Detailed information for compound 830961

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 433.859 | Formula: C20H14ClF2N3O2S
  • H donors: 2 H acceptors: 4 LogP: 4.28 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1Nc2nc(SCc3ccccc3Cl)nc(c2C(C1)c1ccc(cc1F)F)O
  • InChi: 1S/C20H14ClF2N3O2S/c21-14-4-2-1-3-10(14)9-29-20-25-18-17(19(28)26-20)13(8-16(27)24-18)12-6-5-11(22)7-15(12)23/h1-7,13H,8-9H2,(H2,24,25,26,27,28)
  • InChiKey: AKXJWNCHUIKBEI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.003 0.0059
Schistosoma mansoni histone deacetylase hda2 0.0042 0.0256 0.0228
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0075 0.1268
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0013 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0013 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0095 0.0655 0.0655
Giardia lamblia Cysteine protease 0.0095 0.0655 0.1765
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.0655 0.0628
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0095 0.0655 0.0628
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0075 0.0184
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1319 1 1
Echinococcus granulosus cathepsin l1 0.0244 0.1794 0.1794
Onchocerca volvulus 0.0036 0.0207 0.1009
Brugia malayi Cathepsin L-like cysteine proteinase 0.0244 0.1794 0.177
Trypanosoma cruzi cysteine peptidase, putative 0.0244 0.1794 0.1786
Echinococcus multilocularis cysteine protease 0.0244 0.1794 0.1794
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0392 0.1082
Echinococcus granulosus acylamino acid releasing enzyme 0.0014 0.0035 0.0035
Entamoeba histolytica cysteine protease, putative 0.0095 0.0655 0.3522
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0067 0.0038
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0095 0.0655 0.3547
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0244 0.1794 0.5047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.027 0.027
Brugia malayi Trypsin family protein 0.0018 0.0067 0.0038
Loa Loa (eye worm) trypsin family protein 0.0018 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0244 0.1794 0.1794
Echinococcus granulosus glycoprotein Antigen 5 0.0018 0.0067 0.0067
Leishmania major cathepsin L-like protease 0.0244 0.1794 0.5047
Plasmodium falciparum serine repeat antigen 8 0.0095 0.0655 0.3547
Plasmodium vivax vivapain-1 0.0095 0.0655 0.3547
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0067 0.0038
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0075 0.0184
Loa Loa (eye worm) hypothetical protein 0.0018 0.0067 0.0067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0244 0.1794 0.5047
Trypanosoma cruzi histone deacetylase, putative 0.0042 0.0256 0.0247
Plasmodium vivax unspecified product 0.0095 0.0655 0.3547
Leishmania major oligopeptidase b 0.0014 0.0035 0.0073
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0014 0.0035 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0067 0.0067
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0067 0.0038
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0014 0.0035 0.0073
Trypanosoma brucei Aminopeptidase M1, putative 0.0036 0.0207 0.0558
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0014 0.0035 0.0073
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0057 0.037 0.102
Trypanosoma brucei histone deacetylase 4 0.0042 0.0256 0.0697
Trypanosoma brucei prolyl endopeptidase 0.0014 0.0035 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.0655 0.178
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0035 0.0007
Trichomonas vaginalis rotamase, putative 0.0033 0.0181 0.0433
Loa Loa (eye worm) hypothetical protein 0.0042 0.0256 0.0256
Loa Loa (eye worm) prolyl oligopeptidase 0.0014 0.0035 0.0035
Onchocerca volvulus Cathepsin L homolog 0.0095 0.0655 0.3547
Echinococcus multilocularis acylamino acid releasing enzyme 0.0014 0.0035 0.0035
Echinococcus multilocularis aminopeptidase N 0.0036 0.0207 0.0207
Leishmania major cathepsin L-like protease 0.0244 0.1794 0.5047
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0013 0.0029 0.0029
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0075 0.0065
Echinococcus granulosus histone deacetylase 6 0.0042 0.0256 0.0256
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0067 0.0038
Echinococcus multilocularis transmembrane protease serine 3 0.0018 0.0067 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.0184
Loa Loa (eye worm) hypothetical protein 0.0019 0.0075 0.0075
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0392 0.1082
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0057 0.037 0.0343
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0473 0.3545 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0013 0.0035 0.0035
Entamoeba histolytica cysteine proteinase, putative 0.0095 0.0655 0.3522
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0014 0.0035 0.0007
Giardia lamblia Cysteine protease 0.0095 0.0655 0.1765
Trypanosoma brucei unspecified product 0.0013 0.003 0.0059
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0071 0.0239
Trypanosoma cruzi oligopeptidase b 0.0014 0.0035 0.0026
Entamoeba histolytica cysteine protease, putative 0.0095 0.0655 0.3522
