Detailed information for compound 829053

Basic information

Technical information
  • TDR Targets ID: 829053
  • Name: ethyl 4-[[5-chloro-2-[(2-methylphenyl)methyls ulfanyl]pyrimidine-4-carbonyl]amino]benzoate
  • MW: 441.931 | Formula: C22H20ClN3O3S
  • H donors: 1 H acceptors: 4 LogP: 4.92 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc(cc1)NC(=O)c1nc(ncc1Cl)SCc1ccccc1C
  • InChi: 1S/C22H20ClN3O3S/c1-3-29-21(28)15-8-10-17(11-9-15)25-20(27)19-18(23)12-24-22(26-19)30-13-16-7-5-4-6-14(16)2/h4-12H,3,13H2,1-2H3,(H,25,27)
  • InChiKey: KSNWNDWJMDODAG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[[5-chloro-2-[(2-methylphenyl)methylthio]-4-pyrimidinyl]-oxomethyl]amino]benzoic acid ethyl ester
  • 4-[[5-chloro-2-[(2-methylbenzyl)thio]pyrimidine-4-carbonyl]amino]benzoic acid ethyl ester
  • ethyl 4-[[5-chloro-2-[(2-methylphenyl)methylsulfanyl]pyrimidin-4-yl]carbonylamino]benzoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii subtilisin SUB10 0.0104 0.0306 0.0366
Brugia malayi aspartic protease BmAsp-2, identical 0.0064 0.0148 0.0596
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0066 0.0157 0.1098
Echinococcus granulosus tyrosine kinase 0.0037 0.004 0.0062
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Loa Loa (eye worm) hypothetical protein 0.01 0.0291 0.1173
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.0064 0.0196
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0616 0.373
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0306 0.1731
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.01 0.0291 0.1319
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0038 0.0063
Loa Loa (eye worm) TK protein kinase 0.0037 0.004 0.0162
Trypanosoma cruzi N-myristoyl transferase, putative 0.0179 0.06 0.5177
Schistosoma mansoni tyrosine kinase 0.0166 0.0548 0.0512
Trypanosoma brucei N-myristoyltransferase 0.0179 0.06 0.5177
Onchocerca volvulus 0.0064 0.0148 0.1903
Trypanosoma brucei N-myristoyl transferase, putative 0.0179 0.06 0.5177
Echinococcus multilocularis epidermal growth factor receptor 0.0166 0.0548 0.2595
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0066 0.0157 0.1098
Onchocerca volvulus 0.0122 0.0377 0.5868
Echinococcus granulosus tyrosine protein kinase Lyn 0.0043 0.0064 0.0161
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0112 0.0335 0.1918
Echinococcus granulosus membrane bound transcription factor site 1 0.0104 0.0306 0.1145
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.01 0.0291 0.1632
Leishmania major N-myristoyl transferase, putative 0.0179 0.06 0.5177
Loa Loa (eye worm) hypothetical protein 0.0226 0.0787 0.3172
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0312 0.1123 0.2254
Trypanosoma cruzi N-myristoyl transferase, putative 0.0179 0.06 0.5177
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0104 0.0306 0.1395
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.0064 0.0196
Brugia malayi aspartic protease BmAsp-1, identical 0.0064 0.0148 0.0596
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.028 0.0999 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0043 0.0064 0.0196
Brugia malayi Peptidase family M1 containing protein 0.0122 0.0377 0.1521
Plasmodium vivax glycylpeptide N-tetradecanoyltransferase, putative 0.0179 0.06 0.1044
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Echinococcus granulosus epidermal growth factor receptor 0.0166 0.0548 0.2131
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0086 0.0234 0.1813
Echinococcus multilocularis 0.0095 0.0269 0.1212
Plasmodium vivax subtilisin-like protease 2, putative 0.0104 0.0306 0.0366
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0279 0.0994 0.4008
Plasmodium vivax plasmepsin IV, putative 0.01 0.0291 0.0331
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.043 0.1589 1
Loa Loa (eye worm) hypothetical protein 0.0656 0.248 1
Plasmodium falciparum plasmepsin VI 0.01 0.0291 0.0331
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0216 0.0745 0.4562
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0616 0.373
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0066 0.0157 0.1098
Echinococcus granulosus tyrosine protein kinase Blk 0.0037 0.004 0.0062
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0312 0.1123 1
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0066 0.0157 0.1098
Trichomonas vaginalis N-myristoyl transferase, putative 0.0117 0.0358 0.2066
Echinococcus multilocularis membrane bound transcription factor site 1 0.0104 0.0306 0.1395
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0064 0.0148 0.0111
Loa Loa (eye worm) aminopeptidase N 0.0036 0.0038 0.0152
Loa Loa (eye worm) hypothetical protein 0.0104 0.0306 0.1235
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0104 0.0306 0.2474
Loa Loa (eye worm) hypothetical protein 0.0045 0.0074 0.0298
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Brugia malayi proprotein convertase 2 0.0442 0.1636 0.6597
Brugia malayi Guanylate kinase family protein 0.003 0.0013 0.0053
Brugia malayi Furin-like cysteine rich region family protein 0.0307 0.1106 0.446
Entamoeba histolytica glycylpeptide N-tetradecanoyltransferase, putative 0.0179 0.06 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0064 0.0148 0.0111
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0104 0.0306 0.2924
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0104 0.0306 0.2924
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0616 0.373
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0312 0.1123 0.5448
