TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 483.54 | Formula: C23H25N5O5S
H donors: 1 H acceptors: 4 LogP: 1.95 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: COCCCn1c2nnc(n2c2c(c1=O)scc2)CCCC(=O)NCc1ccc2c(c1)OCO2
InChi: 1S/C23H25N5O5S/c1-31-10-3-9-27-22(30)21-16(8-11-34-21)28-19(25-26-23(27)28)4-2-5-20(29)24-13-15-6-7-17-18(12-15)33-14-32-17/h6-8,11-12H,2-5,9-10,13-14H2,1H3,(H,24,29)
InChiKey: JEKQPBXIJFDBBT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	microtubule-associated protein tau	0.0809	0.5953	1
Chlamydia trachomatis	cysteine--tRNA ligase	0.002	0.0059	0.1552
Chlamydia trachomatis	valine--tRNA ligase	0.0022	0.0077	0.204
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0034	0.0168	0.0152
Plasmodium vivax	hypothetical protein, conserved	0.0022	0.0077	0.204
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0056	0.0327	0.1888
Echinococcus granulosus	Threonyl tRNA synthetase C	0.0056	0.0327	0.055
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0	0.0001
Entamoeba histolytica	valyl tRNA synthetase, putative	0.0022	0.0077	0.204
Echinococcus granulosus	leucyl tRNA synthetase	0.0042	0.0224	0.0377
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0071	0.0443	0.0745
Wolbachia endosymbiont of Brugia malayi	cysteinyl-tRNA synthetase	0.002	0.0059	0.0953
Mycobacterium tuberculosis	Possible DNA glycosylase	0.0094	0.0617	0.0601
Echinococcus granulosus	cysteinyl tRNA synthetase	0.002	0.0059	0.0099
Mycobacterium tuberculosis	Isoleucyl-tRNA synthetase IleS	0.004	0.0213	0.0197
Schistosoma mansoni	valine-tRNA ligase	0.0022	0.0077	0.013
Onchocerca volvulus		0.0097	0.064	0.3221
Echinococcus multilocularis	valyl tRNA synthetase	0.0022	0.0077	0.013
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0027	0.0116	0.01
Leishmania major	hypothetical protein, conserved	0.0024	0.009	0.2036
Mycobacterium leprae	PROBABLE VALYL-tRNA SYNTHASE PROTEIN VALS (VALYL-tRNA SYNTHETASE) (VALINE--tRNA LIGASE) (VALINE TRANSLASE) ELONGS TO CLASS-I AMI	0.0022	0.0077	0.0077
Plasmodium falciparum	leucine--tRNA ligase, putative	0.0022	0.0077	0.0987
Mycobacterium ulcerans	formamidopyrimidine-DNA glycosylase	0.0094	0.0617	0.0617
Mycobacterium tuberculosis	Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase)	0.0094	0.0617	0.0601
Loa Loa (eye worm)	cysteinyl tRNA synthetase 1	0.002	0.0059	0.0339
Brugia malayi	nuclear receptor NHR-88	0.0012	0	0.0001
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0369	0.2666	0.2666
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0056	0.0327	0.1888
Echinococcus granulosus	arginyl tRNA synthetase	0.0017	0.0037	0.0061
Brugia malayi	AMP-binding enzyme family protein	0.0034	0.0168	0.0971
Mycobacterium tuberculosis	Possible conserved polyketide synthase associated protein PapA2	0.002	0.0063	0.0047
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.0014	0.0017	0.0017
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0034	0.0168	0.0152
Toxoplasma gondii	valyl-tRNA synthetase	0.0022	0.0077	0.0082
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0	0.0001
Treponema pallidum	leucyl-tRNA synthetase	0.0013	0.0011	0.0293
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0	0.0001
Wolbachia endosymbiont of Brugia malayi	leucyl-tRNA synthetase	0.0022	0.0077	0.1252
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0056	0.0327	0.8638
Plasmodium vivax	SET domain protein, putative	0.0035	0.0173	0.4567
Trichomonas vaginalis	arginyl-tRNA synthetase, putative	0.0017	0.0037	0.0184
Echinococcus multilocularis	arginyl tRNA synthetase, cytoplasmic	0.0029	0.0125	0.0211
Brugia malayi	steroid hormone receptor	0.0012	0	0.0001
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0	0.0001
Schistosoma mansoni	cysteinyl-tRNA synthetase	0.002	0.0059	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0011	0.0064
Brugia malayi	valyl-tRNA synthetase family protein	0.0022	0.0077	0.0446
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.0173	0.0183
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0027	0.0116	0.0123
Plasmodium falciparum	threonine--tRNA ligase	0.0049	0.0278	0.3552
Mycobacterium ulcerans	formamidopyrimidine-DNA glycosylase	0.0094	0.0617	0.0617
