Detailed information for compound 842457

Basic information

Technical information
  • TDR Targets ID: 842457
  • Name: 2-(2,4-dimethoxyphenyl)-7-methyl-3,5-dihydroc hromeno[3,2-e]pyrimidin-4-one
  • MW: 350.368 | Formula: C20H18N2O4
  • H donors: 1 H acceptors: 3 LogP: 4.01 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)OC)c1nc(O)c2c(n1)Oc1c(C2)cc(cc1)C
  • InChi: 1S/C20H18N2O4/c1-11-4-7-16-12(8-11)9-15-19(23)21-18(22-20(15)26-16)14-6-5-13(24-2)10-17(14)25-3/h4-8,10H,9H2,1-3H3,(H,21,22,23)
  • InChiKey: QCSDVNZUQPFEHB-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax DNA repair protein REV1, putative 0.0014 0.0064 0.0482
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0454 0.5406
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0134 0.0455
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0134 0.0455
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0134 0.0455
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.0064 0.0064
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0454 0.5406
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0134 0.0455
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0454 0.5406
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0236 0.0845
Plasmodium vivax vivapain-2 0.002 0.0134 0.1167
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0071 0.0212
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0134 0.1167
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0064 0.0605
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0028 0.0236 0.0845
Brugia malayi Cathepsin L-like precursor 0.0013 0.0053 0.0202
Toxoplasma gondii cathepsin CPL 0.002 0.0134 0.0719
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0092 0.1035 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0438 0.5199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0824 0.995
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0134 0.0455
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.022 0.263 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0028 0.0236 0.272
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0134 0.0455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0134 0.0455
Echinococcus granulosus aryl hydrocarbon receptor 0.0093 0.1049 0.1049
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0279 0.3245
Onchocerca volvulus 0.0034 0.031 0.1178
Schistosoma mansoni hypothetical protein 0.0199 0.2372 0.2372
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0028 0.0236 0.2251
Loa Loa (eye worm) cysteine protease 0.002 0.0134 0.0511
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0236 0.0845
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0781 0.0781
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0015 0.0071 0.0065
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0092 0.1035 0.1035
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0134 0.0134
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0017 0.0066
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0686 0.6407
Onchocerca volvulus 0.002 0.0134 0.0511
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0051 0.053 0.053
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0779 0.2437
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0028 0.0236 0.0845
Leishmania major cathepsin L-like protease 0.002 0.0134 0.0915
Loa Loa (eye worm) hypothetical protein 0.0015 0.0071 0.0269
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.031 0.1178
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0245
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0779 0.2784
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0057 0.0595 0.0595
Leishmania major cathepsin L-like protease 0.002 0.0134 0.0915
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0134 0.0455
Echinococcus granulosus geminin 0.0199 0.2372 0.2372
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0092 0.1035 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0134 0.0455
Brugia malayi hypothetical protein 0.0065 0.0702 0.267
Trichomonas vaginalis dullard protein, putative 0.0015 0.0071 0.0212
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0779 0.0779
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0454 0.5406
Loa Loa (eye worm) hypothetical protein 0.0014 0.0069 0.0261
Leishmania major hypothetical protein, conserved 0.0068 0.0734 0.8769
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0824 0.995
Loa Loa (eye worm) hypothetical protein 0.0028 0.0236 0.0898
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0045 0.0454 0.0454
Trichomonas vaginalis dullard protein, putative 0.0015 0.0071 0.0212
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0454 0.5406
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0015 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0734 0.8844
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0057 0.0595 0.5689
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0028 0.0236 0.272
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0134 0.1167
Schistosoma mansoni aryl hydrocarbon receptor 0.0028 0.024 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0134 0.0455
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0093 0.1049 0.399
Leishmania major DNA polymerase eta, putative 0.0044 0.0438 0.489
Brugia malayi ThiF family protein 0.0057 0.0595 0.2264
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0015 0.0071 0.0212
Brugia malayi cathepsin L-like precursor 0.0013 0.0053 0.0202
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0045 0.0454 0.0454
Brugia malayi PAS domain containing protein 0.0028 0.0236 0.0898
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0028 0.024 0.024
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0824 0.995
Trypanosoma brucei unspecified product 0.0031 0.0279 0.3245
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0454 0.5406
Loa Loa (eye worm) hypothetical protein 0.0013 0.0053 0.0202
