TDR Targets

Basic information

Technical information

TDR Targets ID: 880371
Name: 1-[(2-bromophenyl)methyl]-3-[2-(trifluorometh oxy)phenyl]urea
MW: 389.167 | Formula: C15H12BrF3N2O2
H donors: 2 H acceptors: 1 LogP: 4.29 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccccc1OC(F)(F)F)NCc1ccccc1Br
InChi: 1S/C15H12BrF3N2O2/c16-11-6-2-1-5-10(11)9-20-14(22)21-12-7-3-4-8-13(12)23-15(17,18)19/h1-8H,9H2,(H2,20,21,22)
InChiKey: XPUWFOFKUDHPJT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(2-bromobenzyl)-3-[2-(trifluoromethoxy)phenyl]urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0042	0.0036
Schistosoma mansoni	ap endonuclease	0.0018	0.0039	0.0037
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0014	0.098
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0013	0.0018	0.0018
Loa Loa (eye worm)	ctsf protein	0.0017	0.0033	0.0027
Schistosoma mansoni	cathepsin F (C01 family)	0.0011	0.0012	0.001
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0039	0.5
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0131	0.0478	0.0478
Schistosoma mansoni	survival motor neuron protein	0.0096	0.0342	0.034
Loa Loa (eye worm)	cysteine protease	0.0017	0.0033	0.0027
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.0027	0.1938
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0033	0.1415
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0096	0.0342	0.034
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0006	0.0006
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0006	0.0004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0033	0.2399
Schistosoma mansoni	hypothetical protein	0.0168	0.062	0.0618
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0012	0.0014	0.098
Echinococcus multilocularis	serine threonine protein kinase	0.0056	0.0184	0.0184
Brugia malayi	multidrug resistance protein 3	0.0012	0.0014	0.0012
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.0027	0.1938
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0033	0.2399
Brugia malayi	intermediate filament protein	0.0027	0.0072	0.007
Echinococcus granulosus	cathepsin L cysteine protease	0.0009	0.0002	0.0002
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.0027	0.1938
Echinococcus granulosus	lamin dm0	0.0027	0.0072	0.0072
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0033	0.2399
Leishmania major	cathepsin L-like protease	0.0017	0.0033	0.0937
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0014	0.098
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0002	0.0138
Plasmodium vivax	vivapain-2	0.0017	0.0033	0.2293
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0014	0.098
Schistosoma mansoni	hypothetical protein	0.0168	0.062	0.0618
Entamoeba histolytica	P-glycoprotein 5, putative	0.0012	0.0014	0.0527
Brugia malayi	Protein kinase domain containing protein	0.0015	0.0027	0.0025
Echinococcus granulosus	protein kinase C gamma type	0.0056	0.0184	0.0184
Schistosoma mansoni	multidrug resistance protein	0.0012	0.0014	0.0012
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0033	0.2399
Plasmodium falciparum	histone acetyltransferase GCN5	0.004	0.0125	1
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0033	0.1415
Schistosoma mansoni	lamin	0.0027	0.0072	0.007
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0033	0.0811
Brugia malayi	Protein kinase c protein 2	0.0053	0.0175	0.0173
Entamoeba histolytica	acetyltransferase, GNAT family	0.004	0.0125	0.553
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0012	0.001
Schistosoma mansoni	hypothetical protein	0.0096	0.0342	0.034
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0225	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0033	0.0033
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0033	0.2399
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0014	0.098
Entamoeba histolytica	cysteine proteinase, putative	0.0011	0.0012	0.045
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0006	0.0006
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0033	0.2399
Onchocerca volvulus		0.0096	0.0342	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0044	0.014	0.014
Entamoeba histolytica	P-glycoprotein-2	0.0012	0.0014	0.0527
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0072	0.007
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0014	0.0014
Brugia malayi	hypothetical protein	0.0019	0.0042	0.004
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0006	0.0006
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0147	0.0147
Echinococcus multilocularis	protein kinase c epsilon type	0.0022	0.0055	0.0055
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0033	0.0032
Echinococcus granulosus	cathepsin L	0.0009	0.0002	0.0002
Echinococcus multilocularis	protein kinase c iota type	0.0021	0.005	0.005
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.0027	0.1938
Echinococcus granulosus	cathepsin l1	0.0011	0.0012	0.0012
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0006	0.0006
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0216	0.9614
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0033	0.2399
Plasmodium vivax	multidrug resistance protein 1, putative	0.0012	0.0014	0.0854
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0033	0.2399
Echinococcus multilocularis	cysteine protease	0.0017	0.0033	0.0033
Brugia malayi	Protein kinase domain containing protein	0.0013	0.0018	0.0016
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0033	0.2399
Schistosoma mansoni	thyroid hormone receptor	0.0131	0.0478	0.0476
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0225	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0014	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0144	0.0138
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0012	0.0014	0.0007
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0216	0.9614
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0039	0.2996
