TDR Targets

Basic information

Technical information

TDR Targets ID: 863810
Name: N-cyclopentyl-2-[(phenylmethyl-(pyridin-3-ylm ethyl)carbamothioyl)amino]acetamide
MW: 382.522 | Formula: C21H26N4OS
H donors: 2 H acceptors: 2 LogP: 2.68 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: O=C(NC1CCCC1)CNC(=S)N(Cc1cccnc1)Cc1ccccc1
InChi: 1S/C21H26N4OS/c26-20(24-19-10-4-5-11-19)14-23-21(27)25(15-17-7-2-1-3-8-17)16-18-9-6-12-22-13-18/h1-3,6-9,12-13,19H,4-5,10-11,14-16H2,(H,23,27)(H,24,26)
InChiKey: KBZZYUXQRFEMAI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-cyclopentyl-2-[(phenylmethyl-(3-pyridylmethyl)carbamothioyl)amino]acetamide
N-cyclopentyl-2-[[(phenylmethyl-(3-pyridylmethyl)amino)-thioxomethyl]amino]acetamide
2-[(benzyl-(3-pyridylmethyl)thiocarbamoyl)amino]-N-cyclopentyl-acetamide
N-cyclopentyl-2-[(phenylmethyl-(pyridin-3-ylmethyl)carbamothioyl)amino]ethanamide
SMR000206959
MLS000583973
N~2~-{[benzyl(pyridin-3-ylmethyl)amino]carbonothioyl}-N~1~-cyclopentylglycinamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0057	0.014
Brugia malayi	nuclear hormone receptor family member odr-7	0.0004	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0057	0.014
Onchocerca volvulus	Bile acid receptor homolog	0.0009	0.0057	0.1253
Echinococcus multilocularis	ecdysone induced protein 78C	0.0009	0.0057	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.0313
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0011	0.0082	0.0204
Leishmania major	T-complex protein 1, beta subunit, putative	0.0026	0.0239	0.0614
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0082	0.0204
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.043	0.1107
Echinococcus granulosus	thyroid hormone receptor alpha	0.0004	0.0006	0.0006
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0009	0.0057	0.0138
Echinococcus multilocularis	ferritin	0.0008	0.0042	0.0038
Trichomonas vaginalis	chaperonin-60kD, ch60, putative	0.0026	0.0239	0.0614
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0057	0.014
Trichomonas vaginalis	replication factor C large subunit, putative	0.0011	0.0082	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0006	0.0006
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0009	0.0057	0.014
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0006	0.0029	0.0074
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0004	0.0006	0.0006
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0052	0.0522	0.1333
Brugia malayi	T-complex protein 1, beta subunit	0.0026	0.0239	0.0614
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.043	1
Mycobacterium ulcerans	bacterioferritin BfrB	0.0008	0.0042	0.0504
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0004	0.0006	0.0002
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0009	0.0057	0.0148
Mycobacterium ulcerans	bacterioferritin BfrA	0.0008	0.0042	0.0504
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.043	0.1114
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0052	0.0522	0.1352
Echinococcus granulosus	muscleblind protein	0.0322	0.3441	0.8852
Onchocerca volvulus		0.0043	0.043	1
Treponema pallidum	bacterioferrin (TpF1)	0.0008	0.0042	0.4826
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0082	0.0204
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.043	0.1114
Brugia malayi	latrophilin 2 splice variant baaae	0.0112	0.1173	0.3054
Loa Loa (eye worm)	hypothetical protein	0.0043	0.043	0.1114
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0052	0.0522	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0522	0.1352
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0023	0.0049
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0052	0.0522	0.1333
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0164	0.1735	0.4521
Plasmodium vivax	ubiquitin-conjugating enzyme E2 N, putative	0.0358	0.3832	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0023	0.0049
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.0753	0.1956
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0006	0.0006
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.043	0.1441
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0009	0.0057	0.0148
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0009	0.0057	0.0148
Trypanosoma brucei	T-complex protein 1, beta subunit, putative	0.0026	0.0239	0.0614
Loa Loa (eye worm)	steroid hormone receptor	0.0009	0.0057	0.014
Echinococcus multilocularis	lamin dm0	0.0033	0.0312	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0043	0.043	0.1114
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0009	0.0057	0.014
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.0753	0.0749
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.043	0.1441
Echinococcus granulosus	ferritin	0.0008	0.0042	0.0097
