TDR Targets

Basic information

Technical information

TDR Targets ID: 832176
Name: N-[2-(1-cyclohexenyl)ethyl]-2-[2-[(3-methylph enyl)methylsulfanyl]imidazo[5,4-c]pyridin-3-y l]acetamide
MW: 420.57 | Formula: C24H28N4OS
H donors: 1 H acceptors: 3 LogP: 4.57 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cn1c(SCc2cccc(c2)C)nc2c1cncc2)NCCC1=CCCCC1
InChi: 1S/C24H28N4OS/c1-18-6-5-9-20(14-18)17-30-24-27-21-11-12-25-15-22(21)28(24)16-23(29)26-13-10-19-7-3-2-4-8-19/h5-7,9,11-12,14-15H,2-4,8,10,13,16-17H2,1H3,(H,26,29)
InChiKey: MLPJARDENSLPBE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-(1-cyclohexenyl)ethyl]-2-[2-[(3-methylphenyl)methylthio]-3-imidazo[5,4-c]pyridinyl]acetamide
N-[2-(1-cyclohexenyl)ethyl]-2-[2-[(3-methylbenzyl)thio]imidazo[5,4-c]pyridin-3-yl]acetamide
N-[2-(1-cyclohexenyl)ethyl]-2-[2-[(3-methylphenyl)methylsulfanyl]imidazo[5,4-c]pyridin-3-yl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	beta tubulin	0.1097	1	1
Trypanosoma brucei	beta tubulin	0.0617	0.5555	0.5515
Trichomonas vaginalis	tubulin, putative	0.034	0.299	0.299
Trypanosoma cruzi	tubulin gamma chain	0.0675	0.6086	0.6086
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0454	0.0454
Leishmania major	beta tubulin	0.1097	1	1
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0283	0.246	1
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0493	0.4402	0.4402
Onchocerca volvulus		0.0038	0.0186	0.0633
Plasmodium vivax	tubulin alpha chain, putative	0.0827	0.7498	0.7498
Giardia lamblia	Beta tubulin	0.1097	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0675	0.6086	0.6086
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0544	0.4876	0.4876
Echinococcus multilocularis	beta tubulin	0.1097	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.1097	1	1
Trypanosoma cruzi	tubulin delta chain	0.0637	0.5738	0.5738
Leishmania major	beta tubulin	0.1097	1	1
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0033	0.0144	0.0144
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0334	0.2934	0.2934
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0454	0.0367
Toxoplasma gondii	beta-1 tubulin, putative	0.1097	1	1
Echinococcus granulosus	beta tubulin	0.1097	1	1
Leishmania major	cathepsin L-like protease	0.0066	0.0454	0.0454
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0061	0.0401	0.0401
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0454	0.0367
Plasmodium vivax	tubulin alpha chain, putative	0.0827	0.7498	0.7498
Schistosoma mansoni	tubulin subunit beta	0.1097	1	1
Schistosoma mansoni	tubulin subunit beta	0.0283	0.246	0.246
Trichomonas vaginalis	tubulin alpha chain, putative	0.0617	0.5555	0.5555
Brugia malayi	tubulin alpha chain - mouse	0.0827	0.7498	0.7498
Echinococcus granulosus	tubulin subunit beta	0.1097	1	1
Echinococcus multilocularis	tubulin epsilon chain	0.0674	0.6078	0.6078
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0827	0.7498	0.7498
Brugia malayi	hypothetical protein	0.0075	0.0534	0.0534
Echinococcus granulosus	Tubulin beta 2C chain	0.1097	1	1
Entamoeba histolytica	tubulin gamma chain	0.0675	0.6086	0.6086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0454	0.0367
Toxoplasma gondii	isocitrate dehydrogenase	0.0033	0.0144	0.0144
Brugia malayi	Tubulin gamma chain	0.0675	0.6086	0.6086
Leishmania major	beta tubulin	0.1097	1	1
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0283	0.246	0.5
