Detailed information for compound 828063

Basic information

Technical information
  • TDR Targets ID: 828063
  • Name: 2,2-dimethyl-N-[2-[1-[4-(3-methylphenoxy)buty l]benzimidazol-2-yl]ethyl]propanamide
  • MW: 407.548 | Formula: C25H33N3O2
  • H donors: 1 H acceptors: 2 LogP: 5.13 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)OCCCCn1c(CCNC(=O)C(C)(C)C)nc2c1cccc2
  • InChi: 1S/C25H33N3O2/c1-19-10-9-11-20(18-19)30-17-8-7-16-28-22-13-6-5-12-21(22)27-23(28)14-15-26-24(29)25(2,3)4/h5-6,9-13,18H,7-8,14-17H2,1-4H3,(H,26,29)
  • InChiKey: KTSOTSGRXIIKMB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,2-dimethyl-N-[2-[1-[4-(3-methylphenoxy)butyl]-2-benzimidazolyl]ethyl]propanamide
  • 2,2-dimethyl-N-[2-[1-[4-(3-methylphenoxy)butyl]benzimidazol-2-yl]ethyl]propionamide
  • PB241822602

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0296 0.0816 0.1311
Echinococcus multilocularis endoplasmin 0.0753 0.2219 0.2219
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0296 0.0816 0.3676
Brugia malayi hypothetical protein 0.0565 0.1643 0.264
Loa Loa (eye worm) hypothetical protein 0.0075 0.0137 0.0215
Echinococcus multilocularis glycoprotein Antigen 5 0.0202 0.0528 0.0528
Brugia malayi Thioredoxin reductase 0.0089 0.0178 0.0286
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0182 0.0463 0.074
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.2056 0.6223 1
Brugia malayi pregnancy-associated plasma protein-A 0.0182 0.0463 0.0745
Mycobacterium leprae Probable two-component sensor kinase 0.0296 0.0816 0.3667
Trichomonas vaginalis heat shock protein, putative 0.1049 0.313 1
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0202 0.0528 0.0848
Plasmodium falciparum DNA topoisomerase 2 0.0296 0.0816 0.2607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0038 0.0022 0.0022
Echinococcus multilocularis musashi 0.005 0.0061 0.0061
Trypanosoma cruzi heat shock protein, putative 0.0387 0.1096 0.1762
Schistosoma mansoni hypothetical protein 0.0115 0.026 0.0418
Mycobacterium tuberculosis Probable oxidoreductase 0.0224 0.0595 0.2683
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0094 0.0151
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0296 0.0816 0.3676
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0088 0.0176 0.0282
Leishmania major DNA topoisomerase ii 0.0296 0.0816 0.1311
Echinococcus multilocularis CUB 0.0075 0.0137 0.0137
Mycobacterium tuberculosis Probable two component sensor kinase 0.0296 0.0816 0.3676
Loa Loa (eye worm) hypothetical protein 0.0075 0.0137 0.0215
Trypanosoma cruzi heat shock protein 90, putative 0.0662 0.1939 0.3116
Leishmania major trypanothione reductase 0.0089 0.0178 0.0286
Onchocerca volvulus 0.0075 0.0137 0.0584
Loa Loa (eye worm) hypothetical protein 0.0058 0.0084 0.013
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0109 0.0174
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0202 0.0528 0.0848
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0075 0.0137 0.022
Plasmodium falciparum endoplasmin, putative 0.0684 0.2006 0.6411
Plasmodium falciparum acyl-CoA synthetase 0.0058 0.0084 0.0268
Echinococcus multilocularis laminin 0.0258 0.0697 0.0697
Loa Loa (eye worm) TOPoisomerase family member 0.0296 0.0816 0.1307
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0078 0.0144 0.0649
Toxoplasma gondii rhoptry neck protein RON9 0.0182 0.0463 0.1481
Plasmodium vivax glutathione reductase, putative 0.0089 0.0178 0.0568
Brugia malayi hypothetical protein 0.0032 0.0003 0.0005
Schistosoma mansoni endoplasmin 0.1049 0.313 0.5029
Plasmodium vivax acyl-CoA synthetase, putative 0.0058 0.0084 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0171 0.0432 0.1379
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0258 0.0697 0.1121
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0074 0.0334
Toxoplasma gondii ATPase, AAA family protein 0.0032 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.0078 0.0144 0.0226
Brugia malayi AMP-binding enzyme family protein 0.0078 0.0144 0.0231
Schistosoma mansoni hypothetical protein 0.0075 0.0137 0.022
Brugia malayi glutathione reductase 0.0089 0.0178 0.0286
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.2056 0.6223 0.6223
Trypanosoma brucei heat shock protein 84, putative 0.0387 0.1096 0.1762
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0202 0.0528 0.0528
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0137 0.0438
Schistosoma mansoni hypothetical protein 0.0202 0.0528 0.0848
Trypanosoma cruzi heat shock protein 85, putative 0.1049 0.313 0.5029
Loa Loa (eye worm) hypothetical protein 0.0514 0.1486 0.2385
Loa Loa (eye worm) intermediate filament protein 0.005 0.0061 0.0093
Mycobacterium ulcerans acyl-CoA synthetase 0.0078 0.0144 0.0649
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0032 0.0003 0.001
Echinococcus multilocularis heat shock protein 90 0.1049 0.313 0.313