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0092 0.1035 0.3783
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0092 0.1035 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0134 0.0455
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0071 0.0682
Echinococcus granulosus dnaJ subfamily B 0.048 0.5882 0.5882
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0454 0.5406
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0064 0.0605
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0053 0.0145
Leishmania major cysteine peptidase A (CPA) 0.002 0.0134 0.0915
Loa Loa (eye worm) hypothetical protein 0.0075 0.0828 0.3148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0824 0.995
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0734 0.8844
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0134 0.0134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0824 0.995
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0092 0.1035 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0824 0.995
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.0438 0.3847
Schistosoma mansoni single-minded 0.0028 0.0236 0.0236
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0454 0.5406
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0032 0.0289 0.3366
Echinococcus granulosus cathepsin l1 0.002 0.0134 0.0134
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0071 0.0212
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0454 0.1728
Echinococcus multilocularis dnaJ subfamily B 0.048 0.5882 0.5882
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0064 0.0605
Echinococcus multilocularis geminin 0.0199 0.2372 0.2372
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.022 0.263 1
Echinococcus multilocularis cathepsin L 0.001 0.0015 0.0015
Onchocerca volvulus Cathepsin L homolog 0.002 0.0134 0.0511
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0824 0.995
Onchocerca volvulus 0.002 0.0134 0.0511
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0779 0.0779
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0824 0.995
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0134 0.0134
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0045 0.0454 0.0454
Echinococcus multilocularis aryl hydrocarbon receptor 0.0093 0.1049 0.1049
Trypanosoma cruzi DNA polymerase eta, putative 0.0075 0.0828 1
Onchocerca volvulus Protein cycle homolog 0.0065 0.0702 0.267
Entamoeba histolytica cysteine protease, putative 0.002 0.0134 0.0455
Echinococcus multilocularis cysteine protease 0.002 0.0134 0.0134
Leishmania major protein kinase, putative 0.0028 0.0236 0.2251
Brugia malayi hypothetical protein 0.0093 0.1045 0.3976
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0019 0.0019
Brugia malayi Probable ClpP-like protease 0.0092 0.1035 0.3935
Plasmodium falciparum DNA repair protein REV1, putative 0.0014 0.0064 0.0482
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0779 0.9357
Giardia lamblia DINP protein human, muc B family 0.0045 0.0454 0.152
Onchocerca volvulus Cathepsin F homolog 0.002 0.0134 0.0511
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0454 0.5406
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0134 0.0455
Leishmania major cathepsin L-like protease 0.0075 0.0824 0.9947
Trichomonas vaginalis dullard protein, putative 0.0015 0.0071 0.0212
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0454 0.5406
Trichomonas vaginalis DNA polymerase eta, putative 0.0045 0.0454 0.168
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0015 0.0071 0.0269
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0045 0.0454 0.511
Trypanosoma cruzi cruzipain precursor, putative 0.0075 0.0824 0.995
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0092 0.1035 1
Brugia malayi Cathepsin L-like precursor 0.002 0.0134 0.0511
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0057 0.0595 0.0595
Echinococcus granulosus cathepsin l1 0.0013 0.0053 0.0053
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0045 0.0454 0.168
Trypanosoma brucei unspecified product 0.0045 0.0454 0.5406
Loa Loa (eye worm) histone methyltransferase 0.001 0.0019 0.0073
Onchocerca volvulus 0.002 0.0134 0.0511
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0779 0.0779
Toxoplasma gondii hypothetical protein 0.0057 0.0595 0.547
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.022 0.263 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.022 0.263 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0134 0.0134
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0134 0.0455
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0028 0.0236 0.272
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0236 0.0845
Leishmania major cathepsin L-like protease 0.002 0.0134 0.0915
Onchocerca volvulus 0.002 0.0134 0.0511
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0824 0.995
Loa Loa (eye worm) ctsf protein 0.002 0.0134 0.0511
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0015 0.0071 0.0544
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0068 0.0734 0.2748
Leishmania major cathepsin L-like protease 0.002 0.0134 0.0915
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0065 0.0702 0.267
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0134 0.0511
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0134 0.0455
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0015 0.0015
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.022 0.263 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0134 0.0134
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0454 0.5406
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0045 0.0454 0.1728
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0134 0.0455
Schistosoma mansoni cpg binding protein 0.0036 0.0334 0.0334
Onchocerca volvulus 0.022 0.263 1
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.022 0.263 1
Brugia malayi hypothetical protein 0.0065 0.0698 0.2655