Trypanosoma cruzi	zeta tubulin, putative	0.0875	0.794	0.794
Echinococcus multilocularis	geminin	0.0171	0.1421	0.1421
Leishmania major	alpha tubulin	0.0827	0.7498	0.7498
Toxoplasma gondii	beta-tubulin, putative	0.1097	1	1
Echinococcus granulosus	tubulin alpha chain	0.0827	0.7498	0.7498
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0617	0.5555	0.5555
Plasmodium falciparum	tubulin gamma chain	0.0675	0.6086	0.6086
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0241	0.2073	0.2073
Trypanosoma brucei	epsilon tubulin	0.0674	0.6078	0.6042
Plasmodium falciparum	tubulin beta chain	0.1097	1	1
Echinococcus multilocularis	tubulin subunit TubB	0.0827	0.7498	0.7498
Brugia malayi	bHLH-PAS transcription factor	0.0038	0.0186	0.0186
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.009	0.009
Echinococcus multilocularis	tubulin alpha	0.0617	0.5555	0.5555
Entamoeba histolytica	hypothetical protein	0.0075	0.0534	0.0534
Brugia malayi	hypoxia-induced factor 1	0.0157	0.1291	0.1291
Trypanosoma cruzi	cruzipain precursor, putative	0.0066	0.0454	0.0454
Giardia lamblia	Beta tubulin	0.1097	1	1
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0033	0.0144	0.0144
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0827	0.7498	0.7498
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0283	0.246	0.246
Brugia malayi	Cell division protein ftsZ	0.0283	0.246	0.246
Giardia lamblia	Gamma tubulin	0.0675	0.6086	0.4809
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0033	0.0144	0.0144
Giardia lamblia	Alpha-tubulin	0.0827	0.7498	0.6681
Loa Loa (eye worm)	tubulin alpha chain	0.0827	0.7498	0.7498
Leishmania major	beta tubulin	0.1097	1	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0827	0.7498	0.7498
Echinococcus granulosus	alpha tubulin	0.0827	0.7498	0.7498
Trypanosoma cruzi	beta tubulin, putative	0.1097	1	1
Loa Loa (eye worm)	alpha-tubulin	0.0827	0.7498	0.7498
Leishmania major	beta tubulin	0.1097	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.1097	1	1
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0033	0.0144	0.0054
Entamoeba histolytica	hypothetical protein	0.0075	0.0534	0.0534
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0827	0.7498	0.7498
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0454	0.0454
Echinococcus granulosus	tubulin alpha chain	0.0827	0.7498	0.7498
Trichomonas vaginalis	tubulin, putative	0.0334	0.2934	0.2934
Schistosoma mansoni	aryl hydrocarbon receptor	0.0051	0.0308	0.0308
Echinococcus granulosus	tubulin subunit TubB	0.0827	0.7498	0.7498
Brugia malayi	beta-tubulin, identical	0.1097	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0827	0.7498	0.7498
Echinococcus multilocularis	Tubulin beta 2C chain	0.1097	1	1
Loa Loa (eye worm)	beta-tubulin	0.1097	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0334	0.2934	0.2934
Toxoplasma gondii	beta tubulin	0.1097	1	1
Trypanosoma brucei	tubulin delta chain	0.0637	0.5738	0.5699
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.034	0.2983	0.2983
Trypanosoma brucei	tubulin gamma chain	0.0675	0.6086	0.605
Schistosoma mansoni	single-minded	0.0051	0.0308	0.0308
Giardia lamblia	Alpha-tubulin	0.0827	0.7498	0.6681
Trichomonas vaginalis	tubulin beta chain, putative	0.0827	0.7498	0.7498
Echinococcus multilocularis	peroxisome assembly protein 26	0.0827	0.7498	0.7498
Echinococcus granulosus	tubulin epsilon chain	0.0674	0.6078	0.6078
