Detailed information for compound 848728

Basic information

Technical information
  • TDR Targets ID: 848728
  • Name: 4-[(2-chlorophenyl)methyl]-N-[(2-methoxypheny l)methyl]-3-oxo-1,4-benzothiazine-6-carboxami de
  • MW: 452.953 | Formula: C24H21ClN2O3S
  • H donors: 1 H acceptors: 2 LogP: 4.46 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1CNC(=O)c1ccc2c(c1)N(Cc1ccccc1Cl)C(=O)CS2
  • InChi: 1S/C24H21ClN2O3S/c1-30-21-9-5-3-6-17(21)13-26-24(29)16-10-11-22-20(12-16)27(23(28)15-31-22)14-18-7-2-4-8-19(18)25/h2-12H,13-15H2,1H3,(H,26,29)
  • InChiKey: CVDXAGZKNYLLBH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2-chlorobenzyl)-3-keto-N-(2-methoxybenzyl)-1,4-benzothiazine-6-carboxamide
  • EU-0088516

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.038
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0292 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.002 0.0084 0.038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0094 0.017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0262 0.1222
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0373 0.0363
Loa Loa (eye worm) hypothetical protein 0.0021 0.0094 0.0429
Schistosoma mansoni retinoic acid receptor RXR 0.0044 0.0373 0.0416
Loa Loa (eye worm) hypothetical protein 0.0044 0.0373 0.1749
Brugia malayi hypothetical protein 0.0023 0.0124 0.0538
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0472 0.0462
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0052 0.0466 0.0456
Toxoplasma gondii HEAT repeat-containing protein 0.0016 0.0036 0.0018
Brugia malayi ecdysone receptor 0.0021 0.0094 0.0396
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0035 0.0262 0.051
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0373 0.172
Echinococcus multilocularis GPCR, family 2 0.006 0.0565 0.0555
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0127 0.1371 0.5227
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0035 0.0262 0.0252
Echinococcus granulosus polycomb protein SCMH1 0.0031 0.0211 0.0407
Trichomonas vaginalis esterase, putative 0.002 0.0084 0.2866
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0044 0.0373 0.172
Brugia malayi hypothetical protein 0.0016 0.0031 0.0099
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0044 0.0373 0.0416
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.0094 0.017
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.0124 0.023
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0044 0.0373 0.0416
Echinococcus granulosus importin subunit beta 1 0.0016 0.0036 0.0052
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0373 0.172
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0292 0.3243
Schistosoma mansoni thyroid hormone receptor 0.0044 0.0373 0.0416
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0124 0.0538
Loa Loa (eye worm) hypothetical protein 0.0023 0.0124 0.0571
Brugia malayi mbt repeat family protein 0.0031 0.0211 0.0951
Loa Loa (eye worm) latrophilin receptor protein 2 0.006 0.0565 0.2652
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0031 0.0211 0.1873
Brugia malayi Bromodomain containing protein 0.0048 0.0421 0.1945
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0011 0.0117
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0216 0.0714
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0044 0.0373 0.1749
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0292 0.3243
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0133
Onchocerca volvulus 0.0031 0.0211 0.1873
Loa Loa (eye worm) hypothetical protein 0.0044 0.0373 0.1749
Brugia malayi nuclear receptor NHR-67 0.0021 0.0094 0.0396
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0292 0.3162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0044 0.0373 0.1749
Toxoplasma gondii hypothetical protein 0.0231 0.2613 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0021 0.0094 0.017
Onchocerca volvulus Bile acid receptor homolog 0.0044 0.0373 0.4256
Brugia malayi photoreceptor-specific nuclear receptor 0.0044 0.0373 0.172
Loa Loa (eye worm) hypothetical protein 0.0077 0.0764 0.3596
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0292 0.0572
Schistosoma mansoni bromodomain containing protein 0.004 0.0331 0.0369
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0084 0.0929
Brugia malayi nuclear receptor RXR 0.0021 0.0094 0.0396
Trypanosoma brucei importin beta-1 subunit, putative 0.0016 0.0036 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0044 0.0373 0.172
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0011 0.0117
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0231 0.2613 1
Brugia malayi ecdysteroid receptor 0.0044 0.0373 0.172
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.002 0.0084 0.0281
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0216 0.0205
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0216 0.0714