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0071 0.0061
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0067 0.0038
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.027 0.027
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0014 0.0035 0.5
Onchocerca volvulus 0.0095 0.0655 0.3547
Brugia malayi Trypsin family protein 0.0018 0.0067 0.0038
Schistosoma mansoni histone deacetylase 4 5 0.0042 0.0256 0.0228
Echinococcus granulosus cathepsin L 0.0095 0.0655 0.0655
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.0655 0.178
Trypanosoma cruzi aminopeptidase, putative 0.0013 0.0029 0.0019
Schistosoma mansoni cathepsin F (C01 family) 0.0244 0.1794 0.177
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0075 0.0075
Onchocerca volvulus 0.0018 0.0067 0.0217
Echinococcus multilocularis glycoprotein Antigen 5 0.0018 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0035
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0013 0.0029 0.0054
Leishmania major histone deacetylase, putative 0.0042 0.0256 0.0697
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0071 0.0071
Echinococcus multilocularis histone deacetylase 0.0042 0.0256 0.0256
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0035 0.0026
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0075 0.0075
Toxoplasma gondii preprocathepsin c precursor, putative 0.0095 0.0655 0.1825
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0013 0.0029 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.027 0.0242
Toxoplasma gondii hypothetical protein 0.0014 0.0035 0.0073
Onchocerca volvulus 0.0244 0.1794 1
Echinococcus granulosus Tolloid protein 1 0.0013 0.0035 0.0035
Leishmania major hypothetical protein, conserved 0.0018 0.0068 0.0165
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0095 0.0655 0.3547
Loa Loa (eye worm) TATA binding protein associated factor 0.0013 0.0029 0.0029
Trypanosoma cruzi cruzipain precursor, putative 0.0244 0.1794 0.1786
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0655 0.178
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0095 0.0655 0.3547
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0181 0.0171
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0095 0.0655 0.3547
Echinococcus granulosus Dipeptidyl peptidase 9 0.0057 0.037 0.037
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0095 0.0655 0.0655
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.0184
Plasmodium falciparum serine repeat antigen 7 0.0095 0.0655 0.3547
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0207 0.0207
Echinococcus multilocularis cpg binding protein 0.003 0.0164 0.0164
Giardia lamblia Cathepsin L precursor 0.0095 0.0655 0.1765
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0095 0.0655 0.178
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0071 0.012
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0095 0.0655 0.0628
Entamoeba histolytica cysteine protease, putative 0.0095 0.0655 0.3522
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0054 0.0342 0.0314
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0075 0.0131
Giardia lamblia Cathepsin L precursor 0.0095 0.0655 0.1765
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0095 0.0655 0.3547
Loa Loa (eye worm) TK/ROR protein kinase 0.0018 0.0068 0.0068
Trypanosoma cruzi Aminopeptidase M1, putative 0.0036 0.0207 0.0197
Echinococcus granulosus expressed protein 0.0033 0.0187 0.0187
Echinococcus multilocularis enteropeptidase 0.0018 0.0067 0.0067
Entamoeba histolytica cysteine protease, putative 0.0095 0.0655 0.3522
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0075 0.0046
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0057 0.037 0.102
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0075 0.1268
Trypanosoma cruzi cysteine peptidase, putative 0.0095 0.0655 0.0646
Leishmania major cathepsin L-like protease 0.0244 0.1794 0.5047
Echinococcus granulosus dna polymerase eta 0.0019 0.0075 0.0075
Entamoeba histolytica cysteine protease, putative 0.0095 0.0655 0.3522
Echinococcus granulosus laminin 0.0013 0.0035 0.0035
Trypanosoma brucei prolyl oligopeptidase, putative 0.0014 0.0035 0.0073
Schistosoma mansoni cathepsin F (C01 family) 0.0244 0.1794 0.177
Onchocerca volvulus 0.0244 0.1794 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.0184
Echinococcus multilocularis cathepsin L cysteine protease 0.0244 0.1794 0.1794
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.081 0.6117 0.6117
Plasmodium falciparum serine repeat antigen 3 0.0095 0.0655 0.3547
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0655 0.178
Leishmania major cathepsin L-like protease 0.0244 0.1794 0.5047
Schistosoma mansoni cathepsin C 0.0095 0.0655 0.0628
Trypanosoma brucei histone deacetylase 3 0.0042 0.0256 0.0697
Schistosoma mansoni hypothetical protein 0.041 0.3059 0.3039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.027 0.0242
Giardia lamblia Cysteine protease 0.0095 0.0655 0.1765
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0036 0.0207 0.0558
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0018 0.0068 0.0221
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0207 0.0207
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0035 0.0007