Trypanosoma cruzi DNA topoisomerase II, putative 0.0296 0.0816 0.1311
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0075 0.0137 0.022
Brugia malayi AMP-binding enzyme family protein 0.0078 0.0144 0.0231
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0258 0.0697 0.1116
Leishmania major heat shock protein 83-1 0.1049 0.313 0.5029
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.2056 0.6223 0.6223
Plasmodium vivax heat shock protein 86, putative 0.1049 0.313 1
Echinococcus granulosus tar DNA binding protein 0.0066 0.0109 0.0174
Toxoplasma gondii calcium binding egf domain-containing protein 0.0258 0.0697 0.2228
Loa Loa (eye worm) thioredoxin reductase 0.0089 0.0178 0.0281
Trypanosoma brucei heat shock protein, putative 0.1049 0.313 0.5029
Trypanosoma brucei DNA topoisomerase ii 0.0296 0.0816 0.1311
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0333 0.0929 0.1488
Brugia malayi AMP-binding enzyme family protein 0.0078 0.0144 0.0231
Leishmania major heat shock protein 83-1 0.1049 0.313 0.5029
Schistosoma mansoni c4b-binding protein beta chain 0.0182 0.0463 0.0745
Echinococcus multilocularis enteropeptidase 0.0202 0.0528 0.0528
Schistosoma mansoni survival motor neuron protein 0.0115 0.026 0.0418
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0202 0.0528 0.0848
Leishmania major heat shock protein 83-1 0.1049 0.313 0.5029
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0109 0.0174
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0387 0.1096 0.1096
Brugia malayi Hsp90 protein 0.0387 0.1096 0.1762
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0003 0.0005
Leishmania major mitochondrial DNA topoisomerase II 0.0296 0.0816 0.1311
Onchocerca volvulus 0.0075 0.0137 0.0584
Loa Loa (eye worm) hypothetical protein 0.0182 0.0463 0.074
Trypanosoma brucei heat shock protein 90, putative 0.1049 0.313 0.5029
Schistosoma mansoni endoplasmin 0.1049 0.313 0.5029
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0753 0.2219 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0058 0.0084 0.0378
Echinococcus granulosus enteropeptidase 0.0202 0.0528 0.0848
Loa Loa (eye worm) hypothetical protein 0.0779 0.2299 0.3692
Brugia malayi CUB domain containing protein 0.0075 0.0137 0.022
Echinococcus multilocularis expressed conserved protein 0.0375 0.1057 0.1057
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0296 0.0816 0.3676
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0003 0.001
Echinococcus granulosus C type lectin domian containing protein 0.0182 0.0463 0.0745
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0032 0.0003 0.0005
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0058 0.0084 0.0378
Echinococcus multilocularis heat shock protein 90 0.0753 0.2219 0.2219
Schistosoma mansoni heat shock protein 0.1049 0.313 0.5029
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0202 0.0526 0.236
Loa Loa (eye worm) hypothetical protein 0.0779 0.2299 0.3692
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0528 0.0848
Echinococcus granulosus Tolloid protein 1 0.0333 0.0929 0.1492
Echinococcus multilocularis Niemann Pick C1 protein 0.057 0.1657 0.1657
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0074 0.0334
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0296 0.0816 0.3676
Loa Loa (eye worm) hypothetical protein 0.0399 0.1131 0.1814
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0032 0.0003 0.0014
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0075 0.0137 0.022
Brugia malayi Endoplasmin precursor 0.1049 0.313 0.5029
Loa Loa (eye worm) hypothetical protein 0.0202 0.0528 0.0843
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0753 0.2219 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0078 0.0144 0.0231
Onchocerca volvulus 0.0202 0.0528 0.2284
Loa Loa (eye worm) hypothetical protein 0.0075 0.0137 0.0215
Echinococcus granulosus survival motor neuron protein 1 0.0565 0.1643 0.264
Loa Loa (eye worm) glutathione reductase 0.0089 0.0178 0.0281
Schistosoma mansoni topbp1 0.0032 0.0003 0.0005
Echinococcus granulosus lamin 0.005 0.0061 0.0098
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.2056 0.6223 1
Chlamydia trachomatis DNA ligase 0.0032 0.0003 0.0039
Echinococcus granulosus expressed conserved protein 0.0375 0.1057 0.1699
Onchocerca volvulus 0.0779 0.2299 1
Echinococcus granulosus Mastin 0.0202 0.0528 0.0848
Entamoeba histolytica acyl-coA synthetase, putative 0.0078 0.0144 0.0451
Schistosoma mansoni pyruvate dehydrogenase 0.176 0.5313 0.8537
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0296 0.0816 0.354
Trichomonas vaginalis replication factor C large subunit, putative 0.0032 0.0003 0.001
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0202 0.0528 0.0528
Brugia malayi hypothetical protein 0.0182 0.0463 0.0745