Echinococcus multilocularis microtubule associated protein 2 0.081 1 1
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0779 0.736
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0037 0.0354 0.0354
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0743 0.8952
Brugia malayi CXXC zinc finger family protein 0.0034 0.031 0.1178
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0068 0.0734 0.8844
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0779 0.2784
Leishmania major DNA polymerase kappa, putative 0.0045 0.0454 0.511
Giardia lamblia Ubiquitin-activating enzyme E1 1 0.0018 0.0109 0.0175
Trypanosoma cruzi major cysteine proteinase, putative 0.0059 0.0624 0.7488
Brugia malayi Cathepsin L-like precursor 0.002 0.0134 0.0511
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0028 0.0236 0.0845
Onchocerca volvulus 0.002 0.0134 0.0511
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0028 0.0236 0.272
Leishmania major cathepsin L-like protease 0.0075 0.0824 0.9947
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0037 0.0354 0.3319
Brugia malayi Cathepsin L-like precursor 0.002 0.0134 0.0511
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0152 0.1785 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0028 0.0236 0.272
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0279 0.3245
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0454 0.5406
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0134 0.1167
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0057 0.0595 0.0595
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0454 0.5406
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0015 0.0058
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0037 0.0354 0.4165
Loa Loa (eye worm) hypothetical protein 0.002 0.0134 0.0511
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0065 0.0698 0.2655
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0236 0.0845
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0028 0.0236 0.0845
Echinococcus granulosus cysteine protease 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0065 0.0698 0.2655
Loa Loa (eye worm) hypothetical protein 0.0093 0.1045 0.3976
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0236 0.0845
Echinococcus multilocularis dna polymerase kappa 0.0045 0.0454 0.0454
Entamoeba histolytica deoxycytidyl transferase, putative 0.0045 0.0454 0.168
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0037 0.0354 0.3319
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0134 0.0511
Leishmania major hypothetical protein, conserved 0.0015 0.0071 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0134 0.0455
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0064 0.0605
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0015 0.0071 0.0682
Plasmodium vivax ubiquitin activating enzyme, putative 0.0057 0.0595 0.5689
Echinococcus multilocularis peptidase Clp (S14 family) 0.006 0.064 0.064
Trypanosoma brucei DNA polymerase eta, putative 0.0075 0.0828 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0824 0.995
Brugia malayi Cathepsin L-like precursor 0.002 0.0134 0.0511
Trypanosoma cruzi ubiquitin-activating enzyme-like protein 0.0018 0.0109 0.1157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0053 0.0145
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0028 0.0236 0.272
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0032 0.0284 0.2633
Echinococcus granulosus dna polymerase kappa 0.0045 0.0454 0.0454
Toxoplasma gondii hypothetical protein 0.0032 0.0284 0.226
Schistosoma mansoni hypothetical protein 0.048 0.5882 0.5882
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0779 0.2784
Leishmania major protein kinase, putative 0.0028 0.0236 0.2251
Leishmania major DNA polymerase eta, putative 0.0075 0.0828 1
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0071 0.0212
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0015 0.0071 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0454 0.5406
Onchocerca volvulus 0.0013 0.0053 0.0202
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0134 0.0455
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0454 0.5406
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0134 0.0134
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0092 0.1035 1
Schistosoma mansoni cpg binding protein 0.0034 0.031 0.031
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0032 0.0284 0.0594
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0779 0.0779
Schistosoma mansoni peptidase Clp (S14 family) 0.0092 0.1035 0.1035
Toxoplasma gondii ThiF family protein 0.0037 0.0354 0.2981
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0064 0.0605
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.022 0.263 1
Schistosoma mansoni hypothetical protein 0.0199 0.2372 0.2372
Loa Loa (eye worm) ThiF family protein 0.0037 0.0354 0.1345
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0064 0.0605
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0092 0.1035 1
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0064 0.0605
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.006 0.064 0.1395
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.022 0.263 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0028 0.024 0.024
Entamoeba histolytica protein tyrosine phosphatase, putative 0.022 0.263 1
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0037 0.0354 0.4165
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0028 0.0236 0.0845
Schistosoma mansoni hypothetical protein 0.0014 0.0069 0.0069
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0065 0.0702 0.267
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0018 0.0109 0.0359
Loa Loa (eye worm) hypothetical protein 0.0065 0.0698 0.2655
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.0053 0.0202
Leishmania major cathepsin L-like protease 0.0075 0.0824 0.9947
Brugia malayi Cathepsin L-like precursor 0.002 0.0134 0.0511