Schistosoma mansoni	arginyl-tRNA synthetase	0.0029	0.0125	0.0211
Treponema pallidum	cysteinyl-tRNA synthetase	0.002	0.0059	0.1552
Plasmodium vivax	arginyl-tRNA synthetase, putative	0.0029	0.0125	0.3311
Chlamydia trachomatis	methionine--tRNA ligase	0.0013	0.0011	0.0293
Echinococcus multilocularis	isoleucyl tRNA synthetase, mitochondrial	0.0049	0.0279	0.0469
Schistosoma mansoni	leucyl-tRNA synthetase	0.0022	0.0077	0.013
Mycobacterium leprae	POSSIBLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA5	0.002	0.0063	0.0063
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0097	0.064	0.3689
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0071	0.0443	1
Toxoplasma gondii	tRNA synthetase, putative	0.0022	0.0077	0.0082
Trichomonas vaginalis	isoleucyl tRNA synthetase, putative	0.0063	0.0379	0.1908
Echinococcus granulosus	leucyl tRNA synthetase	0.0022	0.0077	0.013
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0279	0.1612
Trypanosoma cruzi	isoleucyl-tRNA synthetase, putative	0.0063	0.0379	1
Trichomonas vaginalis	leucyl-tRNA synthetase, putative	0.0013	0.0011	0.0056
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0	0.0001
Brugia malayi	AMP-binding enzyme family protein	0.0029	0.0129	0.0747
Chlamydia trachomatis	isoleucine--tRNA ligase	0.0063	0.0379	1
Trypanosoma brucei	hypothetical protein, conserved	0.0027	0.0116	0.3072
Loa Loa (eye worm)	hypothetical protein	0.0097	0.064	0.3689
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0	0.0001
Trypanosoma brucei	arginyl-tRNA synthetase, putative	0.0029	0.0125	0.3311
Schistosoma mansoni	isoleucine--tRNA ligase	0.0063	0.0379	0.0636
Schistosoma mansoni	isoleucine--tRNA ligase	0.0063	0.0379	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0012	0	0.0001
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0049	0.0278	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0012	0	0.0001
Onchocerca volvulus		0.0022	0.0077	0.0389
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0027	0.0116	0.0123
Brugia malayi	Valyl-tRNA synthetase	0.0022	0.0077	0.0446
Mycobacterium ulcerans	pantoate--beta-alanine ligase	0.1278	0.9465	0.9465
Entamoeba histolytica	arginyl-tRNA synthetase	0.0029	0.0125	0.3311
Echinococcus multilocularis	leucyl tRNA synthetase	0.0022	0.0077	0.013
Giardia lamblia	Valine-tRNA ligase	0.0022	0.0077	0.204
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0049	0.0278	0.14
Plasmodium vivax	isoleucine--tRNA ligase, putative	0.0063	0.0379	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0	0.0001
Mycobacterium tuberculosis	Hypothetical protein	0.0024	0.009	0.0074
Mycobacterium leprae	PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA3	0.002	0.0063	0.0063
Trypanosoma cruzi	valyl-tRNA synthetase, putative	0.0013	0.0011	0.0293
Wolbachia endosymbiont of Brugia malayi	valyl-tRNA synthetase	0.0022	0.0077	0.1252
Toxoplasma gondii	aldehyde dehydrogenase	0.0071	0.0443	0.0468
Brugia malayi	Methyltransferase-like protein 4	0.0024	0.009	0.0521
Echinococcus multilocularis	cysteinyl tRNA synthetase	0.002	0.0059	0.0099
Mycobacterium leprae	Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme)	0.1278	0.9465	0.9465
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0	0.0001
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.1077	0.7959	0.7956
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0	0.0001
Brugia malayi	arginyl aa-tRNA synthetase protein 1	0.0029	0.0125	0.0724
Mycobacterium leprae	isoleucyl-tRNA synthetase IleS	0.0063	0.0379	0.0379
Onchocerca volvulus		0.0013	0.0011	0.0055
Echinococcus granulosus	arginyl tRNA synthetase cytoplasmic	0.0029	0.0125	0.0211
Plasmodium falciparum	arginine--tRNA ligase	0.0029	0.0125	0.1603
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0244	0.1734	1
Onchocerca volvulus		0.002	0.0059	0.0295
Schistosoma mansoni	aldehyde dehydrogenase	0.0071	0.0443	0.0745
Entamoeba histolytica	isoleucyl-tRNA synthetase, putative	0.0063	0.0379	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0	0.0001
Onchocerca volvulus		0.0014	0.0017	0.0084
Mycobacterium ulcerans	cysteinyl-tRNA synthetase	0.135	1	1
Mycobacterium tuberculosis	Probable conserved polyketide synthase associated protein PapA3	0.002	0.0063	0.0047