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0018	0.0018
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0015	0.0027	0.0021
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0011	0.0012	0.001
Entamoeba histolytica	P-glycoprotein-2, putative	0.0012	0.0014	0.0527
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0033	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0026	0.007	0.0064
Echinococcus multilocularis	cathepsin L	0.0009	0.0002	0.0002
Schistosoma mansoni	lipoxygenase	0.0053	0.0175	0.0173
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0006	0.0004
Brugia malayi	ecdysteroid receptor	0.001	0.0006	0.0004
Trichomonas vaginalis	ABC transporter, putative	0.0012	0.0014	0.098
Echinococcus granulosus	RNA directed DNA polymerase	0.0039	0.0121	0.0121
Echinococcus granulosus	multidrug resistance protein 1	0.0012	0.0014	0.0014
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0015	0.0027	0.0027
Toxoplasma gondii	cathepsin CPL	0.0017	0.0033	0.1574
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0024	0.0018
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0014	0.098
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0006	0.0004
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.0027	0.1938
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0039	0.2685
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0033	0.2399
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0039	0.1657
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0017	0.0033	0.2558
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0039	0.0039
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0066	0.0225	0.0219
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.0018	0.0016
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0008	0.0001	0.0048
Leishmania major	cathepsin L-like protease	0.0064	0.0216	0.9592
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0012	0.0013	0.0013
Brugia malayi	p70 ribosomal S6 kinase beta	0.0015	0.0027	0.0025
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0006	0.0004
Loa Loa (eye worm)	doublecortin family protein	0.0019	0.0042	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0027
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.2585	1	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0006	0.0004
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0014	0.0014
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0006	0.0004
Toxoplasma gondii	AGC kinase	0.0015	0.0027	0.1063
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0006	0.0004
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0014	0.098
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0216	0.9614
Schistosoma mansoni	polycystin 1-related	0.0019	0.0042	0.004
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0015	0.0027	0.0021
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0009	0.0002	0.0138
Echinococcus granulosus	survival motor neuron protein 1	0.0472	0.1801	0.1801
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.0027	0.1938
Brugia malayi	Doublecortin family protein	0.0019	0.0042	0.004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0216	0.9614
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0146	0.0534	0.0534
Schistosoma mansoni	peptidase	0.001	0.0006	0.0005
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.0027	0.1938
Schistosoma mansoni	serine/threonine protein kinase	0.0015	0.0027	0.0025
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0055	0.0053
Trichomonas vaginalis	abcb9, putative	0.0012	0.0014	0.098
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0015	0.0027	0.0027
Brugia malayi	nuclear hormone receptor	0.001	0.0006	0.0004
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.0216	0.9614
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.0027	0.1938
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0147	0.0145
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0015	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0033	0.2399
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0216	0.9614
Schistosoma mansoni	rab6-interacting	0.0019	0.0042	0.004
Onchocerca volvulus		0.0017	0.0033	0.0811
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0039	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0147	0.0145
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0014	0.098
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0006	0.0006
Onchocerca volvulus		0.0019	0.0042	0.1073
Brugia malayi	hypothetical protein	0.0472	0.1801	0.1799
Echinococcus granulosus	RUN	0.0019	0.0042	0.0042
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0039	0.0033
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0015	0.0027	0.0021
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0033	0.2399
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.0042	0.3272
Schistosoma mansoni	lamin	0.0027	0.0072	0.007
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0033	0.0032
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0147	0.0147
Onchocerca volvulus		0.0017	0.0033	0.0811
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0044	0.014	1
Echinococcus multilocularis	muscleblind protein 1	0.015	0.0552	0.0552
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0033	0.0811
Schistosoma mansoni	rab6-interacting	0.0019	0.0042	0.004
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0015	0.0027	0.0021
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0012	0.0014	0.098
Loa Loa (eye worm)	acetyltransferase	0.015	0.0551	0.0545
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0014	0.0014
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0015	0.0027	0.0027
Echinococcus multilocularis	cysteine protease	0.0017	0.0033	0.0033
Loa Loa (eye worm)	fibroinase	0.0017	0.0033	0.0027
Brugia malayi	nuclear receptor NHR-88	0.001	0.0006	0.0004