Brugia malayi Papain family cysteine protease containing protein 0.0244 0.1794 0.177
Echinococcus granulosus cpg binding protein 0.003 0.0164 0.0164
Trypanosoma brucei oligopeptidase b 0.0014 0.0035 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0067 0.0067
Echinococcus granulosus histone deacetylase 7 0.0042 0.0256 0.0256
Plasmodium falciparum histone deacetylase, putative 0.0042 0.0256 0.1287
Trypanosoma cruzi histone deacetylase, putative 0.0042 0.0256 0.0247
Echinococcus granulosus cathepsin L cysteine protease 0.0095 0.0655 0.0655
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.0184
Toxoplasma gondii calcium binding egf domain-containing protein 0.0013 0.0035 0.0072
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0095 0.0655 0.0646
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0068 0.0058
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0071 0.5
Echinococcus multilocularis histone deacetylase 6 0.0042 0.0256 0.0256
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1319 1 1
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0014 0.0035 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0655 0.178
Schistosoma mansoni egf-like domain protein 0.0013 0.0035 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0095 0.0655 0.1825
Echinococcus multilocularis cathepsin b 0.1319 1 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0095 0.0655 0.3522
Loa Loa (eye worm) hypothetical protein 0.0095 0.0655 0.0655
Loa Loa (eye worm) histone deacetylase 7A 0.0042 0.0256 0.0256
Plasmodium falciparum serine repeat antigen 2 0.0095 0.0655 0.3547
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0655 0.0628
Schistosoma mansoni hypothetical protein 0.0018 0.0067 0.0038
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0181 0.0485
Loa Loa (eye worm) hypothetical protein 0.0244 0.1794 0.1794
Onchocerca volvulus 0.0018 0.0067 0.0217
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0035
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0473 0.3545 0.3526
Echinococcus multilocularis laminin 0.0013 0.0035 0.0035
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0095 0.0655 0.1765
Onchocerca volvulus Prolyl endopeptidase homolog 0.0014 0.0035 0.0038
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0095 0.0655 0.0655
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0067 0.0038
Loa Loa (eye worm) histone deacetylase 0.0042 0.0256 0.0256
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0244 0.1794 0.502
Echinococcus granulosus histone deacetylase 6 0.0042 0.0256 0.0256
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0398 0.037
Onchocerca volvulus 0.0018 0.0068 0.0221
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0244 0.1794 0.502
Toxoplasma gondii kringle domain-containing protein 0.0018 0.0068 0.0165
Giardia lamblia Cysteine protease 0.0095 0.0655 0.1765
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0095 0.0655 0.3547
Plasmodium vivax histone deacetylase 2, putative 0.0042 0.0256 0.1287
Onchocerca volvulus 0.0018 0.0067 0.0217
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0655 0.178
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0207 0.0207
Echinococcus multilocularis cathepsin L cysteine protease 0.0244 0.1794 0.1794
Echinococcus multilocularis prolyl endopeptidase 0.0014 0.0035 0.0035
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0067 0.0038
Leishmania major cathepsin L-like protease 0.0244 0.1794 0.5047
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0013 0.0035 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0244 0.1794 0.502
Trypanosoma cruzi cysteine peptidase, putative 0.0244 0.1794 0.1786
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0244 0.1794 0.502
Onchocerca volvulus Cathepsin L homolog 0.0244 0.1794 1
Echinococcus multilocularis cathepsin L 0.0095 0.0655 0.0655
Entamoeba histolytica cysteine proteinase, putative 0.0244 0.1794 1
Giardia lamblia Cathepsin L precursor 0.0095 0.0655 0.1765
Plasmodium vivax serine-repeat antigen (SERA) 0.0095 0.0655 0.3547
Echinococcus granulosus prolyl endopeptidase 0.0014 0.0035 0.0035
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0095 0.0655 0.0655
Loa Loa (eye worm) hypothetical protein 0.0095 0.0655 0.0655
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0244 0.1794 0.5047
Plasmodium vivax vivapain-3 0.0095 0.0655 0.3547
Echinococcus multilocularis dna polymerase eta 0.0019 0.0075 0.0075
Echinococcus granulosus cathepsin l cysteine peptidase 0.0244 0.1794 0.1794
Onchocerca volvulus 0.0018 0.0067 0.0217
Trypanosoma cruzi oligopeptidase b 0.0014 0.0035 0.0026
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0067 0.0038
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0473 0.3545 0.3539
Trypanosoma cruzi cysteine peptidase, putative 0.0244 0.1794 0.1786
Schistosoma mansoni cpg binding protein 0.0029 0.0152 0.0123
Giardia lamblia Cathepsin B precursor 0.0095 0.0655 0.1765
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0171 0.1235 0.1235
Loa Loa (eye worm) ctsf protein 0.0244 0.1794 0.1794
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.0655 0.178
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0036 0.0207 0.0207
Entamoeba histolytica cysteine protease, putative 0.0095 0.0655 0.3522
