Detailed information for compound 844617

Basic information

Technical information
  • TDR Targets ID: 844617
  • Name: 2,4-di(piperidin-1-yl)-6-prop-2-enoxy-1,3,5-t riazine
  • MW: 303.403 | Formula: C16H25N5O
  • H donors: 0 H acceptors: 3 LogP: 3.52 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCOc1nc(nc(n1)N1CCCCC1)N1CCCCC1
  • InChi: 1S/C16H25N5O/c1-2-13-22-16-18-14(20-9-5-3-6-10-20)17-15(19-16)21-11-7-4-8-12-21/h2H,1,3-13H2
  • InChiKey: RUCDUSPQPFSBES-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-allyloxy-4,6-bis(1-piperidyl)-1,3,5-triazine
  • 2-allyloxy-4,6-dipiperidino-s-triazine
  • Oprea1_876966
  • 1,3,5-Triazine, 2-allyloxy-4,6-di(1-pyperidyl)-
  • ST051134
  • BAS 07466037
  • 2-Allyloxy-4,6-di-piperidin-1-yl-[1,3,5]triazine
  • ZINC02832562

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0041 0.0102 0.0102
Loa Loa (eye worm) intermediate filament protein 0.0054 0.016 0.0824
Schistosoma mansoni hypothetical protein 0.0036 0.0077 0.0178
Loa Loa (eye worm) hypothetical protein 0.0041 0.0102 0.0522
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0077 0.0171
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0393 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.0031 0.0073
Loa Loa (eye worm) CUTiclin-Like family member 0.0041 0.0102 0.0522
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0044 0.3072
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.0031 0.0073
Onchocerca volvulus 0.0023 0.0018 0.009
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.0484 0.0484
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0031 0.0162
Loa Loa (eye worm) hypothetical protein 0.0041 0.0102 0.0522
Toxoplasma gondii aldehyde dehydrogenase 0.0183 0.0743 1
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0041 0.0102 0.0296
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.0031 0.0073
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.0393 0.0393
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.0393 0.5
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0393 0.1785
Onchocerca volvulus 0.0041 0.0102 0.0507
Echinococcus granulosus collagen alpha 1VII chain 0.0041 0.0102 0.0102
Loa Loa (eye worm) cytochrome P450 family protein 0.0068 0.022 0.1132
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0033 0.0033
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.0031 0.0031
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0223 0.0924 0.0924
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0223 0.0924 0.2141
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0031 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0031 0.0162
Brugia malayi nuclear receptor NHR-88 0.0026 0.0031 0.0162
Entamoeba histolytica hypothetical protein 0.0036 0.0077 0.0952
Loa Loa (eye worm) hypothetical protein 0.0041 0.0102 0.0522
Echinococcus multilocularis expressed protein 0.0364 0.1559 0.1559
Brugia malayi Pre-SET motif family protein 0.0058 0.0177 0.0912
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0183 0.0743 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0028 0.0273
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0028 0.1226
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0041 0.0102 0.0522
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0102 0.0522
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.0031 0.0073
Loa Loa (eye worm) TK/ROR protein kinase 0.0023 0.0018 0.0093
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0393 0.1785
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0162
Schistosoma mansoni cell polarity protein 0.0052 0.015 0.0348
Brugia malayi hypothetical protein 0.023 0.0956 0.4917
Echinococcus granulosus neurogenic locus notch protein 0.0052 0.015 0.015
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0077 0.0817
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0077 0.0077
Entamoeba histolytica hypothetical protein, conserved 0.0041 0.0102 0.1656
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0102 0.5243
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.0945 0.4861
Brugia malayi nuclear hormone receptor 0.0026 0.0031 0.0162
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0393 0.0912
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.0031 0.0073
Onchocerca volvulus 0.0054 0.016 0.08
Loa Loa (eye worm) hypothetical protein 0.0309 0.1312 0.6748
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0393 1
Brugia malayi laminin alpha chain 0.0052 0.015 0.0772
Schistosoma mansoni coup transcription factor 0.0026 0.0031 0.0073
Loa Loa (eye worm) hypothetical protein 0.0041 0.0102 0.0522
Mycobacterium ulcerans aldehyde dehydrogenase 0.0183 0.0743 1
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0046 0.0237
Loa Loa (eye worm) hypothetical protein 0.0025 0.0028 0.0145
Schistosoma mansoni serine-rich repeat protein 0.0524 0.2283 0.5293
Echinococcus granulosus voltage dependent calcium channel subunit 0.1014 0.4501 0.4501
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0044 0.0354
Onchocerca volvulus 0.0041 0.0102 0.0507
Onchocerca volvulus 0.0461 0.2002 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0102 0.0522
