Detailed information for compound 838747

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 496.572 | Formula: C31H29FN2O3
  • H donors: 0 H acceptors: 2 LogP: 5.4 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)c1cccc(c1)C(=O)N(Cc1ccc(cc1)OCc1cccnc1)CC1CCCO1
  • InChi: 1S/C31H29FN2O3/c32-28-12-10-25(11-13-28)26-5-1-6-27(18-26)31(35)34(21-30-7-3-17-36-30)20-23-8-14-29(15-9-23)37-22-24-4-2-16-33-19-24/h1-2,4-6,8-16,18-19,30H,3,7,17,20-22H2
  • InChiKey: PUSUCFZCGNGEET-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei calpain-like protein, putative 0.0041 0.0314 0.077
Brugia malayi calpain D 0.0012 0.0042 0.0042
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0173 0.0173
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0278 0.3845
Loa Loa (eye worm) calpain 5 0.0029 0.0197 0.0197
Schistosoma mansoni gamma-secretase subunit aph-1 0.0991 0.9266 0.9266
Brugia malayi beta-lactamase 0.0077 0.0655 0.0655
Onchocerca volvulus 0.0342 0.3152 0.3032
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0009 0.0013 0.0013
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0092 0.0092
Schistosoma mansoni cpg binding protein 0.006 0.0496 0.0496
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0492 0.0492
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0048 0.009
Schistosoma mansoni calpain C (C02 family) 0.0041 0.0314 0.0314
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0045 0.0353 0.5078
Echinococcus multilocularis sodium channel protein 0.0036 0.027 0.027
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0655 0.0655
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0048 0.009
Schistosoma mansoni pyruvate kinase 0.0032 0.023 0.023
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0162 0.0162
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0423 0.0423
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0114 0.1001 0.1001
Schistosoma mansoni glutamate receptor AMPA 0.0025 0.0162 0.0162
Schistosoma mansoni inhibitor of apoptosis protein 0.1069 1 1
Echinococcus granulosus lamin dm0 0.0026 0.0173 0.0173
Echinococcus multilocularis calpain family protein 1, d 0.008 0.0683 0.0683
Loa Loa (eye worm) cathepsin B 0.0045 0.0353 0.0353
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0162 0.0162
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0009 0.0013 0.0013
Schistosoma mansoni tyrosine kinase 0.0069 0.0573 0.0573
Toxoplasma gondii ABC1 family protein 0.0077 0.0655 0.6769
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0048 0.009
Echinococcus multilocularis epidermal growth factor receptor 0.0071 0.0593 0.0593
Echinococcus multilocularis pyruvate kinase 0.0017 0.0082 0.0082
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.023 0.023
Echinococcus granulosus cpg binding protein 0.006 0.0496 0.0496
Schistosoma mansoni cpg binding protein 0.006 0.0496 0.0496
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0048 0.009
Brugia malayi hypothetical protein 0.0342 0.3152 0.3152
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0122 0.0226
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0045 0.0045
Loa Loa (eye worm) MBCTL1 0.006 0.0492 0.0492
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0122 0.0122
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.006 0.006
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0058 0.0058
Schistosoma mansoni lamin 0.0026 0.0173 0.0173
Echinococcus granulosus glutamate receptor subunit protein glur 0.0009 0.0013 0.0013
Schistosoma mansoni tyrosine kinase 0.0155 0.1383 0.1383
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0655 0.1194
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.127 0.127
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0655 0.0655
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0122 0.0226
Trypanosoma brucei cysteine peptidase C (CPC) 0.0045 0.0353 0.0883
Schistosoma mansoni lamin 0.0026 0.0173 0.0173
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0045
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.006 0.006
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0655 1
Trypanosoma brucei calpain-like protein, putative 0.0041 0.0314 0.077
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.023 0.307
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0206 0.0206
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0114 0.1001 0.1001
Echinococcus multilocularis glutamate receptor 2 0.003 0.0206 0.0206
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0212 0.1926 0.1926
Echinococcus granulosus calpain A 0.0114 0.1001 0.1001
