.07 0.1191
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0056 0.0015 0.0052
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0053 0.0009 0.0032
Schistosoma mansoni hypothetical protein 0.0059 0.0019 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.0059 0.0019 0.0027
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.4288 0.6984 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0286 0.0394 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0059 0.0019 0.0019
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0059 0.0019 0.0027
Brugia malayi neuropeptide F receptor 0.0059 0.0019 0.0064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0019 0.0027
Brugia malayi Serotonin receptor 0.0059 0.0019 0.0064
Brugia malayi Fibronectin type III domain containing protein 0.0248 0.0332 0.1118
Loa Loa (eye worm) hypothetical protein 0.0248 0.0332 0.1118
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0059 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0059 0.0019 0.0019
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0059 0.0019 0.0027
Brugia malayi Prion-like- 0.0053 0.0009 0.0032
Echinococcus multilocularis neuroglian 0.0271 0.0369 0.0528
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Echinococcus granulosus hemicentin 1 0.0053 0.0009 0.0013
Echinococcus multilocularis roundabout 2 0.0056 0.0015 0.0022
Schistosoma mansoni septate junction protein 0.0053 0.0009 0.0009
Schistosoma mansoni neuropeptide F-like receptor 0.0059 0.0019 0.0019
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0271 0.0369 0.0529
Echinococcus multilocularis dro:myosuppressin receptor 0.0059 0.0019 0.0027
Echinococcus granulosus neuropeptides capa receptor 0.0059 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Loa Loa (eye worm) hypothetical protein 0.0248 0.0332 0.1118
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0124 0.0126 0.018
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Mycobacterium leprae Conserved hypothetical protein 0.0286 0.0394 0.5
Brugia malayi hypothetical protein 0.0059 0.0019 0.0064
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Onchocerca volvulus 0.0059 0.0019 0.0064
Echinococcus granulosus neuropeptides capa receptor 0.0059 0.0019 0.0027
Schistosoma mansoni nephrin 0.0056 0.0015 0.0015
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0124 0.0126 0.018
Echinococcus multilocularis neuropeptide receptor A26 0.0059 0.0019 0.0027
Onchocerca volvulus Tyrosine kinase homolog 0.126 0.1997 0.6731
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Onchocerca volvulus 0.0059 0.0019 0.0064
Entamoeba histolytica serine/threonine protein kinase, putative 0.1848 0.2967 1
Loa Loa (eye worm) hypothetical protein 0.0297 0.0412 0.139
Loa Loa (eye worm) AUR protein kinase 0.0677 0.1037 0.3495
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0019 0.0027
Echinococcus multilocularis Immunoglobulin 0.0245 0.0326 0.0466
Brugia malayi hypothetical protein 0.0059 0.0019 0.0064
Brugia malayi hypothetical protein 0.0059 0.0019 0.0064
Echinococcus multilocularis neuropeptides capa receptor 0.0059 0.0019 0.0027
Brugia malayi Cytochrome P450 family protein 0.0472 0.07 0.2361
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Trypanosoma brucei cytochrome P450, putative 0.0472 0.07 0.1191
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Brugia malayi hypothetical protein 0.0059 0.0019 0.0064
Onchocerca volvulus 0.0059 0.0019 0.0064
Loa Loa (eye worm) hypothetical protein 0.0053 0.001 0.0033
Loa Loa (eye worm) hypothetical protein 0.0248 0.0332 0.1118
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0059 0.0019 0.0064
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0286 0.0394 0.5
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0286 0.0394 0.5
Echinococcus granulosus defective proboscis extension response 0.0245 0.0326 0.0466
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Schistosoma mansoni biogenic amine (5HT) receptor 0.0059 0.0019 0.0019
Echinococcus multilocularis neuropeptide receptor 0.0059 0.0019 0.0027
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0059 0.0019 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0286 0.0394 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.1096 0.1728 0.5826