Mycobacterium tuberculosis Conserved protein 0.0296 0.0816 0.3676
Loa Loa (eye worm) hypothetical protein 0.0058 0.0084 0.013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0074 0.0334
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.005 0.0061 0.0273
Chlamydia trachomatis DNA gyrase subunit B 0.0296 0.0816 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0089 0.0178 0.0286
Onchocerca volvulus Arrow homolog 0.0258 0.0697 0.3023
Echinococcus granulosus neuropeptide s receptor 0.0384 0.1086 0.1744
Echinococcus multilocularis protein dispatched 1 0.0195 0.0506 0.0506
Brugia malayi Sushi domain 0.0182 0.0463 0.0745
Mycobacterium tuberculosis Probable reductase 0.0202 0.0526 0.2371
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0094 0.0151
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0296 0.0816 0.3676
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0171 0.0432 0.0689
Plasmodium falciparum heat shock protein 90 0.1049 0.313 1
Onchocerca volvulus 0.0577 0.1677 0.7292
Brugia malayi Trypsin-like protease protein 5 0.0202 0.0528 0.0848
Giardia lamblia Grp94/Hsp90 0.0753 0.2219 0.7092
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0296 0.0816 0.3676
Echinococcus multilocularis Tolloid protein 1 0.0333 0.0929 0.0929
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0258 0.0697 0.1116
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0296 0.0816 0.2607
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0078 0.0144 0.0649
Echinococcus multilocularis transmembrane protease serine 3 0.0202 0.0528 0.0528
Chlamydia trachomatis DNA gyrase subunit B 0.0296 0.0816 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0038 0.0022 0.0031
Toxoplasma gondii calcium binding egf domain-containing protein 0.0258 0.0697 0.2228
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0089 0.0178 0.0801
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0038 0.0022 0.0036
Leishmania major 4-coumarate:coa ligase-like protein 0.0078 0.0144 0.0231
Trichomonas vaginalis heat shock protein, putative 0.0753 0.2219 0.7092
Schistosoma mansoni hypothetical protein 0.0075 0.0137 0.022
Plasmodium vivax replication factor C subunit 1, putative 0.0032 0.0003 0.001
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0296 0.0816 0.3667
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0078 0.0144 0.0649
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0078 0.0144 0.0649
Onchocerca volvulus 0.0182 0.0463 0.2004
Onchocerca volvulus 0.0182 0.0463 0.2004
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0003 0.001
Brugia malayi Lectin C-type domain containing protein 0.0075 0.0137 0.022
Onchocerca volvulus 0.0075 0.0137 0.0584
Schistosoma mansoni heat shock protein 0.1049 0.313 0.5029
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0296 0.0816 0.3676
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0296 0.0816 0.3676
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.005 0.0061 0.0097
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0038 0.0022 0.0036
Trichomonas vaginalis endoplasmin, putative 0.0684 0.2006 0.6411
Leishmania major heat shock protein 83-1 0.1049 0.313 0.5029
Loa Loa (eye worm) hypothetical protein 0.0296 0.0816 0.1307
Mycobacterium ulcerans two component regulator - sensor kinase 0.0296 0.0816 0.3676
Echinococcus granulosus heat shock protein 90 0.1049 0.313 0.5029
Echinococcus multilocularis cubilin 0.0075 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0258 0.0697 0.1116
Brugia malayi CUB domain containing protein 0.0075 0.0137 0.022
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0202 0.0526 0.2371
Loa Loa (eye worm) heat shock protein 75 0.0387 0.1096 0.1757
Plasmodium falciparum replication factor C subunit 1, putative 0.0032 0.0003 0.001
Brugia malayi kinase, mitochondrial precursor 0.2056 0.6223 1
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0296 0.0816 0.3667
Schistosoma mansoni hypothetical protein 0.0202 0.0528 0.0848
Schistosoma mansoni egf-like domain protein 0.0258 0.0697 0.1121
Entamoeba histolytica acyl-CoA synthetase, putative 0.0078 0.0144 0.0451
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0058 0.0084 0.1027
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0109 0.0174
Trypanosoma brucei heat shock protein, putative 0.1049 0.313 0.5029
Mycobacterium ulcerans aldehyde dehydrogenase 0.005 0.0061 0.0273
Brugia malayi CHE-14 protein 0.0171 0.0432 0.0694
Loa Loa (eye worm) DPY-31 protein 0.0075 0.0137 0.0215
Loa Loa (eye worm) heat shock protein 90 0.1049 0.313 0.5027
Loa Loa (eye worm) hypothetical protein 0.0202 0.0528 0.0843
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0296 0.0816 0.3676
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0094 0.0094
Onchocerca volvulus 0.0182 0.0463 0.2004
Entamoeba histolytica hypothetical protein 0.0088 0.0176 0.0551
Echinococcus granulosus cubilin 0.0075 0.0137 0.022
