Detailed information for compound 867869

Basic information

Technical information
  • TDR Targets ID: 867869
  • Name: ZINC02917214
  • MW: 324.377 | Formula: C18H20N4O2
  • H donors: 0 H acceptors: 2 LogP: 1.63 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cc2c(n1C)nc1n(c2=O)cccc1C)N1CCCCC1
  • InChi: 1S/C18H20N4O2/c1-12-7-6-10-22-15(12)19-16-13(17(22)23)11-14(20(16)2)18(24)21-8-4-3-5-9-21/h6-7,10-11H,3-5,8-9H2,1-2H3
  • InChiKey: VEOMWNLPZWYGCJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • T5433564

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0454 0.0367
Brugia malayi hypothetical protein 0.0028 0.009 0.009
Leishmania major beta tubulin 0.1142 1 1
Leishmania major beta tubulin 0.1142 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0534 0.0534
Echinococcus multilocularis tubulin delta chain 0.0295 0.246 0.246
Schistosoma mansoni tubulin subunit beta 0.1142 1 1
Trypanosoma cruzi tubulin gamma chain 0.0702 0.6086 0.6086
Giardia lamblia Beta tubulin 0.1142 1 1
Echinococcus granulosus tubulin alpha 1C chain 0.0861 0.7498 0.7498
Mycobacterium leprae cell division protein FtsZ 0.0295 0.246 0.5
Trypanosoma brucei beta tubulin 0.1142 1 1
Schistosoma mansoni tubulin subunit beta 0.0295 0.246 0.246
Trypanosoma brucei beta tubulin 0.1142 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.009 0.009
Plasmodium falciparum tubulin beta chain 0.1142 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.1142 1 1
Echinococcus granulosus tubulin delta chain 0.0295 0.246 0.246
Entamoeba histolytica tubulin family protein 0.1142 1 1
Leishmania major beta tubulin 0.1142 1 1
Echinococcus granulosus tubulin beta 4A class IVa 0.1142 1 1
Brugia malayi Tubulin beta chain 0.0295 0.246 0.246
Trypanosoma brucei alpha tubulin 0.0861 0.7498 0.7475
Trypanosoma brucei alpha tubulin, putative 0.0348 0.2934 0.287
Brugia malayi follicle stimulating hormone receptor 0.0251 0.2073 0.2073
Trypanosoma brucei beta tubulin 0.1142 1 1
Plasmodium falciparum tubulin delta chain, putative 0.0295 0.246 0.246
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.009 0.009
Brugia malayi hypothetical protein 0.0177 0.1413 0.1413
Schistosoma mansoni hypothetical protein 0.0078 0.0534 0.0534
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0144 0.0144
Leishmania major alpha tubulin 0.0861 0.7498 0.7498
Leishmania major cathepsin L-like protease 0.0069 0.0454 0.0454
Leishmania major beta tubulin 0.1142 1 1
Trypanosoma brucei beta tubulin 0.0643 0.5555 0.5515
Echinococcus granulosus Tubulin alpha 1 chain 0.0861 0.7498 0.7498
Loa Loa (eye worm) tubulin beta-2A chain 0.1142 1 1
Schistosoma mansoni tubulin subunit delta 0.0295 0.246 0.246
Plasmodium falciparum alpha tubulin 2 0.0861 0.7498 0.7498
Schistosoma mansoni tubulin subunit beta 0.1142 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0454 0.0367
Trichomonas vaginalis tubulin beta chain, putative 0.0861 0.7498 0.7498
Trypanosoma cruzi tubulin delta chain 0.0663 0.5738 0.5738
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0566 0.4876 0.4876
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0454 0.0367
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0144 0.0054
Leishmania major cathepsin L-like protease 0.0069 0.0454 0.0454
Echinococcus granulosus Tubulin beta 2C chain 0.1142 1 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0861 0.7498 0.7498
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0144 0.0144
Brugia malayi tubulin alpha-2 chain 0.0861 0.7498 0.7498
Echinococcus granulosus tubulin alpha chain 0.0861 0.7498 0.7498
Schistosoma mansoni alpha tubulin 0.0861 0.7498 0.7498
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0454 0.0367
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0144 0.0144
Entamoeba histolytica hypothetical protein 0.0078 0.0534 0.0534
Loa Loa (eye worm) tubulin alpha 2 0.0566 0.4876 0.4876
Trichomonas vaginalis tubulin gamma chain, putative 0.0701 0.6078 0.6078
