Detailed information for compound 884173

Basic information

Technical information
  • TDR Targets ID: 884173
  • Name: ethyl 4-[(3-chloro-2-methylphenyl)carbamothio yl]piperazine-1-carboxylate
  • MW: 341.856 | Formula: C15H20ClN3O2S
  • H donors: 1 H acceptors: 1 LogP: 2.74 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)N1CCN(CC1)C(=S)Nc1cccc(c1C)Cl
  • InChi: 1S/C15H20ClN3O2S/c1-3-21-15(20)19-9-7-18(8-10-19)14(22)17-13-6-4-5-12(16)11(13)2/h4-6H,3,7-10H2,1-2H3,(H,17,22)
  • InChiKey: UQTWXHCIPAFWLD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 4-[(3-chloro-2-methyl-phenyl)carbamothioyl]piperazine-1-carboxylate
  • 4-[[(3-chloro-2-methylphenyl)amino]-thioxomethyl]-1-piperazinecarboxylic acid ethyl ester
  • 4-[(3-chloro-2-methyl-phenyl)thiocarbamoyl]piperazine-1-carboxylic acid ethyl ester
  • Oprea1_337001
  • ZINC06046900

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0237 0.0902 1
Schistosoma mansoni hypothetical protein 0.0076 0.0259 0.1033
Plasmodium falciparum glutathione reductase 0.0093 0.0329 0.8769
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0356 0.1379 0.76
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0049 0.0152 0.0255
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.019 0.0714 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0049 0.0152 0.0152
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0049 0.0152 0.0152
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0085 0.029
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0458 0.1788 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0049 0.0152 0.0395
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0085 0.029
Loa Loa (eye worm) phosphatidylinositol 3 0.012 0.0436 0.1945
Entamoeba histolytica hypothetical protein 0.0114 0.0411 0.158
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.037 0.1672
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0103 0.0366 0.4625
Giardia lamblia Hypothetical protein 0.0049 0.0152 0.0654
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0085 0.0056
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0458 0.1788 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.019 0.0714 0.1916
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0103 0.0366 0.0886
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0152 0.068
Onchocerca volvulus 0.0049 0.0152 0.1527
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0085 0.0056
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0356 0.1379 0.76
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.037 0.0898
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0213 0.0807 0.8837
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0051 0.0283
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0085 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Echinococcus multilocularis serine protein kinase ATM 0.0114 0.0411 0.0411
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.019 0.0714 0.1811
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0085 0.0053
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0103 0.0366 0.1305
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0458 0.1788 0.5094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0411 0.1912
Loa Loa (eye worm) hypothetical protein 0.0187 0.0703 0.3138
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0005 0.0005
Entamoeba histolytica protein kinase rad3, putative 0.0114 0.0411 0.158
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0458 0.1788 0.5094
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0085 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0049 0.0152 0.0152
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0085 0.0056
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0085 0.029
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0103 0.0366 0.0837
Schistosoma mansoni cpg binding protein 0.0031 0.0082 0.0326
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0152 0.068
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0103 0.0366 0.1633
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0152 0.2873
Onchocerca volvulus Serine\/threonine kinase homolog 0.0104 0.037 0.371
Toxoplasma gondii target of rapamycin (TOR), putative 0.019 0.0714 1
Echinococcus granulosus serine protein kinase ATM 0.0114 0.0411 0.0411
Echinococcus multilocularis cpg binding protein 0.0033 0.0089 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.037 0.1672
Brugia malayi Pre-SET motif family protein 0.0033 0.0089 0.05
Leishmania major hypothetical protein, conserved 0.0922 0.3643 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0085 0.029
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0103 0.0366 0.1648
Loa Loa (eye worm) glutathione reductase 0.0093 0.0329 0.1468
Trypanosoma brucei trypanothione reductase 0.0093 0.0329 0.4056
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.019 0.0714 0.1916
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0103 0.0366 0.0366
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0085 0.0628
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0458 0.1788 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0089 0.0356
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.018 0.0674 0.377
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0085 0.5
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0169 0.0632 0.8741
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0214 0.0758
Toxoplasma gondii thioredoxin reductase 0.0093 0.0329 0.4056
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0152 0.068
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0082 0.0364
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0049 0.0152 0.0255
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0089 0.0357
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0104 0.037 0.1651
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0051 0.0283
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0085 0.0053
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.019 0.0714 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0169 0.0632 0.2522
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0237 0.0902 1
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0076 0.0259 0.0259
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.037 0.1672
Loa Loa (eye worm) hypothetical protein 0.0271 0.1041 0.4647
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0411 0.1912
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0114 0.0411 0.158
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0638 0.2507 1
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.037 0.1672
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.037 0.1672
Leishmania major trypanothione reductase 0.0093 0.0329 0.0734
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0049 0.0152 0.0255
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0392 0.1522 0.8371
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0104 0.037 0.037
Onchocerca volvulus 0.0031 0.0082 0.0819
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0103 0.0366 0.4625
Brugia malayi MH2 domain containing protein 0.0131 0.0479 0.2679
Brugia malayi hypothetical protein 0.0028 0.0066 0.037
Treponema pallidum NADH oxidase 0.0032 0.0085 0.5