Schistosoma mansoni biogenic amine receptor 0.0059 0.0019 0.0019
Schistosoma mansoni biogenic amine (5HT) receptor 0.0059 0.0019 0.0019
Loa Loa (eye worm) G-protein coupled receptor 0.0059 0.0019 0.0064
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Brugia malayi neuropeptide F receptor 0.0059 0.0019 0.0064
Schistosoma mansoni tyrosine kinase 0.0077 0.005 0.005
Brugia malayi AKH receptor 0.0059 0.0019 0.0064
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0286 0.0394 0.5
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.1848 0.2967 0.4247
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0056 0.0015 0.0022
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0059 0.0019 0.0027
Onchocerca volvulus Serine\/threonine kinase homolog 0.1848 0.2967 1
Trichomonas vaginalis CAMK family protein kinase 0.1848 0.2967 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0056 0.0015 0.0022
Schistosoma mansoni amine GPCR 0.0059 0.0019 0.0019
Brugia malayi Immunoglobulin I-set domain containing protein 0.1505 0.2401 0.8092
Trichomonas vaginalis CAMK family protein kinase 0.1848 0.2967 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0019 0.0019
Schistosoma mansoni growth hormone secretagogue receptor 0.0059 0.0019 0.0019
Schistosoma mansoni opsin-like receptor 0.0059 0.0019 0.0019
Echinococcus granulosus aurora kinase A 0.0677 0.1037 0.1484
Echinococcus granulosus neuropeptide Y receptor 0.0059 0.0019 0.0027
Onchocerca volvulus 0.0059 0.0019 0.0064
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0059 0.0019 0.0027
Onchocerca volvulus Neuropeptide F receptor homolog 0.0059 0.0019 0.0064
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.1848 0.2967 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0059 0.0019 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0019 0.0027
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0059 0.0019 0.0064
Echinococcus multilocularis peroxidasin 0.0053 0.001 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0019 0.0019
Schistosoma mansoni septate junction protein 0.0053 0.0009 0.0009
Schistosoma mansoni roundabout 0.0053 0.0009 0.0009
Echinococcus multilocularis neuropeptide Y receptor 0.0059 0.0019 0.0027
Leishmania major protein kinase, putative 0.0677 0.1037 0.2498
Loa Loa (eye worm) hypothetical protein 0.0056 0.0015 0.0052
Brugia malayi Peroxidasin 0.0053 0.001 0.0033
Echinococcus granulosus serotonin receptor 0.0059 0.0019 0.0027
Brugia malayi hypothetical protein 0.0059 0.0019 0.0064
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0059 0.0019 0.0064
Brugia malayi G-protein coupled receptor 0.0059 0.0019 0.0064
Echinococcus multilocularis orexin receptor type 2 0.0059 0.0019 0.0027
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0059 0.0019 0.0027
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0286 0.0394 0.5
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0286 0.0394 0.5
Brugia malayi hypothetical protein 0.0319 0.0447 0.1508
Echinococcus granulosus cytochrome P450 2K1 0.0286 0.0394 0.0564
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0074 0.0044 0.0148
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0059 0.0019 0.0064
Echinococcus granulosus neuropeptide Y receptor 0.0059 0.0019 0.0027
Echinococcus multilocularis g protein coupled receptor 0.0059 0.0019 0.0027
Brugia malayi Dopamine receptor protein 1 0.0059 0.0019 0.0064
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0053 0.0009 0.0032
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0056 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Onchocerca volvulus 0.0059 0.0019 0.0064
Echinococcus multilocularis aurora kinase A 0.0677 0.1037 0.1484
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Brugia malayi G-protein coupled receptor 0.0059 0.0019 0.0064
Onchocerca volvulus 0.0059 0.0019 0.0064
Echinococcus multilocularis somatostatin receptor 0.0059 0.0019 0.0027
Onchocerca volvulus 0.1209 0.1914 0.6451
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0059 0.0019 0.0064
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0059 0.0019 0.0064
