TDR Targets

Basic information

Technical information

TDR Targets ID: 892102
Name: 2-imino-6-nitro-N-[3-(trifluoromethyl)phenyl] chromene-3-carboxamide
MW: 377.274 | Formula: C17H10F3N3O4
H donors: 1 H acceptors: 3 LogP: 3.76 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cc2cc(ccc2oc1=N)[N+](=O)[O-])Nc1cccc(c1)C(F)(F)F
InChi: 1S/C17H10F3N3O4/c18-17(19,20)10-2-1-3-11(8-10)22-16(24)13-7-9-6-12(23(25)26)4-5-14(9)27-15(13)21/h1-8,21H,(H,22,24)
InChiKey: ZUCLCGHSBRCYBI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-imino-6-nitro-N-[3-(trifluoromethyl)phenyl]-3-chromenecarboxamide
EU-0002237
ZINC04511161

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cercarial elastase (S01 family)	0.0129	0.0425	0.1772
Mycobacterium tuberculosis	Probable oxidoreductase	0.0119	0.0379	1
Onchocerca volvulus		0.0035	0.003	0.0108
Onchocerca volvulus	Pyruvate kinase homolog	0.0032	0.0018	0.0056
Schistosoma mansoni	hypothetical protein	0.0121	0.0391	0.163
Loa Loa (eye worm)	pyruvate kinase	0.0032	0.0018	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0472	0.1859	0.7821
Echinococcus multilocularis	GPCR, family 2	0.0064	0.0149	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0179	0.0735
Brugia malayi	GCC2 and GCC3 family protein	0.0035	0.003	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0126	0.041	0.171
Onchocerca volvulus		0.0129	0.0425	0.1772
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0425	0.1772
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0018	0.0056
Brugia malayi	Trypsin family protein	0.0596	0.2375	1
Brugia malayi	PAN domain containing protein	0.0168	0.0587	0.2456
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0129	0.0425	0.042
Schistosoma mansoni	slit	0.0035	0.003	0.0108
Onchocerca volvulus		0.0168	0.0587	0.2456
Onchocerca volvulus		0.0472	0.1859	0.7821
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Echinococcus granulosus	sterol regulatory element binding protein	0.0126	0.041	0.2206
Onchocerca volvulus		0.0071	0.0179	0.0735
Onchocerca volvulus	Neurogenic locus notch homolog	0.0035	0.003	0.0108
Onchocerca volvulus		0.0129	0.0425	0.1772
Brugia malayi	Pre-SET motif family protein	0.0203	0.0731	0.3064
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0298	0.113	0.4748
Brugia malayi	Pax transcription activation domain interacting protein	0.0029	0.0005	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Onchocerca volvulus		0.0168	0.0587	0.2456
Echinococcus granulosus	notch	0.0035	0.003	0.0162
Leishmania major	4-coumarate:coa ligase-like protein	0.0071	0.0179	0.0874
Brugia malayi	Fibulin-1 precursor	0.0039	0.0047	0.018
Onchocerca volvulus		0.0129	0.0425	0.1772
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0104	0.0419
Toxoplasma gondii	microneme protein MIC17B	0.0168	0.0587	0.1066
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0129	0.0425	0.2284
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0458	0.1912
Schistosoma mansoni	hypothetical protein	0.0064	0.0149	0.0609
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0078	0.0309
Echinococcus multilocularis	slit 2 protein	0.0035	0.003	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Schistosoma mansoni	egf-like domain protein	0.0039	0.0047	0.018
Brugia malayi	PAN domain containing protein	0.0168	0.0587	0.2456
Loa Loa (eye worm)	hypothetical protein	0.0228	0.0839	0.3518
Onchocerca volvulus	Pyruvate kinase homolog	0.0032	0.0018	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Onchocerca volvulus	Pyruvate kinase homolog	0.0032	0.0018	0.0056
Echinococcus granulosus	Tolloid protein 1	0.0039	0.0047	0.0254
Mycobacterium ulcerans	hypothetical protein	0.0129	0.0425	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0005	0.0002
Brugia malayi	glutathione reductase	0.0047	0.0079	0.0313
Onchocerca volvulus		0.0168	0.0587	0.2456
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0047	0.018
Onchocerca volvulus	Slit protein homolog	0.0035	0.003	0.0108
Plasmodium vivax	pyruvate kinase, putative	0.0032	0.0018	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0104	0.0419
Brugia malayi	PAN domain containing protein	0.0168	0.0587	0.2456
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0032	0.0018	0.0068
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0064	0.0149	0.0145
