Detailed information for compound 83272

Basic information

Technical information
  • TDR Targets ID: 83272
  • Name: 4-(2-amino-5-iodo-4-oxo-1H-pyrimidin-6-yl)ben zoic acid
  • MW: 357.104 | Formula: C11H8IN3O3
  • H donors: 3 H acceptors: 5 LogP: 1.67 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc(O)c(c(n1)c1ccc(cc1)C(=O)O)I
  • InChi: 1S/C11H8IN3O3/c12-7-8(14-11(13)15-9(7)16)5-1-3-6(4-2-5)10(17)18/h1-4H,(H,17,18)(H3,13,14,15,16)
  • InChiKey: CFUXWDHAJRBQQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(2-azanyl-5-iodo-4-oxo-1H-pyrimidin-6-yl)benzoic acid
  • 4-(2-amino-5-iodo-4-keto-1H-pyrimidin-6-yl)benzoic acid
  • 4-(2-amino-5-iodo-6-oxo-3H-pyrimidin-4-yl)benzoic acid
  • 4-(2-amino-5-iodo-6-keto-3H-pyrimidin-4-yl)benzoic acid
  • AIDS-220760
  • AIDS220760
  • Benzoic acid, 4-(2-amino-1,6-dihydro-5-iodo-6-oxo-4-pyrimidinyl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi leucyl-tRNA synthetase, putative 0.0064 0.0165 0.2574
Mycobacterium ulcerans thioesterase 0.0521 0.1989 0.1985
Entamoeba histolytica acyl-CoA synthetase, putative 0.0036 0.0055 0.0563
Echinococcus multilocularis glycyl tRNA synthetase 0.0122 0.0397 0.4009
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.0102 0.0318 0.0314
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0038 0.0064 0.0944
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.006 0.0151 0.165
Leishmania major threonyl-tRNA synthetase, putative 0.006 0.0151 0.234
Chlamydia trachomatis isoleucine--tRNA ligase 0.018 0.0629 0.6276
Loa Loa (eye worm) hypothetical protein 0.0064 0.0165 0.1945
Plasmodium vivax valine--tRNA ligase, putative 0.0064 0.0165 0.2574
Onchocerca volvulus 0.0036 0.0055 0.1057
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0068 0.0181 0.0176
Plasmodium vivax methionine--tRNA ligase, putative 0.0037 0.0057 0.0842
Mycobacterium tuberculosis Conserved protein 0.0037 0.0059 0.0055
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.1144 0.4471 0.4468
Trichomonas vaginalis isoleucyl tRNA synthetase, putative 0.018 0.0629 1
Leishmania major methionyl-tRNA synthetase, putative 0.0037 0.0057 0.0842
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0026 0.0013 0.02
Brugia malayi Methyltransferase-like protein 4 0.0037 0.0059 0.0617
Toxoplasma gondii tRNA synthetase, putative 0.0064 0.0165 0.0161
Echinococcus multilocularis arginyl tRNA synthetase, cytoplasmic 0.003 0.0031 0.0272
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0209 0.0744 0.8946
Echinococcus multilocularis methionine tRNA synthetase 0.0037 0.0057 0.0537
Trypanosoma brucei arginyl-tRNA synthetase, putative 0.003 0.0031 0.0426
Echinococcus multilocularis isoleucyl tRNA synthetase, mitochondrial 0.0142 0.0476 0.4815
Plasmodium vivax hypothetical protein, conserved 0.0101 0.0312 0.492
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0055 0.005
Brugia malayi isoleucyl-tRNA synthetase family protein 0.018 0.0629 0.705
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0075 0.021 0.0205
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0068 0.0181 0.0176
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.2531 1 1
Plasmodium vivax arginyl-tRNA synthetase, putative 0.003 0.0031 0.0426
Brugia malayi AMP-binding enzyme family protein 0.0068 0.0181 0.1987
Mycobacterium tuberculosis Probable valyl-tRNA synthase protein ValS (valyl-tRNA synthetase) (valine--tRNA ligase) (valine translase) 0.0064 0.0165 0.0161
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0122 0.0397 0.4751
Mycobacterium ulcerans arginyl-tRNA synthetase 0.003 0.0031 0.0027
Giardia lamblia Valine-tRNA ligase 0.0064 0.0165 0.1891
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0038 0.0064 0.1013
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0053 0.0122 0.0118
Entamoeba histolytica arginyl-tRNA synthetase 0.003 0.0031 0.03
Toxoplasma gondii Isoleucine-tRNA ligase 0.0026 0.0013 0.0008
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.1444 0.5668 0.5666
Echinococcus granulosus glycyl tRNA synthetase 0.0122 0.0397 0.4009
Echinococcus multilocularis valyl tRNA synthetase 0.0064 0.0165 0.1641
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0068 0.0181 0.0176