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0454	0.0367
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0075	0.0534	0.0534
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0033	0.0144	0.0144
Schistosoma mansoni	hypothetical protein	0.0171	0.1421	0.1421
Brugia malayi	Tubulin alpha-2 chain	0.0827	0.7498	0.7498
Echinococcus granulosus	Tubulin beta 2C chain	0.1097	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0283	0.246	0.246
Trypanosoma cruzi	alpha tubulin, putative	0.0827	0.7498	0.7498
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0493	0.4402	0.4402
Leishmania major	alpha tubulin	0.0827	0.7498	0.7498
Trypanosoma cruzi	epsilon tubulin, putative	0.0674	0.6078	0.6078
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0544	0.4876	0.4876
Loa Loa (eye worm)	tubulin alpha 2	0.021	0.1781	0.1781
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.009	0.009
Trypanosoma cruzi	tubulin delta chain	0.0637	0.5738	0.5738
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0033	0.0144	0.0144
Brugia malayi	PAS domain containing protein	0.0051	0.0308	0.0308
Entamoeba histolytica	tubulin family protein	0.1097	1	1
Echinococcus multilocularis	hypothetical protein	0.0827	0.7498	0.7498
Trypanosoma brucei	beta tubulin	0.1097	1	1
Echinococcus granulosus	beta tubulin	0.1097	1	1
Trypanosoma brucei	epsilon tubulin	0.0617	0.5555	0.5515
Schistosoma mansoni	tubulin subunit gamma	0.0675	0.6086	0.6086
Trichomonas vaginalis	tubulin gamma chain, putative	0.0674	0.6078	0.6078
Brugia malayi	Isocitrate dehydrogenase	0.0033	0.0144	0.0144
Leishmania major	alpha tubulin	0.0827	0.7498	0.7498
Trichomonas vaginalis	tubulin alpha chain, putative	0.1097	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.1097	1	1
Echinococcus granulosus	tubulin gamma 1 chain	0.0675	0.6086	0.6086
Leishmania major	beta tubulin	0.1097	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0827	0.7498	0.7498
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0454	0.0367
Onchocerca volvulus		0.0334	0.2934	1
Leishmania major	alpha tubulin	0.0827	0.7498	0.7498
Echinococcus multilocularis	tubulin alpha chain	0.0827	0.7498	0.7498
Toxoplasma gondii	alpha-tubulin I, putative	0.0827	0.7498	0.7498
Brugia malayi	hypothetical protein	0.0027	0.009	0.009
Trichomonas vaginalis	tubulin epsilon chain, putative	0.1097	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0827	0.7498	0.7498
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0033	0.0144	0.0144
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0454	0.0367
Loa Loa (eye worm)	alpha-tubulin	0.0827	0.7498	0.7498
Leishmania major	beta tubulin	0.1097	1	1
Mycobacterium leprae	cell division protein FtsZ	0.0283	0.246	0.5
Trichomonas vaginalis	tubulin beta chain, putative	0.0827	0.7498	0.7498
Loa Loa (eye worm)	tubulin beta-4 chain	0.1097	1	1
Leishmania major	beta tubulin	0.1097	1	1
Echinococcus granulosus	single minded 2	0.0038	0.0186	0.0186
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.009	0.009
Trypanosoma brucei	alpha tubulin, putative	0.0334	0.2934	0.287
Leishmania major	alpha tubulin	0.0827	0.7498	0.7498
Trichomonas vaginalis	tubulin epsilon chain, putative	0.1097	1	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0033	0.0144	0.0144
Entamoeba histolytica	hypothetical protein	0.0075	0.0534	0.0534
Schistosoma mansoni	tubulin subunit beta	0.1097	1	1
Loa Loa (eye worm)	tubulin beta-2A chain	0.1097	1	1