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0202 0.0528 0.0848
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0528 0.0848
Loa Loa (eye worm) trypsin family protein 0.0202 0.0528 0.0843
Echinococcus multilocularis sterol regulatory element binding protein 0.0171 0.0432 0.0432
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0094 0.0151
Plasmodium vivax DNA topoisomerase II, putative 0.0296 0.0816 0.2607
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0202 0.0528 0.0848
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.0075 0.0137 0.0137
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0296 0.0816 0.3676
Mycobacterium ulcerans putative regultory protein 0.0296 0.0816 0.3676
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0003 0.001
Echinococcus multilocularis heat shock protein 0.1049 0.313 0.313
Echinococcus granulosus nibrin 0.0032 0.0003 0.0005
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0032 0.0003 0.001
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0296 0.0816 0.3676
Leishmania major heat shock protein 83-1 0.1049 0.313 0.5029
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.005 0.0061 0.0061
Leishmania major heat shock protein 83-1 0.1049 0.313 0.5029
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0651 0.1907 0.3065
Brugia malayi hypothetical protein 0.0075 0.0137 0.022
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0651 0.1907 0.3065
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0038 0.0022 0.0022
Onchocerca volvulus 0.0202 0.0528 0.2284
Brugia malayi Probable DNA topoisomerase II 0.0296 0.0816 0.1311
Brugia malayi Calcium binding EGF domain containing protein 0.0075 0.0137 0.022
Loa Loa (eye worm) hypothetical protein 0.0333 0.0929 0.1488
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0528 0.0848
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0078 0.0144 0.0636
Echinococcus multilocularis lamin dm0 0.005 0.0061 0.0061
Trypanosoma brucei heat shock protein, putative 0.1049 0.313 0.5029
Brugia malayi hypothetical protein 0.0032 0.0003 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0038 0.0022 0.0036
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0075 0.0137 0.0215
Echinococcus granulosus replication factor c subunit 1 0.0032 0.0003 0.0005
Echinococcus multilocularis survival motor neuron protein 1 0.0565 0.1643 0.1643
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0528 0.0848
Plasmodium falciparum DNA gyrase subunit B 0.0296 0.0816 0.2607
Entamoeba histolytica heat shock protein 90, putative 0.1049 0.313 1
Onchocerca volvulus 0.0182 0.0463 0.2004
Loa Loa (eye worm) hypothetical protein 0.0182 0.0463 0.074
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0651 0.1907 0.3065
Mycobacterium ulcerans hypothetical protein 0.0078 0.0144 0.0649
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0296 0.0816 0.3676
Mycobacterium leprae Probable two component sensor kinase MprB 0.0296 0.0816 0.3667
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0296 0.0816 0.1311
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0202 0.0528 0.0848
Schistosoma mansoni pyruvate dehydrogenase 0.2056 0.6223 1
Onchocerca volvulus 0.0182 0.0463 0.2004
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0296 0.0816 0.3676
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0296 0.0816 0.3676
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0296 0.0816 0.2607
Brugia malayi Nematode astacin protease protein 30 0.0075 0.0137 0.022
Brugia malayi hypothetical protein 0.0088 0.0176 0.0282
Schistosoma mansoni aldehyde dehydrogenase 0.005 0.0061 0.0097
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0094 0.0151
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0224 0.0595 0.2683
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0075 0.0137 0.022
Loa Loa (eye worm) hypothetical protein 0.0202 0.0528 0.0843
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0296 0.0816 0.2607
Trypanosoma cruzi FHA domain containing protein, putative 0.0032 0.0003 0.0005
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0296 0.0816 0.2607
Schistosoma mansoni hypothetical protein 0.0075 0.0137 0.022
Trichomonas vaginalis heat shock protein, putative 0.0753 0.2219 0.7092
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0032 0.0003 0.0005
Echinococcus multilocularis protein patched 0.0171 0.0432 0.0432
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0296 0.0816 0.354
Trypanosoma cruzi trypanothione reductase, putative 0.0089 0.0178 0.0286
Loa Loa (eye worm) hypothetical protein 0.0202 0.0528 0.0843
Loa Loa (eye worm) hypothetical protein 0.0058 0.0084 0.013
Loa Loa (eye worm) CUB domain-containing protein 0.0075 0.0137 0.0215
Mycobacterium ulcerans heat shock protein 90 0.0753 0.2219 1
Loa Loa (eye worm) hypothetical protein 0.0296 0.0816 0.1307
