Detailed information for compound 880698

Basic information

Technical information
  • TDR Targets ID: 880698
  • Name: 2-(4-ethylsulfanylphenyl)-3-[2-(phenoxy)ethyl ]-1,3-thiazolidin-4-one
  • MW: 359.506 | Formula: C19H21NO2S2
  • H donors: 0 H acceptors: 1 LogP: 4.35 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCSc1ccc(cc1)C1SCC(=O)N1CCOc1ccccc1
  • InChi: 1S/C19H21NO2S2/c1-2-23-17-10-8-15(9-11-17)19-20(18(21)14-24-19)12-13-22-16-6-4-3-5-7-16/h3-11,19H,2,12-14H2,1H3
  • InChiKey: DDLGCBTUEIGQEW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-ethylsulfanylphenyl)-3-[2-(phenoxy)ethyl]thiazolidin-4-one
  • 2-[4-(ethylthio)phenyl]-3-[2-(phenoxy)ethyl]-4-thiazolidinone
  • 2-[4-(ethylthio)phenyl]-3-[2-(phenoxy)ethyl]thiazolidin-4-one
  • Oprea1_649654

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0284 0.0284
Brugia malayi intermediate filament protein 0.0054 0.0634 0.1238
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0361 0.5119 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0136 0.0024
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0361 0.5119 0.5119
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0289 0.407 0.7939
Schistosoma mansoni nuclear hormone receptor 0.002 0.0139 0.0139
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0124 0.0243
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0634 0.1238
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0139 0.0139
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.1915 0.1915
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0267 0.0522
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0375 0.0308
Loa Loa (eye worm) hypothetical protein 0.0043 0.0466 0.0911
Brugia malayi PAS domain containing protein 0.0049 0.0561 0.1095
Schistosoma mansoni hypothetical protein 0.0049 0.0554 0.0554
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0267 0.0522
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1888 0.1888
Brugia malayi hypothetical protein 0.0238 0.3325 0.6494
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0124 0.0124
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0466 0.0466
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.1367 0.267
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0139 0.0139
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0124 0.5
Trypanosoma cruzi DNA polymerase zeta catalytic subunit, putative 0.0057 0.0685 0.1286
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0139 0.0271
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0018 0.0114 0.0084
Loa Loa (eye worm) hypothetical protein 0.0026 0.0229 0.0447
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0136 0.0024
Echinococcus granulosus FTZ F1 alpha 0.002 0.0139 0.0139
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0031 0.0031
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0284 0.0284
Schistosoma mansoni survival motor neuron protein 0.0049 0.0554 0.0554
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0139 0.0271
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0057 0.0685 0.1339
Brugia malayi MAP kinase sur-1 0.0051 0.0586 0.1144
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0138 0.1863 0.3601
Schistosoma mansoni hypothetical protein 0.0125 0.1676 0.1676
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0549 0.0549
Brugia malayi hypothetical protein 0.0123 0.1648 0.3218
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0136 0.0208
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0124 0.0184
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0037 0.0013
Schistosoma mansoni patched 1 0.0043 0.0466 0.0466
Trichomonas vaginalis DNA polymerase II, putative 0.0138 0.1863 0.3601
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.1294 0.2341
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0136 0.0266
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.2071 0.4046
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0139 0.0139
Schistosoma mansoni hypothetical protein 0.0041 0.0444 0.0444
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0139 0.0139
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0129 0.1734 0.1734
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0057 0.0685 0.1339
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0024 0.0193 0.0319
Entamoeba histolytica DNA polymerase zeta catalytic subunit, putative 0.0057 0.0685 0.1123
Onchocerca volvulus DNA polymerase homolog 0.0129 0.1734 0.3348
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0139 0.0271
Onchocerca volvulus 0.0054 0.0634 0.1185
Brugia malayi ecdysteroid receptor 0.002 0.0139 0.0271
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0129 0.1734 0.3348
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0129 0.1734 0.1734
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0139 0.0271
Trypanosoma brucei protein kinase, putative 0.0051 0.0586 0.0924
Schistosoma mansoni lamin 0.0054 0.0634 0.0634
Echinococcus multilocularis lamin dm0 0.0054 0.0634 0.0634
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0031 0.0031
Trichomonas vaginalis sensor histidine kinase, putative 0.0024 0.0193 0.0319
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0031 0.03 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0139 0.0271
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0129 0.1734 0.3348
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0284 0.0284
Echinococcus granulosus lamin 0.0054 0.0634 0.0634
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0634 0.1238
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0586 0.1091
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0549 0.1073
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0139 0.0139
Echinococcus granulosus bloom syndrome protein 0.002 0.0136 0.0136
Echinococcus multilocularis bloom syndrome protein 0.002 0.0136 0.0136
Schistosoma mansoni microtubule-associated protein tau 0.0694 1 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0586 0.1091
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.0025 0.0211 0.0412