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0009	0.0057	0.0053
Brugia malayi	nuclear receptor RXR	0.0005	0.0012	0.002
Toxoplasma gondii	ATPase, AAA family protein	0.0011	0.0082	0.0204
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0046	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0006	0.0006
Brugia malayi	hypothetical protein	0.0004	0.0006	0.0006
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.043	0.1441
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0009	0.0057	0.014
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0009	0.0057	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0057	0.014
Mycobacterium ulcerans	lipase LipD	0.0043	0.043	0.5692
Onchocerca volvulus		0.0009	0.0057	0.1253
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0048	0.0483	0.125
Entamoeba histolytica	hypothetical protein	0.0111	0.1164	0.3029
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0312	0.0806
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0753	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0004	0.0006	0.0006
Loa Loa (eye worm)	beta-lactamase	0.0043	0.043	0.1114
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0067	0.0681	0.1769
Brugia malayi	tailless protein	0.0004	0.0006	0.0006
Schistosoma mansoni	cpg binding protein	0.0026	0.0236	0.0608
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0005	0.0012	0.003
Trichomonas vaginalis	ferritin, putative	0.0008	0.0042	0.0099
Brugia malayi	nuclear receptor NHR-67	0.0004	0.0006	0.0006
Brugia malayi	orphan nuclear receptor NR2E1	0.0004	0.0006	0.0006
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0004	0.0006	0.0051
Brugia malayi	photoreceptor-specific nuclear receptor	0.0009	0.0057	0.014
Schistosoma mansoni	cpg binding protein	0.0027	0.0252	0.0648
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0026	0.0239	0.0616
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0026	0.0239	0.0616
Echinococcus multilocularis	geminin	0.0181	0.1912	0.1909
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0006	0.0006
Brugia malayi	hypothetical protein	0.0005	0.0012	0.002
Brugia malayi	F/Y-rich N-terminus family protein	0.0008	0.0045	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0043	0.043	0.1114
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0011	0.0082	0.0204
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0023	0.0049
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0004	0.0006	0.0006
Echinococcus multilocularis	chaperonin containing TCP1, subunit 2 (beta)	0.0026	0.0239	0.0235
Mycobacterium leprae	Probable lipase LipE	0.0043	0.043	1
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0006	0.0006
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0082	0.0204
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.043	0.0427
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0004	0.0006	0.0006
Schistosoma mansoni	retinoic acid receptor RXR	0.0009	0.0057	0.0148
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0009	0.0057	0.0138
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0149	0.0379
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0023	0.0049
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0023	0.0049
Echinococcus multilocularis	GPCR, family 2	0.0052	0.0522	0.0518
Trypanosoma brucei	ubiquitin-protein ligase, putative	0.0358	0.3832	1
Echinococcus granulosus	geminin	0.0181	0.1912	0.4914
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0004	0.0006	0.0002
Brugia malayi	nuclear hormone receptor	0.0004	0.0006	0.0006
Giardia lamblia	TCP-1 chaperonin subunit beta	0.0026	0.0239	1
Trypanosoma cruzi	T-complex protein 1, beta subunit, putative	0.0026	0.0239	0.0614
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0009	0.0057	0.014
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0004	0.0006	0.0006
Schistosoma mansoni	apoferritin-2	0.0008	0.0042	0.0108
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0358	0.3832	1
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0312	0.0806
Schistosoma mansoni	zinc finger protein	0.0004	0.0006	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0082	0.0204
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0006	0.0029	0.0025
Brugia malayi	ecdysteroid receptor	0.0009	0.0057	0.014
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0009	0.0057	0.014
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.043	0.1441
Loa Loa (eye worm)	hypothetical protein	0.0322	0.3441	0.8978
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.043	0.1441
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0011	0.0082	0.0204
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0067	0.0681	0.1744
Plasmodium falciparum	T-complex protein 1 subunit beta	0.0026	0.0239	0.0418
Onchocerca volvulus		0.0033	0.0312	0.7233
Loa Loa (eye worm)	hypothetical protein	0.0322	0.3441	0.8978