Echinococcus granulosus contactin 0.0056 0.0015 0.0022
Onchocerca volvulus 0.0059 0.0019 0.0064
Echinococcus granulosus somatostatin receptor 0.0059 0.0019 0.0027
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0286 0.0394 0.5
Echinococcus granulosus g protein coupled receptor 0.0059 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0319 0.0447 0.1508
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0059 0.0019 0.0019
Brugia malayi serine/threonine kinase 12 0.0677 0.1037 0.3495
Schistosoma mansoni neuropeptide receptor 0.0059 0.0019 0.0019
Schistosoma mansoni amine GPCR 0.0059 0.0019 0.0019
Schistosoma mansoni myosin xvIII 0.0059 0.0019 0.0019
Onchocerca volvulus 0.0059 0.0019 0.0064
Echinococcus granulosus allatostatin A receptor 0.0059 0.0019 0.0027
Brugia malayi serine/threonine protein kinase 6 0.0677 0.1037 0.3495
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0059 0.0019 0.0019
Mycobacterium leprae putative cytochrome p450 0.0286 0.0394 0.5
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Brugia malayi serine/threonine-protein kinase 6 0.0677 0.1037 0.3495
Echinococcus granulosus G protein coupled receptor 139 0.0059 0.0019 0.0027
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0124 0.0126 0.018
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0677 0.1037 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0059 0.0019 0.0064
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0053 0.0009 0.0032
Echinococcus multilocularis g protein coupled receptor 0.0059 0.0019 0.0027
Echinococcus multilocularis g-protein coupled receptor 0.0059 0.0019 0.0027
Echinococcus multilocularis neuropeptides capa receptor 0.0059 0.0019 0.0027
Echinococcus granulosus peroxidasin 0.0053 0.001 0.0014
Brugia malayi Cytochrome P450 family protein 0.0472 0.07 0.2361
Schistosoma mansoni serine/threonine protein kinase 0.0677 0.1037 0.1037
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0019 0.0027
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0059 0.0019 0.0027
Brugia malayi Dopamine receptor protein 2 0.0059 0.0019 0.0064
Schistosoma mansoni opsin-like receptor 0.0059 0.0019 0.0019
Brugia malayi Immunoglobulin I-set domain containing protein 0.0248 0.0332 0.1118
Echinococcus multilocularis neuropeptide s receptor 0.0059 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0053 0.0009 0.0032
Echinococcus granulosus serine:threonine protein kinase PLK1 0.1848 0.2967 0.4247
Brugia malayi larval opioid receptor 0.0059 0.0019 0.0064
Schistosoma mansoni neuropeptide F-like receptor 0.0059 0.0019 0.0019
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0059 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Brugia malayi hypothetical protein 0.0248 0.0332 0.1118
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Echinococcus granulosus tyrosine protein kinase otk 0.0053 0.0009 0.0013
Echinococcus multilocularis neuropeptide Y receptor 0.0059 0.0019 0.0027
Loa Loa (eye worm) cytochrome P450 family protein 0.0472 0.07 0.2361
Schistosoma mansoni cell adhesion molecule 0.0056 0.0015 0.0015
Loa Loa (eye worm) AUR protein kinase 0.0677 0.1037 0.3495
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0245 0.0326 0.0466
Echinococcus multilocularis neuropeptide receptor 0.0059 0.0019 0.0027
Echinococcus multilocularis sex peptide receptor 0.0059 0.0019 0.0027
Echinococcus granulosus g protein coupled receptor 0.0059 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0297 0.0412 0.139
Schistosoma mansoni amine GPCR 0.0059 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Schistosoma mansoni hypothetical protein 0.0059 0.0019 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0019 0.0027
Echinococcus multilocularis tyrosine protein kinase otk 0.0053 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0271 0.0369 0.1245
Schistosoma mansoni neuropeptide receptor 0.0059 0.0019 0.0019
Schistosoma mansoni alpha-1 adrenergic receptor 0.0059 0.0019 0.0019
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0056 0.0015 0.0022
Brugia malayi hypothetical protein 0.0059 0.0019 0.0064
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0059 0.0019 0.0027
Echinococcus multilocularis neuroglian 0.0056 0.0015 0.0022