Toxoplasma gondii	PAN domain-containing protein	0.0168	0.0587	0.1066
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0168	0.0587	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.0079	0.0313
Echinococcus multilocularis	neurogenic locus protein delta	0.0035	0.003	0.0026
Echinococcus granulosus	fibropellin Ia	0.0035	0.003	0.0162
Toxoplasma gondii	PAN domain-containing protein	0.0168	0.0587	0.1066
Plasmodium falciparum	acyl-CoA synthetase	0.0053	0.0104	0.0533
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0139	0.0567
Plasmodium vivax	glutathione reductase, putative	0.0047	0.0079	0.04
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0064	0.0149	0.0609
Schistosoma mansoni	cercarial elastase (S01 family)	0.0129	0.0425	0.1772
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0388	0.1619
Loa Loa (eye worm)	Notch2	0.0035	0.003	0.0108
Echinococcus multilocularis	protein dispatched 1	0.0144	0.0484	0.048
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Echinococcus granulosus	laminin	0.0039	0.0047	0.0254
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0039	0.0047	0.018
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0072	0.0183	0.0983
Schistosoma mansoni	transcription factor LCR-F1	0.0072	0.0183	0.0752
Toxoplasma gondii	microneme protein MIC17A	0.0168	0.0587	0.1066
Schistosoma mansoni	hypothetical protein	0.0035	0.003	0.0108
Onchocerca volvulus		0.0168	0.0587	0.2456
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0596	0.2375	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Brugia malayi	TAR-binding protein	0.0061	0.0139	0.0567
Loa Loa (eye worm)	PAN domain-containing protein	0.0168	0.0587	0.2456
Schistosoma mansoni	hypothetical protein	0.0035	0.003	0.0108
Leishmania major	4-coumarate:coa ligase-like protein	0.0071	0.0179	0.0874
Echinococcus granulosus	tar DNA binding protein	0.0061	0.0139	0.0747
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.0039	0.0034
Echinococcus granulosus	Niemann Pick C1 protein	0.0294	0.1111	0.5979
Brugia malayi	Protein kinase domain containing protein	0.0472	0.1859	0.7821
Onchocerca volvulus		0.0168	0.0587	0.2456
Echinococcus granulosus	Mastin	0.0129	0.0425	0.2284
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0203	0.0731	0.3064
Brugia malayi	hypothetical protein	0.0129	0.0425	0.1772
Trypanosoma brucei	pyruvate kinase 1, putative	0.0032	0.0018	0.0862
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0053	0.0104	0.2356
Schistosoma mansoni	cercarial elastase (S01 family)	0.0129	0.0425	0.1772
Schistosoma mansoni	topbp1	0.0029	0.0005	0.0002
Onchocerca volvulus		0.0047	0.0078	0.0309
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.0139	0.0567
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0071	0.0179	0.4451
Brugia malayi	hypothetical protein	0.0072	0.0183	0.0752
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.0029	0.0005	0.5
Schistosoma mansoni	hypothetical protein	0.0035	0.003	0.0108
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0039	0.0047	0.0078
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0129	0.0425	0.2284
Brugia malayi	EGF-like domain containing protein	0.0035	0.003	0.0108
Brugia malayi	hypothetical protein	0.0228	0.0839	0.3518
Onchocerca volvulus		0.0168	0.0587	0.2456
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Brugia malayi	latrophilin 2 splice variant baaae	0.0137	0.0458	0.1912
Schistosoma mansoni	patched 1	0.0126	0.041	0.171
Echinococcus granulosus	neurogenic locus notch protein 4	0.0035	0.003	0.0162
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0201	0.0724	0.3034
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0179	0.0735
Schistosoma mansoni	cercarial elastase (S01 family)	0.0129	0.0425	0.1772
Echinococcus granulosus	transmembrane protease serine 3	0.0129	0.0425	0.2284
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0064	0.0152	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0425	0.1772
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0152	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0228	0.0839	0.0834
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0107	0.0329	0.8622
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0029	0.0005	0.0002
Plasmodium falciparum	cysteine repeat modular protein 1	0.0472	0.1859	1
