Detailed information for compound 83272

Basic information

Technical information
  • TDR Targets ID: 83272
  • Name: 4-(2-amino-5-iodo-4-oxo-1H-pyrimidin-6-yl)ben zoic acid
  • MW: 357.104 | Formula: C11H8IN3O3
  • H donors: 3 H acceptors: 5 LogP: 1.67 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc(O)c(c(n1)c1ccc(cc1)C(=O)O)I
  • InChi: 1S/C11H8IN3O3/c12-7-8(14-11(13)15-9(7)16)5-1-3-6(4-2-5)10(17)18/h1-4H,(H,17,18)(H3,13,14,15,16)
  • InChiKey: CFUXWDHAJRBQQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(2-azanyl-5-iodo-4-oxo-1H-pyrimidin-6-yl)benzoic acid
  • 4-(2-amino-5-iodo-4-keto-1H-pyrimidin-6-yl)benzoic acid
  • 4-(2-amino-5-iodo-6-oxo-3H-pyrimidin-4-yl)benzoic acid
  • 4-(2-amino-5-iodo-6-keto-3H-pyrimidin-4-yl)benzoic acid
  • AIDS-220760
  • AIDS220760
  • Benzoic acid, 4-(2-amino-1,6-dihydro-5-iodo-6-oxo-4-pyrimidinyl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum methionine--tRNA ligase 0.0037 0.0057 0.0842
Plasmodium vivax threonine--tRNA ligase, putative 0.0053 0.0122 0.1884
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0094
Trypanosoma brucei arginyl-tRNA synthetase, putative 0.003 0.0031 0.0426
Leishmania major leucyl-tRNA synthetase, putative 0.0101 0.0312 0.492
Entamoeba histolytica arginyl-tRNA synthetase 0.003 0.0031 0.03
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0026 0.0013 0.0125
Echinococcus granulosus leucyl tRNA synthetase 0.0085 0.0249 0.2499
Echinococcus granulosus leucyl tRNA synthetase 0.0064 0.0165 0.1641
Plasmodium falciparum isoleucine--tRNA ligase, putative 0.0166 0.0573 0.9101
Wolbachia endosymbiont of Brugia malayi formamidopyrimidine-DNA glycosylase 0.0102 0.0318 0.4801
Entamoeba histolytica acyl-CoA synthetase, putative 0.0036 0.0055 0.0563
Mycobacterium tuberculosis Unknown protein 0.0032 0.0037 0.0032
Treponema pallidum methionyl-tRNA synthetase 0.0246 0.089 1
Leishmania major hypothetical protein, conserved 0.0037 0.0059 0.0876
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0059 0.0945
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0589 0.2259 0.2255
Schistosoma mansoni methionine-tRNA synthetase 0.0037 0.0057 0.0537
Plasmodium falciparum leucine--tRNA ligase, putative 0.0064 0.0165 0.2574
Mycobacterium tuberculosis Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase) 0.0102 0.0318 0.0314
Schistosoma mansoni leucyl-tRNA synthetase 0.0026 0.0013 0.008
Trypanosoma brucei leucyl-tRNA synthetase, putative 0.0064 0.0165 0.2574
Brugia malayi AMP-binding enzyme family protein 0.0068 0.0181 0.1987
Brugia malayi protein ZK524.3 0.0062 0.0159 0.1742
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0037 0.0057 0.0911
Toxoplasma gondii isoleucyl-tRNA synthetase family protein 0.018 0.0629 0.0624
Echinococcus multilocularis methionine tRNA synthetase 0.0037 0.0057 0.0537
Mycobacterium tuberculosis Hypothetical protein 0.0037 0.0059 0.0055
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0026 0.0013 0.02
Loa Loa (eye worm) hypothetical protein 0.0075 0.021 0.2487
Plasmodium falciparum isoleucine--tRNA ligase, putative 0.018 0.0629 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.1694 0.6662 0.666
Schistosoma mansoni isoleucine--tRNA ligase 0.018 0.0629 0.6377
Echinococcus granulosus isoleucyl trna synthetase mitochondrial 0.0142 0.0476 0.4815
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0246 0.089 1
Onchocerca volvulus 0.0036 0.0055 0.1057
Entamoeba histolytica valyl-tRNA synthetase, putative 0.0064 0.0165 0.1814
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0037 0.0057 0.0636
Brugia malayi glycyl-tRNA synthetase 0.0122 0.0397 0.4432
Leishmania major valyl-tRNA synthetase, putative 0.0064 0.0165 0.2574
Brugia malayi arginyl aa-tRNA synthetase protein 1 0.003 0.0031 0.03
Toxoplasma gondii isoleucyl-tRNA synthetase, putative 0.0064 0.0165 0.0161
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.006 0.0151 0.234
Plasmodium vivax valine--tRNA ligase, putative 0.0026 0.0013 0.0125
Loa Loa (eye worm) hypothetical protein 0.0142 0.0476 0.5707
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0037 0.0057 0.0842
Trichomonas vaginalis isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative 0.0038 0.0064 0.1013