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0059 0.0019 0.0064
Echinococcus granulosus biogenic amine 5HT receptor 0.0059 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Loa Loa (eye worm) TK protein kinase 0.015 0.0169 0.057
Brugia malayi Cytochrome P450 family protein 0.0286 0.0394 0.1329
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0009 0.0032
Brugia malayi hypothetical protein 0.0059 0.0019 0.0064
Brugia malayi Dopamine receptor 0.0059 0.0019 0.0064
Trichomonas vaginalis CAMK family protein kinase 0.1848 0.2967 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0059 0.0019 0.0027
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0286 0.0394 0.5
Echinococcus multilocularis serotonin receptor 0.0059 0.0019 0.0027
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0059 0.0019 0.0027
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0245 0.0326 0.0326
Echinococcus multilocularis g protein coupled receptor 0.0059 0.0019 0.0027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0019 0.0027
Trypanosoma cruzi aurora B kinase, putative 0.0677 0.1037 0.2498
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0019 0.0027
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0286 0.0394 0.5
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Leishmania major cytochrome p450-like protein 0.0472 0.07 0.1191
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0009 0.0032
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Echinococcus granulosus neuropeptide receptor 0.0059 0.0019 0.0027
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0019 0.0019
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0059 0.0019 0.0027
Trypanosoma brucei polo-like protein kinase 0.1848 0.2967 1
Onchocerca volvulus 0.0059 0.0019 0.0064
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0053 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Echinococcus granulosus tachykinin peptides receptor 99D 0.0059 0.0019 0.0027
Schistosoma mansoni histamine h1 receptor 0.0059 0.0019 0.0019
Plasmodium falciparum serine/threonine protein kinase, putative 0.0677 0.1037 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.0009 0.0032
Loa Loa (eye worm) neuropeptide F receptor 0.0059 0.0019 0.0064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0019 0.0019
Loa Loa (eye worm) TK/ROR protein kinase 0.0051 0.0006 0.002
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0059 0.0019 0.0019
Brugia malayi Immunoglobulin I-set domain containing protein 0.0056 0.0015 0.0052
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0059 0.0019 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0019 0.0019
Echinococcus multilocularis lachesin 0.0053 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Loa Loa (eye worm) G-protein coupled receptor 0.0059 0.0019 0.0064
Brugia malayi ORL1-like opioid receptor 0.0059 0.0019 0.0064
Schistosoma mansoni neuropeptide receptor 0.0059 0.0019 0.0019
Echinococcus multilocularis roundabout 2 0.0301 0.0418 0.0599
Echinococcus granulosus sex peptide receptor 0.0059 0.0019 0.0027
Brugia malayi RE15519p 0.0059 0.0019 0.0064
Brugia malayi Melatonin receptor type 1A 0.0059 0.0019 0.0064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0019 0.0019
Schistosoma mansoni biogenic amine receptor 0.0059 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Echinococcus granulosus alpha 1A adrenergic receptor 0.0059 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Loa Loa (eye worm) hypothetical protein 0.0053 0.0009 0.0032
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0056 0.0015 0.0022
Echinococcus multilocularis allatostatin A receptor 0.0059 0.0019 0.0027
Brugia malayi Tachykinin-like peptides receptor 99D 0.0059 0.0019 0.0064
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0059 0.0019 0.0027
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0059 0.0019 0.0019
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.4288 0.6984 1
Brugia malayi hypothetical protein 0.0059 0.0019 0.0064
Brugia malayi Cytochrome P450 family protein 0.1096 0.1728 0.5826
Schistosoma mansoni biogenic amine receptor 0.0059 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Echinococcus multilocularis serotonin receptor 0.0059 0.0019 0.0027