Echinococcus granulosus tubulin alpha chain 0.0861 0.7498 0.7498
Loa Loa (eye worm) hypothetical protein 0.0513 0.4402 0.4402
Giardia lamblia Alpha-tubulin 0.0861 0.7498 0.6681
Trichomonas vaginalis tubulin alpha chain, putative 0.0348 0.2934 0.2934
Echinococcus granulosus beta tubulin 0.1142 1 1
Brugia malayi Cell division protein ftsZ 0.0295 0.246 0.246
Schistosoma mansoni alpha tubulin 0.0861 0.7498 0.7498
Plasmodium vivax tubulin beta chain, putative 0.1142 1 1
Toxoplasma gondii alpha tubulin TUBA1 0.0861 0.7498 0.7498
Giardia lamblia Epsilon tubulin 0.0353 0.2983 0.0694
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0144 0.0144
Brugia malayi beta-tubulin, identical 0.1142 1 1
Leishmania major beta tubulin 0.1142 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0861 0.7498 0.7498
Trichomonas vaginalis tubulin alpha chain, putative 0.0348 0.2934 0.2934
Plasmodium vivax tubulin epsilon chain, putative 0.0701 0.6078 0.6078
Loa Loa (eye worm) tubulin alpha 2 0.0218 0.1781 0.1781
Echinococcus multilocularis hypothetical protein 0.0861 0.7498 0.7498
Loa Loa (eye worm) hypothetical protein 0.0861 0.7498 0.7498
Echinococcus multilocularis tubulin gamma 1 chain 0.0702 0.6086 0.6086
Echinococcus multilocularis tubulin alpha chain 0.0861 0.7498 0.7498
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0295 0.246 0.246
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.0454 0.0454
Schistosoma mansoni tubulin subunit alpha 0.0861 0.7498 0.7498
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0454 0.0367
Echinococcus granulosus Tubulin alpha 1 chain 0.0861 0.7498 0.7498
Trichomonas vaginalis tubulin beta chain, putative 0.0861 0.7498 0.7498
Echinococcus granulosus tubulin beta 1 chain 0.1142 1 1
Echinococcus granulosus tubulin alpha chain 0.0861 0.7498 0.7498
Schistosoma mansoni tubulin subunit epsilon 0.0701 0.6078 0.6078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0454 0.0367
Echinococcus multilocularis Tubulin alpha 1 chain 0.0861 0.7498 0.7498
Echinococcus granulosus tubulin alpha 0.0643 0.5555 0.5555
Loa Loa (eye worm) tubulin beta chain 0.1142 1 1
Leishmania major alpha tubulin 0.0861 0.7498 0.7498
Loa Loa (eye worm) tubulin beta-1 chain 0.1142 1 1
Trichomonas vaginalis tubulin, putative 0.0348 0.2934 0.2934
Entamoeba histolytica tubulin alpha chain, putative 0.0861 0.7498 0.7498
Giardia lamblia Beta tubulin 0.1142 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0513 0.4402 0.4402
Plasmodium vivax tubulin alpha chain, putative 0.0861 0.7498 0.7498
Giardia lamblia Alpha-tubulin 0.0861 0.7498 0.6681
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0251 0.2073 0.2073
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0144 0.0144
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0144 0.0144
Brugia malayi PAS domain containing protein 0.0053 0.0308 0.0308
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0144 0.0144
Loa Loa (eye worm) tubulin alpha-3 chain 0.0513 0.4402 0.4402
Echinococcus multilocularis tubulin alpha 1C chain 0.0861 0.7498 0.7498
Trichomonas vaginalis conserved hypothetical protein 0.0295 0.246 0.246
Brugia malayi tubulin alpha chain - mouse 0.0861 0.7498 0.7498
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0322 0.0322
Echinococcus multilocularis Tubulin beta 2C chain 0.1142 1 1
Brugia malayi alpha-tubulin 0.0861 0.7498 0.7498
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0454 0.0367
Trichomonas vaginalis tubulin alpha chain, putative 0.1142 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.1142 1 1
Plasmodium falciparum alpha tubulin 1 0.0861 0.7498 0.7498
Trypanosoma brucei alpha tubulin 0.0861 0.7498 0.7475
Trichomonas vaginalis tubulin epsilon chain, putative 0.1142 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0861 0.7498 0.7498
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.009 0.009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0454 0.0367