Toxoplasma gondii	alpha tubulin TUBA1	0.0827	0.7498	0.7498
Trichomonas vaginalis	tubulin beta chain, putative	0.0827	0.7498	0.7498
Echinococcus granulosus	tubulin alpha 1C chain	0.0827	0.7498	0.7498
Loa Loa (eye worm)	hypothetical protein	0.0827	0.7498	0.7498
Echinococcus granulosus	tubulin alpha 3 chain	0.0827	0.7498	0.7498
Echinococcus multilocularis	Tubulin beta 2C chain	0.1097	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0283	0.246	0.246
Echinococcus granulosus	tubulin alpha	0.0617	0.5555	0.5555
Loa Loa (eye worm)	tubulin beta-1 chain	0.1097	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.1097	1	1
Leishmania major	alpha tubulin	0.0827	0.7498	0.7498
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0033	0.0144	0.0144
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.009	0.009
Echinococcus multilocularis	tubulin alpha chain	0.0827	0.7498	0.7498
Trypanosoma brucei	zeta tubulin	0.0875	0.794	0.7921
Leishmania major	alpha tubulin	0.0827	0.7498	0.7498
Trypanosoma brucei	zeta tubulin, putative	0.0875	0.794	0.7921
Echinococcus granulosus	tubulin beta 4A class IVa	0.1097	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0454	0.0367
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0283	0.246	0.246
Loa Loa (eye worm)	tubulin alpha 2	0.0544	0.4876	0.4876
Loa Loa (eye worm)	BEN-1 protein	0.1097	1	1
Toxoplasma gondii	isocitrate dehydrogenase	0.0033	0.0144	0.0144
Leishmania major	delta tubulin, putative	0.0637	0.5738	0.5738
Brugia malayi	isocitrate dehydrogenase	0.0033	0.0144	0.0144
Leishmania major	cathepsin L-like protease	0.0066	0.0454	0.0454
Schistosoma mansoni	tubulin subunit beta	0.1097	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0827	0.7498	0.7498
Loa Loa (eye worm)	BEN-1 protein	0.1097	1	1
Loa Loa (eye worm)	hypothetical protein	0.017	0.1413	0.1413
Echinococcus multilocularis	Tubulin beta 2C chain	0.1097	1	1
Echinococcus multilocularis	tubulin delta chain	0.0283	0.246	0.246
Trichomonas vaginalis	tubulin gamma chain, putative	0.1097	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0283	0.246	0.246
Plasmodium vivax	tubulin gamma chain, putative	0.0675	0.6086	0.6086
Leishmania major	alpha tubulin	0.0827	0.7498	0.7498
Echinococcus multilocularis	tubulin alpha 1C chain	0.0827	0.7498	0.7498
Giardia lamblia	Beta tubulin	0.1097	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0827	0.7498	0.7498
Trypanosoma brucei	beta tubulin	0.1097	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0827	0.7498	0.7498
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.009	0.009
Trypanosoma brucei	alpha tubulin	0.0827	0.7498	0.7475
Loa Loa (eye worm)	hypothetical protein	0.0544	0.4876	0.4876
Brugia malayi	hypothetical protein	0.0018	0.0001	0.0001
Schistosoma mansoni	tubulin subunit alpha	0.0827	0.7498	0.7498
Mycobacterium ulcerans	cell division protein FtsZ	0.0283	0.246	1
Loa Loa (eye worm)	tubulin beta chain	0.0283	0.246	0.246
Leishmania major	beta tubulin	0.1097	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0827	0.7498	0.7498
Giardia lamblia	Epsilon tubulin	0.034	0.2983	0.0694
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0454	0.0367
Leishmania major	epsilon tubulin, putative	0.0674	0.6078	0.6078
Leishmania major	beta tubulin	0.1097	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0454	0.0367
Schistosoma mansoni	alpha tubulin	0.0827	0.7498	0.7498