Mycobacterium tuberculosis Possible conserved polyketide synthase associated protein PapA2 0.0032 0.0037 0.0032
Toxoplasma gondii isoleucyl-tRNA synthetase family protein 0.018 0.0629 0.0624
Loa Loa (eye worm) hypothetical protein 0.0142 0.0476 0.5707
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0064 0.0165 0.2574
Giardia lamblia Isoleucyl-tRNA synthetase 0.018 0.0629 1
Trypanosoma brucei isoleucyl-tRNA synthetase, putative 0.018 0.0629 1
Plasmodium falciparum isoleucine--tRNA ligase, putative 0.0166 0.0573 0.9101
Plasmodium falciparum threonine--tRNA ligase 0.0053 0.0122 0.1884
Leishmania major hypothetical protein, conserved 0.0037 0.0059 0.0876
Onchocerca volvulus 0.0068 0.0181 0.3733
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0068 0.0181 0.0176
Entamoeba histolytica valyl tRNA synthetase, putative 0.0064 0.0165 0.1814
Schistosoma mansoni valine-tRNA ligase 0.0064 0.0165 0.1641
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.0005 0.0076
Loa Loa (eye worm) hypothetical protein 0.0075 0.021 0.2487
Toxoplasma gondii pantoate-beta-alanine ligase 0.2531 1 1
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0037 0.0057 0.0435
Toxoplasma gondii valyl-tRNA synthetase 0.0064 0.0165 0.0161
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0044 0.0087 0.0082
Toxoplasma gondii tRNA ligases class I (M) protein 0.0037 0.0057 0.0053
Trypanosoma brucei valyl-tRNA synthetase, putative 0.0064 0.0165 0.2574
Mycobacterium tuberculosis Possible conserved polyketide synthase associated protein PapA5 0.0032 0.0037 0.0032
Echinococcus granulosus methionine tRNA synthetase 0.0037 0.0057 0.0537
Trichomonas vaginalis isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative 0.0038 0.0064 0.1013
Plasmodium vivax methionine--tRNA ligase, putative 0.0037 0.0057 0.0842
Trypanosoma brucei leucyl-tRNA synthetase, putative 0.0064 0.0165 0.2574
Mycobacterium tuberculosis Probable conserved polyketide synthase associated protein PapA3 0.0032 0.0037 0.0032
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.006 0.0151 0.234
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0269 0.0983 1
Plasmodium falciparum valine--tRNA ligase, putative 0.0064 0.0165 0.2574
Toxoplasma gondii isoleucyl-tRNA synthetase, putative 0.0064 0.0165 0.0161
Brugia malayi AMP-binding enzyme family protein 0.0047 0.01 0.1074
Treponema pallidum leucyl-tRNA synthetase 0.0075 0.021 0.2082
Plasmodium falciparum leucine--tRNA ligase, putative 0.0064 0.0165 0.2574
Brugia malayi glycyl-tRNA synthetase 0.0122 0.0397 0.4432
Treponema pallidum threonyl-tRNA synthetase 0.0053 0.0122 0.106
Plasmodium falciparum methionine--tRNA ligase, putative 0.0037 0.0057 0.0842
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.2531 1 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.1694 0.6662 0.666
Leishmania major leucyl-tRNA synthetase, putative 0.0101 0.0312 0.492
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.1144 0.4471 0.4468
Schistosoma mansoni methionine-tRNA synthetase 0.0037 0.0057 0.0537
Brugia malayi isoleucyl-tRNA synthetase 0.018 0.0629 0.705
Leishmania major isoleucyl-tRNA synthetase, putative 0.018 0.0629 1
Entamoeba histolytica valyl-tRNA synthetase, putative 0.0064 0.0165 0.1814
Echinococcus granulosus isoleucyl trna synthetase mitochondrial 0.0142 0.0476 0.4815
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0044 0.0087 0.0082
Trypanosoma cruzi leucyl-tRNA synthetase, putative 0.0026 0.0013 0.0125
Treponema pallidum isoleucyl-tRNA synthetase 0.018 0.0629 0.6959
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0037 0.0057 0.0636
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.1444 0.5668 0.5666
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0053 0.0122 0.0118
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0026 0.0013 0.02
Loa Loa (eye worm) isoleucyl-tRNA synthetase 0.018 0.0629 0.7557
Echinococcus granulosus isoleucyl tRNA synthetase, cytoplasmic 0.018 0.0629 0.6377
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0068 0.0181 0.213
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.0102 0.0318 0.0314
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0269 0.0983 1
Plasmodium falciparum arginine--tRNA ligase 0.003 0.0031 0.0426