Trypanosoma brucei developmentally regulated phosphoprotein 0.2056 0.6223 1
Brugia malayi CUB domain containing protein 0.0075 0.0137 0.022
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0075 0.0137 0.022
Trypanosoma cruzi DNA topoisomerase II, putative 0.0296 0.0816 0.1311
Echinococcus granulosus lamin dm0 0.005 0.0061 0.0098
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0296 0.0816 0.3676
Brugia malayi TAR-binding protein 0.0066 0.0109 0.0174
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0078 0.0144 0.0636
Schistosoma mansoni hypothetical protein 0.0165 0.0413 0.0663
Brugia malayi CUB domain containing protein 0.0075 0.0137 0.022
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0094 0.0146
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0202 0.0526 0.2371
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0202 0.0528 0.0848
Schistosoma mansoni heat shock protein 0.0387 0.1096 0.1762
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0296 0.0816 0.3676
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0296 0.0816 0.1311
Giardia lamblia Replication factor C, subunit 1 0.0032 0.0003 0.001
Mycobacterium ulcerans hypothetical protein 0.0202 0.0528 0.2377
Echinococcus multilocularis lamin 0.005 0.0061 0.0061
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0528 0.0848
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0296 0.0816 0.3676
Trypanosoma brucei heat shock protein, putative 0.1049 0.313 0.5029
Brugia malayi Trypsin family protein 0.0202 0.0528 0.0848
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0039 0.0025 0.0035
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0753 0.2219 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0753 0.2219 0.3567
Echinococcus granulosus CUB 0.0075 0.0137 0.022
Echinococcus granulosus endoplasmin 0.0753 0.2219 0.3567
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0948 0.2818 0.9003
Giardia lamblia Pms1-like protein 0.0296 0.0816 0.2607
Mycobacterium tuberculosis Possible two component sensor kinase 0.0296 0.0816 0.3676
Echinococcus multilocularis neuropeptide receptor A26 0.0384 0.1086 0.1086
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0296 0.0816 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0032 0.0003 0.001
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0296 0.0816 0.1311
Loa Loa (eye worm) endoplasmin 0.1049 0.313 0.5027
Brugia malayi DKFZp564C0469 protein 0.0032 0.0003 0.0005
Schistosoma mansoni topbp1 0.0032 0.0003 0.0005
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0296 0.0816 0.3676
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0651 0.1907 0.6094
Brugia malayi Intermediate filament tail domain containing protein 0.005 0.0061 0.0098
Mycobacterium ulcerans acyl-CoA synthetase 0.0078 0.0144 0.0649
Trypanosoma cruzi Heat shock protein 83, putative 0.1049 0.313 0.5029
Mycobacterium ulcerans aldehyde dehydrogenase 0.005 0.0061 0.0273
Plasmodium vivax endoplasmin, putative 0.1049 0.313 1
Brugia malayi hypothetical protein 0.0182 0.0463 0.0745
Treponema pallidum DNA ligase (lig) 0.0032 0.0003 0.0014
Brugia malayi heat shock protein 90 0.1049 0.313 0.5029
Echinococcus multilocularis Mastin 0.0202 0.0528 0.0528
Leishmania major 4-coumarate:coa ligase-like protein 0.0078 0.0144 0.0231
Trypanosoma brucei heat shock protein, putative 0.1049 0.313 0.5029
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0078 0.0144 0.0649
Toxoplasma gondii DNA topoisomerase 2, putative 0.0296 0.0816 0.2607
Brugia malayi jmjC domain containing protein 0.0061 0.0094 0.0151
Loa Loa (eye worm) hypothetical protein 0.0182 0.0463 0.074
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0528 0.0848
Loa Loa (eye worm) hypothetical protein 0.0075 0.0137 0.0215
Plasmodium falciparum thioredoxin reductase 0.0089 0.0178 0.0568
Schistosoma mansoni hypothetical protein 0.0075 0.0137 0.022
Loa Loa (eye worm) hypothetical protein 0.005 0.0061 0.0093
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0038 0.0022 0.0036
Leishmania major heat shock protein 83-1 0.1049 0.313 0.5029
Onchocerca volvulus 0.005 0.0061 0.0251
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0075 0.0137 0.0215
Onchocerca volvulus 0.0182 0.0463 0.2004
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0202 0.0526 0.2371
Echinococcus granulosus transmembrane protease serine 3 0.0202 0.0528 0.0848
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0003 0.001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.005 0.0061 0.0093
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0854 0.2531 0.4067
Leishmania major heat shock protein 83-1 0.1049 0.313 0.5029
Echinococcus multilocularis fibrillin 1 0.0258 0.0697 0.0697
Loa Loa (eye worm) hypothetical protein 0.0182 0.0463 0.074
Loa Loa (eye worm) hypothetical protein 0.0258 0.0697 0.1116
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0109 0.0174