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0013	0.0018	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0033	0.2399
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0066	0.0225	0.0223
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0014	0.098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0216	0.9614
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0042	0.0042
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0006	0.0004
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0006	0.0004
Echinococcus granulosus	multidrug resistance protein 1	0.0012	0.0014	0.0014
Schistosoma mansoni	lipoxygenase	0.0019	0.0042	0.004
Echinococcus multilocularis	muscleblind protein	0.015	0.0552	0.0552
Brugia malayi	protein kinase C II.	0.0022	0.0055	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0018	0.0012
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0014	0.098
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0006	0.0006
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0015	0.0027	0.0021
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0006	0.0004
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0017	0.0033	0.2558
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0013	0.0018	0.0012
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.2585	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0033	0.2399
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0015	0.0027	0.0021
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.0042	0.0042
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0216	0.9614
Echinococcus granulosus	protein kinase c epsilon type	0.0022	0.0055	0.0055
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0017	0.0033	0.2558
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0006	0.0004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0216	0.9614
Brugia malayi	Hr1 repeat family protein	0.0015	0.0027	0.0025
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.0207	0.0206
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0039	0.2786
Schistosoma mansoni	thyroid hormone receptor	0.0131	0.0478	0.0476
Echinococcus multilocularis	ATP binding cassette sub family B	0.0012	0.0013	0.0013
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0042	0.0042
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0033	0.2399
Echinococcus granulosus	muscleblind protein	0.015	0.0552	0.0552
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0014	0.0014
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0044	0.014	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0216	0.9614
Brugia malayi	hypothetical protein	0.0019	0.0042	0.004
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0039	0.0037
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.0225	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0014	0.098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0216	0.9614
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0014	0.0007
Onchocerca volvulus		0.0012	0.0014	0.022
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0033	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0027	0.0021
Brugia malayi	acetyltransferase, GNAT family protein	0.015	0.0551	0.0549
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0006	0.0004
Echinococcus granulosus	transcription factor Dp 1	0.0038	0.0117	0.0117
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0014	0.098
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0033	0.2399
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0147	0.0145
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0014	0.098
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0006	0.0004
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.0033	0.0033
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.0027	0.1938
Echinococcus granulosus	protein kinase c iota type	0.0021	0.005	0.005
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0039	0.1657
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0022	0.0055	0.0049
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0014	0.0014
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0015	0.0027	0.0027
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.015	0.0551	0.0551
Trichomonas vaginalis	ABC transporter, putative	0.0012	0.0014	0.098
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0012	0.0014	0.5
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0033	0.0027
Echinococcus granulosus	geminin	0.0168	0.062	0.062
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0014	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0007
Brugia malayi	cathepsin L-like precursor	0.0011	0.0012	0.001
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0033	0.0032
Loa Loa (eye worm)	hypothetical protein	0.015	0.0552	0.0546
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0033	0.2399
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.0027	0.1938
Schistosoma mansoni	serine/threonine protein kinase	0.0015	0.0027	0.0025
Entamoeba histolytica	P-glycoprotein-1	0.0012	0.0014	0.0527
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0006	0.0006
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0006	0.0006
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0044	0.014	1
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0006	0.0004
Schistosoma mansoni	coup transcription factor	0.001	0.0006	0.0004
Schistosoma mansoni	hypothetical protein	0.0122	0.044	0.0439
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0033	0.0033
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0012	0.0014	0.098
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0039	1
Echinococcus granulosus	NDR protein kinase	0.0015	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0033	0.2399
Echinococcus multilocularis	multidrug resistance protein 1	0.0012	0.0014	0.0014
Trichomonas vaginalis	ABC transporter, putative	0.0012	0.0014	0.098