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0465 0.0465
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0278 0.3845
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0071 0.0593 0.0593
Echinococcus multilocularis calpain A 0.0114 0.1001 0.1001
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.003 0.0206 0.0206
Brugia malayi Protein kinase domain containing protein 0.0155 0.1383 0.1383
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0655 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0278 0.0278
Echinococcus multilocularis musashi 0.0026 0.0173 0.0173
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0138 0.1222 0.1222
Loa Loa (eye worm) hypothetical protein 0.0023 0.0138 0.0138
Echinococcus granulosus cathepsin b 0.0138 0.1222 0.1222
Loa Loa (eye worm) glutamate receptor 2 0.0025 0.0162 0.0162
Echinococcus multilocularis insulin receptor 0.0155 0.1383 0.1383
Onchocerca volvulus Deterin homolog 0.1069 1 1
Onchocerca volvulus Cell death protein 3 homolog 0.0342 0.3152 0.3032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0048 0.009
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.023 0.0059
Mycobacterium tuberculosis Conserved protein 0.0077 0.0655 0.1194
Giardia lamblia Pyruvate kinase 0.0032 0.023 0.5467
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0114 0.1001 0.1001
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0655 0.1739
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0488 0.4525 0.4525
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0077 0.0655 0.0655
Echinococcus granulosus calpain A 0.0041 0.0314 0.0314
Echinococcus multilocularis caspase 2 0.0342 0.3152 0.3152
Echinococcus multilocularis cathepsin b 0.0138 0.1222 0.1222
Loa Loa (eye worm) hypothetical protein 0.0077 0.0655 0.0655
Mycobacterium tuberculosis Conserved protein 0.0077 0.0655 0.1194
Leishmania major kinesin, putative 0.0029 0.0197 0.2526
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0042
Echinococcus granulosus intermediate filament protein 0.0026 0.0173 0.0173
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0655 0.0655
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0241 0.0249
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0423 0.0423
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0655 0.0655
Schistosoma mansoni hypothetical protein 0.0009 0.0013 0.0013
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0173 0.0173
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0278 0.3845
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0492 0.0492
Echinococcus multilocularis nmda type glutamate receptor 0.0033 0.0237 0.0237
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0045 0.0353 0.5078
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0048 0.009
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0024 0.015 0.0519
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0278 0.0669
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0492 0.0492
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0114 0.1001 0.1001
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0009 0.0013 0.0013
Schistosoma mansoni glutamate receptor NMDA 0.003 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0053 0.0423 0.0423
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0423 0.0423
Schistosoma mansoni tyrosine kinase 0.0069 0.0573 0.0573
Echinococcus multilocularis calpain 0.0041 0.0314 0.0314
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0122 0.1299
Schistosoma mansoni calpain-7 (C02 family) 0.0041 0.0314 0.0314
Echinococcus granulosus glutamate receptor 2 0.003 0.0206 0.0206
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0278 0.2926
Plasmodium falciparum pyruvate kinase 0.0032 0.023 1
Trypanosoma cruzi Aph-1 protein, putative 0.0386 0.3565 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.1222 0.1222
Chlamydia trachomatis pyruvate kinase 0.0032 0.023 1
Echinococcus granulosus pyruvate kinase 0.0032 0.023 0.023
Trypanosoma cruzi Aph-1 protein, putative 0.0386 0.3565 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.127 0.127
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0048 0.009
Echinococcus granulosus epidermal growth factor receptor 0.0071 0.0593 0.0593
Onchocerca volvulus 0.0077 0.0655 0.0491
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.1069 0.1069
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0314 0.077
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0278 0.2603
Schistosoma mansoni tyrosine kinase 0.0069 0.0573 0.0573
Brugia malayi gamma-secretase subunit aph-1 0.0991 0.9266 0.9266
