TDR Targets

Basic information

Technical information

TDR Targets ID: 887118
Name: 1-(2-chlorophenyl)-4-[3-(trifluoromethyl)phen yl]sulfonylpiperazine
MW: 404.834 | Formula: C17H16ClF3N2O2S
H donors: 0 H acceptors: 2 LogP: 4.17 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccccc1N1CCN(CC1)S(=O)(=O)c1cccc(c1)C(F)(F)F
InChi: 1S/C17H16ClF3N2O2S/c18-15-6-1-2-7-16(15)22-8-10-23(11-9-22)26(24,25)14-5-3-4-13(12-14)17(19,20)21/h1-7,12H,8-11H2
InChiKey: UABRWZHFFKAPHR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(2-chlorophenyl)-4-[3-(trifluoromethyl)phenyl]sulfonyl-piperazine
ZINC07059775

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0329	0.0351
Echinococcus multilocularis	farnesyl pyrophosphate synthase	0.0101	0.205	0.2905
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0584	0.0705
Trypanosoma cruzi	farnesyl pyrophosphate synthase, putative	0.0101	0.205	1
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0033	0.0569	0.0683
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.0584	0.0705
Loa Loa (eye worm)	acetylcholinesterase 1	0.0071	0.1402	0.1933
Trypanosoma brucei	DNA polymerase eta, putative	0.0015	0.0177	0.0775
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0378	0.1241
Trypanosoma brucei	DNA polymerase kappa, putative	0.0032	0.0551	0.2616
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0188	0.0144
Entamoeba histolytica	bifunctional short chain isoprenyl diphosphate synthase, putative	0.0026	0.0406	0.4299
Brugia malayi	hypothetical protein	0.0015	0.0188	0.0144
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.0688	0.2725
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0551	0.0656
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0188	0.0348
Trypanosoma brucei	sugar transporter, putative	0.0015	0.0188	0.0826
Trichomonas vaginalis	glucose transporter, putative	0.0034	0.0593	0.2252
Onchocerca volvulus		0.0015	0.0188	0.0144
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0188	0.0111
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0326	0.1506
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0038	0.0688	0.0902
Mycobacterium ulcerans	DNA polymerase IV	0.0043	0.0776	0.3449
Echinococcus granulosus	dna polymerase eta	0.0015	0.0177	0.0096
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0034	0.0584	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0188	0.0111
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0071	0.1402	0.1933
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0034	0.0584	0.0404
Trypanosoma brucei	DNA polymerase kappa, putative	0.0032	0.0551	0.2616
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0012	0.0114	0.0554
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0447	0.0501
Plasmodium falciparum	ubiquitin-conjugating enzyme E2 N, putative	0.0039	0.071	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0458	0.0517
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0688	0.2725
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0776	0.3723
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0776	0.3723
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0329	0.1523
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0034	0.0584	0.0742
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0043	0.0776	0.3195
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0584	0.0705
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0188	0.0111
Giardia lamblia	Prolyl-tRNA synthetase	0.0033	0.0569	0.2046
Trypanosoma cruzi	polyprenyl synthase, putative	0.0026	0.0406	0.1223
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0025	0.0385	0.111
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0378	0.107
Plasmodium vivax	hexose transporter	0.011	0.2243	0.2094
Echinococcus granulosus	lamin dm0	0.0028	0.0458	0.0517
Toxoplasma gondii	ubiquitin-conjugating enzyme subfamily protein	0.0039	0.071	0.0936
Brugia malayi	polk-prov protein	0.0032	0.0551	0.0849
Onchocerca volvulus		0.0015	0.0188	0.0144
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0188	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0188	0.0111
Schistosoma mansoni	DNA polymerase eta	0.0015	0.0177	0.0096
Schistosoma mansoni	glucose transport protein	0.011	0.2243	0.3194
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0593	0.2252
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Echinococcus multilocularis	decaprenyl diphosphate synthase subunit 1	0.0026	0.0406	0.0439
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0188	0.0144
Onchocerca volvulus		0.0015	0.0188	0.0144
Onchocerca volvulus		0.0015	0.0188	0.0144
Schistosoma mansoni	lamin	0.0028	0.0458	0.0517
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0593	0.2823
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0034	0.0584	0.0912
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.0225	0.1008
Schistosoma mansoni	sugar transporter	0.0015	0.0188	0.0111
Loa Loa (eye worm)	hypothetical protein	0.003	0.0501	0.058
Onchocerca volvulus		0.0015	0.0188	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0188	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0434	0.0481
