TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 398.272 | Formula: C16H16BrNO4S
H donors: 1 H acceptors: 3 LogP: 3.56 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)[C@H](c1ccccc1)NS(=O)(=O)c1ccccc1Br
InChi: 1S/C16H16BrNO4S/c1-2-22-16(19)15(12-8-4-3-5-9-12)18-23(20,21)14-11-7-6-10-13(14)17/h3-11,15,18H,2H2,1H3/t15-/m1/s1
InChiKey: RFDQZAURRYLJSK-OAHLLOKOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nuclear hormone receptor	0.0052	0.0288	0.025
Plasmodium falciparum	LCCL domain-containing protein	0.0142	0.1268	0.5
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0049	0.025	0.0202
Echinococcus multilocularis	transfer RNA-Lys	0.004	0.0153	0.0082
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0934	0.1336
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0144	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0288	0.0412
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0494	1
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0049	0.0245	0.0197
Brugia malayi	RNA binding protein	0.0067	0.0445	0.0637
Schistosoma mansoni	hypothetical protein	0.023	0.2246	0.2692
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0144	0.5
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0187	0.177	0.2532
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0111	0.0934	0.1056
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0144	0.0144
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0144	0.007
Onchocerca volvulus		0.0054	0.0303	0.1403
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0273	0.039
Onchocerca volvulus	Netrin receptor homolog	0.0049	0.0245	0.1136
Brugia malayi	Steroid receptor seven-up type 2	0.0111	0.0934	0.1336
Echinococcus multilocularis	FTZ F1 alpha	0.0111	0.0934	0.1056
Echinococcus granulosus	RUN	0.0142	0.1268	0.1473
Brugia malayi	Nuclear hormone receptor-like 1	0.0059	0.0357	0.0511
Mycobacterium ulcerans	proteasome PrcA	0.0935	1	1
Brugia malayi	bHLH-PAS transcription factor	0.004	0.0153	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0662	0.6992	1
Schistosoma mansoni	ankyrin 23/unc44	0.0049	0.0245	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0288	0.0412
Onchocerca volvulus		0.0142	0.1268	0.5872
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0052	0.0288	0.025
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0494	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0357	0.0511
Schistosoma mansoni	hypothetical protein	0.0185	0.1747	0.207
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0144	0.0206
Loa Loa (eye worm)	ShTK domain-containing protein	0.0187	0.177	0.2532
Trypanosoma cruzi	cysteine peptidase, putative	0.0071	0.0494	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0494	1
Brugia malayi	Common central domain of tyrosinase family protein	0.0187	0.177	0.2532
Schistosoma mansoni	RAR-like nuclear receptor	0.0111	0.0934	0.1056
Echinococcus granulosus	nuclear receptor nhr 48	0.0052	0.0288	0.025
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0052	0.0288	0.025
Schistosoma mansoni	lipoxygenase	0.0463	0.4805	0.5884
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0445	0.0446
Loa Loa (eye worm)	nuclear hormone receptor	0.0052	0.0288	0.0412
Loa Loa (eye worm)	CYP4Cod1	0.003	0.0042	0.006
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0052	0.0288	0.025
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0283	0.283	0.342
Trichomonas vaginalis	esterase, putative	0.0039	0.0144	0.5
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.0144	0.0144
Loa Loa (eye worm)	tyrosinase 1	0.0187	0.177	0.2532
Loa Loa (eye worm)	hypothetical protein	0.0187	0.177	0.2532
Trypanosoma cruzi	cysteine peptidase, putative	0.0071	0.0494	1
Onchocerca volvulus		0.0142	0.1268	0.5872
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0187	0.177	0.2532
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0052	0.0288	0.025
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0111	0.0934	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0934	0.1336
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.0042	0.006
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0288	0.0412
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0494	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.0142	0.1268	0.1473
Echinococcus multilocularis	tar DNA binding protein	0.0067	0.0445	0.0446
Schistosoma mansoni	rab6-interacting	0.0142	0.1268	0.1473
Brugia malayi	conserved hypotetical protein	0.0052	0.0288	0.0412
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0049	0.0245	0.0197
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0111	0.0934	0.1056
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0144	0.0144
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0111	0.0934	0.1056
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0288	0.0412