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.0454	0.0454
Leishmania major	alpha tubulin	0.0827	0.7498	0.7498
Echinococcus multilocularis	beta tubulin	0.1097	1	1
Schistosoma mansoni	hypothetical protein	0.0075	0.0534	0.0534
Trypanosoma brucei	alpha tubulin	0.0827	0.7498	0.7475
Leishmania major	beta tubulin	0.1097	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0334	0.2934	0.2934
Loa Loa (eye worm)	tubulin alpha 2	0.0544	0.4876	0.4876
Leishmania major	cathepsin L-like protease	0.0066	0.0454	0.0454
Trypanosoma brucei	beta tubulin	0.1097	1	1
Schistosoma mansoni	alpha tubulin	0.0827	0.7498	0.7498
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.009	0.009
Brugia malayi	Tubulin beta chain	0.0283	0.246	0.246
Echinococcus granulosus	tubulin alpha chain	0.0827	0.7498	0.7498
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0033	0.0144	0.0144
Plasmodium falciparum	tubulin delta chain, putative	0.0283	0.246	0.246
Plasmodium vivax	delta tubulin, putative	0.0283	0.246	0.246
Trypanosoma cruzi	epsilon tubulin, putative	0.0674	0.6078	0.6078
Loa Loa (eye worm)	hypothetical protein	0.0493	0.4402	0.4402
Brugia malayi	Tubulin alpha chain	0.0283	0.246	0.246
Leishmania major	beta tubulin	0.1097	1	1
Leishmania major	beta tubulin	0.1097	1	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0075	0.0534	0.0534
Trichomonas vaginalis	tubulin alpha chain, putative	0.0334	0.2934	0.2934
Schistosoma mansoni	tubulin subunit alpha	0.0283	0.246	0.246
Trichomonas vaginalis	tubulin, putative	0.0334	0.2934	0.2934
Leishmania major	beta tubulin	0.1097	1	1
Entamoeba histolytica	tubulin alpha chain, putative	0.0827	0.7498	0.7498
Loa Loa (eye worm)	hypothetical protein	0.0027	0.009	0.009
Echinococcus granulosus	tubulin alpha chain	0.0827	0.7498	0.7498
Echinococcus multilocularis	tubulin gamma 1 chain	0.0675	0.6086	0.6086
Leishmania major	alpha tubulin	0.0827	0.7498	0.7498
Brugia malayi	Tubulin alpha-2 chain	0.0827	0.7498	0.7498
Trypanosoma cruzi	major cysteine proteinase, putative	0.0052	0.0322	0.0322
Leishmania major	beta tubulin	0.1097	1	1
Trypanosoma brucei	alpha tubulin	0.0827	0.7498	0.7475
Echinococcus multilocularis	tubulin alpha chain	0.0827	0.7498	0.7498
Echinococcus multilocularis	tubulin subunit beta	0.1097	1	1
Echinococcus granulosus	tubulin alpha chain	0.0827	0.7498	0.7498
Schistosoma mansoni	tubulin subunit beta	0.1097	1	1
Brugia malayi	alpha-tubulin	0.0827	0.7498	0.7498
Schistosoma mansoni	tubulin subunit beta	0.1097	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0241	0.2073	0.2073
Trypanosoma brucei	epsilon tubulin	0.0674	0.6078	0.6042
Brugia malayi	Tubulin beta chain	0.0334	0.2934	0.2934
Schistosoma mansoni	hypothetical protein	0.0171	0.1421	0.1421
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0454	0.0367
Trichomonas vaginalis	tubulin alpha chain, putative	0.0334	0.2934	0.2934
Schistosoma mansoni	transcription factor LCR-F1	0.0075	0.0534	0.0534
Echinococcus multilocularis	tubulin alpha 1C chain	0.0827	0.7498	0.7498
Schistosoma mansoni	tubulin subunit epsilon	0.0674	0.6078	0.6078
Brugia malayi	Tubulin alpha chain	0.0827	0.7498	0.7498
Echinococcus granulosus	tubulin beta 1 chain	0.1097	1	1
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0033	0.0144	0.0144
Trypanosoma cruzi	zeta tubulin, putative	0.0875	0.794	0.794
Leishmania major	beta tubulin	0.1097	1	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0827	0.7498	0.7498