Toxoplasma gondii	protein kinase, putative	0.0311	0.6607	1
Trypanosoma brucei	unspecified product	0.001	0.0076	0.0277
Schistosoma mansoni	protein kinase	0.0034	0.0584	0.0705
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0188	0.0111
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0593	0.2823
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0329	0.0418
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0776	0.3723
Schistosoma mansoni	ran	0.0022	0.0329	0.0323
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0043	0.0776	0.3195
Onchocerca volvulus		0.0015	0.0188	0.0144
Brugia malayi	Ubiquitin conjugating enzyme protein 13	0.0039	0.071	0.1157
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0385	0.0408
Loa Loa (eye worm)	carboxylesterase	0.0071	0.1402	0.1933
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0015	0.0188	0.0826
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Schistosoma mansoni	geranylgeranyl pyrophosphate synthase	0.0026	0.0406	0.0439
Echinococcus multilocularis	dna polymerase eta	0.0015	0.0177	0.0096
Leishmania major	glucose transporter, lmgt1	0.0034	0.0593	0.222
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.0225	0.1008
Echinococcus granulosus	geminin	0.0175	0.3666	0.5328
Chlamydia trachomatis	geranylgeranyl pyrophosphate synthase	0.0026	0.0406	1
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0022	0.0319	0.0967
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0178	0.3715	0.3595
Trypanosoma cruzi	solanesyl-diphosphate synthase, putative	0.0026	0.0406	0.1223
Plasmodium falciparum	octaprenyl pyrophosphate synthase	0.0026	0.0406	0.0223
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0458	0.0517
Toxoplasma gondii	facilitative glucose transporter GT1	0.011	0.2243	0.3292
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0501	0.0614
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0467	1	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0034	0.0593	0.222
Brugia malayi	RNA, U transporter 1	0.0085	0.1697	0.3072
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.011	0.2243	0.3194
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Plasmodium falciparum	importin beta, putative	0.003	0.0501	0.0319
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0188	0.0133
Trypanosoma cruzi	sugar transporter, putative	0.0015	0.0188	0.0056
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0178	0.3715	0.3595
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Echinococcus multilocularis	geranylgeranyl pyrophosphate synthase	0.0026	0.0406	0.0439
Onchocerca volvulus		0.0015	0.0188	0.0144
Mycobacterium leprae	PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE)	0.0026	0.0406	0.3847
Wolbachia endosymbiont of Brugia malayi	geranylgeranyl pyrophosphate synthase	0.0026	0.0406	1
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0458	0.0517
Giardia lamblia	Lysyl-tRNA synthetase	0.0025	0.0385	0.106
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0188	0.0111
Echinococcus granulosus	ubiquitin conjugating enzyme E2 N	0.0039	0.071	0.0895
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0593	0.2823
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0015	0.0177	0.0096
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Brugia malayi	hypothetical protein	0.0015	0.0188	0.0144
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0593	0.2823
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0584	0.0705
Giardia lamblia	DINP protein human, muc B family	0.0022	0.0326	0.0741
Mycobacterium ulcerans	geranylgeranyl pyrophosphate synthase	0.0101	0.205	1
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0593	0.2252
Echinococcus granulosus	acetylcholinesterase	0.0071	0.1402	0.1933
Leishmania major	farnesyl pyrophosphate synthase	0.0101	0.205	1
Leishmania major	glucose transporter, lmgt2	0.0034	0.0593	0.222
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0177	0.0095
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0034	0.0584	0.0742
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0458	0.0517
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.0188	0.0056
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0385	0.0408
Entamoeba histolytica	hypothetical protein	0.0024	0.0378	0.3763
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.011	0.2243	0.3194
Plasmodium vivax	ubiquitin-conjugating enzyme E2 N, putative	0.0039	0.071	0.0532
Onchocerca volvulus		0.0015	0.0188	0.0144
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0188	0.0111
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0043	0.0776	0.3195
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0034	0.0584	0.0742
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0593	0.2823
Echinococcus granulosus	prenyl decaprenyl diphosphate synthase	0.0026	0.0406	0.0439
Echinococcus granulosus	lamin	0.0028	0.0458	0.0517
Trypanosoma cruzi	farnesyl pyrophosphate synthase	0.0101	0.205	1
Loa Loa (eye worm)	polyprenyl synthetase	0.0101	0.205	0.2905
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0776	0.3723