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0006	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0012	0.0006
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.0018	0.0016
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0006	0.0004
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0006	0.0006
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0033	0.1415
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0033	0.2399
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0033	0.0033
Schistosoma mansoni	multidrug resistance protein	0.0012	0.0014	0.0012
Echinococcus multilocularis	lamin	0.0027	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0472	0.1801	0.1795
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0015	0.0027	0.0027
Toxoplasma gondii	exonuclease III APE	0.0018	0.0039	0.2002
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0006	0.0004
Echinococcus granulosus	lamin	0.0027	0.0072	0.0072
Brugia malayi	Protein kinase domain containing protein	0.0015	0.0027	0.0025
Trichomonas vaginalis	taga, putative	0.0012	0.0014	0.098
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0012	0.0014	0.098
Onchocerca volvulus		0.0017	0.0033	0.0811
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.0207	0.0206
Plasmodium falciparum	multidrug resistance protein 1	0.0012	0.0014	0.0952
Echinococcus granulosus	cysteine protease	0.0009	0.0002	0.0002
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0147	0.0147
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0033	0.2399
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0033	0.2399
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0006	0.0004
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0042	0.0042
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0006	0.0006
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0006	0.0004
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.2585	1	1
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0015	0.0027	0.1126
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0039	0.1193
Entamoeba histolytica	protein kinase, putative	0.0015	0.0027	0.1126
Onchocerca volvulus	Cathepsin F homolog	0.0017	0.0033	0.0811
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0216	0.9614
Echinococcus granulosus	Protein kinase C brain isozyme	0.0062	0.0207	0.0207
Echinococcus multilocularis	RUN	0.0019	0.0042	0.0042
Schistosoma mansoni	serine/threonine kinase	0.0015	0.0027	0.0025
Trichomonas vaginalis	abcb9, putative	0.0012	0.0014	0.098
Brugia malayi	C1-like domain containing protein	0.0013	0.0018	0.0016
Schistosoma mansoni	multidrug resistance protein	0.0012	0.0014	0.0012
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0013	0.0018	0.0012
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0033	0.0032
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0014	0.0014
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0033	0.2399
Brugia malayi	steroid hormone receptor	0.001	0.0006	0.0004
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0006	0.0004
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0006	0.0004
Trichomonas vaginalis	abcb9, putative	0.0012	0.0014	0.098
Echinococcus multilocularis	transcription factor Dp 1	0.0038	0.0117	0.0117
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0062	0.0207	0.0207
Leishmania major	cathepsin L-like protease	0.0017	0.0033	0.0937
Brugia malayi	protein kinase C3,putative	0.0013	0.0018	0.0016
Echinococcus multilocularis	geminin	0.0168	0.062	0.062
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0042	0.0042
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0015	0.0027	0.0027
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0053	0.0175	0.0175
Echinococcus multilocularis	musashi	0.0027	0.0072	0.0072
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0039	0.0121	0.0121
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0033	0.0033
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0015	0.0027	0.0027
Onchocerca volvulus		0.0027	0.0072	0.1958
Loa Loa (eye worm)	multidrug resistance protein 3	0.0012	0.0014	0.0007
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0024	0.0022
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0058	0.0195	0.8649
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0066	0.0225	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0006	0.0004
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0033	0.0032
Entamoeba histolytica	protein kinase, putative	0.0015	0.0027	0.1126
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0014	0.098
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0012	0.0014	0.098
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0012	0.0014	0.098
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0006	0.0006
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0013	0.0018	0.0016
Schistosoma mansoni	loxhd1	0.0019	0.0042	0.004
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0006	0.0006
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0016	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0012	0.0006
Echinococcus granulosus	serine:threonine protein kinase N2	0.0015	0.0027	0.0027
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0047	0.0152	0.0146
Entamoeba histolytica	protein kinase, putative	0.0015	0.0027	0.1126
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0006	0.0004
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0039	0.0039
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0072	0.0066
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0039	0.2786
Schistosoma mansoni	smdr2	0.0012	0.0014	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0042	0.0036
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0006	0.0004
Echinococcus multilocularis	survival motor neuron protein 1	0.0472	0.1801	0.1801
Trypanosoma cruzi	cruzipain precursor, putative	0.0064	0.0216	0.9614