Loa Loa (eye worm)	steroid hormone receptor	0.0111	0.0934	0.1336
Brugia malayi	nuclear hormone receptor	0.0111	0.0934	0.1336
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0111	0.0934	0.1336
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0111	0.0934	0.1336
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0111	0.0934	0.1056
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.0935	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0111	0.0934	0.1056
Brugia malayi	nuclear receptor RXR	0.0059	0.0357	0.0511
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0052	0.0288	0.025
Schistosoma mansoni	nuclear receptor	0.0052	0.0288	0.025
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0111	0.0934	0.1056
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0144	0.007
Loa Loa (eye worm)	hypothetical protein	0.0264	0.2612	0.3735
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0144	0.5
Onchocerca volvulus		0.0187	0.177	0.8196
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0494	1
Brugia malayi	beta-lactamase	0.0039	0.0144	0.0206
Onchocerca volvulus		0.0111	0.0934	0.4324
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0049	0.0245	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0524	0.075
Loa Loa (eye worm)	TAR-binding protein	0.0067	0.0445	0.0637
Entamoeba histolytica	hypothetical protein	0.0037	0.0116	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0052	0.0288	0.025
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0144	0.0206
Brugia malayi	TAR-binding protein	0.0067	0.0445	0.0637
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.0144	0.0144
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0494	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0111	0.0934	0.1056
Loa Loa (eye worm)	doublecortin family protein	0.0142	0.1268	0.1814
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0718	0.7608	0.938
Brugia malayi	latrophilin 2 splice variant baaae	0.0074	0.0524	0.075
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0245	0.0351
Schistosoma mansoni	nuclear hormone receptor	0.0111	0.0934	0.1056
Brugia malayi	steroid hormone receptor	0.0111	0.0934	0.1336
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0052	0.0288	0.0412
Brugia malayi	Cytochrome P450 family protein	0.003	0.0042	0.006
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0065	0.0426	0.8498
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0187	0.177	0.2532
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0108	0.09	0.1288
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0111	0.0934	0.1336
Echinococcus multilocularis	Polycystic kidney disease protein	0.0142	0.1268	0.1473
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0437	0.452	0.5528
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0144	0.0144
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0249	0.2446	0.2941
Loa Loa (eye worm)	hypothetical protein	0.0276	0.2744	0.3925
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0357	0.0511
Loa Loa (eye worm)	RNA binding protein	0.0067	0.0445	0.0637
Echinococcus multilocularis	survival motor neuron protein 1	0.0264	0.2612	0.3148
Schistosoma mansoni	netrin receptor unc5	0.0049	0.0245	0.0197
Brugia malayi	hypothetical protein	0.0052	0.0288	0.0412
Trypanosoma cruzi	cysteine peptidase, putative	0.0071	0.0494	1
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0144	0.2261
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0111	0.0934	0.1056
Echinococcus multilocularis	jun protein	0.0283	0.283	0.342
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0357	0.0511
Leishmania major	cathepsin L-like protease	0.0071	0.0494	1
Schistosoma mansoni	microtubule-associated protein tau	0.0763	0.8105	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0059	0.0357	0.0336
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0273	0.0231
Schistosoma mansoni	hypothetical protein	0.0074	0.0524	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0288	0.0412
Echinococcus granulosus	tar DNA binding protein	0.0067	0.0445	0.0446
Schistosoma mansoni	rab6-interacting	0.0142	0.1268	0.1473
Brugia malayi	hypothetical protein	0.0182	0.1713	0.245
Toxoplasma gondii	ABC1 family protein	0.0039	0.0144	0.5
Brugia malayi	nuclear hormone receptor	0.0052	0.0288	0.0412
Trypanosoma cruzi	major cysteine proteinase, putative	0.0056	0.0327	0.6295
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0067	0.0445	0.0637
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0934	0.1336
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0111	0.0934	0.1336
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0116	0.0035
Schistosoma mansoni	tyrosinase precursor	0.0187	0.177	0.2099
Loa Loa (eye worm)	hypothetical protein	0.0049	0.025	0.0358