Schistosoma mansoni	tubulin subunit alpha	0.0827	0.7498	0.7498
Leishmania major	beta tubulin	0.1097	1	1
Loa Loa (eye worm)	tubulin beta chain	0.1097	1	1
Entamoeba histolytica	tubulin alpha-1 chain	0.0827	0.7498	0.7498
Plasmodium falciparum	alpha tubulin 1	0.0827	0.7498	0.7498
Plasmodium falciparum	tubulin epsilon chain, putative	0.0674	0.6078	0.6078
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.0454	0.0367
Echinococcus granulosus	peroxisome assembly protein 26	0.0827	0.7498	0.7498
Leishmania major	hypothetical protein, conserved	0.0027	0.009	0.009
Entamoeba histolytica	tubulin family protein	0.1097	1	1
Plasmodium falciparum	alpha tubulin 2	0.0827	0.7498	0.7498
Schistosoma mansoni	tubulin subunit delta	0.0283	0.246	0.246
Loa Loa (eye worm)	tubulin gamma chain	0.0675	0.6086	0.6086
Toxoplasma gondii	tubulin, putative	0.0056	0.0361	0.0361
Echinococcus granulosus	Tubulin alpha 1 chain	0.0827	0.7498	0.7498
Echinococcus multilocularis	transfer RNA-Lys	0.0038	0.0186	0.0186
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0033	0.0144	0.0144
Echinococcus multilocularis	isocitrate dehydrogenase	0.0033	0.0144	0.0144
Schistosoma mansoni	tubulin subunit beta	0.1097	1	1
Leishmania major	gamma-tubulin	0.0675	0.6086	0.6086
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.1097	1	1
Trypanosoma brucei	alpha tubulin	0.0827	0.7498	0.7475
Entamoeba histolytica	hypothetical protein	0.0075	0.0534	0.0534
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0827	0.7498	0.7498
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0033	0.0144	0.0054
Trichomonas vaginalis	tubulin beta chain, putative	0.0827	0.7498	0.7498
Trichomonas vaginalis	tubulin, putative	0.1097	1	1
Leishmania major	alpha tubulin	0.0827	0.7498	0.7498
Schistosoma mansoni	alpha tubulin	0.0827	0.7498	0.7498
Leishmania major	zeta tubulin, putative	0.0875	0.794	0.794
Treponema pallidum	cell division protein FtsZ	0.0283	0.246	0.5
Brugia malayi	hypothetical protein	0.017	0.1413	0.1413
Leishmania major	alpha tubulin	0.0827	0.7498	0.7498
Echinococcus granulosus	tubulin alpha 3 chain	0.0827	0.7498	0.7498
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0157	0.1291	0.1291
Echinococcus granulosus	Tubulin beta 2C chain	0.1097	1	1
Brugia malayi	tubulin alpha-2 chain	0.0827	0.7498	0.7498
Echinococcus multilocularis	Tubulin beta 2C chain	0.1097	1	1
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0033	0.0144	0.0144
Leishmania major	beta tubulin	0.1097	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0827	0.7498	0.7498
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0637	0.5738	0.5738
Plasmodium vivax	tubulin beta chain, putative	0.1097	1	1
Brugia malayi	Cytochrome P450 family protein	0.0027	0.0091	0.0091
Echinococcus granulosus	tubulin delta chain	0.0283	0.246	0.246
Echinococcus multilocularis	tubulin alpha 3 chain	0.0827	0.7498	0.7498
Loa Loa (eye worm)	cytochrome P450 family protein	0.0027	0.0091	0.0091
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0827	0.7498	0.7498
Loa Loa (eye worm)	tubulin alpha chain	0.0827	0.7498	0.7498
Echinococcus multilocularis	tubulin beta 1 chain	0.1097	1	1
Plasmodium vivax	tubulin epsilon chain, putative	0.0674	0.6078	0.6078
Schistosoma mansoni	tubulin subunit alpha	0.0827	0.7498	0.7498
Echinococcus granulosus	geminin	0.0171	0.1421	0.1421

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 832176