Echinococcus multilocularis	laminin	0.0039	0.0047	0.0043
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0107	0.0329	0.8622
Plasmodium vivax	acyl-CoA synthetase, putative	0.0053	0.0104	0.0536
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0129	0.0425	0.1772
Brugia malayi	CHE-14 protein	0.0126	0.041	0.171
Echinococcus multilocularis	nibrin	0.0029	0.0005	0.0001
Echinococcus granulosus	protein jagged 2	0.0035	0.003	0.0162
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0129	0.0425	0.1772
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0005	0.0002
Echinococcus multilocularis	protein jagged 1	0.0035	0.003	0.0026
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0004	0.0024
Echinococcus granulosus	protein jagged 2	0.0035	0.003	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0149	0.0609
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0035	0.003	0.0026
Brugia malayi	EGF-like domain containing protein	0.0035	0.003	0.0108
Brugia malayi	Kringle domain containing protein	0.0472	0.1859	0.7821
Echinococcus multilocularis	protein jagged 2	0.0035	0.003	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0083	0.033
Schistosoma mansoni	notch	0.0035	0.003	0.0108
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.005	0.0092	0.205
Schistosoma mansoni	pyruvate kinase	0.0032	0.0018	0.0056
Trypanosoma brucei	pyruvate kinase 1	0.0032	0.0018	0.0862
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0587	0.2456
Schistosoma mansoni	hypothetical protein	0.0064	0.0149	0.0609
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0472	0.1859	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0071	0.0179	0.4139
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0071	0.0179	0.4139
Onchocerca volvulus		0.0035	0.003	0.0108
Brugia malayi	EGF-like domain containing protein	0.0035	0.003	0.0108
Loa Loa (eye worm)	pyruvate kinase	0.0032	0.0018	0.0056
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0294	0.1111	1
Echinococcus multilocularis	Mastin	0.0129	0.0425	0.042
Echinococcus multilocularis	tissue type plasminogen activator	0.0472	0.1859	0.1855
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0107	0.0329	0.8622
Toxoplasma gondii	ATPase, AAA family protein	0.0029	0.0005	0.0001
Echinococcus granulosus	neurogenic locus notch protein	0.0035	0.003	0.0162
Brugia malayi	PAN domain containing protein	0.0168	0.0587	0.2456
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0129	0.0425	0.1772
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0587	0.2456
Schistosoma mansoni	laminin gamma-3 chain	0.0035	0.003	0.0108
Echinococcus granulosus	neurogenic locus notch protein	0.0035	0.003	0.0162
Onchocerca volvulus	Huntingtin homolog	0.0121	0.0388	0.1619
Onchocerca volvulus		0.0231	0.0848	0.3558
Loa Loa (eye worm)	PAN domain-containing protein	0.0168	0.0587	0.2456
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Echinococcus granulosus	tissue type plasminogen activator	0.0472	0.1859	1
Echinococcus granulosus	protein jagged 1	0.0035	0.003	0.0162
Onchocerca volvulus		0.0035	0.003	0.0108
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0064	0.0152	0.0729
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0139	0.0567
Echinococcus granulosus	pyruvate kinase	0.0032	0.0018	0.0095
Schistosoma mansoni	hypothetical protein	0.0137	0.0458	0.1912
Echinococcus multilocularis	neurogenic locus protein delta	0.0035	0.003	0.0026
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0107	0.0329	0.8668
Brugia malayi	PAN domain containing protein	0.0168	0.0587	0.2456
Schistosoma mansoni	notch	0.0035	0.003	0.0108
Toxoplasma gondii	PAN domain-containing protein	0.1334	0.5465	1
Toxoplasma gondii	thioredoxin reductase	0.0047	0.0079	0.0136
Trichomonas vaginalis	conserved hypothetical protein	0.0126	0.041	0.4804
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0078	0.0309
Brugia malayi	Trypsin family protein	0.0129	0.0425	0.1772
Brugia malayi	notch-like transmembrane receptor	0.0035	0.003	0.0108
Plasmodium vivax	replication factor C subunit 1, putative	0.0029	0.0005	0.0003
Toxoplasma gondii	PAN domain-containing protein	0.0168	0.0587	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0425	0.1772
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.005	0.0092	0.205