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0207 0.0207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0244 0.1794 0.502
Loa Loa (eye worm) hypothetical protein 0.0013 0.0035 0.0035
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.0655 0.0628
Onchocerca volvulus 0.0244 0.1794 1
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0013 0.0035 0.0035
Trypanosoma brucei histone deacetylase, putative 0.0042 0.0256 0.0697
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1319 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0095 0.0655 0.178
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0171 0.1235 0.6836
Onchocerca volvulus Arrow homolog 0.0013 0.0035 0.0035
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0095 0.0655 0.3547
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0392 0.0365
Brugia malayi hypothetical protein 0.0044 0.0267 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.003 0.0059
Trypanosoma cruzi prolyl endopeptidase 0.0014 0.0035 0.0026
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1319 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0067 0.0067
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0181 0.0827
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0655 0.0628
Trypanosoma cruzi cysteine protease, putative 0.0095 0.0655 0.0646
Giardia lamblia Hypothetical protein 0.0095 0.0655 0.1765
Giardia lamblia Cathepsin L precursor 0.0095 0.0655 0.1765
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.027 0.027
Echinococcus multilocularis histone deacetylase 7 0.0042 0.0256 0.0256
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0013 0.0035 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.0655 0.178
Toxoplasma gondii aminopeptidase N protein 0.0013 0.0029 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0655 0.178
Loa Loa (eye worm) hypothetical protein 0.0095 0.0655 0.0655
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0207 0.0207
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0067 0.0038
Schistosoma mansoni cathepsin F (C01 family) 0.0244 0.1794 0.177
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0036 0.0207 0.0197
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0075 0.0075
Brugia malayi Cathepsin L-like precursor 0.0244 0.1794 0.177
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0181 0.0485
Plasmodium falciparum serine repeat antigen 1 0.0095 0.0655 0.3547
Toxoplasma gondii calcium binding egf domain-containing protein 0.0013 0.0035 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0035 0.0019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.027 0.027
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0075 0.0065
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0095 0.0655 0.0628
Echinococcus multilocularis fibrillin 1 0.0013 0.0035 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0244 0.1794 0.502
Brugia malayi Trypsin family protein 0.0018 0.0067 0.0038
Schistosoma mansoni cpg binding protein 0.003 0.0164 0.0136
Loa Loa (eye worm) hypothetical protein 0.1319 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0095 0.0655 0.0628
Schistosoma mansoni histone deacetylase 4 5 0.0042 0.0256 0.0228
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0244 0.1794 0.502
Onchocerca volvulus 0.0036 0.0207 0.1009
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0013 0.0029 0.0029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0013 0.0035 0.0035
Brugia malayi Fibulin-1 precursor 0.0013 0.0035 0.0006
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0095 0.0655 0.1765
Trypanosoma cruzi major cysteine proteinase, putative 0.0095 0.0655 0.0646
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0071 0.0061
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0473 0.3545 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0075 0.0046
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.0655 0.0628
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0095 0.0655 0.3547
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.0655 0.0628
Entamoeba histolytica cysteine protease, putative 0.0095 0.0655 0.3522
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0036 0.0207 0.0558
Onchocerca volvulus Cathepsin F homolog 0.0244 0.1794 1
Brugia malayi hypothetical protein 0.0036 0.0207 0.0179
Giardia lamblia Cathepsin B precursor 0.0095 0.0655 0.1765
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.0184
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0071 0.0071
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0095 0.0655 0.3547
Onchocerca volvulus 0.0244 0.1794 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0095 0.0655 0.178
Brugia malayi cathepsin L-like cysteine proteinase 0.0095 0.0655 0.0628
Plasmodium falciparum serine repeat antigen 9 0.0095 0.0655 0.3547
Mycobacterium ulcerans hypothetical protein 0.0018 0.0067 0.1054
Onchocerca volvulus Cathepsin L homolog 0.0244 0.1794 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0067 0.0038
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0018 0.0067 0.0038
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0095 0.0655 0.3522
Schistosoma mansoni hypothetical protein 0.0018 0.0068 0.0039