Schistosoma mansoni valine-tRNA ligase 0.0064 0.0165 0.1641
Plasmodium falciparum leucine--tRNA ligase, putative 0.0026 0.0013 0.0125
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0037 0.0057 0.0911
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0037 0.0057 0.0842
Loa Loa (eye worm) VRS-2 protein 0.0026 0.0013 0.0094
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0037 0.0057 0.0842
Toxoplasma gondii methionyl-tRNA synthetase 0.0052 0.0117 0.0112
Mycobacterium tuberculosis Unknown protein 0.0032 0.0037 0.0032
Plasmodium vivax threonine--tRNA ligase, putative 0.0053 0.0122 0.1884
Schistosoma mansoni methionine-tRNA synthetase 0.0269 0.0983 1
Brugia malayi leucyl-tRNA synthetase 0.0064 0.0165 0.1814
Echinococcus granulosus leucyl tRNA synthetase 0.0064 0.0165 0.1641
Schistosoma mansoni arginyl-tRNA synthetase 0.003 0.0031 0.0272
Brugia malayi Valyl-tRNA synthetase 0.0064 0.0165 0.1814
Echinococcus multilocularis valyl tRNA synthetase 0.0064 0.0165 0.1641
Toxoplasma gondii leucyl-tRNA synthetase 0.0064 0.0165 0.0161
Schistosoma mansoni threonyl-tRNA synthetase 0.0048 0.0102 0.0993
Plasmodium falciparum valine--tRNA ligase, putative 0.0064 0.0165 0.2574
Wolbachia endosymbiont of Brugia malayi valyl-tRNA synthetase 0.0064 0.0165 0.2243
Giardia lamblia Leucyl-tRNA synthetase 0.0062 0.0159 0.1779
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.0005 0.0076
Schistosoma mansoni glycyl-tRNA synthetase 0.0122 0.0397 0.4009
Mycobacterium tuberculosis Conserved polyketide synthase associated protein PapA1 0.0032 0.0037 0.0032
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0064 0.0165 0.263
Giardia lamblia Threonyl-tRNA synthetase 0.0053 0.0122 0.1138
Echinococcus granulosus arginyl tRNA synthetase cytoplasmic 0.003 0.0031 0.0272
Treponema pallidum valyl-tRNA synthetase 0.0064 0.0165 0.1561
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0036 0.0055 0.005
Mycobacterium tuberculosis Possible DNA glycosylase 0.0102 0.0318 0.0314
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0026 0.0013 0.0125
Loa Loa (eye worm) hypothetical protein 0.0038 0.0064 0.0713
Echinococcus granulosus valyl tRNA synthetase 0.0064 0.0165 0.1641
Mycobacterium leprae isoleucyl-tRNA synthetase IleS 0.018 0.0629 0.0624
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0122 0.0397 0.4432
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0053 0.0122 0.0118
Mycobacterium tuberculosis Isoleucyl-tRNA synthetase IleS 0.0116 0.0374 0.037
Loa Loa (eye worm) hypothetical protein 0.0231 0.0831 1
Schistosoma mansoni leucyl-tRNA synthetase 0.0026 0.0013 0.008
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0053 0.0122 0.1328
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.006 0.0151 0.234
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0101 0.0312 0.4694
Entamoeba histolytica isoleucyl-tRNA synthetase, putative 0.018 0.0629 0.705
Brugia malayi methionyl-tRNA synthetase 0.0246 0.089 1
Onchocerca volvulus 0.0068 0.0181 0.3733
Mycobacterium ulcerans isoleucyl-tRNA synthetase 0.018 0.0629 0.0624
Plasmodium vivax valine--tRNA ligase, putative 0.0026 0.0013 0.0125
Trichomonas vaginalis isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative 0.0026 0.0013 0.02
Brugia malayi arginyl aa-tRNA synthetase protein 1 0.003 0.0031 0.03
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0094
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0246 0.089 1
Leishmania major arginyl-tRNA synthetase, putative 0.003 0.0031 0.0426
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0059 0.0945
Mycobacterium ulcerans valyl-tRNA synthetase 0.0064 0.0165 0.0161
Mycobacterium leprae PROBABLE VALYL-tRNA SYNTHASE PROTEIN VALS (VALYL-tRNA SYNTHETASE) (VALINE--tRNA LIGASE) (VALINE TRANSLASE) ELONGS TO CLASS-I AMI 0.0064 0.0165 0.0161
Chlamydia trachomatis leucine--tRNA ligase 0.0075 0.021 0.1878
Entamoeba histolytica leucyl-tRNA synthetase, putative 0.0064 0.0165 0.1814
Echinococcus granulosus valyl tRNA synthetase 0.0064 0.0165 0.1641
Trypanosoma cruzi isoleucyl-tRNA synthetase, putative 0.018 0.0629 1
Chlamydia trachomatis threonine--tRNA ligase 0.006 0.0151 0.1255
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0064 0.0165 0.263
Onchocerca volvulus 0.0064 0.0165 0.3408