Schistosoma mansoni leucyl-tRNA synthetase 0.0026 0.0013 0.008
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0044 0.0087 0.0082
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.0005 0.0076
Treponema pallidum isoleucyl-tRNA synthetase 0.018 0.0629 0.6959
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.1444 0.5668 0.5666
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.0102 0.0318 0.0314
Echinococcus multilocularis glycyl tRNA synthetase 0.0122 0.0397 0.4009
Plasmodium falciparum threonine--tRNA ligase 0.0053 0.0122 0.1884
Onchocerca volvulus 0.0064 0.0165 0.3408
Echinococcus multilocularis leucyl tRNA synthetase 0.0101 0.0312 0.3138
Echinococcus granulosus methionine tRNA synthetase 0.0037 0.0057 0.0537
Toxoplasma gondii Isoleucine-tRNA ligase 0.0026 0.0013 0.0008
Entamoeba histolytica isoleucyl-tRNA synthetase, putative 0.018 0.0629 0.705
Wolbachia endosymbiont of Brugia malayi valyl-tRNA synthetase 0.0064 0.0165 0.2243
Mycobacterium tuberculosis Possible conserved polyketide synthase associated protein PapA2 0.0032 0.0037 0.0032
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0269 0.0983 1
Brugia malayi methionyl-tRNA synthetase 0.0037 0.0057 0.0594
Plasmodium vivax arginyl-tRNA synthetase, putative 0.003 0.0031 0.0426
Loa Loa (eye worm) hypothetical protein 0.0047 0.01 0.1151
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0053 0.0122 0.1946
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0122 0.0397 0.4751
Toxoplasma gondii tRNA ligases class I (M) protein 0.0037 0.0057 0.0053
Schistosoma mansoni methyltransferase-related 0.0037 0.0059 0.0558
Schistosoma mansoni leucyl-tRNA synthetase 0.0101 0.0312 0.3138
Chlamydia trachomatis valine--tRNA ligase 0.0064 0.0165 0.1408
Mycobacterium tuberculosis Isoleucyl-tRNA synthetase IleS 0.0116 0.0374 0.037
Mycobacterium leprae Probable cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.1444 0.5668 0.5666
Giardia lamblia Valine-tRNA ligase 0.0064 0.0165 0.1891
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0036 0.0055 0.0563
Schistosoma mansoni threonyl-tRNA synthetase 0.0048 0.0102 0.0993
Brugia malayi Valyl-tRNA synthetase 0.0064 0.0165 0.1814
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.2531 1 1
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0026 0.0013 0.02
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0037 0.0057 0.0053
Loa Loa (eye worm) isoleucyl-tRNA synthetase 0.018 0.0629 0.7557
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0053 0.0122 0.0118
Mycobacterium tuberculosis Conserved protein 0.0037 0.0059 0.0055
Trypanosoma brucei isoleucyl-tRNA synthetase, putative 0.018 0.0629 1
Treponema pallidum leucyl-tRNA synthetase 0.0075 0.021 0.2082
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0038 0.0064 0.1013
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.1144 0.4471 0.4468
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0068 0.0181 0.0176
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0037 0.0057 0.0053
Chlamydia trachomatis methionine--tRNA ligase 0.0269 0.0983 1
Echinococcus multilocularis arginyl tRNA synthetase, cytoplasmic 0.003 0.0031 0.0272
Leishmania major methionyl-tRNA synthetase, putative 0.0037 0.0057 0.0842
Leishmania major arginyl-tRNA synthetase, putative 0.003 0.0031 0.0426
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0053 0.0122 0.0118
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0209 0.0744 0.8946
Schistosoma mansoni valine-tRNA ligase 0.0064 0.0165 0.1641
Wolbachia endosymbiont of Brugia malayi isoleucyl-tRNA synthetase 0.018 0.0629 1
Echinococcus multilocularis valyl tRNA synthetase 0.0064 0.0165 0.1641
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0053 0.0122 0.1328
Echinococcus granulosus valyl tRNA synthetase 0.0064 0.0165 0.1641
Mycobacterium leprae POSSIBLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA5 0.0032 0.0037 0.0032
Mycobacterium leprae PROBABLE VALYL-tRNA SYNTHASE PROTEIN VALS (VALYL-tRNA SYNTHETASE) (VALINE--tRNA LIGASE) (VALINE TRANSLASE) ELONGS TO CLASS-I AMI 0.0064 0.0165 0.0161
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0068 0.0181 0.0176
Schistosoma mansoni glycyl-tRNA synthetase 0.0122 0.0397 0.4009
Plasmodium vivax isoleucine--tRNA ligase, putative 0.018 0.0629 1