Onchocerca volvulus Cathepsin L homolog 0.002 0.0134 0.0511
Schistosoma mansoni microtubule-associated protein tau 0.081 1 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0092 0.1035 0.1035
Trypanosoma brucei unspecified product 0.0031 0.0279 0.3245
Entamoeba histolytica protein tyrosine phosphatase, putative 0.022 0.263 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0824 0.995
Onchocerca volvulus 0.002 0.0134 0.0511
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0053 0.0145
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.0018 0.0109 0.0359
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0015 0.0071 0.0544
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0454 0.152
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0092 0.1035 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.1035 0.3935
Echinococcus multilocularis dna polymerase eta 0.0075 0.0828 0.0828
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.022 0.263 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0698 0.2655
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0032 0.0284 0.2633
Brugia malayi Cathepsin L-like precursor 0.002 0.0134 0.0511
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0134 0.0455
Echinococcus multilocularis cpg binding protein 0.0036 0.0334 0.0334
Echinococcus granulosus cathepsin L 0.001 0.0015 0.0015
Echinococcus multilocularis cysteine protease 0.002 0.0134 0.0134
Schistosoma mansoni terminal deoxycytidyl transferase 0.0045 0.0454 0.0454
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0824 0.995
Plasmodium vivax vivapain-2 0.002 0.0134 0.1167
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0064 0.0605
Leishmania major cathepsin L-like protease 0.002 0.0134 0.0915
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0019 0.0019
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0092 0.1035 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0454 0.5406
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.006 0.064 0.1395
Loa Loa (eye worm) hypothetical protein 0.0057 0.0595 0.2264
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0092 0.1035 0.3783
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0053 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0454 0.5406
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0134 0.0455
Brugia malayi Cathepsin L-like precursor 0.0013 0.0053 0.0202
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0824 0.995
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0279 0.3245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0134 0.0455
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0015 0.0015
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0071 0.0071
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0015 0.0071 0.0071
Echinococcus granulosus peptidase Clp S14 family 0.006 0.064 0.064
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0068 0.0734 0.2748
Echinococcus granulosus dna polymerase eta 0.0075 0.0828 0.0828
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.006 0.064 0.5056
Brugia malayi ThiF family protein 0.0037 0.0354 0.1345
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0454 0.152
Trypanosoma brucei chrX additional, unordered contigs 0.0014 0.0064 0.0605
Onchocerca volvulus 0.0093 0.1045 0.3976
Echinococcus granulosus cpg binding protein 0.0036 0.0334 0.0334
Schistosoma mansoni cpg binding protein 0.0036 0.0334 0.0334
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0134 0.0455
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0134 0.0455
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0064 0.0605
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0134 0.0455
Trichomonas vaginalis adenylate cyclase, putative 0.0028 0.0236 0.0845
Schistosoma mansoni DNA polymerase eta 0.0075 0.0828 0.0828
Loa Loa (eye worm) fibroinase 0.002 0.0134 0.0511
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0134 0.0455
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0015 0.0071 0.0544
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0037 0.0354 0.0354
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0134 0.0134
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0134 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0134 0.0455
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0824 0.995
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0134 0.1464
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0015 0.0015
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0134 0.0455
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0071 0.0071
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0065 0.0702 0.267
Loa Loa (eye worm) hypothetical protein 0.0013 0.0053 0.0202
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0134 0.0455
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.0071 0.0212
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0015 0.0058
Leishmania major ubiquitin-activating enzyme-like protein 0.0037 0.0354 0.3789
Loa Loa (eye worm) hypothetical protein 0.0065 0.0698 0.2655
Brugia malayi polk-prov protein 0.0014 0.0064 0.0245
Echinococcus granulosus CTD small phosphatase protein like 0.0015 0.0071 0.0071
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.022 0.263 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0053 0.0202
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0134 0.0511
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0064 0.0605
Onchocerca volvulus 0.002 0.0134 0.0511
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0065 0.0702 0.0702
Echinococcus multilocularis 0.0015 0.0071 0.0071
Brugia malayi ImpB/MucB/SamB family protein 0.0075 0.0828 0.3148
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0015 0.0071 0.0071
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0037 0.0354 0.0354

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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