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.0042	0.2933
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0006	0.0006
Loa Loa (eye worm)	hypothetical protein	0.015	0.0552	0.0546
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0033	0.0032
Entamoeba histolytica	P-glycoprotein-5	0.0012	0.0014	0.0527
Onchocerca volvulus		0.0017	0.0033	0.0811
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0039	0.1657
Onchocerca volvulus		0.0019	0.0042	0.1073
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0012	0.0014	0.098
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0012	0.0014	0.098
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0039	0.1657
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0044	0.014	1
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.015	0.0551	0.0549
Entamoeba histolytica	P-glycoprotein-2	0.0012	0.0014	0.0527
Onchocerca volvulus		0.0017	0.0033	0.0811
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0006	0.0006
Trypanosoma cruzi	major cysteine proteinase, putative	0.005	0.0163	0.7234
Brugia malayi	ABC transporter family protein	0.0012	0.0014	0.0012
Onchocerca volvulus		0.0027	0.0072	0.1958
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0066	0.0225	1
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0122	0.044	0.044
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0006	0.0006
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0044	0.014	1
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0066	0.0225	0.0223
Echinococcus granulosus	intermediate filament protein	0.0027	0.0072	0.0072
Entamoeba histolytica	P-glyco protein 6, putative	0.0012	0.0014	0.0527
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0033	0.2399
Leishmania major	cathepsin L-like protease	0.0017	0.0033	0.0937
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0016	0.001
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0122	0.044	0.044
Brugia malayi	Muscleblind-like protein	0.015	0.0552	0.055
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0033	0.1415
Schistosoma mansoni	hypothetical protein	0.0019	0.0042	0.004
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0006	0.0006
Trichomonas vaginalis	AGC family protein kinase	0.0015	0.0027	0.1938
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0072	0.0066
Schistosoma mansoni	serine/threonine protein kinase	0.0015	0.0027	0.0025
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0006	0.0004
Leishmania major	cathepsin L-like protease	0.0017	0.0033	0.0937
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.0033	0.0027
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0012	0.001
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0066	0.0225	0.0225
Giardia lamblia	Histone acetyltransferase GCN5	0.004	0.0125	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0039	0.5
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0121	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0012	0.0006
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0012	0.0014	0.098
Schistosoma mansoni	protein kinase C mu	0.0013	0.0018	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0072	0.0066
Echinococcus granulosus	multidrug resistance protein 1	0.0012	0.0014	0.0014
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.0042	0.0042
Plasmodium vivax	vivapain-2	0.0017	0.0033	0.2293
Onchocerca volvulus		0.0017	0.0033	0.0811
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0066	0.0225	0.0225
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0216	0.9614
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0033	0.2399
Echinococcus multilocularis	lamin dm0	0.0027	0.0072	0.0072
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0072	0.007
Echinococcus granulosus	cathepsin l1	0.0017	0.0033	0.0033
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0033	0.0032
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0006	0.0004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.0216	0.9614
Leishmania major	cathepsin L-like protease	0.0064	0.0216	0.9592
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0015	0.0027	0.0021
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0147	0.0141
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0015	0.0027	0.0027
Leishmania major	cysteine peptidase A (CPA)	0.0017	0.0033	0.0937
Brugia malayi	Protein kinase domain containing protein	0.0015	0.0027	0.0025
Schistosoma mansoni	atypical protein kinase C	0.0021	0.005	0.0048
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0033	0.2399
Schistosoma mansoni	ap endonuclease	0.0018	0.0039	0.0037
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0014	0.0014
Schistosoma mansoni	serine/threonine protein kinase	0.0015	0.0027	0.0025
Echinococcus multilocularis	multidrug resistance protein 1	0.0012	0.0014	0.0014
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0012	0.0857
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0053	0.0175	0.0175
Entamoeba histolytica	protein kinase, putative	0.0015	0.0027	0.1126
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.0033	0.0033
Onchocerca volvulus		0.0011	0.0012	0.017
Echinococcus multilocularis	RNA directed DNA polymerase	0.0039	0.0121	0.0121
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0018	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0012	0.0857
Trichomonas vaginalis	ABC transporter, putative	0.0012	0.0014	0.098
Schistosoma mansoni	serine/threonine protein kinase	0.2585	1	1
Leishmania major	cathepsin L-like protease	0.0017	0.0033	0.0937
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0147	0.0145
Leishmania major	cathepsin L-like protease	0.0064	0.0216	0.9592
Onchocerca volvulus		0.0017	0.0033	0.0811
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0014	0.0014
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0147	0.0147

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 880371