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0064 0.0165 0.263
Echinococcus multilocularis isoleucyl tRNA synthetase, mitochondrial 0.0142 0.0476 0.4815
Brugia malayi methionyl-tRNA synthetase 0.0246 0.089 1
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0064 0.0165 0.2574
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0037 0.0057 0.0435
Brugia malayi valyl-tRNA synthetase family protein 0.0064 0.0165 0.1814
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0064 0.0165 0.263
Loa Loa (eye worm) hypothetical protein 0.0231 0.0831 1
Mycobacterium ulcerans thioesterase 0.0521 0.1989 0.1985
Loa Loa (eye worm) hypothetical protein 0.0062 0.0159 0.1868
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.2531 1 1
Plasmodium falciparum arginine--tRNA ligase 0.003 0.0031 0.0426
Trypanosoma cruzi isoleucyl-tRNA synthetase, putative 0.018 0.0629 1
Chlamydia trachomatis isoleucine--tRNA ligase 0.018 0.0629 0.6276
Plasmodium falciparum methionine--tRNA ligase, putative 0.0037 0.0057 0.0842
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.006 0.0151 0.1492
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0122 0.0397 0.4432
Loa Loa (eye worm) threonyl-tRNA synthetase 0.006 0.0151 0.1768
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0101 0.0312 0.4694
Trypanosoma cruzi leucyl-tRNA synthetase, putative 0.0026 0.0013 0.0125
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0036 0.0055 0.005
Mycobacterium tuberculosis Possible conserved polyketide synthase associated protein PapA5 0.0032 0.0037 0.0032
Onchocerca volvulus 0.0068 0.0181 0.3733
Giardia lamblia Isoleucyl-tRNA synthetase 0.018 0.0629 1
Entamoeba histolytica valyl tRNA synthetase, putative 0.0064 0.0165 0.1814
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.1444 0.5668 0.5666
Trichomonas vaginalis antibiotic synthetase, putative 0.0024 0.0005 0.0076
Giardia lamblia Threonyl-tRNA synthetase 0.0053 0.0122 0.1138
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0068 0.0181 0.0176
Toxoplasma gondii methionyl-tRNA synthetase 0.0052 0.0117 0.0112
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.006 0.0151 0.165
Echinococcus multilocularis valyl tRNA synthetase 0.0064 0.0165 0.1641
Echinococcus granulosus isoleucyl tRNA synthetase, cytoplasmic 0.018 0.0629 0.6377
Mycobacterium ulcerans acyl-CoA synthetase 0.0036 0.0055 0.005
Mycobacterium ulcerans polyketide synthase associated protein PapA3 0.0032 0.0037 0.0032
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0036 0.0055 0.005
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0038 0.0064 0.0944
Giardia lamblia Methyltransferase like 2 0.0037 0.0059 0.0037
Plasmodium vivax methionine--tRNA ligase, putative 0.0037 0.0057 0.0842
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0037 0.0057 0.0842
Toxoplasma gondii leucyl-tRNA synthetase 0.0064 0.0165 0.0161
Brugia malayi leucyl-tRNA synthetase 0.0064 0.0165 0.1814
Chlamydia trachomatis threonine--tRNA ligase 0.006 0.0151 0.1255
Mycobacterium tuberculosis Conserved polyketide synthase associated protein PapA1 0.0032 0.0037 0.0032
Echinococcus granulosus glycyl tRNA synthetase 0.0122 0.0397 0.4009
Schistosoma mansoni valine-tRNA ligase 0.0064 0.0165 0.1641
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0053 0.0122 0.0118
Trichomonas vaginalis isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative 0.0026 0.0013 0.02
Brugia malayi isoleucyl-tRNA synthetase family protein 0.018 0.0629 0.705
Echinococcus granulosus valyl tRNA synthetase 0.0064 0.0165 0.1641
Plasmodium falciparum valine--tRNA ligase, putative 0.0064 0.0165 0.2574
Trypanosoma brucei valyl-tRNA synthetase, putative 0.0064 0.0165 0.2574
Onchocerca volvulus 0.0038 0.0064 0.125
Echinococcus multilocularis leucyl tRNA synthetase 0.0064 0.0165 0.1641
Mycobacterium tuberculosis Probable valyl-tRNA synthase protein ValS (valyl-tRNA synthetase) (valine--tRNA ligase) (valine translase) 0.0064 0.0165 0.0161
Schistosoma mansoni methionine-tRNA synthetase 0.0269 0.0983 1
Toxoplasma gondii pantoate-beta-alanine ligase 0.2531 1 1
Onchocerca volvulus 0.0068 0.0181 0.3733
Trichomonas vaginalis isoleucyl tRNA synthetase, putative 0.018 0.0629 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0094