Entamoeba histolytica elongation factor-2 kinase, putative 0.0041 0.0102 0.1656
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0031 0.0162
Schistosoma mansoni hypothetical protein 0.0041 0.0102 0.0235
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0041 0.0102 0.5243
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0223 0.0924 0.475
Echinococcus multilocularis tissue type plasminogen activator 0.0023 0.0018 0.0018
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0077 1
Echinococcus granulosus intermediate filament protein 0.0054 0.016 0.016
Onchocerca volvulus 0.0047 0.0127 0.0634
Entamoeba histolytica hypothetical protein, conserved 0.0041 0.0102 0.1656
Loa Loa (eye worm) hypothetical protein 0.0041 0.0102 0.0522
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0393 1
Onchocerca volvulus 0.0054 0.016 0.08
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.0393 0.0393
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0041 0.0102 0.5243
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0093
Loa Loa (eye worm) hypothetical protein 0.0041 0.0102 0.0522
Loa Loa (eye worm) hypothetical protein 0.0025 0.0028 0.0146
Brugia malayi Pre-SET motif family protein 0.0405 0.1749 0.8991
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0077 0.1342
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0033 0.0033
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0077 0.0397
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0177 0.0177
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0972 0.4314 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.0031 0.0073
Brugia malayi EGF-like domain containing protein 0.0052 0.015 0.0772
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0162
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0041 0.0102 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0183 0.0743 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0031 0.0162
Plasmodium vivax thrombospondin-related anonymous protein 0.0041 0.0102 0.5243
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0041 0.0102 0.0522
Echinococcus granulosus slit 2 protein 0.0052 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0162
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0077 0.0077
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.0031 0.0031
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0102 0.0522
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0077 0.0171
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.0031 0.0162
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0102 0.0522
Onchocerca volvulus 0.0058 0.0177 0.0886
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0031 0.0162
Loa Loa (eye worm) hypothetical protein 0.0052 0.015 0.0772
Onchocerca volvulus 0.0041 0.0102 0.0507
Brugia malayi Protein kinase domain containing protein 0.0023 0.0018 0.0093
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0031 0.0162
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0162
Brugia malayi Zona pellucida-like domain containing protein 0.0041 0.0102 0.0522
Loa Loa (eye worm) hypothetical protein 0.0041 0.0102 0.0522
Loa Loa (eye worm) hypothetical protein 0.0025 0.0028 0.0146
Plasmodium falciparum thrombospondin-related anonymous protein 0.0041 0.0102 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0031 0.0031
Echinococcus multilocularis musashi 0.0054 0.016 0.016
Onchocerca volvulus 0.0041 0.0102 0.0507
Toxoplasma gondii microneme protein MIC2 0.0041 0.0102 0.1153
Loa Loa (eye worm) abnormal epIthelia family member 0.0052 0.015 0.0772
Onchocerca volvulus 0.0026 0.0031 0.0157
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0028 0.0141
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0393 0.2022
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0138 0.032
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0077 0.0077
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0028 0.1226
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0168 0.0168
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0177 0.0177
Schistosoma mansoni hypothetical protein 0.0126 0.0484 0.1121
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.0031 0.0157
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0031 0.0073
Loa Loa (eye worm) hypothetical protein 0.0026 0.0033 0.0169
Loa Loa (eye worm) hypothetical protein 0.0058 0.0177 0.0912
Treponema pallidum hypothetical protein 0.0041 0.0102 0.0123
Loa Loa (eye worm) hypothetical protein 0.023 0.0956 0.4917
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0183 0.0743 0.0743
Loa Loa (eye worm) hypothetical protein 0.0053 0.0156 0.08
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0177 0.0411
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0028 0.0643
Loa Loa (eye worm) hypothetical protein 0.0052 0.015 0.0772
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0044 0.161
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0177 0.0177
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0177 0.0411
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0031 0.0031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0183 0.0743 1
Loa Loa (eye worm) phosphofructokinase 0.0106 0.0393 0.2022