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0139 0.0271
Loa Loa (eye worm) hypothetical protein 0.0238 0.3325 0.6494
Trichomonas vaginalis receptor histidine kinase, putative 0.0024 0.0193 0.0319
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0136 0.0266
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.3325 0.3325
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0018 0.0114 0.0084
Schistosoma mansoni thyroid hormone receptor 0.0145 0.197 0.197
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0129 0.1734 0.3223
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0018 0.0114 0.0084
Schistosoma mansoni single-minded 0.0049 0.0561 0.0561
Schistosoma mansoni hypothetical protein 0.0041 0.0444 0.0444
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0129 0.1734 0.1734
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0586 0.1144
Loa Loa (eye worm) hypothetical protein 0.0025 0.0211 0.0412
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0129 0.1734 0.3388
Loa Loa (eye worm) hypothetical protein 0.0026 0.0225 0.044
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0586 0.1091
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0375 0.0732
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.1915 0.1915
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0284 0.0284
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.1294 0.2527
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0024 0.0193 0.0319
Schistosoma mansoni DNA helicase recq5 0.002 0.0136 0.0136
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0124 0.0184
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.1294 0.1294
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0586 0.0586
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0124 0.0184
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1888 0.1888
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0685 0.1286
Loa Loa (eye worm) hypothetical protein 0.0072 0.0894 0.1746
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0139 0.0271
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.019 0.2618 0.5084
Schistosoma mansoni hypothetical protein 0.0048 0.0549 0.0549
Plasmodium vivax SET domain protein, putative 0.003 0.0284 0.032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1888 0.1888
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0549 0.1073
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0136 0.0024
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0129 0.1734 0.1734
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0124 0.0184
Loa Loa (eye worm) hypothetical protein 0.0053 0.0619 0.121
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0225 0.0225
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0072 0.0894 0.1746
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0136 0.0136
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0129 0.1734 0.1734
Echinococcus multilocularis protein dispatched 1 0.0049 0.0554 0.0554
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0271
Schistosoma mansoni hypothetical protein 0.0048 0.0549 0.0549
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0139 0.0139
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0139 0.0271
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0136 0.0136
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0549 0.0549
Onchocerca volvulus 0.003 0.0284 0.0498
Brugia malayi CHE-14 protein 0.0043 0.0466 0.0911
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1888 0.1888
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0136 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0139 0.0271
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0066 0.0814 0.1381
Echinococcus multilocularis protein patched 0.0043 0.0466 0.0466
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0031 0.006
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0136 0.0024
Onchocerca volvulus 0.0036 0.0375 0.0676
Schistosoma mansoni hypothetical protein 0.0048 0.0549 0.0549
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0361 0.5119 1
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0138 0.1863 0.3601
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0136 0.0208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0139 0.0271
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0139 0.0271
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0169 0.2316 0.2316
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0066 0.0814 0.1381
Trichomonas vaginalis set domain proteins, putative 0.0238 0.3331 0.6485
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.1316 0.1316
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0136 0.0266
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0361 0.5119 1
Brugia malayi nuclear hormone receptor 0.002 0.0139 0.0271
Loa Loa (eye worm) hypothetical protein 0.0099 0.1294 0.2527
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0048 0.0549 0.1073
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0271
Echinococcus granulosus intermediate filament protein 0.0054 0.0634 0.0634
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0361 0.5119 1
Echinococcus multilocularis GPCR, family 2 0.0048 0.0549 0.0549
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.2071 0.4046
Loa Loa (eye worm) hypothetical protein 0.0057 0.0685 0.1339
Schistosoma mansoni ap endonuclease 0.0019 0.0124 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0139 0.0271
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0018 0.0114 1
Brugia malayi DNA polymerase alpha catalytic subunit 0.0159 0.2164 0.4228
Loa Loa (eye worm) hypothetical protein 0.0072 0.0894 0.1746
Loa Loa (eye worm) hypothetical protein 0.0054 0.0634 0.1238
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0561 0.0561
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0586 0.0924
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0139 0.0139
Plasmodium falciparum DNA polymerase zeta catalytic subunit, putative 0.0057 0.0685 0.1123
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0466 0.0466