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0015	0.0177	0.0096
Echinococcus multilocularis	snurportin 1	0.0319	0.678	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0584	0.0705
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0188	0.0111
Schistosoma mansoni	glucose transport protein	0.011	0.2243	0.3194
Onchocerca volvulus		0.0015	0.0188	0.0144
Chlamydia trachomatis	lysine--tRNA ligase	0.0025	0.0385	0.9299
Echinococcus multilocularis	lamin dm0	0.0028	0.0458	0.0517
Mycobacterium ulcerans	carboxylesterase, LipT	0.0012	0.0114	0.0045
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0776	0.3723
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0025	0.0385	0.1799
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0188	0.0426
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0015	0.0177	0.0096
Echinococcus multilocularis	lysyl tRNA synthetase	0.0025	0.0385	0.0408
Echinococcus granulosus	solute carrier family 22	0.0015	0.0188	0.0111
Trypanosoma brucei	glucose transporter 1E	0.0034	0.0593	0.2823
Brugia malayi	geranylgeranyl pyrophosphate synthetase	0.0026	0.0406	0.0568
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0033	0.0569	0.0883
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0188	0.0111
Mycobacterium ulcerans	geranylgeranyl pyrophosphate synthase	0.0101	0.205	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0188	0.0348
Echinococcus granulosus	snurportin 1	0.0319	0.678	1
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0188	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0188	0.0111
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0776	0.3723
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0015	0.0188	0.0916
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.0225	0.1008
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0177	0.0122
Echinococcus granulosus	dna polymerase kappa	0.0043	0.0776	0.0993
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0133	0.003
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0385	0.1441
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0034	0.0584	0.0404
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0329	0.0811
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0593	0.2823
Brugia malayi	Importin beta-1 subunit	0.003	0.0501	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0133	0.003
Trichomonas vaginalis	CAMK family protein kinase	0.0034	0.0584	0.2208
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0034	0.0584	0.0404
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0188	0.0111
Leishmania major	GTP-binding protein, putative	0.0022	0.0329	0.0811
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Brugia malayi	intermediate filament protein	0.0028	0.0458	0.0669
Trypanosoma cruzi	glucose transporter, putative	0.0015	0.0188	0.0056
Brugia malayi	Sugar transporter family protein	0.0015	0.0188	0.0144
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0034	0.0584	0.0705
Brugia malayi	hypothetical protein	0.0015	0.0188	0.0144
Plasmodium vivax	importin-beta 2, putative	0.003	0.0501	0.0319
Loa Loa (eye worm)	sugar transporter	0.011	0.2243	0.3194
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0033	0.0569	0.7349
Plasmodium falciparum	lysine--tRNA ligase	0.0025	0.0385	0.0201
Entamoeba histolytica	Ran family GTPase	0.0022	0.0329	0.285
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0319	0.678	1
Schistosoma mansoni	hypothetical protein	0.011	0.2243	0.3194
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0043	0.0776	0.311
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0039	0.071	0.2802
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0569	0.0683
Onchocerca volvulus		0.0249	0.5269	1
Leishmania major	protein kinase, putative	0.0034	0.0584	0.217
Leishmania major	hypothetical protein, conserved	0.0015	0.0188	0.0056
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0593	0.2823
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.011	0.2243	0.3194
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0039	0.071	0.0895
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0025	0.0385	0.1276
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0188	0.0111
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0458	0.0669
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Echinococcus granulosus	calcium dependent protein kinase	0.0032	0.0538	0.0637
Trypanosoma cruzi	polyprenyl synthase, putative	0.0026	0.0406	0.1223
Trichomonas vaginalis	geranylgeranyl pyrophosphate synthase, putative	0.0101	0.205	0.9097
Leishmania major	glucose transporter, lmgt3	0.0034	0.0593	0.222
Echinococcus multilocularis	acetylcholinesterase	0.0071	0.1402	0.1933
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0188	0.0348
Plasmodium vivax	octaprenyl pyrophosphate synthase, putative	0.0026	0.0406	0.0223
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0593	0.2823
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0015	0.0177	0.0096
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0188	0.0111