Loa Loa (eye worm) hypoxia-induced factor 1 0.0163 0.1291 0.1291
Trypanosoma cruzi zeta tubulin, putative 0.0911 0.794 0.794
Trichomonas vaginalis tubulin gamma chain, putative 0.0295 0.246 0.246
Leishmania major alpha tubulin 0.0861 0.7498 0.7498
Schistosoma mansoni hypothetical protein 0.0178 0.1421 0.1421
Loa Loa (eye worm) tubulin beta chain 0.0295 0.246 0.246
Echinococcus granulosus Tubulin beta 2C chain 0.1142 1 1
Leishmania major alpha tubulin 0.0861 0.7498 0.7498
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0144 0.0144
Schistosoma mansoni tubulin subunit beta 0.1142 1 1
Loa Loa (eye worm) tubulin alpha chain 0.0861 0.7498 0.7498
Leishmania major alpha tubulin 0.0861 0.7498 0.7498
Schistosoma mansoni tubulin subunit beta 0.1142 1 1
Echinococcus multilocularis tubulin beta 1 chain 0.1142 1 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0401 0.0401
Loa Loa (eye worm) hypothetical protein 0.0177 0.1413 0.1413
Trichomonas vaginalis tubulin beta chain, putative 0.0861 0.7498 0.7498
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0663 0.5738 0.5738
Loa Loa (eye worm) hypothetical protein 0.0028 0.009 0.009
Trichomonas vaginalis tubulin beta chain, putative 0.0861 0.7498 0.7498
Treponema pallidum cell division protein FtsZ 0.0295 0.246 0.5
Echinococcus granulosus peroxisome assembly protein 26 0.0861 0.7498 0.7498
Trypanosoma brucei alpha tubulin 0.0861 0.7498 0.7475
Leishmania major beta tubulin 0.1142 1 1
Echinococcus granulosus single minded 2 0.0039 0.0186 0.0186
Echinococcus granulosus Tubulin alpha 1 chain 0.0861 0.7498 0.7498
Echinococcus multilocularis Tubulin beta 2C chain 0.1142 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0454 0.0454
Leishmania major beta tubulin 0.1142 1 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0144 0.0144
Leishmania major alpha tubulin 0.0861 0.7498 0.7498
Trypanosoma brucei alpha tubulin 0.0861 0.7498 0.7475
Toxoplasma gondii beta tubulin 0.1142 1 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0348 0.2934 0.2934
Echinococcus granulosus Tubulin beta 2C chain 0.1142 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0454 0.0367
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0144 0.0144
Schistosoma mansoni tubulin subunit alpha 0.0861 0.7498 0.7498
Trypanosoma brucei beta tubulin 0.1142 1 1
Echinococcus multilocularis tubulin subunit TubB 0.0861 0.7498 0.7498
Giardia lamblia Beta tubulin 0.1142 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.1142 1 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0144 0.0144
Leishmania major beta tubulin 0.1142 1 1
Loa Loa (eye worm) tubulin alpha 2 0.0566 0.4876 0.4876
Echinococcus multilocularis tubulin alpha 3 chain 0.0861 0.7498 0.7498
Echinococcus multilocularis Tubulin alpha 1 chain 0.0861 0.7498 0.7498
Echinococcus granulosus beta tubulin 0.1142 1 1
Onchocerca volvulus 0.0039 0.0186 0.0633
Mycobacterium tuberculosis Cell division protein FtsZ 0.0295 0.246 1
Loa Loa (eye worm) BEN-1 protein 0.1142 1 1
Leishmania major gamma-tubulin 0.0702 0.6086 0.6086
Toxoplasma gondii alpha-tubulin I, putative 0.0861 0.7498 0.7498
Echinococcus multilocularis tubulin subunit beta 0.1142 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0702 0.6086 0.6086
Brugia malayi hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni tubulin subunit gamma 0.0702 0.6086 0.6086
Trichomonas vaginalis tubulin, putative 0.0354 0.299 0.299
Schistosoma mansoni tubulin subunit alpha 0.0295 0.246 0.246
Echinococcus multilocularis Tubulin beta 2C chain 0.1142 1 1
Trypanosoma brucei epsilon tubulin 0.0701 0.6078 0.6042
Leishmania major beta tubulin 0.1142 1 1
Entamoeba histolytica hypothetical protein 0.0078 0.0534 0.0534
Mycobacterium ulcerans cell division protein FtsZ 0.0295 0.246 1
Trypanosoma cruzi zeta tubulin, putative 0.0911 0.794 0.794
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0144 0.0144
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0186 0.0186