Mycobacterium tuberculosis	Probable dehydrogenase	0.0107	0.0329	0.8622
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0587	0.2456
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0064	0.0149	0.0145
Onchocerca volvulus		0.0035	0.003	0.0108
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0119	0.0379	1
Chlamydia trachomatis	pyruvate kinase	0.0032	0.0018	0.1279
Schistosoma mansoni	pyruvate kinase	0.0032	0.0018	0.0056
Schistosoma mansoni	septate junction protein	0.0035	0.003	0.0108
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0039	0.0047	0.018
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Echinococcus multilocularis	fibrillin 1	0.0039	0.0047	0.0043
Brugia malayi	hypothetical protein	0.0029	0.0005	0.0002
Toxoplasma gondii	PAN domain-containing protein	0.0168	0.0587	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0047	0.018
Loa Loa (eye worm)	RNA binding protein	0.0061	0.0139	0.0567
Toxoplasma gondii	kringle domain-containing protein	0.0472	0.1859	0.3396
Brugia malayi	Trypsin family protein	0.0129	0.0425	0.1772
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0032	0.0018	0.0056
Echinococcus granulosus	slit 2 protein	0.0035	0.003	0.0162
Schistosoma mansoni	cercarial elastase (S01 family)	0.0129	0.0425	0.1772
Echinococcus granulosus	protein jagged 1	0.0035	0.003	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0005	0.0002
Echinococcus granulosus	Protein patched homolog 1	0.0126	0.041	0.2206
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.0079	0.0074
Schistosoma mansoni	hypothetical protein	0.0035	0.003	0.0108
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0064	0.0152	0.0621
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0005	0.0002
Mycobacterium ulcerans	pyruvate kinase	0.0032	0.0018	0.0301
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0064	0.0149	0.0801
Mycobacterium ulcerans	acyl-CoA synthetase	0.0071	0.0179	0.4139
Brugia malayi	Muscle positioning protein 4	0.0035	0.003	0.0108
Onchocerca volvulus		0.0129	0.0425	0.1772
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0064	0.0152	0.0621
Treponema pallidum	DNA ligase (lig)	0.0029	0.0005	0.5
Brugia malayi	EGF-like domain containing protein	0.0035	0.003	0.0108
Brugia malayi	Delta serrate ligand family protein	0.0035	0.003	0.0108
Brugia malayi	Calcium binding EGF domain containing protein	0.0039	0.0047	0.018
Brugia malayi	Calcium binding EGF domain containing protein	0.0035	0.003	0.0108
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0129	0.0425	0.1772
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0047	0.0079	0.1686
Schistosoma mansoni	notch	0.0035	0.003	0.0108
Brugia malayi	EGF-like domain containing protein	0.0035	0.003	0.0108
Echinococcus multilocularis	replication factor c subunit 1	0.0029	0.0005	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0596	0.2375	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0047	0.018
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0119	0.0379	1
Mycobacterium ulcerans	hypothetical protein	0.0071	0.0179	0.4139
Onchocerca volvulus		0.0168	0.0587	0.2456
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0071	0.0179	0.157
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Schistosoma mansoni	hypothetical protein	0.0072	0.0183	0.0752
Schistosoma mansoni	cell polarity protein	0.0035	0.003	0.0108
Toxoplasma gondii	subtilisin SUB12	0.0168	0.0587	0.1066
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0029	0.0005	0.000004115
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0139	0.0567
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0053	0.0104	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0129	0.0425	0.1772
Brugia malayi	Trypsin family protein	0.0129	0.0425	0.1772
Loa Loa (eye worm)	PAN domain-containing protein	0.0168	0.0587	0.2456
Echinococcus granulosus	Niemann Pick C1 protein	0.042	0.1638	0.8815
Plasmodium falciparum	pyruvate kinase	0.0032	0.0018	0.0068
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.0079	0.0423
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0032	0.0018	0.0338
Onchocerca volvulus		0.0029	0.0005	0.0002
Brugia malayi	Cadherin domain containing protein	0.0035	0.003	0.0108
Echinococcus multilocularis	enteropeptidase	0.0129	0.0425	0.042