Leishmania major pyruvate kinase 0.0032 0.023 0.307
Toxoplasma gondii cathepsin B 0.0045 0.0353 0.3437
Trypanosoma brucei calpain-like protein, putative 0.0041 0.0314 0.077
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0122 0.1299
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0138 0.1222 0.1222
Echinococcus multilocularis glutamate receptor 2 0.0025 0.0162 0.0162
Brugia malayi calpain 7 0.0041 0.0314 0.0314
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0655 0.1194
Echinococcus granulosus nmda type glutamate receptor 0.0033 0.0237 0.0237
Brugia malayi calpain family protein 1 0.0109 0.0954 0.0954
Schistosoma mansoni tyrosine kinase 0.0071 0.0593 0.0593
Loa Loa (eye worm) calpain D 0.0012 0.0042 0.0042
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0314 0.443
Loa Loa (eye worm) hypothetical protein 0.0068 0.0566 0.0566
Echinococcus multilocularis pyruvate kinase 0.0017 0.0082 0.0082
Brugia malayi beta-lactamase family protein 0.0077 0.0655 0.0655
Echinococcus granulosus caspase 2 0.0342 0.3152 0.3152
Schistosoma mansoni hypothetical protein 0.0165 0.1478 0.1478
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0173 0.0173
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0033 0.0237 0.0237
Toxoplasma gondii exonuclease III APE 0.0021 0.0122 0.0879
Echinococcus granulosus insulin receptor 0.0155 0.1383 0.1383
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.023 0.023
Loa Loa (eye worm) TK/EGFR protein kinase 0.0071 0.0593 0.0593
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0155 0.1383 0.1383
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0048 0.009
Schistosoma mansoni caspase-7 (C14 family) 0.0342 0.3152 0.3152
Brugia malayi calpain 5 0.0012 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0026 0.0173 0.0173
Mycobacterium ulcerans hypothetical protein 0.0077 0.0655 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0122 0.3377
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0155 0.1383 0.1383
Schistosoma mansoni tyrosine kinase 0.0071 0.0593 0.0593
Echinococcus multilocularis pyruvate kinase 0.0032 0.023 0.023
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0009 0.0013 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0048 0.009
Loa Loa (eye worm) hypothetical protein 0.1069 1 1
Schistosoma mansoni glutamate receptor NMDA 0.0025 0.0162 0.0162
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0655 0.1739
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0138 0.407
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0655 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0082 0.0082
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0122 0.0122
Onchocerca volvulus 0.1069 1 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0206 0.0206
Echinococcus granulosus calpain 0.0041 0.0314 0.0314
Echinococcus granulosus calpain 7 C02 family 0.0041 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.1069 1 1
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0009 0.0013 0.0013
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0036 0.027 0.027
Echinococcus granulosus glutamate receptor 2 0.0021 0.0119 0.0119
Loa Loa (eye worm) glutamate receptor 1 0.0025 0.0162 0.0162
Schistosoma mansoni tyrosine kinase 0.0071 0.0593 0.0593
Brugia malayi mbt repeat family protein 0.0053 0.0423 0.0423
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0024 0.015 0.0062
Trypanosoma cruzi kinesin, putative 0.0029 0.0197 0.0439
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.006 0.006
Entamoeba histolytica protein kinase, putative 0.0029 0.0197 0.6569
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0024 0.015 1
Echinococcus multilocularis apoptotic protease activating factor 1 0.0342 0.3152 0.3152
Brugia malayi calpain 5 0.0029 0.0197 0.0197
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0143 0.127 0.127
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0122 0.1467
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0278 1
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0082 0.2114
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0077 0.0655 0.0655
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0494 0.4584 1
Echinococcus granulosus pyruvate kinase 0.0032 0.023 0.023
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0655 1
Loa Loa (eye worm) beta-lactamase 0.0077 0.0655 0.0655
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0488 0.4525 0.4525
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0314 0.077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.127 0.127
Brugia malayi CXXC zinc finger family protein 0.0057 0.0465 0.0465