Toxoplasma gondii cathepsin CPC1 0.0095 0.0655 0.1825
Loa Loa (eye worm) hypothetical protein 0.0244 0.1794 0.1794
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0067 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.0655 0.178
Leishmania major histone deacetylase, putative 0.0042 0.0256 0.0697
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0014 0.0035 0.0007
Leishmania major cathepsin L-like protease 0.0244 0.1794 0.5047
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0095 0.0655 0.1765
Toxoplasma gondii cathepsin B 0.0473 0.3545 1
Echinococcus multilocularis dnaJ subfamily B 0.041 0.3059 0.3059
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0095 0.0655 0.3522
Leishmania major DNA polymerase kappa, putative 0.0019 0.0075 0.0184
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0057 0.037 0.037
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0014 0.0035 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0071 0.012
Echinococcus granulosus cathepsin b 0.1319 1 1
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0023 0.011 0.0101
Loa Loa (eye worm) hypothetical protein 0.0095 0.0655 0.0655
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0171 0.1235 0.121
Giardia lamblia Cathepsin B precursor 0.0473 0.3545 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0075 0.0065
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0057 0.037 0.102
Loa Loa (eye worm) cysteine protease 0.0244 0.1794 0.1794
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0655 0.178
Entamoeba histolytica cysteine protease, putative 0.0095 0.0655 0.3522
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0244 0.1794 0.5047
Entamoeba histolytica cysteine protease, putative 0.0095 0.0655 0.3522
Plasmodium vivax vivapain-2 0.0244 0.1794 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0075 0.0065
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0348 0.0958
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0029
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0057 0.037 0.0361
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0071 0.0173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0244 0.1794 0.5047
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.0184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0244 0.1794 0.5047
Trypanosoma cruzi cysteine proteinase, putative 0.0095 0.0655 0.0646
Echinococcus multilocularis Tolloid protein 1 0.0013 0.0035 0.0035
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0095 0.0655 0.3547
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0014 0.0035 0.0026
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0244 0.1794 0.1786
Brugia malayi prolyl oligopeptidase family protein 0.0057 0.037 0.0343
Echinococcus granulosus tissue type plasminogen activator 0.0018 0.0068 0.0068
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0075 0.0184
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0095 0.0655 0.0628
Toxoplasma gondii exonuclease III APE 0.0018 0.0071 0.0173
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0095 0.0655 0.0628
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0244 0.1794 0.502
Echinococcus granulosus cathepsin L cysteine proteinase 0.0244 0.1794 0.1794
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0075 0.0075
Schistosoma mansoni cathepsin B (C01 family) 0.0095 0.0655 0.0628
Echinococcus multilocularis expressed protein 0.0033 0.0187 0.0187
Brugia malayi Papain family cysteine protease containing protein 0.0095 0.0655 0.0628
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0244 0.1794 0.502
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0207 0.0207
Entamoeba histolytica cysteine protease, putative 0.0095 0.0655 0.3522
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0095 0.0655 0.0628
Leishmania major cathepsin L-like protease 0.0244 0.1794 0.5047
Brugia malayi Peptidase family M1 containing protein 0.0036 0.0207 0.0179
Toxoplasma gondii aminopeptidase N, putative 0.0013 0.0029 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0095 0.0655 0.1825
Entamoeba histolytica cysteine proteinase, putative 0.0244 0.1794 1
Entamoeba histolytica cysteine protease, putative 0.0095 0.0655 0.3522
Brugia malayi Cathepsin L-like precursor 0.0244 0.1794 0.177
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0029
Loa Loa (eye worm) aminopeptidase N 0.0036 0.0207 0.0207
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0071 0.0101
Echinococcus granulosus leukotriene A 4 hydrolase 0.0013 0.0029 0.0029
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0075 0.0046
Plasmodium falciparum serine repeat antigen 6 0.0095 0.0655 0.3547
Echinococcus granulosus histone deacetylase 0.0042 0.0256 0.0256
Trypanosoma cruzi aminopeptidase, putative 0.0036 0.0207 0.0197
Onchocerca volvulus 0.0018 0.0067 0.0217
Brugia malayi Cathepsin L-like precursor 0.0244 0.1794 0.177
Brugia malayi cathepsin L-like precursor 0.0244 0.1794 0.177
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0075 0.0184
Entamoeba histolytica cysteine protease, putative 0.0244 0.1794 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.0184
Loa Loa (eye worm) hypothetical protein 0.0013 0.0035 0.0035