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0201	0.0724	0.3034
Toxoplasma gondii	microneme protein, putative	0.0168	0.0587	0.1066
Brugia malayi	Thioredoxin reductase	0.0047	0.0079	0.0313
Brugia malayi	PAN domain containing protein	0.0168	0.0587	0.2456
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0071	0.0179	0.157
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0047	0.018
Echinococcus multilocularis	fibropellin Ia	0.0035	0.003	0.0026
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0032	0.0018	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0425	0.1772
Loa Loa (eye worm)	hypothetical protein	0.0596	0.2375	1
Loa Loa (eye worm)	trypsin family protein	0.0129	0.0425	0.1772
Schistosoma mansoni	hypothetical protein	0.0121	0.0391	0.163
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0107	0.0329	0.8622
Brugia malayi	hypothetical protein	0.0121	0.0388	0.1619
Brugia malayi	PAN domain containing protein	0.0168	0.0587	0.2456
Toxoplasma gondii	hypothetical protein	0.0168	0.0587	0.1066
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.0079	0.0397
Brugia malayi	EGF-like domain containing protein	0.0035	0.003	0.0108
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0119	0.0379	1
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0126	0.041	0.171
Echinococcus granulosus	GPCR family 2	0.0064	0.0149	0.0801
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.0139	0.0567
Trichomonas vaginalis	set domain proteins, putative	0.0231	0.0848	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0047	0.018
Brugia malayi	topoisomerase	0.0029	0.0005	0.0002
Brugia malayi	Cadherin domain containing protein	0.0035	0.003	0.0108
Echinococcus multilocularis	sterol regulatory element binding protein	0.0126	0.041	0.0406
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0071	0.0179	0.4451
Giardia lamblia	Pyruvate kinase	0.0032	0.0018	0.5044
Giardia lamblia	High cysteine protein	0.0035	0.003	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Onchocerca volvulus		0.0596	0.2375	1
Echinococcus multilocularis	neurogenic locus notch protein	0.0035	0.003	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0104	0.0419
Trichomonas vaginalis	pyruvate kinase, putative	0.0032	0.0018	0.015
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0596	0.2375	1
Loa Loa (eye worm)	glutathione reductase	0.0047	0.0079	0.0313
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0168	0.0587	0.1066
Schistosoma mansoni	cercarial elastase (S01 family)	0.0129	0.0425	0.1772
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.0139	0.0567
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.0029	0.0005	0.000004115
Echinococcus granulosus	glycoprotein Antigen 5	0.0129	0.0425	0.2284
Schistosoma mansoni	topbp1	0.0029	0.0005	0.0002
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0032	0.0018	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Echinococcus granulosus	neurogenic locus protein delta	0.0035	0.003	0.0162
Leishmania major	hypothetical protein, conserved	0.0472	0.1859	1
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0129	0.0425	0.042
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0064	0.0149	0.0801
Echinococcus granulosus	survival motor neuron protein 1	0.0228	0.0839	0.4512
Loa Loa (eye worm)	PAN domain-containing protein	0.0168	0.0587	0.2456
Schistosoma mansoni	hypothetical protein	0.0035	0.003	0.0108
Echinococcus multilocularis	pyruvate kinase	0.0032	0.0018	0.0013
Trypanosoma brucei	trypanothione reductase	0.0047	0.0079	0.5017
Toxoplasma gondii	pyruvate kinase PyK1	0.0032	0.0018	0.0024
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.0139	0.0134
Toxoplasma gondii	PAN domain-containing protein	0.1334	0.5465	1
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0039	0.0047	0.018
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0071	0.0179	0.4639
Schistosoma mansoni	cercarial elastase (S01 family)	0.0129	0.0425	0.1772
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0039	0.0047	0.0078
Echinococcus granulosus	pyruvate kinase	0.0032	0.0018	0.0095
Schistosoma mansoni	hypothetical protein	0.0047	0.0078	0.0309
Brugia malayi	PAN domain containing protein	0.0168	0.0587	0.2456
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.005	0.0092	0.205