Brugia malayi	topoisomerase	0.0011	0.0082	0.0204
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0005	0.0012	0.0008
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0067	0.0681	0.1753
Onchocerca volvulus		0.0004	0.0006	0.0051
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0009	0.0057	0.014
Loa Loa (eye worm)	hypothetical protein	0.0043	0.043	0.1114
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0009	0.0057	0.014
Echinococcus granulosus	ubiquitin conjugating enzyme E2 N	0.0358	0.3832	0.9859
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0008	0.0042	0.0128
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0006	0.0029	0.0064
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0111	0.1164	0.116
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0008	0.0042	0.0128
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0005	0.0012	0.003
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0009	0.0057	0.0148
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0023	0.0049
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0026	0.0239	0.0616
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0016	0.013	0.0325
Trichomonas vaginalis	helicase, putative	0.0006	0.0023	0.0049
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0004	0.0006	0.0051
Schistosoma mansoni	ferritin light chain	0.0008	0.0042	0.0108
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0358	0.3832	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0009	0.0057	0.0138
Schistosoma mansoni	aldehyde dehydrogenase	0.0004	0.0004	0.001
Echinococcus granulosus	nibrin	0.0011	0.0082	0.0202
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0012	0.002
Toxoplasma gondii	ubiquitin-conjugating enzyme subfamily protein	0.0358	0.3832	1
Echinococcus granulosus	replication factor c subunit 1	0.0011	0.0082	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0006	0.0006
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0358	0.3832	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0006	0.0029	0.0064
Schistosoma mansoni	lamin	0.0033	0.0312	0.0804
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0023	0.0049
Brugia malayi	beta-lactamase family protein	0.0043	0.043	0.1114
Brugia malayi	beta-lactamase	0.0043	0.043	0.1114
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0006	0.0029	0.0025
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0005	0.0012	0.002
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0067	0.0681	0.0678
Schistosoma mansoni	cpg binding protein	0.0027	0.0252	0.0648
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0009	0.0057	0.0148
Echinococcus multilocularis	nuclear receptor nhr 48	0.0004	0.0006	0.0002
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0164	0.1735	0.4521
Schistosoma mansoni	aldehyde dehydrogenase	0.0004	0.0004	0.001
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0006	0.0006
Schistosoma mansoni	hypothetical protein	0.0181	0.1912	0.4919
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0312	0.0806
Schistosoma mansoni	ferritin light chain	0.0008	0.0042	0.0108
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0009	0.0057	0.0148
Schistosoma mansoni	transcription factor LCR-F1	0.0111	0.1164	0.2994
Brugia malayi	nuclear receptor NHR-88	0.0004	0.0006	0.0006
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0753	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0009	0.0057	0.014
Echinococcus multilocularis	cpg binding protein	0.0027	0.0252	0.0248
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0753	1
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.043	0.0928
Echinococcus granulosus	lamin	0.0033	0.0312	0.0794
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0004	0.0006	0.0016
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.0011	0.0082	0.0204
Schistosoma mansoni	nuclear receptor nhr-48	0.0004	0.0006	0.0016
Trichomonas vaginalis	chaperonin, putative	0.0026	0.0239	0.0614
Brugia malayi	Steroid receptor seven-up type 2	0.0009	0.0057	0.014
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0082	0.0204
Entamoeba histolytica	hypothetical protein	0.0011	0.0082	0.0204
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0054	0.0545	0.1403
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0023	0.0049
Brugia malayi	hypothetical protein	0.0005	0.0012	0.002
Echinococcus multilocularis	musashi	0.0033	0.0312	0.0309
Chlamydia trachomatis	DNA ligase	0.0011	0.0082	0.5
Schistosoma mansoni	coup transcription factor	0.0009	0.0057	0.0148
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0009	0.0057	0.014
Brugia malayi	Pax transcription activation domain interacting protein	0.0011	0.0082	0.0204
Echinococcus multilocularis	ubiquitin conjugating enzyme E2 N	0.0358	0.3832	0.383
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0026	0.0236	0.0606