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0059	0.0357	0.0336
Brugia malayi	PAS domain containing protein	0.0054	0.0308	0.0441
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0111	0.0934	0.1336
Brugia malayi	beta-lactamase family protein	0.0039	0.0144	0.0206
Onchocerca volvulus		0.0223	0.216	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0494	1
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0445	0.0446
Brugia malayi	photoreceptor-specific nuclear receptor	0.0111	0.0934	0.1336
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0049	0.0245	0.0351
Schistosoma mansoni	hypothetical protein	0.0049	0.0245	0.0197
Brugia malayi	ShTK domain containing protein	0.0187	0.177	0.2532
Brugia malayi	nuclear receptor NHR-88	0.0052	0.0288	0.0412
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0111	0.0934	0.1056
Schistosoma mansoni	tyrosinase precursor	0.0187	0.177	0.2099
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0111	0.0934	0.1336
Echinococcus granulosus	Polycystic kidney disease protein	0.0142	0.1268	0.1473
Schistosoma mansoni	thyroid hormone receptor	0.0111	0.0934	0.1056
Schistosoma mansoni	single-minded	0.0054	0.0308	0.0275
Brugia malayi	tailless protein	0.0052	0.0288	0.0412
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0144	0.0206
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0494	1
Loa Loa (eye worm)	hypothetical protein	0.0182	0.1713	0.245
Trypanosoma cruzi	cruzipain precursor, putative	0.0071	0.0494	1
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0187	0.177	0.2532
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0283	0.283	0.342
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0494	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0494	1
Entamoeba histolytica	hypothetical protein	0.0037	0.0116	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0288	0.0412
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0052	0.0288	0.025
Brugia malayi	nuclear receptor NHR-88	0.0111	0.0934	0.1336
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0052	0.0288	0.1334
Onchocerca volvulus		0.0187	0.177	0.8196
Brugia malayi	Nuclear hormone receptor E75	0.0052	0.0288	0.0412
Echinococcus granulosus	geminin	0.0185	0.1747	0.207
Echinococcus granulosus	lipoxygenase domain containing protein	0.0142	0.1268	0.1473
Echinococcus granulosus	jun protein	0.0283	0.283	0.342
Echinococcus multilocularis	microtubule associated protein 2	0.0763	0.8105	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0162	0.1497	0.1758
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0144	0.0144
Leishmania major	cytochrome p450-like protein	0.003	0.0042	0.085
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0288	0.0412
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0111	0.0934	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0288	0.0412
Schistosoma mansoni	survival motor neuron protein	0.0054	0.0303	0.0269
Brugia malayi	nuclear receptor RXR	0.0052	0.0288	0.0412
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0111	0.0934	0.1056
Schistosoma mansoni	nuclear hormone receptor	0.0052	0.0288	0.025
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0052	0.0288	0.025
Echinococcus granulosus	netrin receptor unc 5	0.0049	0.0245	0.0197
Onchocerca volvulus		0.0039	0.0144	0.0667
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0111	0.0934	0.1056
Brugia malayi	hypothetical protein	0.0223	0.216	0.309
Brugia malayi	hypothetical protein	0.0142	0.1268	0.1814
Brugia malayi	Nuclear hormone receptor-like 1	0.0059	0.0357	0.0511
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.0144	0.0144
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0273	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0088	0.0126
Schistosoma mansoni	lipoxygenase	0.0718	0.7608	0.938
Brugia malayi	bZIP transcription factor family protein	0.0283	0.283	0.4047
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0144	0.0144
Schistosoma mansoni	loxhd1	0.0142	0.1268	0.1473
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0111	0.0934	0.1056
Brugia malayi	Nuclear hormone receptor E75	0.0052	0.0288	0.0412
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0071	0.0494	1
Schistosoma mansoni	jun-related protein	0.023	0.2246	0.2692
Brugia malayi	nuclear hormone receptor family member odr-7	0.0052	0.0288	0.0412
Onchocerca volvulus		0.0187	0.177	0.8196
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.003	0.0042	0.0042
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0144	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0288	0.0412
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0168	0.1558	0.2228
Mycobacterium ulcerans	lipase LipD	0.0039	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0288	0.0412
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0224	0.2173	0.3108