Mycobacterium ulcerans acyl-CoA synthetase 0.0078 0.0144 0.0649
Brugia malayi astacin protease protein 30 0.0075 0.0137 0.022
Echinococcus multilocularis C type lectin domian containing protein 0.0182 0.0463 0.0463
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0387 0.1096 0.3496
Loa Loa (eye worm) CUB domain-containing protein 0.0075 0.0137 0.0215
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0296 0.0816 0.354
Loa Loa (eye worm) hypothetical protein 0.0075 0.0137 0.0215
Echinococcus granulosus microtubule associated protein 2 0.0573 0.1666 0.2678
Loa Loa (eye worm) hypothetical protein 0.0039 0.0025 0.0035
Echinococcus granulosus c4b binding protein beta chain 0.0182 0.0463 0.0745
Brugia malayi Trypsin family protein 0.0779 0.2299 0.3695
Toxoplasma gondii thioredoxin reductase 0.0089 0.0178 0.0568
Echinococcus multilocularis thioredoxin glutathione reductase 0.0089 0.0178 0.0178
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0278 0.0759 0.122
Leishmania major heat shock protein 83-1 0.1049 0.313 0.5029
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0224 0.0595 0.2683
Mycobacterium tuberculosis Probable dehydrogenase 0.0202 0.0526 0.2371
Onchocerca volvulus 0.0182 0.0463 0.2004
Onchocerca volvulus 0.0182 0.0463 0.2004
Loa Loa (eye worm) hypothetical protein 0.0182 0.0463 0.074
Entamoeba histolytica acyl-CoA synthetase, putative 0.0078 0.0144 0.0451
Plasmodium vivax heat shock protein, putative 0.0387 0.1096 0.3503
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0333 0.0929 0.1492
Entamoeba histolytica heat shock protein 90, putative 0.1049 0.313 1
Plasmodium vivax apical sushi protein, putative 0.0182 0.0463 0.1481
Trichomonas vaginalis heat shock protein, putative 0.0387 0.1096 0.3503
Toxoplasma gondii rhoptry neck protein RON1 0.0182 0.0463 0.1481
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0109 0.0174
Loa Loa (eye worm) hypothetical protein 0.0171 0.0432 0.0689
Loa Loa (eye worm) hypothetical protein 0.0258 0.0697 0.1116
Schistosoma mansoni microtubule-associated protein tau 0.0573 0.1666 0.2678
Brugia malayi CUB domain containing protein 0.0075 0.0137 0.022
Echinococcus multilocularis nibrin 0.0032 0.0003 0.0003
Giardia lamblia Heat shock protein HSP 90-alpha 0.0753 0.2219 0.7092
Loa Loa (eye worm) hypothetical protein 0.0182 0.0463 0.074
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0109 0.0169
Plasmodium falciparum apical sushi protein 0.0182 0.0463 0.1481
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0202 0.0526 0.2371
Schistosoma mansoni hypothetical protein 0.0165 0.0413 0.0663
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0075 0.0137 0.022
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0075 0.0137 0.022
Trypanosoma cruzi heat shock protein 85, putative 0.1049 0.313 0.5029
Toxoplasma gondii heat shock protein 75, putative 0.0387 0.1096 0.3503
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0039 0.0025 0.0041
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.005 0.0061 0.0097
Brugia malayi hypothetical protein 0.0182 0.0463 0.0745
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0296 0.0816 0.1311
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0296 0.0816 0.0816
Trypanosoma brucei heat shock protein 90, putative 0.1049 0.313 0.5029
Brugia malayi hypothetical protein 0.0182 0.0463 0.0745
Treponema pallidum heat shock protein 90 0.0753 0.2219 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0399 0.1131 0.1818
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0296 0.0816 0.3676
Trypanosoma cruzi heat shock protein 90, putative 0.0753 0.2219 0.3567
Trichomonas vaginalis heat shock protein, putative 0.0684 0.2006 0.6411
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0032 0.0003 0.0014
Plasmodium falciparum glutathione reductase 0.0089 0.0178 0.0568
Loa Loa (eye worm) hypothetical protein 0.005 0.0058 0.0088
Loa Loa (eye worm) hypothetical protein 0.0058 0.0084 0.013
Echinococcus multilocularis c4b binding protein beta chain 0.0182 0.0463 0.0463
Echinococcus granulosus Protein patched homolog 1 0.0171 0.0432 0.0694
Echinococcus granulosus neuropeptide receptor A26 0.0384 0.1086 0.1744
Loa Loa (eye worm) hypothetical protein 0.0075 0.0137 0.0215
Trypanosoma brucei heat shock protein, putative 0.1049 0.313 0.5029
Trichomonas vaginalis heat shock protein, putative 0.0753 0.2219 0.7092
Brugia malayi Calcium binding EGF domain containing protein 0.0258 0.0697 0.1121
Schistosoma mansoni hypothetical protein 0.0165 0.0413 0.0663
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0528 0.0848
Echinococcus multilocularis cubilin 0.0075 0.0137 0.0137
Brugia malayi Nematode astacin protease protein 30 0.0075 0.0137 0.022
Loa Loa (eye worm) hypothetical protein 0.0058 0.0084 0.013
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0528 0.0848