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0139 0.0139
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0634 0.1238
Toxoplasma gondii DNA polymerase 0.0361 0.5119 1
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0586 0.0586
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0139 0.0271
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0037 0.0013
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0136 0.0208
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.2907 0.5679
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0266
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0554 0.1083
Brugia malayi steroid hormone receptor 0.002 0.0139 0.0271
Loa Loa (eye worm) hypothetical protein 0.0123 0.1648 0.3218
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0586 0.0586
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0139 0.0139
Brugia malayi DNA polymerase family B containing protein 0.0129 0.1734 0.3388
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0136 0.0024
Schistosoma mansoni DNA helicase recq1 0.002 0.0136 0.0136
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0139 0.0139
Echinococcus multilocularis musashi 0.0054 0.0634 0.0634
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0549 0.0549
Toxoplasma gondii DNA polymerase family B protein 0.0057 0.0685 0.1123
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0139 0.0139
Trypanosoma cruzi UDP-glucoronosyl and UDP-glucosyl transferase, putative 0.0026 0.0229 0.039
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0136 0.0208
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0136 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0139 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0139 0.0271
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0271
Echinococcus granulosus single minded 2 0.0036 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0013 0.0031 0.006
Schistosoma mansoni hypothetical protein 0.0041 0.0444 0.0444
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0139 0.0139
Schistosoma mansoni intermediate filament proteins 0.0054 0.0634 0.0634
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0139 0.0139
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0139 0.0139
Giardia lamblia DNA polymerase alpha subunit A 0.0097 0.1268 0.2289
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0361 0.5119 1
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0018 0.0114 0.0084
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0139 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0139 0.0271
Brugia malayi DNA polymerase delta catalytic subunit 0.0361 0.5119 1
Onchocerca volvulus 0.0049 0.0554 0.1029
Echinococcus multilocularis microtubule associated protein 2 0.0694 1 1
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0361 0.5119 0.5119
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0139 0.0139
Mycobacterium tuberculosis Probable oxidoreductase 0.0596 0.8567 1
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0138 0.1863 0.3601
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0139 0.0139
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0284 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0139 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0139 0.0271
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0586 0.1091
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0169 0.2316 0.2316
Onchocerca volvulus 0.0238 0.3331 0.6485
Loa Loa (eye worm) hypothetical protein 0.0164 0.2246 0.4388
Mycobacterium ulcerans short chain dehydrogenase 0.0596 0.8567 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0124 0.0124
Loa Loa (eye worm) hypoxia-induced factor 1 0.0152 0.206 0.4025
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0159 0.2164 0.4084
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0361 0.5119 1
Schistosoma mansoni thyroid hormone receptor 0.0145 0.197 0.197
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.1676 0.1676
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0021 0.0146 0.0146
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0018 0.0114 0.0084
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.1294 0.1294
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0466 0.0911
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0124 0.0012
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0024 0.0193 0.0319
Schistosoma mansoni hypothetical protein 0.0048 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.019 0.2618 0.5113
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0136 0.0208
Echinococcus multilocularis expressed conserved protein 0.0093 0.1206 0.1206
Schistosoma mansoni coup transcription factor 0.002 0.0139 0.0139
Brugia malayi hypothetical protein 0.0164 0.2246 0.4388
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0139 0.0212
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0024 0.0193 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0139 0.0139
Onchocerca volvulus 0.0054 0.0634 0.1185
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0129 0.1734 0.1734
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0138 0.1863 0.3481
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1888 0.1888
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0139 0.0139
Schistosoma mansoni ap endonuclease 0.0019 0.0124 0.0124
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0361 0.5119 0.5119
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0139 0.0271
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0586 0.1091
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.1888 0.3688
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0139 0.0139
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0271
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0129 0.1734 0.3223
Loa Loa (eye worm) hypothetical protein 0.0152 0.2071 0.4046
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.3325 0.3325
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0586 0.1091