Echinococcus granulosus	enteropeptidase	0.0129	0.0425	0.2284
Brugia malayi	RNA binding protein	0.0061	0.0139	0.0567
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0129	0.0425	0.1772
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0587	0.2456
Loa Loa (eye worm)	PAN domain-containing protein	0.0168	0.0587	0.2456
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0388	0.1619
Echinococcus granulosus	tumor protein p63	0.0326	0.1248	0.6717
Echinococcus multilocularis	glycoprotein Antigen 5	0.0129	0.0425	0.042
Schistosoma mansoni	hypothetical protein	0.0064	0.0149	0.0609
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0129	0.0425	0.1772
Plasmodium falciparum	glutathione reductase	0.0047	0.0079	0.0397
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0071	0.0179	0.4639
Onchocerca volvulus		0.0168	0.0587	0.2456
Onchocerca volvulus		0.0466	0.1834	0.7715
Entamoeba histolytica	hypothetical protein	0.0072	0.0183	0.1607
Brugia malayi	PAN domain containing protein	0.0168	0.0587	0.2456
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0072	0.0183	0.0178
Onchocerca volvulus		0.0035	0.003	0.0108
Echinococcus multilocularis	neurogenic locus notch protein	0.0035	0.003	0.0026
Loa Loa (eye worm)	TK/ROR protein kinase	0.0472	0.1859	0.7821
Onchocerca volvulus		0.0129	0.0425	0.1772
Onchocerca volvulus		0.0048	0.0083	0.033
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0005	0.0002
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0039	0.0047	0.018
Leishmania major	trypanothione reductase	0.0047	0.0079	0.0331
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0064	0.0152	0.0817
Mycobacterium ulcerans	acyl-CoA synthetase	0.0071	0.0179	0.4139
Schistosoma mansoni	hypothetical protein	0.0472	0.1859	0.7821
Brugia malayi	EGF-like domain containing protein	0.0035	0.003	0.0108
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0035	0.003	0.0108
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0029	0.0005	0.0000031356
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0152	0.0792
Toxoplasma gondii	EGF family domain-containing protein	0.0035	0.003	0.0047
Schistosoma mansoni	cercarial elastase (S01 family)	0.0129	0.0425	0.1772
Mycobacterium tuberculosis	Probable reductase	0.0107	0.0329	0.8622
Entamoeba histolytica	hypothetical protein	0.0072	0.0183	0.1607
Onchocerca volvulus		0.0168	0.0587	0.2456
Echinococcus multilocularis	notch	0.0035	0.003	0.0026
Toxoplasma gondii	microneme protein MIC4	0.0168	0.0587	0.1066
Plasmodium falciparum	thioredoxin reductase	0.0047	0.0079	0.0397
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0071	0.0179	0.4139
Echinococcus granulosus	replication factor c subunit 1	0.0029	0.0005	0.0027
Onchocerca volvulus		0.0168	0.0587	0.2456
Echinococcus granulosus	expressed conserved protein	0.0276	0.1037	0.5578
Entamoeba histolytica	acyl-coA synthetase, putative	0.0071	0.0179	0.157
Echinococcus multilocularis	expressed conserved protein	0.0276	0.1037	0.1033
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0064	0.0149	0.0609
Schistosoma mansoni	hypothetical protein	0.0035	0.003	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0587	0.2456
Brugia malayi	Calcium binding EGF domain containing protein	0.0035	0.003	0.0108
Brugia malayi	AMP-binding enzyme family protein	0.0071	0.0179	0.0735
Schistosoma mansoni	DNA ligase IV	0.0029	0.0005	0.0002
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0035	0.003	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0005	0.0002
Brugia malayi	hypothetical protein	0.0029	0.0005	0.0002
Echinococcus multilocularis	tumor protein p63	0.0326	0.1248	0.1245
Schistosoma mansoni	hypothetical protein	0.0121	0.0391	0.163
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0035	0.003	0.0108
Echinococcus multilocularis	protein patched	0.0126	0.041	0.0406
Brugia malayi	Trypsin-like protease protein 5	0.0129	0.0425	0.1772
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0039	0.0047	0.018
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0071	0.0179	0.4139
Echinococcus granulosus	neural cadherin	0.0035	0.003	0.0162
Entamoeba histolytica	hypothetical protein	0.0072	0.0183	0.1607
Brugia malayi	Niemann-Pick C1 protein precursor	0.0294	0.1111	0.4668
Loa Loa (eye worm)	hypothetical protein	0.0294	0.1111	0.4668