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0534 0.0534
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0454 0.0367
Loa Loa (eye worm) alpha-tubulin 0.0861 0.7498 0.7498
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0091 0.0091
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0861 0.7498 0.7498
Loa Loa (eye worm) BEN-1 protein 0.1142 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.009 0.009
Echinococcus multilocularis tubulin alpha chain 0.0861 0.7498 0.7498
Trichomonas vaginalis tubulin, putative 0.1142 1 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0144 0.0144
Echinococcus multilocularis tubulin epsilon chain 0.0701 0.6078 0.6078
Toxoplasma gondii tubulin, putative 0.0059 0.0361 0.0361
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.009 0.009
Leishmania major cathepsin L-like protease 0.0069 0.0454 0.0454
Trichomonas vaginalis tubulin beta chain, putative 0.0348 0.2934 0.2934
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0144 0.0144
Echinococcus granulosus tubulin alpha chain 0.0861 0.7498 0.7498
Leishmania major delta tubulin, putative 0.0663 0.5738 0.5738
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0454 0.0454
Leishmania major zeta tubulin, putative 0.0911 0.794 0.794
Leishmania major beta tubulin 0.1142 1 1
Loa Loa (eye worm) tubulin alpha chain 0.0861 0.7498 0.7498
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0566 0.4876 0.4876
Echinococcus granulosus tubulin subunit TubB 0.0861 0.7498 0.7498
Echinococcus granulosus tubulin alpha 1C chain 0.0861 0.7498 0.7498
Brugia malayi hypoxia-induced factor 1 0.0163 0.1291 0.1291
Trichomonas vaginalis conserved hypothetical protein 0.0295 0.246 0.246
Leishmania major alpha tubulin 0.0861 0.7498 0.7498
Echinococcus multilocularis tubulin alpha chain 0.0861 0.7498 0.7498
Echinococcus multilocularis tubulin alpha chain 0.0861 0.7498 0.7498
Leishmania major alpha tubulin 0.0861 0.7498 0.7498
Leishmania major alpha tubulin 0.0861 0.7498 0.7498
Leishmania major beta tubulin 0.1142 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0454 0.0367
Echinococcus granulosus tubulin alpha chain 0.0861 0.7498 0.7498
Brugia malayi Tubulin gamma chain 0.0702 0.6086 0.6086
Leishmania major beta tubulin 0.1142 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0295 0.246 0.246
Echinococcus granulosus Tubulin beta 2C chain 0.1142 1 1
Brugia malayi Tubulin alpha chain 0.0295 0.246 0.246
Toxoplasma gondii beta-1 tubulin, putative 0.1142 1 1
Schistosoma mansoni tubulin subunit beta 0.1142 1 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.1142 1 1
Plasmodium falciparum tubulin gamma chain 0.0702 0.6086 0.6086
Brugia malayi Cytochrome P450 family protein 0.0028 0.0091 0.0091
Brugia malayi Tubulin alpha-2 chain 0.0861 0.7498 0.7498
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0295 0.246 0.5
Trypanosoma cruzi beta tubulin, putative 0.1142 1 1
Entamoeba histolytica hypothetical protein 0.0078 0.0534 0.0534
Schistosoma mansoni alpha tubulin 0.0861 0.7498 0.7498
Echinococcus multilocularis peroxisome assembly protein 26 0.0861 0.7498 0.7498
Trypanosoma brucei zeta tubulin, putative 0.0911 0.794 0.7921
Trichomonas vaginalis tubulin beta chain, putative 0.1142 1 1
Trypanosoma brucei epsilon tubulin 0.0701 0.6078 0.6042
Leishmania major beta tubulin 0.1142 1 1
Trypanosoma brucei epsilon tubulin 0.0643 0.5555 0.5515
Schistosoma mansoni hypothetical protein 0.0178 0.1421 0.1421
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0186 0.0186
Plasmodium vivax tubulin gamma chain, putative 0.0702 0.6086 0.6086
Loa Loa (eye worm) hypothetical protein 0.0566 0.4876 0.4876
Plasmodium falciparum tubulin epsilon chain, putative 0.0701 0.6078 0.6078
Leishmania major beta tubulin 0.1142 1 1
Echinococcus granulosus alpha tubulin 0.0861 0.7498 0.7498
Onchocerca volvulus 0.0348 0.2934 1
Loa Loa (eye worm) alpha-tubulin 0.0861 0.7498 0.7498
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.009 0.009