Loa Loa (eye worm) hypothetical protein 0.0449 0.1945 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.0031 0.0031
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0127 0.0652
Echinococcus multilocularis pikachurin 0.0052 0.015 0.015
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.0956 0.0956
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0183 0.0743 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0102 0.0522
Brugia malayi hypothetical protein 0.0041 0.0102 0.0522
Onchocerca volvulus 0.0049 0.0138 0.0689
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0102 0.0522
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0031 0.0162
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0077 0.0178
Schistosoma mansoni thyroid hormone receptor 0.0152 0.0601 0.1393
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0031 0.0162
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0041 0.0102 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0162
Plasmodium vivax SET domain protein, putative 0.0058 0.0177 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0102 0.0522
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0077 0.096
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0102 0.0522
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.016 0.0824
Loa Loa (eye worm) hypothetical protein 0.0054 0.016 0.0824
Echinococcus multilocularis tumor protein p63 0.0338 0.1442 0.1442
Trichomonas vaginalis set domain proteins, putative 0.0461 0.2002 1
Schistosoma mansoni lamin 0.0054 0.016 0.0371
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0077 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0031 0.0162
Brugia malayi ecdysteroid receptor 0.0026 0.0031 0.0162
Schistosoma mansoni intermediate filament proteins 0.0054 0.016 0.0371
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0028 0.0273
Loa Loa (eye worm) hypothetical protein 0.0041 0.0102 0.0522
Echinococcus granulosus survival motor neuron protein 1 0.023 0.0956 0.0956
Schistosoma mansoni hypothetical protein 0.0041 0.0102 0.0235
Brugia malayi 6-phosphofructokinase 0.0106 0.0393 0.2022
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0077 0.0171
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.0031 0.0031
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0077 0.0077
Brugia malayi hypothetical protein 0.0103 0.0378 0.1946
Loa Loa (eye worm) hypothetical protein 0.0041 0.0102 0.0522
Echinococcus multilocularis thyroid hormone receptor alpha 0.0152 0.0601 0.0601
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0031 0.0162
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0177 0.22
Loa Loa (eye worm) hypothetical protein 0.0052 0.015 0.0772
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0102 0.0522
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.0031 0.0157
Brugia malayi von Willebrand Factor 0.0041 0.0102 0.0522
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0031 0.0031
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0041 0.0102 0.1153
Loa Loa (eye worm) hypothetical protein 0.0041 0.0102 0.0522
Echinococcus granulosus leukotriene A 4 hydrolase 0.0223 0.0924 0.0924
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0031 0.0162
Schistosoma mansoni hypothetical protein 0.0023 0.0018 0.0042
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.049 0.2132 0.4943
Schistosoma mansoni thyroid hormone receptor 0.0152 0.0601 0.1393
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0044 0.5
Echinococcus multilocularis lamin 0.0054 0.016 0.016
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.0031 0.0073
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.0031 0.0073
Echinococcus granulosus FTZ F1 alpha 0.0026 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0031 0.0162
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0077 0.0179
Echinococcus granulosus tissue type plasminogen activator 0.0023 0.0018 0.0018
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0077 0.0077
Echinococcus multilocularis slit 2 protein 0.0052 0.015 0.015
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0031 0.0162
Treponema pallidum 76K protein 0.0041 0.0102 0.0123
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0044 0.161
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0031 0.0162
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0041 0.0102 0.0522
Onchocerca volvulus 0.0041 0.0102 0.0507
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0162
Entamoeba histolytica hypothetical protein 0.0036 0.0077 0.0952
Brugia malayi Kringle domain containing protein 0.0023 0.0018 0.0093
Echinococcus multilocularis neurogenic locus notch protein 0.0052 0.015 0.015
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.0031 0.0031
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.0031 0.0031
Brugia malayi laminin-like protein K08C7.3 precursor 0.0052 0.015 0.0772
Brugia malayi follicle stimulating hormone receptor 0.0228 0.0945 0.4861
Onchocerca volvulus 0.0041 0.0102 0.0507
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0162
Brugia malayi 6-phosphofructokinase 0.0106 0.0393 0.2022
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0077 0.0179