Chlamydia trachomatis	arginine--tRNA ligase	0.0029	0.0125	0.3311
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0379	0.2185
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0	0.0001
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0027	0.0116	0.3072
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0	0.0001
Mycobacterium ulcerans	arginyl-tRNA synthetase	0.0029	0.0125	0.0125
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0014	0.0017	0.0443
Loa Loa (eye worm)	isoleucyl-tRNA synthetase	0.0063	0.0379	0.2185
Treponema pallidum	isoleucyl-tRNA synthetase	0.0063	0.0379	1
Trypanosoma brucei	valyl-tRNA synthetase, putative	0.0022	0.0077	0.204
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0097	0.064	0.1074
Leishmania major	phosphopantetheinyl transferase-like protein	0.0027	0.0116	0.2626
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0034	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.002	0.0059	0.0339
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0	0.0001
Mycobacterium ulcerans	cysteinyl-tRNA synthetase	0.002	0.0059	0.0059
Treponema pallidum	threonyl-tRNA synthetase	0.0049	0.0278	0.7338
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0097	0.064	0.1074
Brugia malayi	leucyl-tRNA synthetase	0.0022	0.0077	0.0446
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0049	0.0278	0.0294
Toxoplasma gondii	isoleucyl-tRNA synthetase, putative	0.0022	0.0077	0.0082
Schistosoma mansoni	hypothetical protein	0.0199	0.1395	0.2344
Mycobacterium leprae	conserved hypothetical protein	0.0027	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0012	0	0.0001
Loa Loa (eye worm)	arginyl aa-tRNA synthetase 1	0.0012	0	0.0002
Mycobacterium tuberculosis	Unknown protein	0.002	0.0063	0.0047
Trichomonas vaginalis	leucyl-tRNA synthetase, putative	0.0022	0.0077	0.0389
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0	0.0001
Onchocerca volvulus		0.0278	0.1985	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0	0.0001
Entamoeba histolytica	leucyl-tRNA synthetase, putative	0.0022	0.0077	0.204
Leishmania major	arginyl-tRNA synthetase, putative	0.0029	0.0125	0.283
Mycobacterium tuberculosis	Probable valyl-tRNA synthase protein ValS (valyl-tRNA synthetase) (valine--tRNA ligase) (valine translase)	0.0022	0.0077	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0129	0.0747
Entamoeba histolytica	cysteinyl-tRNA synthetase, putative	0.002	0.0059	0.1552
Echinococcus granulosus	microtubule associated protein 2	0.0809	0.5953	1
Brugia malayi	nuclear hormone receptor	0.0012	0	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0012	0	0.0001
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0049	0.0278	0.0278
Brugia malayi	cysteinyl tRNA synthetase protein 1	0.002	0.0059	0.0339
Echinococcus multilocularis	geminin	0.0199	0.1395	0.2344
Echinococcus granulosus	valyl tRNA synthetase	0.0022	0.0077	0.013
Plasmodium falciparum	cysteine--tRNA ligase	0.002	0.0059	0.0751
Mycobacterium leprae	Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE)	0.0094	0.0617	0.0617
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0027	0.0116	0.0116
Trypanosoma cruzi	leucyl-tRNA synthetase, putative	0.0022	0.0077	0.204
Trichomonas vaginalis	set domain proteins, putative	0.0278	0.1985	1
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0049	0.0278	0.0278
Giardia lamblia	Isoleucyl-tRNA synthetase	0.0063	0.0379	1
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0027	0.0116	0.3072
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0077	0.0446
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.0443	0.0443
Brugia malayi	isoleucyl-tRNA synthetase	0.0063	0.0379	0.2185
Echinococcus granulosus	geminin	0.0199	0.1395	0.2344
Trichomonas vaginalis	cysteinyl-tRNA synthetase, putative	0.002	0.0059	0.0296
Schistosoma mansoni	methionine-tRNA synthetase	0.0013	0.0011	0.0019
Plasmodium vivax	valine--tRNA ligase, putative	0.0022	0.0077	0.204
Brugia malayi	Pre-SET motif family protein	0.0035	0.0173	0.0998
Onchocerca volvulus		0.0049	0.0279	0.1407
Mycobacterium tuberculosis	Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC	0.135	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0	0.0001
Giardia lamblia	Methyltransferase like 2	0.0024	0.009	0.2383