Schistosoma mansoni	hypothetical protein	0.0052	0.0522	0.1343
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0067	0.0681	0.1769
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0306	0.0789
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0312	0.0806
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0009	0.0057	0.0053
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0009	0.0057	0.014
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.2963	1
Schistosoma mansoni	hypothetical protein	0.0052	0.0522	0.1343
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0009	0.0057	0.0138
Brugia malayi	Muscleblind-like protein	0.0322	0.3441	0.8978
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0009	0.0057	0.1253
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.043	0.1114
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0009	0.0057	0.014
Schistosoma mansoni	hypothetical protein	0.0111	0.1164	0.2994
Onchocerca volvulus		0.0033	0.0312	0.7233
Schistosoma mansoni	ubiquitin conjugating enzyme 13	0.0358	0.3832	0.9859
Schistosoma mansoni	ferritin	0.0008	0.0042	0.0108
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0011	0.0082	0.0204
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.0753	0.1956
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0753	0.1937
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0009	0.0057	0.0138
Schistosoma mansoni	nuclear hormone receptor	0.0004	0.0006	0.0016
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.043	0.1114
Brugia malayi	Ubiquitin conjugating enzyme protein 13	0.0358	0.3832	1
Mycobacterium tuberculosis	Conserved protein	0.0043	0.043	0.1441
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0012	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0023	0.0049
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0067	0.0681	0.1769
Schistosoma mansoni	ferritin	0.0008	0.0042	0.0108
Brugia malayi	CXXC zinc finger family protein	0.0026	0.0236	0.0606
Brugia malayi	nuclear receptor NHR-88	0.0009	0.0057	0.014
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.043	0.5692
Mycobacterium tuberculosis	Conserved protein	0.0043	0.043	0.1441
Echinococcus multilocularis	transcription factor Dp 1	0.0039	0.0378	0.0374
Echinococcus multilocularis	dnaJ subfamily B	0.0363	0.3887	0.3885
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.0753	0.2531
Brugia malayi	Nuclear hormone receptor E75	0.0004	0.0006	0.0006
Schistosoma mansoni	delta 1-pyrroline-5-carboxylate synthetase	0.0004	0.0004	0.001
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.0011	0.0082	0.0204
Treponema pallidum	DNA ligase (lig)	0.0011	0.0082	1
Brugia malayi	Latrophilin receptor protein 2	0.0052	0.0522	0.1352
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0052	0.0522	0.0518
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0009	0.0057	0.014
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0009	0.0057	0.0053
Brugia malayi	nuclear hormone receptor	0.0009	0.0057	0.014
Plasmodium falciparum	ubiquitin-conjugating enzyme E2 N, putative	0.0358	0.3832	1
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0082	0.0204
Onchocerca volvulus	Protein ultraspiracle homolog	0.0009	0.0057	0.1253
Onchocerca volvulus		0.0026	0.0236	0.5444
Schistosoma mansoni	DNA ligase IV	0.0011	0.0082	0.0212
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0005	0.0012	0.002
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0016	0.013	0.0126
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0009	0.0057	0.0138
Schistosoma mansoni	aldehyde dehydrogenase	0.0004	0.0004	0.001
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0004	0.0006	0.0006
Schistosoma mansoni	nuclear receptor	0.0004	0.0006	0.0016
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.043	0.5692
Trypanosoma cruzi	hypothetical protein, conserved	0.0011	0.0082	0.0204
Echinococcus multilocularis	expressed protein	0.0008	0.0042	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0023	0.0049
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0358	0.3832	1
Echinococcus granulosus	expressed protein	0.0008	0.0042	0.0097
Echinococcus granulosus	nuclear receptor nhr 48	0.0004	0.0006	0.0006
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0111	0.1164	0.2986
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0023	0.0049
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0164	0.1735	0.4521
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0004	0.0006	0.0016
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0358	0.3832	1
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0011	0.0082	0.0204
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0067	0.0681	0.1769
Onchocerca volvulus		0.0043	0.043	1
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.043	0.1441
Loa Loa (eye worm)	hypothetical protein	0.0043	0.043	0.1114