Schistosoma mansoni hypothetical protein 0.006 0.0565 0.0632
Toxoplasma gondii exonuclease III APE 0.0037 0.0292 0.101
Brugia malayi nuclear receptor NHR-88 0.0044 0.0373 0.172
Trypanosoma cruzi Peptide deformylase 2, putative 0.0088 0.0901 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0044 0.0373 0.0737
Loa Loa (eye worm) beta-lactamase 0.002 0.0084 0.038
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0044 0.0373 0.0737
Mycobacterium tuberculosis Probable lipase LipD 0.002 0.0084 0.0281
Mycobacterium ulcerans peptide deformylase 0.0231 0.2613 1
Schistosoma mansoni hypothetical protein 0.013 0.14 0.1571
Chlamydia trachomatis peptide deformylase 0.0231 0.2613 0.5
Schistosoma mansoni myelin transcription factor 1 myt1 0.0035 0.0262 0.0291
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0216 0.0416
Schistosoma mansoni nuclear receptor 0.0021 0.0094 0.0102
Brugia malayi beta-lactamase family protein 0.002 0.0084 0.0347
Trichomonas vaginalis penicillin-binding protein, putative 0.002 0.0084 0.2866
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0052 0.0466 0.5166
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0216 0.0205
Brugia malayi nuclear hormone receptor 0.0044 0.0373 0.172
Echinococcus multilocularis beta LACTamase domain containing family member 0.002 0.0084 0.0073
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0094 0.0429
Mycobacterium tuberculosis Probable hydrolase 0.002 0.0084 0.0281
Schistosoma mansoni aldehyde dehydrogenase 0.0052 0.0466 0.052
Mycobacterium tuberculosis Probable lipase LipE 0.002 0.0084 0.0281
Loa Loa (eye worm) mbt repeat family protein 0.0031 0.0211 0.0982
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0216 0.1003
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0216 0.0239
Leishmania major DNA polymerase eta, putative 0.0014 0.0011 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0044 0.0373 0.172
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0472 0.2189
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0216 0.2394
Echinococcus granulosus histone acetyltransferase MYST2 0.0035 0.0262 0.051
Entamoeba histolytica deoxycytidyl transferase, putative 0.0014 0.0011 0.0362
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0044 0.0373 0.0416
Schistosoma mansoni aldehyde dehydrogenase 0.0052 0.0466 0.052
Brugia malayi PHD-finger family protein 0.0016 0.0036 0.0121
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0021 0.0094 0.0154
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0044 0.0373 0.0737
Mycobacterium ulcerans beta-lactamase 0.002 0.0084 0.0281
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0216 0.2303
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0292 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.038
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0014 0.0011 0.0362
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0044 0.0373 0.4256
Schistosoma mansoni ap endonuclease 0.0037 0.0292 0.0325
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0044 0.0373 0.0363
Mycobacterium ulcerans hypothetical protein 0.002 0.0084 0.0281
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0094 0.0396
Loa Loa (eye worm) hypothetical protein 0.0023 0.0124 0.0571
Trypanosoma cruzi PAB1-binding protein , putative 0.0016 0.0031 0.0349
Loa Loa (eye worm) nuclear receptor NHR-67 0.0021 0.0094 0.0429
Brugia malayi latrophilin 2 splice variant baaae 0.013 0.14 0.6587
Loa Loa (eye worm) hypothetical protein 0.0031 0.0211 0.0982
Plasmodium vivax importin-beta 2, putative 0.0016 0.0036 0.0018
Loa Loa (eye worm) hypothetical protein 0.0023 0.0124 0.0571
Schistosoma mansoni hypothetical protein 0.006 0.0565 0.0632
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0292 0.1335
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0292 0.3243
Trypanosoma cruzi PAB1-binding protein , putative 0.0016 0.0031 0.0349
Loa Loa (eye worm) hypothetical protein 0.0021 0.0094 0.0429
Echinococcus granulosus FTZ F1 alpha 0.0044 0.0373 0.0737
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0216 0.0205
Loa Loa (eye worm) hypothetical protein 0.0025 0.014 0.0644
Schistosoma mansoni sex comb on midleg homolog 0.0031 0.0211 0.0234
Trypanosoma brucei importin beta-1 subunit, putative 0.0016 0.0036 0.0287
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.0094 0.0084
Echinococcus granulosus snurportin 1 0.017 0.1887 0.3809
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.006 0.0565 0.1125
Brugia malayi steroid hormone receptor 0.0044 0.0373 0.172
Plasmodium vivax hypothetical protein, conserved 0.002 0.0084 0.0203
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0021 0.0094 0.0084
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0231 0.2613 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0044 0.0373 0.172
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0216 0.0714
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.019 0.212 1