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0187 0.0187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0655 0.178
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0244 0.1794 0.502
Plasmodium falciparum cysteine proteinase falcipain 1 0.0095 0.0655 0.3547
Echinococcus multilocularis Mastin 0.0018 0.0067 0.0067
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0057 0.037 0.102
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0071 0.0071
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0207 0.0207
Schistosoma mansoni ap endonuclease 0.0018 0.0071 0.0042
Echinococcus multilocularis histone deacetylase 6 0.0042 0.0256 0.0256
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0013 0.0029 0.0019
Toxoplasma gondii aminopeptidase n, putative 0.0013 0.0029 0.0054
Echinococcus multilocularis cathepsin b 0.1319 1 1
Brugia malayi Histone deacetylase family protein 0.0042 0.0256 0.0228
Onchocerca volvulus 0.0244 0.1794 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0187 0.045
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.027 0.0242
Loa Loa (eye worm) hypothetical protein 0.0244 0.1794 0.1794
Loa Loa (eye worm) prolyl oligopeptidase 0.0171 0.1235 0.1235
Brugia malayi CXXC zinc finger family protein 0.0029 0.0152 0.0123
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0244 0.1794 0.502
Schistosoma mansoni cpg binding protein 0.003 0.0164 0.0136
Entamoeba histolytica cysteine proteinase 2 0.0095 0.0655 0.3522
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0392 0.0365
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0036 0.0207 0.0558
Entamoeba histolytica cysteine proteinase, putative 0.0244 0.1794 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0095 0.0655 0.3547
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0067 0.0038
Entamoeba histolytica cysteine protease, putative 0.0095 0.0655 0.3522
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0392 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0068
Trypanosoma brucei unspecified product 0.0013 0.003 0.0059
Echinococcus multilocularis tissue type plasminogen activator 0.0018 0.0068 0.0068
Entamoeba histolytica hypothetical protein 0.0095 0.0655 0.3522
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0018 0.0067 0.0067
Echinococcus granulosus cathepsin l1 0.0244 0.1794 0.1794
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0095 0.0655 0.178
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0067 0.0038
Giardia lamblia Cathepsin B precursor 0.0095 0.0655 0.1765
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0013 0.0035 0.0035
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0655 0.0628
Loa Loa (eye worm) hypothetical protein 0.0023 0.011 0.011
Plasmodium falciparum cysteine repeat modular protein 1 0.0018 0.0068 0.0221
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0075 0.1103
Entamoeba histolytica aminopeptidase, putative 0.0036 0.0207 0.0974
Schistosoma mansoni ap endonuclease 0.0018 0.0071 0.0042
Brugia malayi Cathepsin L-like precursor 0.0244 0.1794 0.177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0244 0.1794 0.5047
Toxoplasma gondii histone deacetylase HDAC1 0.0042 0.0256 0.0697
Trypanosoma brucei cysteine peptidase C (CPC) 0.0473 0.3545 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0014 0.0035 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0244 0.1794 0.502
Trichomonas vaginalis rotamase, putative 0.0033 0.0187 0.045
Echinococcus granulosus aminopeptidase N 0.0036 0.0207 0.0207
Trypanosoma cruzi cysteine peptidase, putative 0.0244 0.1794 0.1786
Plasmodium vivax unspecified product 0.0095 0.0655 0.3547
Echinococcus multilocularis cathepsin L 0.0095 0.0655 0.0655
Plasmodium vivax histone deacetylase, putative 0.0042 0.0256 0.1287
Trypanosoma brucei unspecified product 0.0019 0.0075 0.0184
Brugia malayi Histone deacetylase family protein 0.0042 0.0256 0.0228
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0187 0.0159
Trypanosoma brucei Aminopeptidase M1, putative 0.0036 0.0207 0.0558
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0392 0.0392
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0035 0.0038
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0036 0.0207 0.0506
Entamoeba histolytica cysteine protease, putative 0.0095 0.0655 0.3522
Brugia malayi Kringle domain containing protein 0.0018 0.0068 0.0039
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0181 0.0485
Entamoeba histolytica cysteine protease, putative 0.0095 0.0655 0.3522
Onchocerca volvulus 0.0244 0.1794 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0075 0.0131
Entamoeba histolytica cysteine proteinase, putative 0.0095 0.0655 0.3522
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0013 0.0035 0.0006
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0207 0.0207
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0013 0.0029 0.0019
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0014 0.0035 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0244 0.1794 0.5047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0244 0.1794 0.502
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0014 0.0035 0.0026
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0075 0.0184