Trichomonas vaginalis	esterase, putative	0.0043	0.043	0.1114
Schistosoma mansoni	lamin	0.0033	0.0312	0.0804
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0004	0.0006	0.0002
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0023	0.0049
Loa Loa (eye worm)	nuclear hormone receptor	0.0004	0.0006	0.0006
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0067	0.0681	0.1769
Echinococcus multilocularis	nibrin	0.0011	0.0082	0.0078
Schistosoma mansoni	hypothetical protein	0.0004	0.0004	0.001
Loa Loa (eye worm)	hypothetical protein	0.0043	0.043	0.1114
Brugia malayi	nuclear receptor RXR	0.0004	0.0006	0.0006
Brugia malayi	conserved hypotetical protein	0.0004	0.0006	0.0006
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0009	0.0057	0.014
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.043	0.1114
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0082	0.0204
Echinococcus multilocularis	replication factor c subunit 1	0.0011	0.0082	0.0078
Schistosoma mansoni	ferritin	0.0008	0.0042	0.0108
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0012	0.002
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.0011	0.0082	0.1836
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.043	0.1098
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0004	0.0006	0.0002
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0004	0.0006	0.0006
Echinococcus granulosus	FTZ F1 alpha	0.0009	0.0057	0.0138
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0009	0.0057	0.0053
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0067	0.0681	0.1769
Loa Loa (eye worm)	hypothetical protein	0.0164	0.1735	0.4521
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0023	0.0049
Schistosoma mansoni	hypothetical protein	0.0363	0.3887	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0011	0.0082	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0012	0.002
Schistosoma mansoni	RAR-like nuclear receptor	0.0009	0.0057	0.0148
Brugia malayi	ecdysone receptor	0.0004	0.0006	0.0006
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0008	0.0042	0.0886
Trypanosoma cruzi	FHA domain containing protein, putative	0.0011	0.0082	0.0204
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.0753	0.1929
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0009	0.0057	0.014
Schistosoma mansoni	nuclear receptor	0.0004	0.0006	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1173	0.3054
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0009	0.0057	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0082	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0057	0.014
Schistosoma mansoni	apoferritin-2	0.0008	0.0042	0.0108
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0009	0.0057	0.0148
Brugia malayi	hypothetical protein	0.0011	0.0082	0.0204
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.043	0.1114
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0009	0.0057	0.0138
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.043	0.1441
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0023	0.0049
Brugia malayi	hypothetical protein	0.0011	0.0082	0.0204
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0046	0.0042
Echinococcus granulosus	intermediate filament protein	0.0033	0.0312	0.0794
Schistosoma mansoni	hypothetical protein	0.0181	0.1912	0.4919
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0009	0.0057	0.014
Schistosoma mansoni	topbp1	0.0011	0.0082	0.0212
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0023	0.0049
Mycobacterium ulcerans	beta-lactamase	0.0043	0.043	0.5692
Leishmania major	ubiquitin-conjugating enzyme e2, putative	0.0358	0.3832	1
Entamoeba histolytica	hypothetical protein	0.0111	0.1164	0.3029
Echinococcus multilocularis	FTZ F1 alpha	0.0009	0.0057	0.0053
Brugia malayi	Nuclear hormone receptor-like 1	0.0009	0.0057	0.014
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0012	0.002
Brugia malayi	hypothetical protein	0.0111	0.1164	0.3029
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0082	0.0204
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0011	0.0082	0.0204
Brugia malayi	T-complex protein 1, beta subunit	0.0026	0.0239	0.0614
Echinococcus granulosus	dnaJ subfamily B	0.0363	0.3887	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0753	0.1937
Schistosoma mansoni	succinate semialdehyde dehydrogenase	0.0004	0.0004	0.001
Onchocerca volvulus		0.0011	0.0082	0.1836
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.0011	0.0082	0.1045
Leishmania major	hypothetical protein, conserved	0.0043	0.043	0.1114
Loa Loa (eye worm)	DR-78	0.0004	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0006	0.0006
Brugia malayi	beta-lactamase family protein	0.0043	0.043	0.1114
Echinococcus granulosus	GPCR family 2	0.0052	0.0522	0.1333
Onchocerca volvulus		0.0004	0.0006	0.0051