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0329	0.0811
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0034	0.0584	0.2776
Mycobacterium tuberculosis	Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate	0.0026	0.0406	0.1982
Trypanosoma brucei	DNA polymerase IV, putative	0.0043	0.0776	0.3723
Schistosoma mansoni	hypothetical protein	0.0175	0.3666	0.5328
Trypanosoma brucei	DNA polymerase IV, putative	0.0043	0.0776	0.3723
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0033	0.0569	0.0683
Echinococcus granulosus	solute carrier family 22	0.0015	0.0188	0.0111
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0501	0.2367
Mycobacterium tuberculosis	Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase)	0.0026	0.0406	0.1982
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0034	0.0584	0.0705
Trypanosoma brucei	glucose transporter 2A	0.0034	0.0593	0.2823
Trypanosoma brucei	ubiquitin-protein ligase, putative	0.0039	0.071	0.3399
Trichomonas vaginalis	ran, putative	0.0022	0.0329	0.1013
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0039	0.071	0.2845
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0188	0.0111
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0329	0.0323
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0188	0.0348
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0034	0.0584	0.0404
Brugia malayi	ubiquitin conjugating enzyme protein 13	0.0039	0.071	0.1157
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0188	0.0348
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0688	0.2725
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0593	0.2823
Loa Loa (eye worm)	geranylgeranyl pyrophosphate synthetase	0.0026	0.0406	0.0439
Echinococcus multilocularis	lamin	0.0028	0.0458	0.0517
Entamoeba histolytica	ubiquitin-conjugating enzyme family protein	0.0039	0.071	1
Schistosoma mansoni	protein kinase	0.0034	0.0584	0.0705
Trypanosoma cruzi	hexose transporter, putative	0.0019	0.0257	0.0425
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0329	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0188	0.0111
Brugia malayi	major facilitator superfamily protein	0.0015	0.0188	0.0144
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0015	0.0177	0.0096
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0593	0.2252
Entamoeba histolytica	protein kinase, putative	0.0034	0.0584	0.7627
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0188	0.0348
Loa Loa (eye worm)	sugar transporter	0.0015	0.0188	0.0111
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0188	0.0111
Echinococcus granulosus	decaprenyl diphosphate synthase subunit 1	0.0026	0.0406	0.0439
Echinococcus granulosus	geranylgeranyl pyrophosphate synthase	0.0026	0.0406	0.0439
Echinococcus granulosus	farnesyl pyrophosphate synthase	0.0101	0.205	0.2905
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0034	0.0584	0.0404
Schistosoma mansoni	trans-prenyltransferase	0.0026	0.0406	0.0439
Echinococcus granulosus	lysyl tRNA synthetase	0.0025	0.0385	0.0408
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0584	0.0705
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0408
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0012	0.0114	0.0554
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0378	0.1241
Echinococcus multilocularis	musashi	0.0028	0.0458	0.0517
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0022	0.0329	0.0759
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0188	0.0111
Echinococcus multilocularis	General substrate transporter	0.0094	0.1906	0.2689
Mycobacterium tuberculosis	Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase)	0.0026	0.0406	0.1982
Brugia malayi	Cam kinase protein 1	0.0034	0.0584	0.0912
Trypanosoma brucei	farnesyl pyrophosphate synthase	0.0101	0.205	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0569	0.0683
Schistosoma mansoni	farnesyl pyrophosphate synthase	0.0101	0.205	0.2905
Plasmodium vivax	proline--tRNA ligase, putative	0.0038	0.0688	0.051
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0022	0.0326	0.1589
Trichomonas vaginalis	geranylgeranyl pyrophosphate synthase, putative	0.0101	0.205	0.9097
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.011	0.2243	0.3194
Onchocerca volvulus		0.0015	0.0188	0.0144
Leishmania major	polyprenyl synthase, putative	0.0026	0.0406	0.1223
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0584	0.0705
Trypanosoma brucei	unspecified product	0.001	0.0076	0.0277
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0593	0.222
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0188	0.0133
Treponema pallidum	octaprenyl-diphosphate synthase	0.0026	0.0406	1
Trichomonas vaginalis	DNA polymerase eta, putative	0.0043	0.0776	0.311
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0034	0.0584	0.0404
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0584	0.0705
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0144	0.0046
Schistosoma mansoni	lamin	0.0028	0.0458	0.0517
Echinococcus multilocularis	acetylcholinesterase	0.0071	0.1402	0.1933
Echinococcus granulosus	importin subunit beta 1	0.003	0.0501	0.058