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0071 0.0201
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0095 0.0655 0.3547
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0071 0.1158
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0036 0.0207 0.0506
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0655 0.0628
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0244 0.1794 0.1794
Giardia lamblia Encystation-specific protease 0.0095 0.0655 0.1765
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0655 0.178
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0152 0.0152
Toxoplasma gondii prolyl endopeptidase 0.0014 0.0035 0.0073
Onchocerca volvulus 0.0029 0.0152 0.0697
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0075 0.0046
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0013 0.0029 0.0019
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0095 0.0655 0.0628
Echinococcus granulosus cysteine protease 0.0095 0.0655 0.0655
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0207 0.0207
Plasmodium vivax vivapain-2 0.0244 0.1794 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0244 0.1794 0.502
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.0184
Brugia malayi Trypsin family protein 0.0018 0.0067 0.0038
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0071 0.0239
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0095 0.0655 0.1765
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0057 0.037 0.0361
Echinococcus granulosus Mastin 0.0018 0.0067 0.0067
Plasmodium falciparum serine repeat antigen 5 0.0095 0.0655 0.3547
Schistosoma mansoni DNA polymerase eta 0.0019 0.0075 0.0046
Brugia malayi Cathepsin L-like precursor 0.0244 0.1794 0.177
Giardia lamblia Hypothetical protein 0.0095 0.0655 0.1765
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0392 0.0392
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0023 0.011 0.011
Leishmania major cathepsin L-like protease 0.0244 0.1794 0.5047
Plasmodium falciparum peptidase, putative 0.0014 0.0035 0.0038
Brugia malayi cathepsin Z-like cysteine proteinase 0.0095 0.0655 0.0628
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0095 0.0655 0.178
Echinococcus granulosus histone deacetylase 6 0.0042 0.0256 0.0256
Trypanosoma cruzi cysteine proteinase, putative 0.0095 0.0655 0.0646
Trypanosoma cruzi histone deacetylase, putative 0.0042 0.0256 0.0247
Onchocerca volvulus 0.0244 0.1794 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0244 0.1794 0.502
Trichomonas vaginalis conserved hypothetical protein 0.0095 0.0655 0.178
Giardia lamblia Cathepsin L precursor 0.0095 0.0655 0.1765
Toxoplasma gondii cathepsin CPC2 0.0095 0.0655 0.1825
Brugia malayi Cathepsin L-like precursor 0.0244 0.1794 0.177
Entamoeba histolytica cysteine protease, putative 0.0095 0.0655 0.3522
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0244 0.1794 0.1794
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0071 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0244 0.1794 0.1794
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0035 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0244 0.1794 0.502
Giardia lamblia DINP protein human, muc B family 0.0019 0.0075 0.0112
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0014 0.0035 0.0185
Echinococcus multilocularis histone deacetylase 6 0.0042 0.0256 0.0256
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0067 0.0038
Entamoeba histolytica cysteine protease, putative 0.0095 0.0655 0.3522
Plasmodium falciparum histone deacetylase 2 0.0042 0.0256 0.1287
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0244 0.1794 0.502
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0075 0.0224
Onchocerca volvulus 0.0018 0.0067 0.0217
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0035 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0244 0.1794 0.502
Echinococcus granulosus enteropeptidase 0.0018 0.0067 0.0067
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0095 0.0655 0.0628
Echinococcus granulosus transmembrane protease serine 3 0.0018 0.0067 0.0067
Brugia malayi cathepsin F-like cysteine proteinase 0.0095 0.0655 0.0628
Entamoeba histolytica cysteine protease, putative 0.0095 0.0655 0.3522
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0181 0.0171
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0244 0.1794 0.502
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0244 0.1794 0.5047
Plasmodium falciparum serine repeat antigen 4 0.0095 0.0655 0.3547
Brugia malayi Calcium binding EGF domain containing protein 0.0013 0.0035 0.0006
Echinococcus granulosus dnaJ subfamily B 0.041 0.3059 0.3059
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0067 0.0038
Brugia malayi fibroinase precursor 0.0095 0.0655 0.0628
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0013 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0018 0.0067 0.0038
Plasmodium vivax serine-repeat antigen (SERA) 0.0095 0.0655 0.3547
Loa Loa (eye worm) peptidase family M1 containing protein 0.0013 0.0029 0.0029
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0018 0.0067 0.0067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0244 0.1794 0.502
Entamoeba histolytica cysteine proteinase, putative 0.0095 0.0655 0.3522