Onchocerca volvulus 0.0077 0.0655 0.0491
Echinococcus granulosus max protein X 0.0488 0.4525 0.4525
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0041 0.0314 0.077
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.006 0.006
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.003 0.0206 0.0206
Echinococcus granulosus calpain 5 0.0041 0.0314 0.0314
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0164 0.1468 0.1468
Schistosoma mansoni hypothetical protein 0.0342 0.3152 0.3152
Mycobacterium ulcerans pyruvate kinase 0.0032 0.023 0.2036
Echinococcus granulosus pyruvate kinase 0.0017 0.0082 0.0082
Trypanosoma brucei pyruvate kinase 1 0.0032 0.023 0.0534
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.009 0.009
Schistosoma mansoni pyruvate kinase 0.0032 0.023 0.023
Plasmodium vivax pyruvate kinase, putative 0.0032 0.023 0.2589
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.127 0.127
Loa Loa (eye worm) hypothetical protein 0.0342 0.3152 0.3152
Brugia malayi Glutamate receptor 1 precursor 0.0025 0.0162 0.0162
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.0314 0.077
Echinococcus granulosus baculoviral IAP repeat containing protein 0.1069 1 1
Loa Loa (eye worm) pyruvate kinase 0.0032 0.023 0.023
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0122 0.1299
Loa Loa (eye worm) hypothetical protein 0.008 0.0683 0.0683
Echinococcus multilocularis NMDA receptor 0.0009 0.0013 0.0013
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.023 0.307
Loa Loa (eye worm) hypothetical protein 0.0109 0.0954 0.0954
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0048 0.009
Trypanosoma brucei calpain-like protein, putative 0.0041 0.0314 0.077
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0314 0.077
Echinococcus multilocularis lamin 0.0026 0.0173 0.0173
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0122 0.0226
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.0314 0.077
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.0314 0.077
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0092 0.0092
Loa Loa (eye worm) calpain family protein 1 0.008 0.0683 0.0683
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0082 0.0439
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.006 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0048 0.009
Echinococcus granulosus glutamate NMDA receptor subunit 0.0025 0.0162 0.0162
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0048 0.009
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0143 0.127 0.127
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0655 0.1194
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.0947 1
Trichomonas vaginalis esterase, putative 0.0077 0.0655 1
Brugia malayi Furin-like cysteine rich region family protein 0.0071 0.0593 0.0593
Loa Loa (eye worm) calpain family protein 1 0.0109 0.0954 0.0954
Echinococcus granulosus lamin 0.0026 0.0173 0.0173
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0025 0.0162 0.0162
Schistosoma mansoni hypothetical protein 0.0165 0.1478 0.1478
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0009 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0342 0.3152 0.3152
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.1069 1 1
Schistosoma mansoni calpain-2 (C02 family) 0.0012 0.0042 0.0042
Echinococcus multilocularis hypothetical protein 0.0041 0.0314 0.0314
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0143 0.127 0.127
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0012 0.004 0.004
Echinococcus multilocularis calpain 7 (C02 family) 0.0041 0.0314 0.0314
Loa Loa (eye worm) hypothetical protein 0.0097 0.0838 0.0838
Echinococcus multilocularis pyruvate kinase 0.0026 0.0166 0.0166
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.1069 1 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0138 0.0138
Echinococcus multilocularis gamma secretase subunit aph 1 0.0991 0.9266 0.9266
Plasmodium vivax calpain, putative 0.0041 0.0314 0.4043
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0492 0.0492
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.023 0.0243
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0423 0.0423
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0122 0.423
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.0314 0.077
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.003 0.0206 0.0206
Schistosoma mansoni hypothetical protein 0.0012 0.0042 0.0042
Echinococcus multilocularis cathepsin b 0.0138 0.1222 0.1222
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.023 0.0534