Schistosoma mansoni nephrin 0.0275 0.0375 0.0375
Schistosoma mansoni tyrosine kinase 0.0124 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0053 0.0009 0.0032
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.1848 0.2967 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0059 0.0019 0.0027
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0059 0.0019 0.0064
Echinococcus granulosus fmrfamide receptor 0.0059 0.0019 0.0027
Brugia malayi follicle stimulating hormone receptor 0.0059 0.0019 0.0064
Echinococcus granulosus neuroglian 0.0271 0.0369 0.0528
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0051 0.0006 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0019 0.0027
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0059 0.0019 0.0027
Trypanosoma cruzi polo-like protein kinase, putative 0.1848 0.2967 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0056 0.0015 0.0022
Brugia malayi putative neuropeptide receptor 0.0059 0.0019 0.0064
Toxoplasma gondii aurora kinase 0.0677 0.1037 1
Trypanosoma brucei aurora B kinase 0.0677 0.1037 0.2498
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0245 0.0326 0.1097
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0009 0.0032
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Loa Loa (eye worm) TYRA-2 protein 0.0059 0.0019 0.0064
Echinococcus multilocularis fmrfamide receptor 0.0059 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Schistosoma mansoni cell adhesion molecule 0.0275 0.0375 0.0375
Onchocerca volvulus 0.0059 0.0019 0.0064
Echinococcus granulosus dro:myosuppressin receptor 0.0059 0.0019 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.1848 0.2967 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0059 0.0019 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.1848 0.2967 1
Echinococcus multilocularis G protein coupled receptor 139 0.0059 0.0019 0.0027
Echinococcus granulosus fibroblast growth factor receptor 4 0.0124 0.0126 0.018
Brugia malayi sulfakinin receptor protein 0.0059 0.0019 0.0064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0019 0.0027
Onchocerca volvulus 0.0059 0.0019 0.0064
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0059 0.0019 0.0019
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0059 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Echinococcus granulosus neuropeptide receptor 0.0059 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0059 0.0019 0.0027
Echinococcus multilocularis G-protein coupled receptor, putative 0.0059 0.0019 0.0027
Trichomonas vaginalis CAMK family protein kinase 0.1848 0.2967 1
Echinococcus multilocularis fmrfamide receptor 0.0059 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0186 0.0229 0.0771
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Schistosoma mansoni neuropeptide receptor 0.0059 0.0019 0.0019
Giardia lamblia Kinase, PLK 0.1848 0.2967 1
Schistosoma mansoni vesicular amine transporter 0.0245 0.0326 0.0326
Echinococcus granulosus tm gpcr rhodopsin 0.0059 0.0019 0.0027
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0286 0.0394 0.5
Onchocerca volvulus 0.0059 0.0019 0.0064
Brugia malayi Immunoglobulin I-set domain containing protein 0.0056 0.0015 0.0052
Loa Loa (eye worm) neuropeptide F receptor 0.0059 0.0019 0.0064
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Schistosoma mansoni adenoreceptor 0.0059 0.0019 0.0019
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0677 0.1037 0.1484
Loa Loa (eye worm) cytochrome P450 0.0286 0.0394 0.1329
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0059 0.0019 0.0019
Schistosoma mansoni amine GPCR 0.0059 0.0019 0.0019
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0286 0.0394 0.5
Brugia malayi cytochrome P450 0.0286 0.0394 0.1329
Schistosoma mansoni opsin-like receptor 0.0059 0.0019 0.0019
Brugia malayi G protein-coupled receptor 0.0059 0.0019 0.0064
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0053 0.0009 0.0009
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0053 0.0009 0.0032
Echinococcus multilocularis roundabout 2 0.0056 0.0015 0.0022