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0	0.0001
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	0.0028	0.0123	0.0123
Wolbachia endosymbiont of Brugia malayi	isoleucyl-tRNA synthetase	0.0063	0.0379	0.6139
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0027	0.0116	0.1886
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0	0.0001
Leishmania major	leucyl-tRNA synthetase, putative	0.0022	0.0077	0.1744
Leishmania major	isoleucyl-tRNA synthetase, putative	0.0063	0.0379	0.8547
Giardia lamblia	Arginyl-tRNA synthetase	0.0017	0.0037	0.0965
Leishmania major	valyl-tRNA synthetase, putative	0.0022	0.0077	0.1744
Toxoplasma gondii	isoleucyl-tRNA synthetase family protein	0.0063	0.0379	0.04
Trichomonas vaginalis	isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative	0.0013	0.0011	0.0056
Mycobacterium ulcerans	thioesterase	0.0334	0.2409	0.2409
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0027	0.0116	0.0116
Echinococcus granulosus	histone lysine methyltransferase setb	0.0035	0.0173	0.0291
Mycobacterium tuberculosis	Conserved protein	0.0024	0.009	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0012	0	0.0001
Plasmodium vivax	cysteine--tRNA ligase, putative	0.002	0.0059	0.1552
Toxoplasma gondii	cysteine-tRNA synthetase (CysRS)	0.002	0.0059	0.0062
Treponema pallidum	valyl-tRNA synthetase	0.0022	0.0077	0.204
Leishmania major	cysteinyl-tRNA synthetase, putative	0.002	0.0059	0.1326
Onchocerca volvulus		0.0034	0.0168	0.0847
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0173	0.0291
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0	0.0001
Echinococcus multilocularis	microtubule associated protein 2	0.0809	0.5953	1
Brugia malayi	ecdysteroid receptor	0.0012	0	0.0001
Mycobacterium ulcerans	valyl-tRNA synthetase	0.0022	0.0077	0.0077
Plasmodium falciparum	valine--tRNA ligase, putative	0.0022	0.0077	0.0987
Giardia lamblia	Threonyl-tRNA synthetase	0.0049	0.0278	0.7338
Entamoeba histolytica	valyl-tRNA synthetase, putative	0.0022	0.0077	0.204
Schistosoma mansoni	valine-tRNA ligase	0.0022	0.0077	0.013
Trypanosoma brucei	isoleucyl-tRNA synthetase, putative	0.0063	0.0379	1
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0034	0.0168	0.0168
Trypanosoma cruzi	valyl-tRNA synthetase, putative	0.0022	0.0077	0.204
Trypanosoma brucei	leucyl-tRNA synthetase, putative	0.0022	0.0077	0.204
Schistosoma mansoni	hypothetical protein	0.0199	0.1395	0.2344
Toxoplasma gondii	leucyl-tRNA synthetase	0.0022	0.0077	0.0082
Giardia lamblia	Cysteinyl-tRNA synthetase	0.002	0.0059	0.1552
Schistosoma mansoni	methyltransferase-related	0.0024	0.009	0.0152
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0027	0.0116	0.1487
Entamoeba histolytica	hypothetical protein	0.0027	0.0116	0.3072
Toxoplasma gondii	pantoate-beta-alanine ligase	0.1278	0.9465	1
Plasmodium falciparum	isoleucine--tRNA ligase, putative	0.0063	0.0379	0.484
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0027	0.0116	0.3072
Schistosoma mansoni	threonyl-tRNA synthetase	0.0044	0.0243	0.0408
Trichomonas vaginalis	conserved hypothetical protein	0.0024	0.009	0.0455
Plasmodium falciparum	isoleucine--tRNA ligase, putative	0.0117	0.0783	1
Trypanosoma cruzi	cysteinyl-tRNA synthetase, putative	0.002	0.0059	0.1552
Echinococcus granulosus	L aminoadipate semialdehyde	0.0097	0.064	0.1074
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0173	0.0291
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0071	0.0443	0.0745
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0056	0.0327	0.8638
Mycobacterium tuberculosis	Conserved polyketide synthase associated protein PapA1	0.002	0.0063	0.0047
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0	0.0001
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0034	0.0168	0.0152
Echinococcus granulosus	methionyl tRNA synthetase cytoplasmic	0.0013	0.0011	0.0019
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0035	0.0173	0.0291
Chlamydia trachomatis	threonine--tRNA ligase	0.0056	0.0327	0.8638
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0035	0.0173	0.0291
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0	0.0001
Plasmodium falciparum	cysteine--tRNA ligase	0.002	0.0059	0.0751