Brugia malayi orphan nuclear receptor NR2E1 0.0021 0.0094 0.0396
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0124 0.0538
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0472 0.0528
Schistosoma mansoni DNA polymerase eta 0.0014 0.0011 0.0008
Echinococcus granulosus GPCR family 2 0.006 0.0565 0.1125
Echinococcus multilocularis snurportin 1 0.017 0.1887 0.1879
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0292 0.1082
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0754 0.8892 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0021 0.0094 0.0084
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.017 0.1887 0.89
Brugia malayi beta-lactamase family protein 0.002 0.0084 0.0347
Brugia malayi hypothetical protein 0.0023 0.0124 0.0538
Brugia malayi nuclear hormone receptor family member odr-7 0.0021 0.0094 0.0396
Loa Loa (eye worm) hypothetical protein 0.0044 0.0373 0.1749
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0044 0.0373 0.0363
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0216 0.0714
Brugia malayi tailless protein 0.0021 0.0094 0.0396
Brugia malayi hypothetical protein 0.0021 0.0094 0.0396
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0292 0.1082
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.002 0.0084 0.0347
Mycobacterium ulcerans aldehyde dehydrogenase 0.0052 0.0466 0.1748
Loa Loa (eye worm) hypothetical protein 0.0026 0.0158 0.0729
Echinococcus multilocularis thyroid hormone receptor alpha 0.0044 0.0373 0.0363
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0292 0.1365
Loa Loa (eye worm) hypothetical protein 0.0021 0.0094 0.0429
Brugia malayi Steroid receptor seven-up type 2 0.0044 0.0373 0.172
Mycobacterium ulcerans aldehyde dehydrogenase 0.0052 0.0466 0.1748
Loa Loa (eye worm) hypothetical protein 0.0021 0.0094 0.0429
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0216 0.2394
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0124 0.0136
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0014 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0044 0.0373 0.1749
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0044 0.0373 0.0363
Brugia malayi hypothetical protein 0.0021 0.0094 0.0396
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0023 0.0121 0.0224
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0373 0.0737
Schistosoma mansoni RAR-like nuclear receptor 0.0044 0.0373 0.0416
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0044 0.0373 0.172
Mycobacterium tuberculosis Conserved protein 0.002 0.0084 0.0281
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.006 0.0565 0.1125
Toxoplasma gondii ABC1 family protein 0.002 0.0084 0.0203
Mycobacterium tuberculosis Conserved protein 0.002 0.0084 0.0281
Brugia malayi RNA, U transporter 1 0.0045 0.0389 0.1793
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0216 0.2303
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0373 0.0416
Brugia malayi hypothetical protein 0.0077 0.0764 0.3574
Loa Loa (eye worm) hypothetical protein 0.0016 0.0036 0.0155
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0373 0.172
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0472 0.0462
Echinococcus multilocularis polycomb protein SCMH1 0.0031 0.0211 0.0201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0044 0.0373 0.1749
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0014 0.0018 0.0017
Brugia malayi nuclear hormone receptor family member nhr-6 0.0021 0.0094 0.0396
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0373 0.172
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.038
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0011 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0044 0.0373 0.1749
Schistosoma mansoni hypothetical protein 0.0193 0.2162 0.2429
Loa Loa (eye worm) hypothetical protein 0.0021 0.0094 0.0429
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0216 0.0205
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0034
Loa Loa (eye worm) hypothetical protein 0.0027 0.0172 0.0799
Plasmodium vivax peptide deformylase, putative 0.0231 0.2613 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.019 0.212 1
Schistosoma mansoni sex comb on midleg homolog 0.0031 0.0211 0.0234
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.006 0.0565 0.2627
Echinococcus multilocularis SAM and MBT domain containing protein 0.0031 0.0211 0.0201
Loa Loa (eye worm) hypothetical protein 0.0023 0.0124 0.0571
Loa Loa (eye worm) hypothetical protein 0.0023 0.0124 0.0571
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0021 0.0094 0.0154
Loa Loa (eye worm) hypothetical protein 0.0044 0.0373 0.1749
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0044 0.0373 0.172
Loa Loa (eye worm) hypothetical protein 0.0021 0.0094 0.0429
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0088 0.0901 1
Trichomonas vaginalis D-aminoacylase, putative 0.002 0.0084 0.2866