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.019 0.0714 0.1916
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0085 0.0339
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0085 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0411 0.1912
Mycobacterium tuberculosis Probable dehydrogenase 0.0213 0.0807 0.8837
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0085 0.029
Brugia malayi hypothetical protein 0.0018 0.0027 0.0151
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0049 0.0152 0.2873
Schistosoma mansoni cpg binding protein 0.0033 0.0089 0.0354
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.019 0.0714 0.1916
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0169 0.0632 0.3213
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.019 0.0714 0.0714
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0049 0.0152 0.0607
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.0455 0.2175
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0085 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0214 0.0758
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Leishmania major phosphatidylinositol kinase, putative 0.0049 0.0152 0.0241
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0638 0.2507 0.2507
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.019 0.0714 0.1811
Brugia malayi CXXC zinc finger family protein 0.0031 0.0082 0.0456
Echinococcus multilocularis Zinc finger, PHD finger 0.0103 0.0366 0.0366
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.019 0.0714 0.3433
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0103 0.0366 0.0886
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0085 0.0085
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0085 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Brugia malayi serine/threonine-protein kinase plk-2 0.0104 0.037 0.2068
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0114 0.0411 0.1019
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0161 0.0444
Onchocerca volvulus 0.0033 0.0089 0.0896
Schistosoma mansoni hypothetical protein 0.0049 0.0152 0.0607
Leishmania major phosphatidylinositol kinase related protein, putative 0.0049 0.0152 0.0241
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.019 0.0714 0.3992
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0085 0.5
Echinococcus granulosus cpg binding protein 0.0033 0.0089 0.0089
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.019 0.0714 0.0714
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Leishmania major phosphatidylinositol 4-kinase, putative 0.0049 0.0152 0.0241
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.019 0.0714 0.1811
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0152 0.0395
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0205 0.0774 0.3803
Leishmania major phosphatidylinositol 3-kinase, putative 0.0103 0.0366 0.0837
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0049 0.0152 0.0255
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0114 0.0411 0.0411
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0152 0.068
Loa Loa (eye worm) hypothetical protein 0.0125 0.0455 0.2033
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0169 0.0632 0.3213
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0065 0.0214 0.0437
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.019 0.0714 0.2848
Trypanosoma brucei target of rapamycin kinase 3, putative 0.019 0.0714 1
Giardia lamblia Kinase, PLK 0.0104 0.037 0.2771
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Mycobacterium tuberculosis Probable reductase 0.0213 0.0807 0.8837
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.0479 0.2139
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0082 0.0082
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0103 0.0366 0.2045
Loa Loa (eye worm) hypothetical protein 0.0076 0.0259 0.1156
Loa Loa (eye worm) phosphatidylinositol kinase 0.0049 0.0152 0.068
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0152 0.0851
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0049 0.0152 0.2873
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0169 0.0632 0.1675
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0114 0.0411 0.5319
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0169 0.0632 0.3536
Leishmania major phosphatidylinositol 3-related kinase, putative 0.019 0.0714 0.1811
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0409 0.1592 0.8798
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0076 0.0259 0.0259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0152 0.0395
Mycobacterium tuberculosis Probable oxidoreductase 0.0237 0.0902 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0085 0.5
Plasmodium falciparum thioredoxin reductase 0.0093 0.0329 0.8769
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Onchocerca volvulus 0.0049 0.0152 0.1527
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0213 0.0807 0.8837
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0213 0.0807 0.8837
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0259 0.1021
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.019 0.0714 0.3992
Loa Loa (eye worm) thioredoxin reductase 0.0093 0.0329 0.1468
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0089 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0085 0.0628
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0103 0.0366 0.0366
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0103 0.0366 0.1459
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0169 0.0632 0.3213
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0049 0.0152 0.2873
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0458 0.1788 1
Plasmodium vivax hypothetical protein 0.0049 0.0152 0.2873
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0152 0.0851
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0169 0.0632 0.2934
Brugia malayi glutathione reductase 0.0093 0.0329 0.1839
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0085 0.5
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0049 0.0152 0.1329
Loa Loa (eye worm) hypothetical protein 0.0065 0.0214 0.0956
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.0479 0.2139
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0049 0.0152 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0458 0.1788 1
Brugia malayi FAT domain containing protein 0.0076 0.0259 0.1448
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0049 0.0152 0.1329
Brugia malayi Pre-SET motif family protein 0.0229 0.0871 0.4871
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0229 0.0871 0.3888
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0103 0.0366 0.1648
Plasmodium vivax thioredoxin reductase, putative 0.0093 0.0329 0.8769
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0085 0.0628
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0411 0.1912
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.037 0.1672
Onchocerca volvulus 0.026 0.0997 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0104 0.037 0.0849
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0103 0.0366 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0049 0.0152 0.0395