Echinococcus multilocularis beta tubulin 0.1142 1 1
Trypanosoma cruzi epsilon tubulin, putative 0.0701 0.6078 0.6078
Plasmodium vivax tubulin alpha chain, putative 0.0861 0.7498 0.7498
Echinococcus granulosus tubulin subunit beta 0.1142 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0454 0.0454
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0643 0.5555 0.5555
Brugia malayi isocitrate dehydrogenase 0.0034 0.0144 0.0144
Plasmodium vivax delta tubulin, putative 0.0295 0.246 0.246
Trypanosoma cruzi tubulin delta chain 0.0663 0.5738 0.5738
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0144 0.0144
Loa Loa (eye worm) tubulin alpha-2 chain 0.0861 0.7498 0.7498
Trypanosoma brucei tubulin delta chain 0.0663 0.5738 0.5699
Leishmania major beta tubulin 0.1142 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0861 0.7498 0.7498
Echinococcus granulosus tubulin epsilon chain 0.0701 0.6078 0.6078
Leishmania major alpha tubulin 0.0861 0.7498 0.7498
Brugia malayi Tubulin alpha-2 chain 0.0861 0.7498 0.7498
Trichomonas vaginalis tubulin epsilon chain, putative 0.1142 1 1
Echinococcus granulosus tubulin alpha 3 chain 0.0861 0.7498 0.7498
Trypanosoma cruzi alpha tubulin, putative 0.0861 0.7498 0.7498
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0308 0.0308
Brugia malayi Tubulin alpha chain 0.0861 0.7498 0.7498
Trichomonas vaginalis tubulin alpha chain, putative 0.0643 0.5555 0.5555
Leishmania major alpha tubulin 0.0861 0.7498 0.7498
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0534 0.0534
Loa Loa (eye worm) tubulin beta-4 chain 0.1142 1 1
Leishmania major hypothetical protein, conserved 0.0028 0.009 0.009
Leishmania major beta tubulin 0.1142 1 1
Trypanosoma brucei zeta tubulin 0.0911 0.794 0.7921
Trichomonas vaginalis tubulin epsilon chain, putative 0.0861 0.7498 0.7498
Leishmania major beta tubulin 0.1142 1 1
Echinococcus granulosus tubulin alpha 3 chain 0.0861 0.7498 0.7498
Schistosoma mansoni tubulin subunit beta 0.1142 1 1
Schistosoma mansoni tubulin subunit alpha 0.0861 0.7498 0.7498
Trichomonas vaginalis tubulin, putative 0.0348 0.2934 0.2934
Entamoeba histolytica hypothetical protein 0.0078 0.0534 0.0534
Loa Loa (eye worm) beta-tubulin 0.1142 1 1
Entamoeba histolytica tubulin family protein 0.1142 1 1
Entamoeba histolytica tubulin gamma chain 0.0702 0.6086 0.6086
Trypanosoma brucei tubulin gamma chain 0.0702 0.6086 0.605
Brugia malayi hypothetical protein 0.0078 0.0534 0.0534
Loa Loa (eye worm) tubulin gamma chain 0.0702 0.6086 0.6086
Echinococcus multilocularis tubulin alpha chain 0.0861 0.7498 0.7498
Echinococcus multilocularis geminin 0.0178 0.1421 0.1421
Leishmania major beta tubulin 0.1142 1 1
Giardia lamblia Gamma tubulin 0.0702 0.6086 0.4809
Trichomonas vaginalis tubulin epsilon chain, putative 0.0861 0.7498 0.7498
Entamoeba histolytica tubulin alpha-1 chain 0.0861 0.7498 0.7498
Trypanosoma cruzi epsilon tubulin, putative 0.0701 0.6078 0.6078
Echinococcus granulosus geminin 0.0178 0.1421 0.1421
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0353 0.2983 0.2983
Leishmania major alpha tubulin 0.0861 0.7498 0.7498
Toxoplasma gondii beta-tubulin, putative 0.1142 1 1
Echinococcus granulosus tubulin gamma 1 chain 0.0702 0.6086 0.6086
Echinococcus multilocularis tubulin alpha 0.0643 0.5555 0.5555
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0144 0.0054
Echinococcus multilocularis beta tubulin 0.1142 1 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0348 0.2934 0.2934
Echinococcus multilocularis Tubulin alpha 1 chain 0.0861 0.7498 0.7498
Leishmania major epsilon tubulin, putative 0.0701 0.6078 0.6078
Trichomonas vaginalis tubulin gamma chain, putative 0.1142 1 1
Brugia malayi Tubulin beta chain 0.0348 0.2934 0.2934
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0144 0.0144
Schistosoma mansoni single-minded 0.0053 0.0308 0.0308

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.