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0357	0.0511
Schistosoma mansoni	thyroid hormone receptor	0.0111	0.0934	0.1056
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0111	0.0934	0.1056
Brugia malayi	nuclear receptor NHR-67	0.0052	0.0288	0.0412
Echinococcus granulosus	death domain containing protein	0.0049	0.0245	0.0197
Loa Loa (eye worm)	ShTK domain-containing protein	0.0187	0.177	0.2532
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0445	0.0446
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0052	0.0288	0.025
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0054	0.0303	0.0434
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0142	0.1268	0.1473
Schistosoma mansoni	polycystin 1-related	0.0142	0.1268	0.1473
Onchocerca volvulus		0.0052	0.0288	0.1334
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0108	0.09	0.1288
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0111	0.0934	0.1336
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0111	0.0934	0.1336
Leishmania major	cathepsin L-like protease	0.0071	0.0494	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0059	0.0357	0.0511
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0273	0.0231
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0288	0.0412
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0052	0.0288	0.1334
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0445	0.0446
Brugia malayi	ecdysone receptor	0.0052	0.0288	0.0412
Echinococcus granulosus	FTZ F1 alpha	0.0111	0.0934	0.1056
Loa Loa (eye worm)	hypothetical protein	0.0108	0.09	0.1288
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0221	0.2143	0.2563
Mycobacterium ulcerans	putative regulatory protein	0.004	0.0153	0.0153
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0111	0.0934	0.1056
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0111	0.0934	0.1056
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0111	0.0934	0.1336
Echinococcus granulosus	survival motor neuron protein 1	0.0264	0.2612	0.3148
Onchocerca volvulus		0.004	0.0153	0.0709
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0111	0.0934	0.1336
Schistosoma mansoni	hypothetical protein	0.0037	0.0116	0.0035
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0273	0.0231
Leishmania major	cathepsin L-like protease	0.0071	0.0494	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0111	0.0934	0.1056
Onchocerca volvulus	Protein ultraspiracle homolog	0.0111	0.0934	0.4324
Brugia malayi	hypothetical protein	0.0059	0.0357	0.0511
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0059	0.0357	0.0336
Brugia malayi	orphan nuclear receptor NR2E1	0.0052	0.0288	0.0412
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0088	0.0126
Echinococcus granulosus	microtubule associated protein 2	0.0763	0.8105	1
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0144	0.0206
Schistosoma mansoni	hypothetical protein	0.0054	0.0303	0.0269
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0116	0.0035
Echinococcus granulosus	Ankyrin	0.0049	0.025	0.0202
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0245	0.0351
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0052	0.0288	0.0412
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0111	0.0934	0.1336
Brugia malayi	Death domain containing protein	0.0049	0.0245	0.0351
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0088	0.0126
Loa Loa (eye worm)	DR-78	0.0052	0.0288	0.0412
Brugia malayi	Cytochrome P450 family protein	0.0101	0.0822	0.1176
Echinococcus multilocularis	netrin receptor unc 5	0.0049	0.0245	0.0197
Echinococcus granulosus	single minded 2	0.004	0.0153	0.0082
Leishmania major	hypothetical protein, conserved	0.0039	0.0144	0.2919
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0059	0.0357	0.0336
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0111	0.0934	0.1336
Brugia malayi	Nuclear hormone receptor-like 1	0.0111	0.0934	0.1336
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0144	0.2261
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0718	0.7608	0.938
Loa Loa (eye worm)	cytochrome P450 family protein	0.0101	0.0822	0.1176
Brugia malayi	small heat shock protein	0.0662	0.6992	1
Schistosoma mansoni	nuclear receptor	0.0052	0.0288	0.025
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1268	0.1814
Brugia malayi	hypoxia-induced factor 1	0.0168	0.1558	0.2228
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0052	0.0288	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1268	0.1814
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0111	0.0934	0.1336
Onchocerca volvulus		0.0039	0.0144	0.0667
Brugia malayi	hypothetical protein	0.0052	0.0288	0.0412
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0273	0.039
Entamoeba histolytica	hypothetical protein	0.0037	0.0116	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0111	0.0934	0.4324