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0021 0.0094 0.0429
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0472 0.0528
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0472 0.2216
Plasmodium falciparum importin beta, putative 0.0016 0.0036 0.0018
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.006 0.0565 0.0555
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0021 0.0094 0.017
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0084 0.0929
Schistosoma mansoni thyroid hormone receptor 0.0044 0.0373 0.0416
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0303 0.0293
Echinococcus multilocularis importin subunit beta 1 0.0016 0.0036 0.0026
Loa Loa (eye worm) hypothetical protein 0.0044 0.0373 0.1749
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0044 0.0373 0.0416
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.038
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0031 0.0211 0.0234
Trichomonas vaginalis DNA polymerase eta, putative 0.0014 0.0011 0.0362
Trypanosoma cruzi DNA polymerase kappa, putative 0.0014 0.0011 0.0117
Echinococcus multilocularis FTZ F1 alpha 0.0044 0.0373 0.0363
Mycobacterium tuberculosis Probable conserved lipoprotein 0.002 0.0084 0.0281
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0044 0.0373 0.1749
Schistosoma mansoni importin beta-1 0.0016 0.0036 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0044 0.0373 0.172
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0292 0.101
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0128 0.1379 0.137
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0044 0.0373 0.0416
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0044 0.0373 0.1749
Brugia malayi Bromodomain containing protein 0.0025 0.0139 0.0609
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.006 0.0565 0.0555
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0044 0.0373 0.1749
Loa Loa (eye worm) hypothetical protein 0.0021 0.0094 0.0429
Trypanosoma cruzi DNA polymerase eta, putative 0.0014 0.0011 0.0117
Schistosoma mansoni steroid hormone receptor ad4bp 0.0044 0.0373 0.0416
Trypanosoma brucei PAB1-binding protein , putative 0.0016 0.0031 0.0234
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0216 0.2394
Echinococcus multilocularis ecdysone induced protein 78C 0.0044 0.0373 0.0363
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0373 0.0416
Brugia malayi nuclear receptor NHR-88 0.0021 0.0094 0.0396
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0044 0.0373 0.0737
Schistosoma mansoni coup transcription factor 0.0044 0.0373 0.0416
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.038
Mycobacterium ulcerans esterase/lipase LipP 0.002 0.0084 0.0281
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0216 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0044 0.0373 0.172
Trichomonas vaginalis D-aminoacylase, putative 0.002 0.0084 0.2866
Echinococcus granulosus Nuclear hormone receptor HR96 0.0021 0.0094 0.017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0094 0.0429
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0216 0.0972
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.002 0.0084 0.009
Loa Loa (eye worm) hypothetical protein 0.0045 0.0388 0.1818
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0014 0.0011 0.0117
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0303 0.0594
Echinococcus granulosus ecdysone induced protein 78C 0.0044 0.0373 0.0737
Leishmania major polypeptide deformylase-like protein, putative 0.0088 0.0901 1
Brugia malayi Latrophilin receptor protein 2 0.006 0.0565 0.2627
Schistosoma mansoni hypothetical protein 0.0424 0.4938 0.5551
Loa Loa (eye worm) DR-78 0.0021 0.0094 0.0429
Leishmania major hypothetical protein, conserved 0.0016 0.0031 0.0349
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0088 0.0901 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0292 1
Schistosoma mansoni hypothetical protein 0.006 0.0565 0.0632
Mycobacterium ulcerans lipase LipD 0.002 0.0084 0.0281
Schistosoma mansoni hypothetical protein 0.0424 0.4938 0.5551
Trypanosoma brucei Polypeptide deformylase 1 0.0088 0.0901 1
Loa Loa (eye worm) hypothetical protein 0.013 0.14 0.6599
Echinococcus granulosus nuclear receptor nhr 48 0.0021 0.0094 0.017
Echinococcus granulosus geminin 0.0424 0.4938 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0472 0.0937
Plasmodium falciparum peptide deformylase 0.0231 0.2613 1
Brugia malayi Nuclear hormone receptor E75 0.0021 0.0094 0.0396
Echinococcus multilocularis geminin 0.0424 0.4938 0.4933
Loa Loa (eye worm) hypothetical protein 0.0021 0.0094 0.0429
Echinococcus granulosus beta LACTamase domain containing family member 0.002 0.0084 0.0148
Brugia malayi isocitrate dehydrogenase 0.0031 0.0216 0.0972
Loa Loa (eye worm) hypothetical protein 0.0021 0.0094 0.0429
Loa Loa (eye worm) hypothetical protein 0.0021 0.0094 0.0429