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0776	0.3723
Trypanosoma brucei	DNA polymerase IV, putative	0.0036	0.0627	0.2991
Leishmania major	solanesyl-diphosphate synthase, putative	0.0026	0.0406	0.1223
Brugia malayi	lysyl-tRNA synthetase	0.0025	0.0385	0.0527
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Schistosoma mansoni	glucose transporter	0.0015	0.0188	0.0111
Mycobacterium ulcerans	polyprenyl synthetase IdsB	0.0026	0.0406	0.155
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0188	0.0111
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0033	0.0569	0.0683
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0501	0.058
Brugia malayi	Polyprenyl synthetase family protein	0.0101	0.205	0.3757
Entamoeba histolytica	protein kinase, putative	0.0034	0.0584	0.7627
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0025	0.0385	0.3046
Plasmodium falciparum	hexose transporter	0.011	0.2243	0.2094
Onchocerca volvulus		0.0028	0.0458	0.0669
Toxoplasma gondii	lysine-tRNA ligase	0.0025	0.0385	0.0437
Leishmania major	DNA polymerase kappa, putative	0.0022	0.0326	0.0793
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0188	0.0426
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0593	0.2252
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0188	0.0111
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.0329	0.0144
Brugia malayi	major facilitator superfamily protein	0.0015	0.0188	0.0144
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0593	0.2252
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0021	0.0305	0.1486
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0188	0.0111
Echinococcus multilocularis	dna polymerase kappa	0.0043	0.0776	0.0993
Leishmania major	ubiquitin-conjugating enzyme e2, putative	0.0039	0.071	0.2845
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0188	0.0111
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.0688	0.2725
Brugia malayi	Sugar transporter family protein	0.011	0.2243	0.413
Brugia malayi	Carboxylesterase family protein	0.0071	0.1402	0.25
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0039	0.071	0.2802
Trypanosoma cruzi	ubiquitin-conjugating enzyme E2, putative	0.0039	0.071	0.2845
Loa Loa (eye worm)	ubiquitin conjugating enzyme protein 13	0.0039	0.071	0.0895
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0015	0.0188	0.0916
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0043	0.0776	0.3195
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0188	0.0144
Mycobacterium ulcerans	DNA polymerase IV	0.0043	0.0776	0.3449
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0015	0.0177	0.0865
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.011	0.2243	0.3194
Echinococcus granulosus	carboxylesterase 5A	0.0071	0.1402	0.1933
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0188	0.0111
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Onchocerca volvulus		0.0015	0.0188	0.0144
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0584	0.0705
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0188	0.0111
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0033	0.0569	0.0683
Entamoeba histolytica	geranylgeranyl pyrophosphate synthetase, putative	0.0026	0.0406	0.4299
Echinococcus granulosus	intermediate filament protein	0.0028	0.0458	0.0517
Schistosoma mansoni	sugar transporter	0.0015	0.0188	0.0111
Schistosoma mansoni	glucose transport protein	0.011	0.2243	0.3194
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0378	0.1241
Mycobacterium ulcerans	sugar transporter	0.0015	0.0188	0.0426
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0033	0.0569	0.0883
Leishmania major	myo-inositol/proton symporter (MIT)	0.0015	0.0188	0.0056
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0385	0.1441
Onchocerca volvulus		0.0015	0.0188	0.0144
Toxoplasma gondii	polyprenyl synthetase superfamily protein	0.0026	0.0406	0.0469
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Plasmodium falciparum	proline--tRNA ligase	0.0038	0.0688	0.051
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0593	0.2823
Brugia malayi	ImpB/MucB/SamB family protein	0.0015	0.0177	0.0124
Trypanosoma brucei	unspecified product	0.0036	0.0627	0.2991
Plasmodium falciparum	geranylgeranyl pyrophosphate synthase, putative	0.0101	0.205	0.1898
Trypanosoma cruzi	hexose transporter	0.0034	0.0593	0.222
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.011	0.2243	0.3194
Brugia malayi	Sugar transporter family protein	0.0015	0.0188	0.0144
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0378	0.107
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.011	0.2243	0.3194
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0022	0.0326	0.0793
Schistosoma mansoni	ran	0.0022	0.0329	0.0323
Trypanosoma cruzi	solanesyl-diphosphate synthase	0.0026	0.0406	0.1223
Toxoplasma gondii	polyprenyl synthetase superfamily protein	0.0101	0.205	0.2996
Plasmodium falciparum	protein kinase 7	0.0311	0.6607	0.6542
Onchocerca volvulus		0.0015	0.0188	0.0144