Toxoplasma gondii subtilisin SUB5 0.0104 0.0306 0.0366
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0038 0.0063
Loa Loa (eye worm) hypothetical protein 0.0086 0.0236 0.095
Schistosoma mansoni tyrosine kinase 0.0163 0.0537 0.0501
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0306 0.1731
Onchocerca volvulus 0.0064 0.0148 0.1903
Schistosoma mansoni lipoxygenase 0.0089 0.0246 0.021
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0312 0.1123 0.2254
Brugia malayi Eukaryotic aspartyl protease family protein 0.0064 0.0148 0.0596
Echinococcus multilocularis aminopeptidase N 0.0122 0.0377 0.1748
Loa Loa (eye worm) reprolysin 0.0045 0.0074 0.0298
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0066 0.0157 0.0021
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.0064 0.0196
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0038 0.0052
Brugia malayi endoprotease bli-4 precursor 0.0656 0.248 1
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0066 0.0157 0.1098
Echinococcus granulosus Furin 1 0.0216 0.0745 0.2935
Giardia lamblia High cysteine membrane protein Group 2 0.0214 0.074 1
Loa Loa (eye worm) proprotein convertase 2 0.0216 0.0745 0.3006
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0335 0.1918
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.043 0.1589 0.6372
Echinococcus granulosus insulin receptor 0.0099 0.0286 0.1061
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.009 0.0365
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.0994 0.6163
Brugia malayi Subtilase family protein 0.0104 0.0306 0.1235
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0655 0.398
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0043 0.0064 0.0161
Trichomonas vaginalis glucosylceramidase, putative 0.0193 0.0655 0.398
Loa Loa (eye worm) TK/EGFR protein kinase 0.0307 0.1106 0.446
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Schistosoma mansoni furin-1 (S08 family) 0.033 0.1197 0.1164
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.028 0.0999 1
Loa Loa (eye worm) peptidase family M1 containing protein 0.0099 0.0285 0.1151
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.009 0.0325
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0216 0.0745 0.4562
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0064 0.0148 0.0111
Trichomonas vaginalis N-myristoyl transferase, putative 0.0179 0.06 0.3621
Giardia lamblia CDC72 0.0179 0.06 0.6533
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0306 0.1731
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0066 0.0157 0.1098
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0104 0.0306 0.2924
Mycobacterium ulcerans aminopeptidase N PepN 0.0036 0.0038 0.0182
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0064 0.0148 0.0111
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0312 0.1123 0.4529
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0066 0.0157 0.012
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0066 0.0157 0.1399
Trypanosoma brucei subtilisin peptidase 0.0104 0.0306 0.2474
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0101 0.0293 0.2785
Brugia malayi Pepsin A precursor 0.0064 0.0148 0.0596
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0036 0.0038 0.0063
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0112 0.0335 0.1918
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0104 0.0306 0.1235
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0038 0.0063
Echinococcus granulosus tyrosine protein kinase Src64B 0.0043 0.0064 0.0161
Schistosoma mansoni tyrosine kinase 0.0099 0.0286 0.0249
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0043 0.0064 0.0196
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0064 0.0148 0.0111
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.009 0.0267
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0043 0.0064 0.0196
Plasmodium falciparum plasmepsin IV 0.01 0.0291 0.0331
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.009 0.0053
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0038 0.0063
Plasmodium falciparum subtilisin-like protease 1 0.1163 0.4476 1
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0064 0.0148 0.0596
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0656 0.248 0.2452
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0216 0.0745 0.4562
Plasmodium vivax subtilisin-like protease 1 0.1163 0.4476 1
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0059 0.0129 0.0091
Echinococcus multilocularis neuroendocrine convertase 2 0.0442 0.1636 0.7993
Toxoplasma gondii subtilisin SUB8 0.0104 0.0306 0.0366
Mycobacterium leprae Possible secreted protease 0.0104 0.0306 0.2924
Echinococcus granulosus tyrosine protein kinase Fyn 0.0043 0.0064 0.0161
Echinococcus granulosus tyrosine protein kinase Fyn 0.0043 0.0064 0.0161
Loa Loa (eye worm) hypothetical protein 0.0064 0.0148 0.0596
Schistosoma mansoni lipoxygenase 0.0127 0.0397 0.0361
Echinococcus granulosus furin 0.0656 0.248 1
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0066 0.0157 0.0021
Brugia malayi ribonucleotide reductase 2 0.0066 0.0157 0.0632
Echinococcus granulosus epidermal growth factor receptor 0.0307 0.1106 0.4403
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.0994 0.6163
Loa Loa (eye worm) endoprotease bli-4 0.0656 0.248 1
Plasmodium falciparum glycylpeptide N-tetradecanoyltransferase 0.0179 0.06 0.1044
Echinococcus multilocularis epidermal growth factor receptor 0.0307 0.1106 0.5363
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0312 0.1123 1