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0472 0.07 1
Loa Loa (eye worm) AUR protein kinase 0.0677 0.1037 0.3495
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1505 0.2401 0.8092
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0059 0.0019 0.0019
Echinococcus granulosus neuroglian 0.0056 0.0015 0.0022
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0009 0.0032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0059 0.0019 0.0019
Echinococcus multilocularis hemicentin 1 0.0053 0.0009 0.0013
Schistosoma mansoni cytochrome P450 0.0286 0.0394 0.0394
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0009 0.0032
Onchocerca volvulus 0.0059 0.0019 0.0064
Echinococcus granulosus g-protein coupled receptor 0.0059 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0245 0.0326 0.1097
Schistosoma mansoni titin 0.0053 0.0009 0.0009
Echinococcus granulosus 7TM GPCR rhodopsin 0.0059 0.0019 0.0027
Trypanosoma cruzi polo-like protein kinase, putative 0.1848 0.2967 1
Echinococcus granulosus Immunoglobulin 0.0245 0.0326 0.0466
Trichomonas vaginalis CAMK family protein kinase 0.1848 0.2967 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.015 0.0169 0.057
Onchocerca volvulus 0.0059 0.0019 0.0064
Brugia malayi G protein-coupled receptor F59B2.13 0.0059 0.0019 0.0064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0245 0.0326 0.1099
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0059 0.0019 0.0027
Loa Loa (eye worm) CYP4Cod1 0.0472 0.07 0.2361
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0286 0.0394 0.5
Schistosoma mansoni neuroglian 0.0056 0.0015 0.0015
Echinococcus multilocularis 0.0286 0.0394 0.0564
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0245 0.0326 0.0326
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0677 0.1037 0.1484
Brugia malayi putative neuropeptide receptor NPR1 0.0059 0.0019 0.0064
Schistosoma mansoni cell adhesion molecule 0.0056 0.0015 0.0015
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0059 0.0019 0.0027
Echinococcus granulosus roundabout 2 0.0056 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Brugia malayi serine/threonine-protein kinase plk-2 0.1848 0.2967 1
Echinococcus granulosus twitchin 0.0288 0.0397 0.0569
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0286 0.0394 0.5
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0286 0.0394 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0059 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0059 0.0019 0.0064
Trypanosoma cruzi cytochrome P450, putative 0.0472 0.07 0.1191
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0059 0.0019 0.0027
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0019 0.0027
Brugia malayi hypothetical protein 0.0059 0.0019 0.0064
Onchocerca volvulus 0.0059 0.0019 0.0064
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0051 0.0006 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0059 0.0019 0.0027
Schistosoma mansoni protein kinase 0.0677 0.1037 0.1037
Schistosoma mansoni serine/threonine protein kinase 0.1848 0.2967 0.2967
Brugia malayi Serotonin receptor 0.0059 0.0019 0.0064
Loa Loa (eye worm) melatonin receptor type 1A 0.0059 0.0019 0.0064
Echinococcus granulosus neuropeptide receptor A26 0.0059 0.0019 0.0027
Brugia malayi hypothetical protein 0.0059 0.0019 0.0064
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0059 0.0019 0.0027
Onchocerca volvulus 0.0059 0.0019 0.0064
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0059 0.0019 0.0064
Schistosoma mansoni amine GPCR 0.0059 0.0019 0.0019
Echinococcus granulosus hypothetical protein 0.0059 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0059 0.0019 0.0064
Schistosoma mansoni cell adhesion molecule 0.0053 0.0009 0.0009
Echinococcus granulosus roundabout 2 0.0056 0.0015 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0059 0.0019 0.0027
Brugia malayi Immunoglobulin I-set domain containing protein 0.0053 0.0009 0.0032
Brugia malayi Immunoglobulin I-set domain containing protein 0.0056 0.0015 0.0052
Schistosoma mansoni hypothetical protein 0.0286 0.0394 0.0394
Echinococcus granulosus lachesin 0.0053 0.0009 0.0013

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.