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0528 0.0848
Loa Loa (eye worm) hypothetical protein 0.0078 0.0144 0.0226
Echinococcus granulosus laminin 0.0258 0.0697 0.1121
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0202 0.0528 0.0848
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0296 0.0816 0.3676
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0094 0.0094
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0032 0.0003 0.0005
Onchocerca volvulus 0.0202 0.0528 0.2284
Trypanosoma brucei heat shock protein, putative 0.1049 0.313 0.5029
Loa Loa (eye worm) hypothetical protein 0.0182 0.0463 0.074
Plasmodium vivax heat shock protein 90, putative 0.0387 0.1096 0.3503
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0003 0.001
Schistosoma mansoni patched 1 0.0171 0.0432 0.0694
Onchocerca volvulus 0.005 0.0061 0.0251
Entamoeba histolytica DNA topoisomerase II, putative 0.0296 0.0816 0.26
Brugia malayi hypothetical protein 0.0182 0.0463 0.0745
Echinococcus multilocularis Niemann Pick C1 protein 0.0399 0.1131 0.1131
Onchocerca volvulus 0.0202 0.0528 0.2284
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0003 0.0005
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0387 0.1096 0.476
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0387 0.1096 0.1762
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0075 0.0137 0.022
Echinococcus granulosus glycoprotein Antigen 5 0.0202 0.0528 0.0848
Toxoplasma gondii Hsp90 domain-containing protein 0.0387 0.1096 0.3503
Loa Loa (eye worm) hypothetical protein 0.2056 0.6223 1
Leishmania major hypothetical protein, conserved 0.0296 0.0816 0.1311
Schistosoma mansoni intermediate filament proteins 0.005 0.0061 0.0098
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0753 0.2219 0.3567
Loa Loa (eye worm) hypothetical protein 0.0565 0.1643 0.2636
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0405 0.115 0.1848
Toxoplasma gondii aldehyde dehydrogenase 0.005 0.0061 0.0194
Leishmania major heat shock protein 83-1 0.1049 0.313 0.5029
Onchocerca volvulus Putative cubilin 0.0075 0.0137 0.0584
Schistosoma mansoni aldehyde dehydrogenase 0.005 0.0061 0.0097
Entamoeba histolytica hypothetical protein 0.0088 0.0176 0.0551
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0032 0.0003 0.001
Brugia malayi Fibulin-1 precursor 0.0258 0.0697 0.1121
Leishmania major heat shock protein 83-1 0.1049 0.313 0.5029
Trypanosoma brucei trypanothione reductase 0.0089 0.0178 0.0286
Schistosoma mansoni chromosome transmission fidelity factor 0.0032 0.0003 0.0005
Brugia malayi RNA binding protein 0.0066 0.0109 0.0174
Onchocerca volvulus 0.0075 0.0137 0.0584
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0779 0.2299 0.3695
Trichomonas vaginalis DNA topoisomerase II, putative 0.0296 0.0816 0.2607
Brugia malayi Pax transcription activation domain interacting protein 0.0032 0.0003 0.0005
Leishmania major heat shock protein 83-1 0.1049 0.313 0.5029
Echinococcus multilocularis replication factor c subunit 1 0.0032 0.0003 0.0003
Trypanosoma cruzi heat shock protein 85, putative 0.1049 0.313 0.5029
Brugia malayi hypothetical protein 0.0182 0.0463 0.0745
Onchocerca volvulus 0.0182 0.0463 0.2004
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0296 0.0816 0.3676
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0038 0.0022 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0038 0.0022 0.0036
Mycobacterium ulcerans aldehyde dehydrogenase 0.005 0.0061 0.0273
Schistosoma mansoni pyruvate dehydrogenase 0.176 0.5313 0.8537
Schistosoma mansoni DNA topoisomerase II 0.0296 0.0816 0.1311
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0109 0.0169
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0032 0.0003 0.001
Plasmodium falciparum heat shock protein 90, putative 0.0387 0.1096 0.3503
Loa Loa (eye worm) hypothetical protein 0.0075 0.0137 0.0215
Leishmania major developmentally regulated phosphoprotein-like protein 0.2056 0.6223 1
Trypanosoma brucei heat shock protein, putative 0.1049 0.313 0.5029
Onchocerca volvulus 0.0202 0.0528 0.2284
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0296 0.0816 0.3676
Brugia malayi Trypsin family protein 0.0202 0.0528 0.0848
Toxoplasma gondii heat shock protein 90, putative 0.1049 0.313 1
Leishmania major heat shock protein, putative 0.0387 0.1096 0.1762
Loa Loa (eye worm) hypothetical protein 0.0182 0.0463 0.074
Loa Loa (eye worm) hypothetical protein 0.0075 0.0137 0.0215
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0075 0.0137 0.0215
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0528 0.0848
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0074 0.0334
Loa Loa (eye worm) RNA binding protein 0.0066 0.0109 0.0169
Echinococcus granulosus neuropilin nrp and tolloid tll 0.0075 0.0137 0.022
Trypanosoma cruzi heat shock protein 85, putative 0.0753 0.2219 0.3567