Treponema pallidum polypeptide deformylase (def) 0.0231 0.2613 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0014 0.0018 0.0015
Onchocerca volvulus Protein ultraspiracle homolog 0.0044 0.0373 0.4256
Leishmania major hypothetical protein, conserved 0.002 0.0084 0.0929
Mycobacterium tuberculosis Probable esterase LipL 0.002 0.0084 0.0281
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0044 0.0373 0.1749
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0292 0.101
Loa Loa (eye worm) hypothetical protein 0.019 0.212 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0084 0.038
Brugia malayi mbt repeat family protein 0.0031 0.0211 0.0951
Leishmania major DNA polymerase kappa, putative 0.0014 0.0011 0.0117
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0094 0.0102
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0216 0.0788
Echinococcus multilocularis nuclear receptor nhr 48 0.0021 0.0094 0.0084
Onchocerca volvulus 0.0021 0.0094 0.0154
Schistosoma mansoni nuclear receptor 0.0021 0.0094 0.0102
Brugia malayi nuclear hormone receptor 0.0021 0.0094 0.0396
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0094 0.0102
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.002 0.0084 0.0281
Mycobacterium tuberculosis Conserved protein 0.002 0.0084 0.0281
Trichomonas vaginalis penicillin-binding protein, putative 0.002 0.0084 0.2866
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.0124 0.0571
Onchocerca volvulus 0.0044 0.0373 0.4256
Loa Loa (eye worm) MBCTL1 0.0035 0.0262 0.1222
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0373 0.0363
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0292 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0044 0.0373 0.0737
Loa Loa (eye worm) steroid hormone receptor 0.0044 0.0373 0.1749
Onchocerca volvulus 0.0021 0.0094 0.0154
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0128 0.1379 0.2777
Schistosoma mansoni zinc finger protein 0.0021 0.0094 0.0102
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0011 0.0034
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.002 0.0084 0.009
Schistosoma mansoni ap endonuclease 0.0037 0.0292 0.0325
Loa Loa (eye worm) nuclear hormone receptor 0.0021 0.0094 0.0429
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0472 0.0528
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0021 0.0094 0.0102
Schistosoma mansoni hypothetical protein 0.006 0.0565 0.0632
Echinococcus multilocularis histone acetyltransferase MYST2 0.0035 0.0262 0.0252
Brugia malayi nuclear receptor RXR 0.0023 0.0124 0.0538
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0292 0.0282
Loa Loa (eye worm) pigment dispersing factor receptor c 0.019 0.212 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0021 0.0094 0.0396
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0052 0.0466 0.0924
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0044 0.0373 0.172
Loa Loa (eye worm) hypothetical protein 0.006 0.0565 0.2652
Schistosoma mansoni hypothetical protein 0.017 0.1887 0.2119
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.0124 0.0114
Onchocerca volvulus 0.0077 0.0764 1
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0084 0.0821
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0052 0.0466 0.1748
Brugia malayi conserved hypotetical protein 0.0021 0.0094 0.0396
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0231 0.2613 1
Brugia malayi beta-lactamase 0.002 0.0084 0.0347
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.002 0.0084 0.0281
Loa Loa (eye worm) hypothetical protein 0.0044 0.0373 0.1749
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0094 0.0084
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0044 0.0373 0.0363
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0472 0.0937
Toxoplasma gondii aldehyde dehydrogenase 0.0052 0.0466 0.1682
Mycobacterium ulcerans aldehyde dehydrogenase 0.0052 0.0466 0.1748
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0023 0.0121 0.011
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0021 0.0094 0.0084
Loa Loa (eye worm) hypothetical protein 0.0021 0.0094 0.0429
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0044 0.0373 0.172
Schistosoma mansoni nuclear receptor nhr-48 0.0021 0.0094 0.0102
Trypanosoma cruzi Peptide deformylase 2, putative 0.0088 0.0901 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.0124 0.0136
Trichomonas vaginalis D-aminoacylase, putative 0.002 0.0084 0.2866
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0035 0.0262 0.1192
Trypanosoma brucei Peptide deformylase 2 0.0088 0.0901 1
Brugia malayi Importin beta-1 subunit 0.0016 0.0036 0.0121
Echinococcus granulosus SAM and MBT domain containing protein 0.0031 0.0211 0.0407
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0373 0.0737

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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