Leishmania major isoleucyl-tRNA synthetase, putative 0.018 0.0629 1
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0038 0.0064 0.1013
Echinococcus granulosus Threonyl tRNA synthetase C 0.006 0.0151 0.1492
Brugia malayi isoleucyl-tRNA synthetase 0.018 0.0629 0.705
Trypanosoma cruzi leucyl-tRNA synthetase, putative 0.0064 0.0165 0.2574
Mycobacterium ulcerans arginyl-tRNA synthetase 0.003 0.0031 0.0027
Schistosoma mansoni isoleucine--tRNA ligase 0.018 0.0629 0.6377
Brugia malayi Methyltransferase-like protein 4 0.0037 0.0059 0.0617
Plasmodium vivax methionine--tRNA ligase, putative 0.0037 0.0057 0.0842
Loa Loa (eye worm) VRS-2 protein 0.0026 0.0013 0.0094
Mycobacterium ulcerans isoleucyl-tRNA synthetase 0.018 0.0629 0.0624
Leishmania major threonyl-tRNA synthetase, putative 0.006 0.0151 0.234
Chlamydia trachomatis leucine--tRNA ligase 0.0075 0.021 0.1878
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0075 0.021 0.0205
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0269 0.0983 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0068 0.0181 0.0176
Echinococcus granulosus arginyl tRNA synthetase cytoplasmic 0.003 0.0031 0.0272
Trypanosoma cruzi arginyl-tRNA synthetase, putative 0.003 0.0031 0.0426
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.0102 0.0318 0.0314
Toxoplasma gondii valyl-tRNA synthetase 0.0064 0.0165 0.0161
Plasmodium falciparum valine--tRNA ligase, putative 0.0064 0.0165 0.2574
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0068 0.0181 0.213
Plasmodium vivax valine--tRNA ligase, putative 0.0064 0.0165 0.2574
Plasmodium vivax hypothetical protein, conserved 0.0101 0.0312 0.492
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.006 0.0151 0.234
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0026 0.0013 0.02
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0109 0.0346 0.4133
Mycobacterium ulcerans valyl-tRNA synthetase 0.0064 0.0165 0.0161
Loa Loa (eye worm) hypothetical protein 0.0064 0.0165 0.1945
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0068 0.0181 0.0176
Entamoeba histolytica leucyl-tRNA synthetase, putative 0.0064 0.0165 0.1814
Plasmodium falciparum leucine--tRNA ligase, putative 0.0026 0.0013 0.0125
Echinococcus multilocularis isoleucyl tRNA synthetase, cytoplasmic 0.018 0.0629 0.6377
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0026 0.0013 0.02
Giardia lamblia Leucyl-tRNA synthetase 0.0062 0.0159 0.1779
Mycobacterium tuberculosis Possible DNA glycosylase 0.0102 0.0318 0.0314
Treponema pallidum valyl-tRNA synthetase 0.0064 0.0165 0.1561
Schistosoma mansoni arginyl-tRNA synthetase 0.003 0.0031 0.0272
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0037 0.0057 0.0053
Treponema pallidum threonyl-tRNA synthetase 0.0053 0.0122 0.106
Mycobacterium leprae Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE) 0.0102 0.0318 0.0314
Toxoplasma gondii tRNA synthetase, putative 0.0064 0.0165 0.0161
Mycobacterium leprae isoleucyl-tRNA synthetase IleS 0.018 0.0629 0.0624
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0053 0.0122 0.1523
Toxoplasma gondii leucyl-tRNA synthetase (LeuRS2) 0.0064 0.0165 0.0161
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0053 0.0122 0.0118
Loa Loa (eye worm) hypothetical protein 0.018 0.0629 0.7557
Loa Loa (eye worm) hypothetical protein 0.0038 0.0064 0.0713
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.1144 0.4471 0.4468
Brugia malayi AMP-binding enzyme family protein 0.0047 0.01 0.1074
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.006 0.0151 0.234
Mycobacterium tuberculosis Probable conserved polyketide synthase associated protein PapA3 0.0032 0.0037 0.0032
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0044 0.0087 0.0082
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0068 0.0181 0.0176
Onchocerca volvulus 0.0142 0.0476 1
Mycobacterium leprae PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA3 0.0032 0.0037 0.0032

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 380 mg kg-1 Antiviral activity against Forest virus (SFV) ChEMBL. 2999405

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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