Leishmania major	4-coumarate:coa ligase-like protein	0.0071	0.0179	0.0874
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0083	0.033
Trypanosoma cruzi	hypothetical protein, conserved	0.0472	0.1859	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0035	0.003	0.0108
Toxoplasma gondii	microneme protein MIC17C	0.0168	0.0587	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0064	0.0152	0.0621
Loa Loa (eye worm)	hypothetical protein	0.0129	0.0425	0.1772
Brugia malayi	AMP-binding enzyme family protein	0.0071	0.0179	0.0735
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0139	0.0567
Echinococcus multilocularis	neural cadherin	0.0035	0.003	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0179	0.0735
Schistosoma mansoni	hypothetical protein	0.0129	0.0425	0.1772
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.005	0.0092	0.205
Schistosoma mansoni	chromosome transmission fidelity factor	0.0029	0.0005	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0104	0.0419
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0104	0.0419
Onchocerca volvulus	Huntingtin homolog	0.0121	0.0388	0.1619
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.0039	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0587	0.2456
Echinococcus granulosus	delta-like protein 1	0.0035	0.003	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0529	0.2211
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Trichomonas vaginalis	pyruvate kinase, putative	0.0032	0.0018	0.015
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0035	0.003	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Loa Loa (eye worm)	notch protein	0.0035	0.003	0.0108
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0064	0.0152	0.1327
Schistosoma mansoni	cercarial elastase (S01 family)	0.0129	0.0425	0.1772
Trichomonas vaginalis	replication factor C large subunit, putative	0.0029	0.0005	0.000004115
Schistosoma mansoni	notch	0.0035	0.003	0.0108
Echinococcus granulosus	nibrin	0.0029	0.0005	0.0027
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0029	0.0005	0.0001
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.0079	0.04
Echinococcus multilocularis	Tolloid protein 1	0.0039	0.0047	0.0043
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0064	0.0152	0.0792
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0053	0.0104	0.2383
Schistosoma mansoni	hypothetical protein	0.0121	0.0391	0.163
Schistosoma mansoni	hypothetical protein	0.0035	0.003	0.0108
Schistosoma mansoni	cercarial elastase (S01 family)	0.0129	0.0425	0.1772
Onchocerca volvulus	Putative cubilin	0.0035	0.003	0.0108
Echinococcus multilocularis	transmembrane protease serine 3	0.0129	0.0425	0.042
Onchocerca volvulus		0.0168	0.0587	0.2456
Echinococcus multilocularis	Niemann Pick C1 protein	0.0294	0.1111	0.1107
Schistosoma mansoni	hypothetical protein	0.0129	0.0425	0.1772
Schistosoma mansoni	hypothetical protein	0.0064	0.0149	0.0609
Brugia malayi	DKFZp564C0469 protein	0.0029	0.0005	0.0002
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0129	0.0425	0.1772
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0139	0.0567
Loa Loa (eye worm)	hypothetical protein	0.0035	0.003	0.0108
Echinococcus multilocularis	pyruvate kinase	0.0032	0.0018	0.0013
Brugia malayi	PAN domain containing protein	0.0168	0.0587	0.2456
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0071	0.0179	0.4139
Brugia malayi	Latrophilin receptor protein 2	0.0064	0.0149	0.0609
Loa Loa (eye worm)	hypothetical protein	0.0201	0.0724	0.3034
Echinococcus multilocularis	Niemann Pick C1 protein	0.042	0.1638	0.1635
Onchocerca volvulus	Arrow homolog	0.0039	0.0047	0.018
Brugia malayi	AMP-binding enzyme family protein	0.0071	0.0179	0.0735
Entamoeba histolytica	hypothetical protein	0.0072	0.0183	0.1607
Loa Loa (eye worm)	pyruvate kinase	0.0032	0.0018	0.0056
Schistosoma mansoni	notch	0.0035	0.003	0.0108
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0201	0.0724	0.3034
Loa Loa (eye worm)	hypothetical protein	0.0168	0.0587	0.2456
Toxoplasma gondii	hypothetical protein	0.0168	0.0587	0.1066
Schistosoma mansoni	notch	0.0035	0.003	0.0108
Echinococcus multilocularis	protein jagged 1	0.0035	0.003	0.0026

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 892102