Schistosoma mansoni transcription factor LCR-F1 0.0088 0.0176 0.0282
Echinococcus multilocularis microtubule associated protein 2 0.0573 0.1666 0.1666
Brugia malayi hypothetical protein 0.0182 0.0463 0.0745
Echinococcus granulosus intermediate filament protein 0.005 0.0061 0.0098
Brugia malayi topoisomerase 0.0032 0.0003 0.0005
Echinococcus granulosus sterol regulatory element binding protein 0.0171 0.0432 0.0694
Onchocerca volvulus 0.0078 0.0144 0.0613
Echinococcus granulosus heat shock protein 0.1049 0.313 0.5029
Entamoeba histolytica hypothetical protein 0.0088 0.0176 0.0551
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0296 0.0816 0.3676
Loa Loa (eye worm) hypothetical protein 0.021 0.055 0.0879
Brugia malayi Trypsin family protein 0.0202 0.0528 0.0848
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0296 0.0816 0.2607
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0115 0.026 0.0418
Schistosoma mansoni hypothetical protein 0.0088 0.0176 0.0282
Toxoplasma gondii heat shock protein HSP90 0.1049 0.313 1
Echinococcus granulosus Niemann Pick C1 protein 0.0399 0.1131 0.1818
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0032 0.0003 0.0000011069
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0109 0.0109
Trichomonas vaginalis receptor histidine kinase, putative 0.0296 0.0816 0.2607
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0088 0.0176 0.0176
Schistosoma mansoni DNA ligase IV 0.0032 0.0003 0.0005
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0094 0.0151
Schistosoma mansoni cercarial elastase (S01 family) 0.0202 0.0528 0.0848
Brugia malayi Kelch motif family protein 0.0075 0.0137 0.022
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0296 0.0816 0.1311
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0296 0.0816 0.1311
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0224 0.0595 0.2672
Schistosoma mansoni hypothetical protein 0.0075 0.0137 0.022
Schistosoma mansoni hypothetical protein 0.0165 0.0413 0.0663
Echinococcus granulosus Niemann Pick C1 protein 0.057 0.1657 0.2663
Mycobacterium ulcerans two component sensor kinase MprB 0.0296 0.0816 0.3676
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0296 0.0816 0.1311
Echinococcus granulosus cubilin 0.0075 0.0137 0.022
Giardia lamblia Heat shock protein HSP 90-alpha 0.1049 0.313 1
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0296 0.0816 0.3676
Plasmodium falciparum heat shock protein 90, putative 0.0387 0.1096 0.3503
Leishmania major heat shock protein 83-1 0.1049 0.313 0.5029
Schistosoma mansoni lamin 0.005 0.0061 0.0098
Schistosoma mansoni lamin 0.005 0.0061 0.0098
Trypanosoma cruzi heat shock protein 90, putative 0.1049 0.313 0.5029
Echinococcus granulosus heat shock protein 90 0.0753 0.2219 0.3567
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0296 0.0816 0.2607
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0296 0.0816 0.2607
Leishmania major heat shock protein 83-1 0.1049 0.313 0.5029
Leishmania major heat shock protein 83-1 0.1049 0.313 0.5029
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0078 0.0144 0.0649
Trichomonas vaginalis receptor histidine kinase, putative 0.0296 0.0816 0.2607
Loa Loa (eye worm) hypothetical protein 0.0078 0.0144 0.0226
Brugia malayi Calcitonin receptor-like protein seb-1 0.0039 0.0025 0.0041
Echinococcus multilocularis neuropeptide s receptor 0.0384 0.1086 0.1086
Plasmodium vivax thioredoxin reductase, putative 0.0089 0.0178 0.0568
Brugia malayi hypothetical protein 0.0202 0.0528 0.0848
Loa Loa (eye worm) hypothetical protein 0.0202 0.0528 0.0843
Plasmodium vivax DNA gyrase subunit B, putative 0.0296 0.0816 0.2607
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0399 0.1131 0.3608
Plasmodium vivax hypothetical protein, conserved 0.0296 0.0816 0.2607
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0109 0.0174
Trypanosoma brucei Heat shock protein 83, putative 0.1049 0.313 0.5029
Entamoeba histolytica hypothetical protein 0.0088 0.0176 0.0551
Leishmania major heat shock protein 83-1 0.1049 0.313 0.5029
Leishmania major heat shock protein 83-1 0.1049 0.313 0.5029
Brugia malayi GCC2 and GCC3 family protein 0.0182 0.0463 0.0745
Brugia malayi intermediate filament protein 0.005 0.0061 0.0098
Mycobacterium ulcerans DNA gyrase subunit B 0.0296 0.0816 0.3676
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0296 0.0816 0.2607
Onchocerca volvulus 0.0115 0.026 0.1119
Trichomonas vaginalis sensor histidine kinase, putative 0.0296 0.0816 0.2607
Onchocerca volvulus 0.0182 0.0463 0.2004
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0296 0.0816 0.1311
Loa Loa (eye worm) hypothetical protein 0.0075 0.0137 0.0215
Brugia malayi jmjC domain containing protein 0.0061 0.0094 0.0151

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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