Toxoplasma gondii subtilisin SUB1 0.1163 0.4476 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0038 0.0052
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.028 0.0999 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0312 0.1123 0.4473
Schistosoma mansoni tyrosine kinase 0.0043 0.0064 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0335 0.1918
Leishmania major subtilisin-like serine peptidase 0.0104 0.0306 0.2474
Toxoplasma gondii subtilisin SUB4 0.0104 0.0306 0.0366
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.01 0.0291 0.0331
Schistosoma mansoni site-1 peptidase (S08 family) 0.0104 0.0306 0.027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0216 0.0745 0.4562
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0043 0.0064 0.0196
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0043 0.0064 0.0161
Loa Loa (eye worm) aspartyl protease 6 0.0064 0.0148 0.0596
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0312 0.1123 0.2254
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0166 0.0548 0.2131
Brugia malayi neuroendocrine convertase 1 precursor 0.0442 0.1636 0.6597
Schistosoma mansoni tyrosine kinase 0.0043 0.0064 0.0027
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0037 0.004 0.0062
Schistosoma mansoni tyrosine kinase 0.0163 0.0537 0.0501
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0312 0.1123 1
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0335 0.1918
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0216 0.0745 0.071
Brugia malayi hypothetical protein 0.0036 0.0038 0.0152
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0064 0.0148 0.0111
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0038 0.0063
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0104 0.0306 0.2474
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0104 0.0306 0.027
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0466 0.1733 0.1702
Trichomonas vaginalis hypothetical protein 0.0112 0.0335 0.1918
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.009 0.0267
Echinococcus granulosus tyrosine protein kinase Src42A 0.0034 0.0029 0.0017
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0104 0.0306 0.2924
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.028 0.0999 0.6197
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0104 0.0306 0.2474
Toxoplasma gondii subtilisin SUB7 0.0104 0.0306 0.0366
Loa Loa (eye worm) SRC-1 0.0043 0.0064 0.026
Echinococcus granulosus neuroendocrine convertase 2 0.0442 0.1636 0.6563
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Brugia malayi hypothetical protein 0.0064 0.0148 0.0596
Toxoplasma gondii subtilisin SUB2 0.0104 0.0306 0.0366
Brugia malayi celfurPC protein 0.0545 0.2041 0.8229
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit beta 0.0066 0.0157 0.1242
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0335 0.1918
Toxoplasma gondii subtilisin SUB9 0.0104 0.0306 0.0366
Brugia malayi SRC-1 0.0043 0.0064 0.026
Plasmodium vivax subtilisin-like serine protease, putative 0.0104 0.0306 0.0366
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Schistosoma mansoni tyrosine kinase 0.0307 0.1106 0.1072
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0335 0.1918
Loa Loa (eye worm) hypothetical protein 0.011 0.0327 0.132
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Plasmodium falciparum subtilisin-like protease 2 0.0104 0.0306 0.0366
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0616 0.373
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Brugia malayi Reprolysin 0.0026 0 0.0001
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0066 0.0157 0.0632
Schistosoma mansoni tyrosine kinase 0.0163 0.0537 0.0501
Echinococcus granulosus adam 0.0059 0.0129 0.0423
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0127 0.0397 0.1847
Toxoplasma gondii subtilisin SUB12 0.0104 0.0306 0.0366
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.0994 0.6163
Loa Loa (eye worm) aspartic protease BmAsp-2 0.01 0.0291 0.1173
Brugia malayi N-myristoyltransferase 2 0.0179 0.06 0.2418
Echinococcus multilocularis insulin receptor 0.0099 0.0286 0.1293
Loa Loa (eye worm) TK/INSR protein kinase 0.0099 0.0286 0.1151
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Plasmodium falciparum subtilisin-like protease 3 0.0104 0.0306 0.0366
Brugia malayi hypothetical protein 0.0064 0.0148 0.0596
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0616 0.373
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0216 0.0745 0.4562
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0335 0.1918
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0104 0.0306 0.2924
Echinococcus multilocularis tyrosine protein kinase Blk 0.0037 0.004 0.0075
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0312 0.1123 0.4529
Toxoplasma gondii aspartyl protease ASP1 0.01 0.0291 0.0331
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0335 0.1918
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.0994 0.6163
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0104 0.0306 0.027
Brugia malayi Peptidase family M1 containing protein 0.0036 0.0038 0.0152
Echinococcus multilocularis adam 0.0059 0.0129 0.0515
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0038 0.0052
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0099 0.0286 0.1293
Echinococcus granulosus aminopeptidase N 0.0122 0.0377 0.1435
Loa Loa (eye worm) hypothetical protein 0.0064 0.0148 0.0596
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0616 0.373
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0306 0.1731