Schistosoma mansoni	nuclear receptor nhr-48	0.0052	0.0288	0.025
Schistosoma mansoni	coup transcription factor	0.0111	0.0934	0.1056
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0273	0.0231
Brugia malayi	Cytochrome P450 family protein	0.003	0.0042	0.006
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0116	0.0035
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0111	0.0934	0.1336
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0144	0.007
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0357	0.0511
Brugia malayi	beta-lactamase family protein	0.0039	0.0144	0.0206
Brugia malayi	ecdysteroid receptor	0.0111	0.0934	0.1336
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0273	0.0231
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0111	0.0934	0.1056
Brugia malayi	follicle stimulating hormone receptor	0.0224	0.2173	0.3108
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0142	0.1268	0.1473
Echinococcus multilocularis	ecdysone induced protein 78C	0.0111	0.0934	0.1056
Brugia malayi	RNA recognition motif domain containing protein	0.0067	0.0445	0.0637
Onchocerca volvulus	Bile acid receptor homolog	0.0111	0.0934	0.4324
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0111	0.0934	0.1056
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0187	0.177	0.2532
Brugia malayi	hypothetical protein	0.0059	0.0357	0.0511
Brugia malayi	Doublecortin family protein	0.0142	0.1268	0.1814
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0934	0.1336
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0288	0.0412
Echinococcus multilocularis	nuclear receptor nhr 48	0.0052	0.0288	0.025
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0934	0.1336
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0111	0.0934	0.1336
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0144	0.0206
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0144	0.007
Plasmodium vivax	multidomain scavenger receptor, putative	0.0142	0.1268	1
Onchocerca volvulus		0.0039	0.0144	0.0667
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0445	0.0446
Brugia malayi	hypothetical protein	0.0037	0.0116	0.0166
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0144	0.2261
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0288	0.0412
Brugia malayi	hypothetical protein	0.0142	0.1268	0.1814
Echinococcus multilocularis	Ankyrin	0.0049	0.025	0.0202
Schistosoma mansoni	hypothetical protein	0.0185	0.1747	0.207
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0111	0.0934	0.1056
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0144	0.0206
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0111	0.0934	0.1336
Schistosoma mansoni	retinoic acid receptor RXR	0.0221	0.2143	0.2563
Schistosoma mansoni	aryl hydrocarbon receptor	0.0054	0.0308	0.0275
Echinococcus granulosus	ecdysone induced protein 78C	0.0111	0.0934	0.1056
Onchocerca volvulus		0.0187	0.177	0.8196
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.0144	0.0144
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0144	0.0144
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0111	0.0934	0.1336
Echinococcus multilocularis	geminin	0.0185	0.1747	0.207
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0934	0.1336
Schistosoma mansoni	hypothetical protein	0.0142	0.1268	0.1473
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0052	0.0288	0.0412
Schistosoma mansoni	zinc finger protein	0.0052	0.0288	0.025
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0111	0.0934	0.1056
Brugia malayi	hypothetical protein	0.0264	0.2612	0.3735
Onchocerca volvulus		0.0052	0.0288	0.1334
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0088	0.0126
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0111	0.0934	0.1336
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0144	0.0206
Brugia malayi	Uncoordinated protein 44	0.0049	0.0245	0.0351
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0144	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0934	0.1336
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0108	0.09	0.1288
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0251	0.2475	0.2475
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0144	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0934	0.1336
Echinococcus granulosus	thyroid hormone receptor alpha	0.0052	0.0288	0.025
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.0042	0.006
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0249	0.2446	0.2941
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0144	0.5
Echinococcus multilocularis	RUN	0.0142	0.1268	0.1473
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0273	0.0231
Entamoeba histolytica	hypothetical protein	0.0037	0.0116	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 876307