Echinococcus multilocularis	Threonyl tRNA synthetase, C	0.0056	0.0327	0.055
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0	0.0001
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.0443	0.0443
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.0028	0.0123	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0012	0	0.0001
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0056	0.0327	0.8638
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0011	0.0064
Plasmodium vivax	threonine--tRNA ligase, putative	0.0049	0.0278	0.7338
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0037	0.0211
Echinococcus multilocularis	isoleucyl tRNA synthetase, cytoplasmic	0.0063	0.0379	0.0636
Echinococcus granulosus	isoleucyl tRNA synthetase, cytoplasmic	0.0063	0.0379	0.0636
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0	0.0001
Leishmania major	threonyl-tRNA synthetase, putative	0.0056	0.0327	0.7383
Echinococcus multilocularis	methionyl tRNA synthetase, cytoplasmic	0.0013	0.0011	0.0019
Trichomonas vaginalis	valyl-tRNA synthetase, putative	0.0013	0.0011	0.0056
Brugia malayi	arginyl-tRNA synthetase family protein	0.0012	0	0.0002
Trypanosoma cruzi	cysteinyl-tRNA synthetase, putative	0.002	0.0059	0.1552
Trypanosoma cruzi	arginyl-tRNA synthetase, putative	0.0029	0.0125	0.3311
Trichomonas vaginalis	leucyl-tRNA synthetase, putative	0.0022	0.0077	0.0389
Onchocerca volvulus		0.0035	0.0173	0.0871
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0	0.0001
Echinococcus granulosus	valyl tRNA synthetase	0.0022	0.0077	0.013
Plasmodium falciparum	valine--tRNA ligase, putative	0.0022	0.0077	0.0987
Mycobacterium ulcerans	isoleucyl-tRNA synthetase	0.0063	0.0379	0.0379
Wolbachia endosymbiont of Brugia malayi	threonyl-tRNA synthetase	0.0049	0.0278	0.4505
Mycobacterium tuberculosis	Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme)	0.1278	0.9465	0.9464
Mycobacterium ulcerans	acyl-CoA synthetase	0.0014	0.0017	0.0017
Entamoeba histolytica	threonyl-tRNA synthetase, putative	0.0049	0.0278	0.7338
Wolbachia endosymbiont of Brugia malayi	formamidopyrimidine-DNA glycosylase	0.0094	0.0617	1
Chlamydia trachomatis	leucine--tRNA ligase	0.0013	0.0011	0.0293
Mycobacterium tuberculosis	Possible conserved polyketide synthase associated protein PapA5	0.002	0.0063	0.0047
Brugia malayi	Pre-SET motif family protein	0.0244	0.1734	1
Echinococcus granulosus	isoleucyl trna synthetase mitochondrial	0.0049	0.0279	0.0469
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0034	0.0163	0.0274
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0071	0.0443	0.0427
Treponema pallidum	arginyl-tRNA synthetase	0.0029	0.0125	0.3311
Onchocerca volvulus		0.0034	0.0168	0.0847
Mycobacterium ulcerans	leucyl-tRNA synthetase	0.0013	0.0011	0.0011
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0	0.0001
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0014	0.0017	0.0097
Mycobacterium ulcerans	polyketide synthase associated protein PapA3	0.002	0.0063	0.0063
Toxoplasma gondii	leucyl-tRNA synthetase (LeuRS2)	0.0022	0.0077	0.0082
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0034	0.0168	0.0168
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.0173	0.0291
Schistosoma mansoni	aldehyde dehydrogenase	0.0071	0.0443	0.0745
Echinococcus multilocularis	leucyl tRNA synthetase	0.0022	0.0077	0.013
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0173	0.0291
Brugia malayi	isoleucyl-tRNA synthetase family protein	0.0063	0.0379	0.2185
Trypanosoma brucei	cysteinyl-tRNA synthetase, putative	0.002	0.0059	0.1552
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0034	0.0168	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0173	0.0998
Echinococcus multilocularis	arginyl tRNA synthetase	0.0017	0.0037	0.0061
Wolbachia endosymbiont of Brugia malayi	arginyl-tRNA synthetase	0.0029	0.0125	0.2033
Echinococcus multilocularis	valyl tRNA synthetase	0.0022	0.0077	0.013
Schistosoma mansoni	cysteinyl-tRNA synthetase	0.002	0.0059	0.0099
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.0443	0.0443

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

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Detailed information for compound 864402