Echinococcus granulosus	lamin dm0	0.0033	0.0312	0.0794
Brugia malayi	steroid hormone receptor	0.0009	0.0057	0.014
Schistosoma mansoni	chromosome transmission fidelity factor	0.0011	0.0082	0.0212
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0009	0.0057	0.014
Brugia malayi	hypothetical protein	0.0004	0.0006	0.0006
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0312	0.0804
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0011	0.0082	0.0204
Loa Loa (eye worm)	histone methyltransferase	0.0008	0.0046	0.0109
Mycobacterium tuberculosis	Conserved protein	0.0043	0.043	0.1441
Schistosoma mansoni	thyroid hormone receptor	0.0009	0.0057	0.0148
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0009	0.0057	0.0053
Schistosoma mansoni	thyroid hormone receptor	0.0009	0.0057	0.0148
Echinococcus multilocularis	muscleblind protein 1	0.0322	0.3441	0.3439
Echinococcus granulosus	transcription factor Dp 1	0.0039	0.0378	0.0962
Mycobacterium ulcerans	hypothetical protein	0.0043	0.043	0.5692
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0052	0.0522	0.1352
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0004	0.0006	0.0006
Entamoeba histolytica	T-complex protein 1 beta subunit, putative	0.0026	0.0239	0.0614
Schistosoma mansoni	aldehyde dehydrogenase	0.0004	0.0004	0.001
Giardia lamblia	Replication factor C, subunit 1	0.0011	0.0082	0.3328
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.043	0.1114
Loa Loa (eye worm)	T-complex protein 1	0.0026	0.0239	0.0614
Brugia malayi	ubiquitin conjugating enzyme protein 13	0.0358	0.3832	1
Entamoeba histolytica	ubiquitin-conjugating enzyme family protein	0.0358	0.3832	1
Toxoplasma gondii	ABC1 family protein	0.0043	0.043	0.1114
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.043	0.1114
Echinococcus multilocularis	lamin	0.0033	0.0312	0.0309
Schistosoma mansoni	aldehyde dehydrogenase	0.0004	0.0004	0.001
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0004	0.0006	0.0002
Brugia malayi	Nuclear hormone receptor E75	0.0004	0.0006	0.0006
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0358	0.3832	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.043	0.1107
Schistosoma mansoni	hypothetical protein	0.0112	0.1173	0.3019
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0023	0.0049
Schistosoma mansoni	nuclear hormone receptor	0.0004	0.0006	0.0016
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.0011	0.0082	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.013	0.033
Onchocerca volvulus		0.0043	0.043	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0124	0.0313
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0009	0.0057	0.014
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0008	0.0042	0.4826
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0009	0.0057	0.0138
Schistosoma mansoni	topbp1	0.0011	0.0082	0.0212
Entamoeba histolytica	hypothetical protein	0.0111	0.1164	0.3029
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0009	0.0057	0.014
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0149	0.0379
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.043	0.1114
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0057	0.014
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0057	0.014
Plasmodium vivax	T-complex protein 1 subunit beta, putative	0.0026	0.0239	0.0418
Toxoplasma gondii	t-complex protein beta subunit	0.0026	0.0239	0.0614
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0012	0.002
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.043	0.1114
Schistosoma mansoni	ferritin	0.0008	0.0042	0.0108
Echinococcus granulosus	cpg binding protein	0.0027	0.0252	0.0638
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0057	0.014
Brugia malayi	DKFZp564C0469 protein	0.0011	0.0082	0.0204
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0009	0.0057	0.014
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0023	0.0049
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0082	0.0204
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0009	0.0057	0.014
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0082	0.0204
Echinococcus multilocularis	muscleblind protein	0.0322	0.3441	0.3439
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0012	0.002
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0067	0.0681	0.1769
Echinococcus granulosus	chaperonin containing TCP1 subunit 2 beta	0.0026	0.0239	0.0606
Brugia malayi	intermediate filament protein	0.0033	0.0312	0.0806
Entamoeba histolytica	hypothetical protein	0.0111	0.1164	0.3029
Schistosoma mansoni	hypothetical protein	0.0052	0.0522	0.1343
Schistosoma mansoni	nuclear hormone receptor	0.0009	0.0057	0.0148
Schistosoma mansoni	hypothetical protein	0.0052	0.0522	0.1343

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1353422
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 863810