Schistosoma mansoni isoleucine--tRNA ligase 0.018 0.0629 0.6377
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0053 0.0122 0.1523
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0026 0.0013 0.02
Wolbachia endosymbiont of Brugia malayi formamidopyrimidine-DNA glycosylase 0.0102 0.0318 0.4801
Schistosoma mansoni methyltransferase-related 0.0037 0.0059 0.0558
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0038 0.0064 0.1013
Mycobacterium tuberculosis Hypothetical protein 0.0037 0.0059 0.0055
Mycobacterium tuberculosis Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase) 0.0102 0.0318 0.0314
Leishmania major valyl-tRNA synthetase, putative 0.0064 0.0165 0.2574
Echinococcus granulosus leucyl tRNA synthetase 0.0085 0.0249 0.2499
Loa Loa (eye worm) hypothetical protein 0.0062 0.0159 0.1868
Echinococcus granulosus Threonyl tRNA synthetase C 0.006 0.0151 0.1492
Echinococcus multilocularis leucyl tRNA synthetase 0.0101 0.0312 0.3138
Treponema pallidum methionyl-tRNA synthetase 0.0246 0.089 1
Schistosoma mansoni isoleucine--tRNA ligase 0.018 0.0629 0.6377
Mycobacterium leprae POSSIBLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA5 0.0032 0.0037 0.0032
Mycobacterium ulcerans polyketide synthase associated protein PapA3 0.0032 0.0037 0.0032
Mycobacterium leprae Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE) 0.0102 0.0318 0.0314
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0037 0.0057 0.0053
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0037 0.0057 0.0053
Plasmodium falciparum isoleucine--tRNA ligase, putative 0.018 0.0629 1
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.006 0.0151 0.234
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0037 0.0057 0.0053
Plasmodium falciparum methionine--tRNA ligase 0.0037 0.0057 0.0842
Onchocerca volvulus 0.0142 0.0476 1
Loa Loa (eye worm) threonyl-tRNA synthetase 0.006 0.0151 0.1768
Chlamydia trachomatis valine--tRNA ligase 0.0064 0.0165 0.1408
Wolbachia endosymbiont of Brugia malayi isoleucyl-tRNA synthetase 0.018 0.0629 1
Trypanosoma cruzi arginyl-tRNA synthetase, putative 0.003 0.0031 0.0426
Schistosoma mansoni leucyl-tRNA synthetase 0.0026 0.0013 0.008
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0068 0.0181 0.0176
Echinococcus multilocularis isoleucyl tRNA synthetase, cytoplasmic 0.018 0.0629 0.6377
Schistosoma mansoni leucyl-tRNA synthetase 0.0101 0.0312 0.3138
Loa Loa (eye worm) hypothetical protein 0.018 0.0629 0.7557
Mycobacterium leprae PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA3 0.0032 0.0037 0.0032
Plasmodium vivax isoleucine--tRNA ligase, putative 0.018 0.0629 1
Brugia malayi methionyl-tRNA synthetase 0.0037 0.0057 0.0594
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.006 0.0151 0.1492
Giardia lamblia Methyltransferase like 2 0.0037 0.0059 0.0037
Brugia malayi valyl-tRNA synthetase family protein 0.0064 0.0165 0.1814
Brugia malayi protein ZK524.3 0.0062 0.0159 0.1742
Onchocerca volvulus 0.0038 0.0064 0.125
Loa Loa (eye worm) hypothetical protein 0.0047 0.01 0.1151
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0109 0.0346 0.4133
Chlamydia trachomatis methionine--tRNA ligase 0.0269 0.0983 1
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0053 0.0122 0.1946
Mycobacterium leprae Probable cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.1444 0.5668 0.5666
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0094
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0055 0.0563
Toxoplasma gondii leucyl-tRNA synthetase (LeuRS2) 0.0064 0.0165 0.0161
Echinococcus multilocularis leucyl tRNA synthetase 0.0064 0.0165 0.1641
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0026 0.0013 0.02
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0036 0.0055 0.005
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0053 0.0122 0.0118
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0068 0.0181 0.0176
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0589 0.2259 0.2255

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 380 mg kg-1 Antiviral activity against Forest virus (SFV) ChEMBL. 2999405

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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