Echinococcus multilocularis	ubiquitin conjugating enzyme E2 N	0.0039	0.071	0.0895
Onchocerca volvulus		0.0015	0.0188	0.0144
Entamoeba histolytica	hypothetical protein	0.0025	0.0385	0.3902
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0034	0.0584	0.0404
Echinococcus multilocularis	prenyl (decaprenyl) diphosphate synthase	0.0026	0.0406	0.0439
Loa Loa (eye worm)	polyprenyl synthetase	0.0026	0.0406	0.0439
Wolbachia endosymbiont of Brugia malayi	geranylgeranyl pyrophosphate synthase	0.0026	0.0406	1
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0593	0.222
Schistosoma mansoni	protein kinase	0.0034	0.0584	0.0705
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0776	0.3723
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0329	0.0323
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0188	0.0348
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0593	0.222
Onchocerca volvulus		0.0028	0.0458	0.0669
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Brugia malayi	ImpB/MucB/SamB family protein	0.0015	0.0177	0.0124
Echinococcus granulosus	acetylcholinesterase	0.0071	0.1402	0.1933
Echinococcus multilocularis	geminin	0.0175	0.3666	0.5328
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0776	0.3723
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Schistosoma mansoni	glutathione synthetase	0.0026	0.0406	0.0439
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0034	0.0584	0.0404
Echinococcus granulosus	solute carrier family 22	0.0015	0.0188	0.0111
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0188	0.0111
Brugia malayi	Carboxylesterase family protein	0.0071	0.1402	0.25
Echinococcus granulosus	solute carrier family 22	0.0015	0.0188	0.0111
Schistosoma mansoni	ubiquitin conjugating enzyme 13	0.0039	0.071	0.0895
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0033	0.0569	0.2139
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1402	0.1933
Entamoeba histolytica	geranylgeranyl pyrophosphate synthase, putative	0.0026	0.0406	0.4299
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0593	0.2823
Schistosoma mansoni	hypothetical protein	0.0175	0.3666	0.5328
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0034	0.0584	0.0705
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Onchocerca volvulus		0.0015	0.0188	0.0144
Trichomonas vaginalis	conserved hypothetical protein	0.011	0.2243	1
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0144	0.0046
Trichomonas vaginalis	glucose transporter, putative	0.0034	0.0593	0.2252
Leishmania major	lysyl-tRNA synthetase, putative	0.0025	0.0385	0.111
Trypanosoma brucei	solanesyl-diphosphate synthase, putative	0.0026	0.0406	0.1903
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0033	0.0569	1
Schistosoma mansoni	sugar transporter	0.0015	0.0188	0.0111
Plasmodium vivax	lysine--tRNA ligase, putative	0.0025	0.0385	0.0201
Schistosoma mansoni	sugar transporter	0.0015	0.0188	0.0111
Echinococcus multilocularis	carboxylesterase 5A	0.0071	0.1402	0.1933
Onchocerca volvulus	Putative transporter	0.0015	0.0188	0.0144
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0688	0.3289
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0178	0.3715	0.5555
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0188	0.0348
Brugia malayi	Polyprenyl synthetase family protein	0.0026	0.0406	0.0568
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0014	0.0146	0.0049
Plasmodium vivax	geranylgeranyl pyrophosphate synthase	0.0101	0.205	0.1898
Loa Loa (eye worm)	pax transcription factor protein 2	0.0249	0.5269	0.7733
Schistosoma mansoni	hypothetical protein	0.0319	0.678	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0144	0.0046
Giardia lamblia	Farnesyl diphosphate synthase	0.0101	0.205	1
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0188	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0188	0.0111
Echinococcus granulosus	General substrate transporter	0.0094	0.1906	0.2689
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0501	0.2367
Schistosoma mansoni	importin beta-1	0.003	0.0501	0.058
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0188	0.0426
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.011	0.2243	0.3194
Brugia malayi	Pax transcription factor protein 2	0.0249	0.5269	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1402	0.1933
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.0329	0.0144
Trichomonas vaginalis	geranylgeranyl diphosphate synthase, putative	0.0101	0.205	0.9097
Echinococcus multilocularis	calcium dependent protein kinase	0.0032	0.0538	0.0637
Mycobacterium tuberculosis	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)	0.0101	0.205	1
Trypanosoma cruzi	solanesyl-diphosphate synthase, putative	0.0026	0.0406	0.1223
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0305	0.1486
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0012	0.0114	0.0554
Onchocerca volvulus		0.0015	0.0188	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0177	0.0096
Mycobacterium ulcerans	polyprenyl diphosphate synthetase, GrcC1	0.0026	0.0406	0.155

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 887118