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.023 0.0534
Echinococcus granulosus sodium channel protein 0.0036 0.027 0.027
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.1069 1 1
Schistosoma mansoni tyrosine kinase 0.0161 0.1441 0.1441
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0122 0.0122
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0041 0.0314 0.077
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0018 0.0018
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0423 0.0255
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0138 0.1222 0.1222
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0655 0.0655
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0003 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0655 0.1739
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0655 0.1194
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0122 0.0695
Brugia malayi Glutamate receptor 2 precursor 0.0025 0.0162 0.0162
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0143 0.127 0.127
Brugia malayi intermediate filament protein 0.0026 0.0173 0.0173
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0492 0.0492
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.023 0.0534
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0045 0.0353 0.0353
Loa Loa (eye worm) TK/INSR protein kinase 0.0155 0.1383 0.1383
Schistosoma mansoni tyrosine kinase 0.0155 0.1383 0.1383
Loa Loa (eye worm) pyruvate kinase 0.0032 0.023 0.023
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0122 0.0122
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0655 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.083 0.7744 0.7744
Mycobacterium ulcerans lipase LipD 0.0077 0.0655 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0655 0.0655
Echinococcus multilocularis geminin 0.0165 0.1478 0.1478
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0036 0.027 0.371
Leishmania major hypothetical protein, conserved 0.0077 0.0655 1
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0991 0.9266 0.9266
Trypanosoma brucei kinesin, putative 0.0029 0.0197 0.0439
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0138 0.1222 0.3348
Schistosoma mansoni hypothetical protein 0.0325 0.299 0.299
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0655 0.1194
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0278 0.3845
Brugia malayi cathepsin B-like cysteine proteinase 0.0138 0.1222 0.1222
Entamoeba histolytica calpain large subunit domain III containing protein 0.0029 0.0197 0.6569
Loa Loa (eye worm) hypothetical protein 0.0084 0.0716 0.0716
Echinococcus granulosus epidermal growth factor receptor 0.0071 0.0593 0.0593
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0278 0.0669
Schistosoma mansoni glutamate receptor AMPA 0.0025 0.0162 0.0162
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0278 0.0669
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0041 0.0314 0.077
Onchocerca volvulus 0.0053 0.0423 0.0255
Schistosoma mansoni inositol monophosphatase 0.0037 0.0278 0.0278
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0314 0.443
Schistosoma mansoni bhlhzip transcription factor bigmax 0.0488 0.4525 0.4525
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0143 0.127 0.127
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0492 0.0492
Schistosoma mansoni ap endonuclease 0.0021 0.0122 0.0122
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0278 0.0278
Echinococcus multilocularis cpg binding protein 0.006 0.0496 0.0496
Onchocerca volvulus 0.0057 0.0465 0.0297
Echinococcus multilocularis glutamate receptor 2 0.0021 0.0119 0.0119
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0423 0.0423
Loa Loa (eye worm) hypothetical protein 0.0077 0.0655 0.0655
Schistosoma mansoni calpain (C02 family) 0.0041 0.0314 0.0314
Trichomonas vaginalis helicase, putative 0.0013 0.0048 0.009
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0423 0.0423
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0423 0.0423
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0655 0.1194
Leishmania major pyruvate kinase 0.0032 0.023 0.307
Brugia malayi mbt repeat family protein 0.0053 0.0423 0.0423
Echinococcus multilocularis lamin dm0 0.0026 0.0173 0.0173
Brugia malayi Cell death protein 3 precursor 0.0342 0.3152 0.3152
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.023 0.0059
Loa Loa (eye worm) calpain 0.0041 0.0314 0.0314
Schistosoma mansoni Mername-AA248 (C02 family) 0.0041 0.0314 0.0314
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0655 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0092 0.0092