Echinococcus multilocularis 0.0049 0.0152 0.0152
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0085 0.029
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0089 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0125 0.0455 0.2175
Leishmania major hypothetical protein, unknown function 0.0049 0.0152 0.0241
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0005 0.0005
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.019 0.0714 0.0714
Loa Loa (eye worm) phosphatidylinositol 3 0.019 0.0714 0.3187
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0085 0.0053
Trypanosoma brucei polo-like protein kinase 0.0104 0.037 0.4688
Giardia lamblia Phosphatidylinositol 4-kinase 0.0049 0.0152 0.0654
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0085 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Plasmodium falciparum glutathione reductase 0.0032 0.0085 0.0628
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0085 0.0628
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0103 0.0366 0.1459
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.0331 0.0331
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0271 0.1041 0.1041
Plasmodium falciparum thioredoxin reductase 0.0032 0.0085 0.0628
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Mycobacterium tuberculosis Conserved hypothetical protein 0.0049 0.0152 0.0823
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.0331 0.0331
Trypanosoma cruzi target of rapamycin kinase 3 0.019 0.0714 0.1916
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0152 0.1329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0411 0.1912
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0049 0.0152 0.0255
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0116 0.0419 0.3247
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.019 0.0714 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0237 0.0902 1
Toxoplasma gondii FATC domain-containing protein 0.0114 0.0411 0.5319
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0169 0.0632 0.2934
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.0296
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.019 0.0714 1
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.037 0.1475
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0103 0.0366 0.1648
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0103 0.0366 0.4625
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0638 0.2507 0.2507
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0114 0.0411 0.1019
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0114 0.0411 0.2297
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0085 0.5
Trypanosoma cruzi trypanothione reductase, putative 0.0093 0.0329 0.0777
Loa Loa (eye worm) phosphatidylinositol 3 0.019 0.0714 0.3187
Loa Loa (eye worm) hypothetical protein 0.0033 0.0089 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0114 0.0411 0.1638
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0089 0.0356
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0271 0.1041 0.5822
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0411 0.1912
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.012 0.0436 0.1093
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0049 0.0152 0.1329
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0152 0.0851
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0049 0.0152 0.2873
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0411 0.1912
Giardia lamblia GTOR 0.019 0.0714 0.6118
Plasmodium vivax SET domain protein, putative 0.0033 0.0089 0.0772
Loa Loa (eye worm) phosphatidylinositol 3 0.0571 0.224 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0049 0.0152 0.1329
Trypanosoma cruzi hypothetical protein, conserved 0.0873 0.3447 1
Plasmodium vivax glutathione reductase, putative 0.0093 0.0329 0.8769
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0104 0.037 0.037
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0213 0.0807 0.8733
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0085 0.0056
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0199 0.2051
Entamoeba histolytica serine/threonine protein kinase, putative 0.0104 0.037 0.133
Loa Loa (eye worm) hypothetical protein 0.0049 0.0152 0.068
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0103 0.0366 0.1305
Schistosoma mansoni hypothetical protein 0.0012 0.0005 0.0021
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0089 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Trichomonas vaginalis set domain proteins, putative 0.026 0.0997 0.5355
Trypanosoma cruzi polo-like protein kinase, putative 0.0104 0.037 0.0898
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0114 0.0411 0.0411
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0049 0.0152 0.0152
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.019 0.0714 0.2848
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0049 0.0152 0.2873
Loa Loa (eye worm) hypothetical protein 0.0114 0.0411 0.1833
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0714 0.3692
Schistosoma mansoni cpg binding protein 0.0033 0.0089 0.0354
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0085 0.0475
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0125 0.0455 0.601
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0228 0.0908
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0085 0.0056
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.2512 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0049 0.0152 0.1329
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0089 0.0356
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.019 0.0714 0.3433
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0213 0.0807 0.8837
Schistosoma mansoni kinase 0.0053 0.0166 0.0663
Entamoeba histolytica hypothetical protein 0.0392 0.1522 0.8371
Schistosoma mansoni fkbp-rapamycin associated protein 0.0114 0.0411 0.1638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0114 0.0411 0.1912
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0093 0.0329 0.2985
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0161 0.0444
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0089 0.0356
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0085 0.0085
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0049 0.0152 0.0607
Trichomonas vaginalis CAMK family protein kinase 0.0104 0.037 0.1672
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0289 0.1113 1
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0103 0.0366 0.0366
Leishmania major phosphatidylinositol 3-kinase, putative 0.019 0.0714 0.1811
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0103 0.0366 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0271 0.1041 0.1041
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.019 0.0714 0.0714
Brugia malayi Thioredoxin reductase 0.0093 0.0329 0.1839
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0049 0.0152 0.0607
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0152 0.0395
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0125 0.0455 0.601
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0114 0.0411 0.2297

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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