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.2071 0.4046
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0268 0.0268
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0129 0.1734 0.3223
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0225 0.0225
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0586 0.0924
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0361 0.5119 1
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0549 0.1073
Entamoeba histolytica recQ family helicase, putative 0.002 0.0136 0.0024
Echinococcus multilocularis thyroid hormone receptor alpha 0.0145 0.197 0.197
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0139 0.0271
Echinococcus granulosus expressed conserved protein 0.0093 0.1206 0.1206
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0129 0.1734 0.3223
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0018 0.0114 0.0084
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0586 0.1091
Onchocerca volvulus Huntingtin homolog 0.0123 0.1648 0.3177
Onchocerca volvulus 0.002 0.0139 0.0212
Brugia malayi hypoxia-induced factor 1 0.0152 0.206 0.4025
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0124 0.0243
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0136 0.0136
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0139 0.0212
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0169 0.2316 0.2316
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.0072 0.0894 0.154
Loa Loa (eye worm) hypothetical protein 0.0052 0.0606 0.1184
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0271
Toxoplasma gondii DNA polymerase family B protein 0.0129 0.1734 0.3223
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1888 0.1888
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0139 0.0271
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0139 0.0139
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0284 0.032
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0361 0.5119 1
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0361 0.5119 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0284 0.0555
Trichomonas vaginalis receptor histidine kinase, putative 0.0024 0.0193 0.0319
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0024 0.0193 0.0319
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.1888 0.3688
Echinococcus granulosus GPCR family 2 0.0048 0.0549 0.0549
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0139 0.0271
Schistosoma mansoni lamin 0.0054 0.0634 0.0634
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0361 0.5119 1
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0031 0.0031
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0037 0.0013
Schistosoma mansoni hypothetical protein 0.0041 0.0444 0.0444
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0586 0.0586
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0139 0.0139
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0129 0.1734 0.3223
Echinococcus granulosus lamin dm0 0.0054 0.0634 0.0634
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0139 0.0139
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0037 0.0013
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0586 0.1091
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0466 0.0856
Onchocerca volvulus Huntingtin homolog 0.0123 0.1648 0.3177
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0124 0.0184
Plasmodium vivax DNA polymerase alpha, putative 0.0159 0.2164 0.4084
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0129 0.1734 0.3348
Brugia malayi nuclear receptor NHR-88 0.002 0.0139 0.0271
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0586 0.1091
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0031 0.0031
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0586 0.0924
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0284 0.0284
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0549 0.0549
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0271
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0136 0.0266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0139 0.0271
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0129 0.1734 0.3348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0139 0.0271
Loa Loa (eye worm) hypothetical protein 0.0104 0.1367 0.267
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0139 0.0212
Loa Loa (eye worm) hypothetical protein 0.0123 0.1648 0.3218
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0124 0.0096
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0284 0.0284
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0124 0.1328
Echinococcus multilocularis lamin 0.0054 0.0634 0.0634
Loa Loa (eye worm) RecQ helicase 0.002 0.0136 0.0266
Schistosoma mansoni hypothetical protein 0.0104 0.1367 0.1367
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0018 0.0114 0.0084
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0129 0.1734 0.3348
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0586 0.0586
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0586 0.1091
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.1676 0.1676
Brugia malayi Pre-SET motif family protein 0.003 0.0284 0.0555
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1888 0.1888
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0018 0.0114 1
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0129 0.1734 0.3348
Brugia malayi Pre-SET motif family protein 0.0209 0.2907 0.5679
Leishmania major protein kinase, putative 0.0013 0.0037 0.0013
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0375 0.0375
Mycobacterium leprae Probable two component sensor kinase MprB 0.0018 0.0114 1
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0072 0.0894 0.1696
Loa Loa (eye worm) hypothetical protein 0.002 0.0139 0.0271
Leishmania major DNA polymerase zeta catalytic subunit, putative 0.0057 0.0685 0.1286
Leishmania major protein kinase, putative 0.0013 0.0037 0.0013

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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