Brugia malayi cathepsin L precursor 0.0095 0.0655 0.0628
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0392 1
Brugia malayi prolyl oligopeptidase family protein 0.0171 0.1235 0.121
Echinococcus multilocularis cysteine protease 0.0244 0.1794 0.1794
Brugia malayi hypothetical protein 0.0018 0.0067 0.0038
Echinococcus granulosus cathepsin b 0.1319 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0018 0.0067 0.0038
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0036 0.0207 0.0179
Brugia malayi Protein kinase domain containing protein 0.0018 0.0068 0.0039
Trypanosoma cruzi major cysteine proteinase, putative 0.0095 0.0655 0.0646
Brugia malayi Trypsin-like protease protein 5 0.0018 0.0067 0.0038
Toxoplasma gondii cathepsin CPL 0.0244 0.1794 0.5047
Giardia lamblia Cathepsin B precursor 0.0473 0.3545 1
Schistosoma mansoni cathepsin S (C01 family) 0.0095 0.0655 0.0628
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0095 0.0655 0.178
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0023 0.011 0.0082
Entamoeba histolytica cysteine protease, putative 0.0095 0.0655 0.3522
Giardia lamblia Cathepsin L precursor 0.0095 0.0655 0.1765
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0392 1
Giardia lamblia Cathepsin L-like protease 0.0095 0.0655 0.1765
Trypanosoma brucei aminopeptidase, putative 0.0013 0.0029 0.0054
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0071 0.0042
Loa Loa (eye worm) hypothetical protein 0.0018 0.0067 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0244 0.1794 0.502
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0244 0.1794 0.502
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0035
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0014 0.0035 0.0073
Entamoeba histolytica cysteine protease, putative 0.0095 0.0655 0.3522
Onchocerca volvulus 0.0244 0.1794 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0256 0.0256
Echinococcus granulosus dna polymerase kappa 0.0019 0.0075 0.0075
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0244 0.1794 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0075 0.0184
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0075 0.0065
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0014 0.0035 0.0073
Loa Loa (eye worm) hypothetical protein 0.0044 0.0267 0.0267
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0244 0.1794 0.502
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0018 0.0067 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0244 0.1794 0.502
Brugia malayi Cathepsin L-like precursor 0.0244 0.1794 0.177
Giardia lamblia Cathepsin B precursor 0.0095 0.0655 0.1765
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0013 0.0029 0.0019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0244 0.1794 0.5047
Loa Loa (eye worm) cathepsin B 0.0473 0.3545 0.3545
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0392 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0095 0.0655 0.178
Brugia malayi Cathepsin L-like precursor 0.0244 0.1794 0.177
Loa Loa (eye worm) hypothetical protein 0.0095 0.0655 0.0655
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.027 0.0242
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.003 0.0059
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0244 0.1794 0.502
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.0184
Brugia malayi Peptidase family M1 containing protein 0.0036 0.0207 0.0179
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0171 0.1235 0.1235
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0071 0.0173
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0067 0.0067
Echinococcus granulosus cathepsin L 0.0095 0.0655 0.0655
Giardia lamblia Cathepsin B precursor 0.0095 0.0655 0.1765
Giardia lamblia Cathepsin B precursor 0.0473 0.3545 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0071 0.0991
Mycobacterium ulcerans aminopeptidase N PepN 0.0036 0.0207 0.4898
Leishmania major cysteine peptidase A (CPA) 0.0244 0.1794 0.5047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0244 0.1794 0.502
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0075 0.1103
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1319 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0067 0.0038
Schistosoma mansoni rotamase 0.0033 0.0187 0.0159
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0244 0.1794 0.1794
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0095 0.0655 0.0628
Entamoeba histolytica cysteine proteinase, putative 0.0095 0.0655 0.3522
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0018 0.0067 0.0038
Plasmodium falciparum cysteine proteinase falcipain 3 0.0244 0.1794 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0244 0.1794 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0095 0.0655 0.3547
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0244 0.1794 0.502
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0244 0.1794 0.5047
Giardia lamblia Cathepsin L-like protease 0.0095 0.0655 0.1765
Loa Loa (eye worm) fibroinase 0.0244 0.1794 0.1794
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0075 0.0184

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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