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0335 0.1918
Schistosoma mansoni N-myristoyltransferase 0.0179 0.06 0.0564
Schistosoma mansoni hypothetical protein 0.0112 0.0335 0.0299
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0066 0.0157 0.0654
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0104 0.0306 0.2924
Echinococcus granulosus tyrosine protein kinase Fyn 0.0043 0.0064 0.0161
Onchocerca volvulus Glucosylceramidase homolog 0.0183 0.0616 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0038 0.0052
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.028 0.0999 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0043 0.0064 0.0161
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0104 0.0306 0.2924
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0066 0.0157 0.0021
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.01 0.0291 0.0254
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0066 0.0157 0.1098
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.0616 0.373
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0066 0.0157 0.1098
Loa Loa (eye worm) N-myristoyltransferase 2 0.0179 0.06 0.2418
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0104 0.0306 0.2924
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0335 0.1918
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0045 0.0074 0.0243
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0112 0.0335 0.1918
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0045 0.0074 0.0036
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0045 0.0074 0.0036
Toxoplasma gondii subtilisin SUB11 0.0104 0.0306 0.0366
Onchocerca volvulus 0.0104 0.0306 0.464
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0306 0.1731
Plasmodium falciparum plasmepsin I 0.01 0.0291 0.0331
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.004 0.0075
Schistosoma mansoni cathepsin D (A01 family) 0.0193 0.0656 0.0621
Schistosoma mansoni cathepsin D (A01 family) 0.0193 0.0656 0.0621
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0312 0.1123 0.109
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.0994 0.6163
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0066 0.0157 0.0537
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0045 0.0074 0.0199
Brugia malayi hypothetical protein 0.0059 0.0129 0.0519
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0099 0.0286 0.1061
Echinococcus multilocularis tyrosine protein kinase Srms 0.0037 0.004 0.0075
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0312 0.1123 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0064 0.0148 0.0111
Schistosoma mansoni memapsin-2 (A01 family) 0.1323 0.5106 0.5087
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0104 0.0306 0.1145
Entamoeba histolytica aminopeptidase, putative 0.0036 0.0038 0.0221
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.0994 0.6163
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.043 0.1589 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.009 0.0365
Loa Loa (eye worm) TK protein kinase 0.0033 0.0025 0.0101
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.043 0.1589 0.776
Plasmodium vivax aspartyl proteinase, putative 0.01 0.0291 0.0331
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Echinococcus multilocularis 0.0545 0.2041 1
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0066 0.0157 0.1399
Schistosoma mansoni tyrosine kinase 0.0166 0.0548 0.0512
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.009 0.0053
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Loa Loa (eye worm) subtilase 0.0104 0.0306 0.1235
Brugia malayi Protein kinase domain containing protein 0.0099 0.0286 0.1151
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0279 0.0994 0.4008
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0312 0.1123 1
Schistosoma mansoni site-1 peptidase (S08 family) 0.0104 0.0306 0.027
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0034 0.0029 0.002
Toxoplasma gondii subtilisin SUB6 0.0104 0.0306 0.0366
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.01 0.0291 0.1083
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0104 0.0306 0.2474
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0335 0.1918
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0104 0.0306 0.1731
Brugia malayi protein-tyrosine kinase 0.0037 0.004 0.0162
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0104 0.0306 0.2924
Plasmodium falciparum plasmepsin II 0.01 0.0291 0.0331
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0043 0.0064 0.0196
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.009 0.0053
Schistosoma mansoni tyrosine kinase 0.0099 0.0286 0.0249
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.009 0.0325
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0043 0.0064 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0335 0.1918
Trypanosoma cruzi subtilisin peptidase 0.0104 0.0306 0.2474
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0216 0.0745 0.4562
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0127 0.0397 0.1517
Echinococcus multilocularis glycylpeptide N tetradecanoyltransferase 0.0179 0.06 0.285
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0064 0.0148 0.0111
Echinococcus multilocularis Furin 1 0.0216 0.0745 0.3574
Echinococcus granulosus glycylpeptide N tetradecanoyltransferase 0.0179 0.06 0.234
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0104 0.0306 0.1235

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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