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.0393 0.518
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0044 0.0354
Entamoeba histolytica hypothetical protein 0.0041 0.0102 0.1656
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2229 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0177 0.0411
Loa Loa (eye worm) hypothetical protein 0.0036 0.0077 0.0397
Schistosoma mansoni survival motor neuron protein 0.0047 0.0127 0.0294
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0102 0.0522
Loa Loa (eye worm) hypothetical protein 0.0041 0.0102 0.0522
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0393 0.1785
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0077 0.1578
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.016 0.0824
Schistosoma mansoni aldehyde dehydrogenase 0.0183 0.0743 0.1721
Brugia malayi Cache domain containing protein 0.0449 0.1945 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.0484 0.0484
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0044 0.5
Brugia malayi phosphofructokinase 0.0106 0.0393 0.2022
Schistosoma mansoni hypothetical protein 0.0047 0.0127 0.0294
Echinococcus multilocularis lamin dm0 0.0054 0.016 0.016
Loa Loa (eye worm) CUTiclin family member 0.0041 0.0102 0.0522
Brugia malayi intermediate filament protein 0.0054 0.016 0.0824
Schistosoma mansoni slit 0.0052 0.015 0.0348
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0031 0.0162
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0031 0.0031
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0393 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.0031 0.0031
Schistosoma mansoni aldehyde dehydrogenase 0.0183 0.0743 0.1721
Echinococcus multilocularis voltage dependent calcium channel subunit 0.1014 0.4501 0.4501
Entamoeba histolytica hypothetical protein 0.0036 0.0077 0.0952
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0031 0.0162
Brugia malayi hypothetical protein 0.0025 0.0028 0.0145
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.0031 0.0031
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.0393 0.0742
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0031 0.0073
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0183 0.0743 0.0743
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0044 0.3072
Schistosoma mansoni lamin 0.0054 0.016 0.0371
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0031 0.0162
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0044 0.0354
Entamoeba histolytica hypothetical protein 0.0036 0.0077 0.0952
Echinococcus granulosus lamin dm0 0.0054 0.016 0.016
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0041 0.0102 0.5243
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0031 0.0162
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0393 0.1785
Echinococcus granulosus pikachurin 0.0052 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0041 0.0102 0.0522
Loa Loa (eye worm) hypothetical protein 0.0049 0.0138 0.0709
Schistosoma mansoni laminin gamma-3 chain 0.0052 0.015 0.0348
Brugia malayi hypothetical protein 0.0119 0.0451 0.2317
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.0031 0.0031
Echinococcus granulosus expressed protein 0.0364 0.1559 0.1559
Leishmania major hypothetical protein, conserved 0.0025 0.0028 0.0141
Onchocerca volvulus 0.0041 0.0102 0.0507
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0162
Brugia malayi hypothetical protein 0.0036 0.0077 0.0396
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0393 0.2022
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0393 0.0912
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0052 0.015 0.0772
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0052 0.015 0.0348
Echinococcus granulosus tumor protein p63 0.0338 0.1442 0.1442
Brugia malayi von Willebrand factor type A domain containing protein 0.0041 0.0102 0.0522
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0031 0.0162
Brugia malayi Zona pellucida-like domain containing protein 0.0041 0.0102 0.0522
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0046 0.0237
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0405 0.1749 0.8991
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.0031 0.0157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0031 0.0162
Echinococcus granulosus lamin 0.0054 0.016 0.016
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0031 0.0162
Schistosoma mansoni hypothetical protein 0.0524 0.2283 0.5293
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0393 1
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.107 0.4758 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.0177 0.0411
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0077 0.1578
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0077 0.0077
Brugia malayi Cytochrome P450 family protein 0.0068 0.022 0.1132
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.0031 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0031 0.0162
Brugia malayi steroid hormone receptor 0.0026 0.0031 0.0162

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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