Echinococcus granulosus pyruvate kinase 0.0017 0.0082 0.0082
Echinococcus multilocularis 0.002 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0077 0.0655 0.0655
Echinococcus multilocularis max protein X 0.0488 0.4525 0.4525
Echinococcus granulosus apoptotic protease activating factor 1 0.0342 0.3152 0.3152
Schistosoma mansoni ATP-binding cassette transporter 0.0025 0.0162 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0048 0.009
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0045 0.0353 0.0883
Mycobacterium ulcerans beta-lactamase 0.0077 0.0655 1
Schistosoma mansoni cpg binding protein 0.0057 0.0465 0.0465
Echinococcus multilocularis inhibitor of apoptosis protein 0.1069 1 1
Echinococcus granulosus gamma secretase subunit aph 1 0.0991 0.9266 0.9266
Brugia malayi calpain family protein 1 0.0109 0.0954 0.0954
Brugia malayi Protein kinase domain containing protein 0.0086 0.0735 0.0735
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0058 0.0058
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0138 0.1222 0.1222
Loa Loa (eye worm) hypothetical protein 0.006 0.0492 0.0492
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0048 0.009
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.023 0.2078
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0655 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0278 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0241 0.0267
Mycobacterium tuberculosis Conserved protein 0.0077 0.0655 0.1194
Schistosoma mansoni bhlhzip transcription factor bigmax 0.0488 0.4525 0.4525
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0655 1
Echinococcus multilocularis pyruvate kinase 0.0017 0.0082 0.0082
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0655 0.0655
Schistosoma mansoni calpain-7 (C02 family) 0.0041 0.0314 0.0314
Loa Loa (eye worm) inositol-1 0.0037 0.0278 0.0278
Brugia malayi Inositol-1 0.0037 0.0278 0.0278
Schistosoma mansoni pyruvate kinase 0.0017 0.0082 0.0082
Echinococcus multilocularis epidermal growth factor receptor 0.0071 0.0593 0.0593
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0314 0.077
Trypanosoma cruzi kinesin, putative 0.0029 0.0197 0.0439
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0314 0.443
Onchocerca volvulus 0.0068 0.0566 0.04
Echinococcus granulosus inhibitor of apoptosis protein 0.1069 1 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0164 0.1468 0.1468
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0048 0.009
Giardia lamblia Cathepsin B precursor 0.0045 0.0353 1
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0655 0.1194
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0048 0.009
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0423 0.0423
Onchocerca volvulus 0.0077 0.0655 0.0491
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0045 0.0045
Echinococcus granulosus cathepsin b 0.0138 0.1222 0.1222
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0048 0.009
Schistosoma mansoni ap endonuclease 0.0021 0.0122 0.0122
Echinococcus granulosus geminin 0.0165 0.1478 0.1478
Trypanosoma brucei antigen, putative 0.0041 0.0314 0.077
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0041 0.0314 0.077
Schistosoma mansoni glutamate receptor kainate 0.0025 0.0162 0.0162
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0109 0.0954 0.0954
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0212 0.1926 0.1926
Schistosoma mansoni hypothetical protein 0.1069 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.023 0.023
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.023 0.0059
Loa Loa (eye worm) hypothetical protein 0.0026 0.0168 0.0168
Trypanosoma brucei Aph-1 protein, putative 0.0386 0.3565 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.003 0.0206 0.0206
Brugia malayi beta-lactamase family protein 0.0077 0.0655 0.0655
Mycobacterium leprae Probable lipase LipE 0.0077 0.0655 1
Echinococcus multilocularis calpain 5 0.0041 0.0314 0.0314
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0024 0.015 1
Giardia lamblia Cathepsin B precursor 0.0045 0.0353 1
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0278 0.0278
Schistosoma mansoni intermediate filament proteins 0.0026 0.0173 0.0173
Loa Loa (eye worm) pyruvate kinase 0.0032 0.023 0.023
Giardia lamblia Cathepsin B precursor 0.0045 0.0353 1
Echinococcus multilocularis pyruvate kinase 0.0032 0.023 0.023
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0655 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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