Detailed information for compound 902362

Basic information

Technical information
  • TDR Targets ID: 902362
  • Name: N-[5-[(4-chlorophenyl)methyl]-1,3,4-thiadiazo l-2-yl]-2,2-dimethylpropanamide
  • MW: 309.814 | Formula: C14H16ClN3OS
  • H donors: 1 H acceptors: 3 LogP: 3.86 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)Cc1nnc(s1)NC(=O)C(C)(C)C
  • InChi: 1S/C14H16ClN3OS/c1-14(2,3)12(19)16-13-18-17-11(20-13)8-9-4-6-10(15)7-5-9/h4-7H,8H2,1-3H3,(H,16,18,19)
  • InChiKey: MTZRNOZFXMDDMC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[5-[(4-chlorophenyl)methyl]-1,3,4-thiadiazol-2-yl]-2,2-dimethyl-propanamide
  • N-[5-(4-chlorobenzyl)-1,3,4-thiadiazol-2-yl]-2,2-dimethyl-propionamide
  • ZINC04832363
  • BAS 00641884
  • N-[5-(4-Chloro-benzyl)-[1,3,4]thiadiazol-2-yl]-2,2-dimethyl-propionamide
  • Oprea1_291331
  • STOCK2S-55258
  • ZINC01237353
  • Oprea1_617083

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0185 0.1062 0.1183
Brugia malayi Cathepsin L-like precursor 0.0257 0.157 0.1756
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0078 0.0317 0.0344
Toxoplasma gondii cathepsin CPC2 0.0078 0.0317 0.1032
Brugia malayi ImpB/MucB/SamB family protein 0.0035 0.0015 0.0003
Loa Loa (eye worm) hypothetical protein 0.0089 0.0395 0.0431
Schistosoma mansoni cathepsin C 0.0078 0.0317 0.0344
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0163 0.0909 0.1011
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0013 0.0043
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0456 0.2965 0.333
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0089 0.0395 0.0431
Echinococcus granulosus dro:myosuppressin receptor 0.0163 0.0909 0.1011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0317 0.107
Echinococcus multilocularis cysteine protease 0.0257 0.157 0.1756
Giardia lamblia Cysteine protease 0.0078 0.0317 0.0708
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Giardia lamblia Cathepsin L precursor 0.0078 0.0317 0.0708
Echinococcus granulosus rhodopsin orphan GPCR 0.0163 0.0909 0.1011
Echinococcus granulosus cathepsin b 0.1301 0.8879 1
Giardia lamblia Cathepsin L precursor 0.0078 0.0317 0.0708
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0103 0.049 0.0478
Schistosoma mansoni tyrosine kinase 0.0232 0.1391 0.1554
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0257 0.157 0.5273
Onchocerca volvulus 0.0163 0.0909 0.5792
Brugia malayi hypothetical protein 0.0163 0.0909 0.1011
Trypanosoma cruzi cysteine peptidase, putative 0.0257 0.157 0.1756
Onchocerca volvulus 0.0257 0.157 1
Echinococcus granulosus g protein coupled receptor 0.0163 0.0909 0.1011
Schistosoma mansoni cathepsin S (C01 family) 0.0078 0.0317 0.0344
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0078 0.0317 0.107
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.0291 0.0314
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0116 0.0116
Onchocerca volvulus 0.0163 0.0909 0.5792
Onchocerca volvulus Serine\/threonine kinase homolog 0.0075 0.0291 0.1855
Loa Loa (eye worm) hypothetical protein 0.0185 0.1062 0.1183
Schistosoma mansoni DNA polymerase eta 0.0035 0.0015 0.0003
Echinococcus granulosus tachykinin peptides receptor 99D 0.0163 0.0909 0.1011
Entamoeba histolytica cysteine protease, putative 0.0151 0.0825 0.4176
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0163 0.0909 0.1011
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0456 0.2965 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0163 0.0909 0.1011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0163 0.0909 0.1011
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0078 0.0317 0.0708
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0257 0.157 0.1756
Onchocerca volvulus 0.0257 0.157 1
Entamoeba histolytica cysteine proteinase 2 0.0151 0.0825 0.4176
Entamoeba histolytica cysteine proteinase, putative 0.0151 0.0825 0.4176
Loa Loa (eye worm) TK/INSR protein kinase 0.0139 0.0744 0.0825
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0291 0.0982
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0257 0.157 0.5273
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Plasmodium falciparum serine repeat antigen 4 0.0078 0.0317 0.1186
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0078 0.0317 0.0708
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0163 0.0909 0.1011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0257 0.157 0.5273
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0291 0.0982
Loa Loa (eye worm) hypothetical protein 0.1301 0.8879 1
Leishmania major cathepsin L-like protease 0.0257 0.157 0.5273
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0257 0.157 0.5294
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0078 0.0317 0.1956
Echinococcus granulosus epidermal growth factor receptor 0.0234 0.1408 0.1574
Toxoplasma gondii histone lysine-specific demethylase 0.0103 0.049 0.1615
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0116 0.0116
Brugia malayi Papain family cysteine protease containing protein 0.0151 0.0825 0.0916
Loa Loa (eye worm) hypothetical protein 0.0054 0.0149 0.0153
Brugia malayi Serotonin receptor 0.0163 0.0909 0.1011
Echinococcus granulosus chromobox protein 1 0.0055 0.0152 0.0157
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0257 0.157 0.5273
Loa Loa (eye worm) hypothetical protein 0.0078 0.0317 0.0344
Brugia malayi G-protein coupled receptor 0.0163 0.0909 0.1011
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0078 0.0317 0.0205
Entamoeba histolytica cysteine proteinase, putative 0.0257 0.157 1
Echinococcus granulosus somatostatin receptor 0.0163 0.0909 0.1011
Echinococcus granulosus neuropeptide receptor 0.0163 0.0909 0.1011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0229 0.0244
Onchocerca volvulus 0.0163 0.0909 0.5792
Echinococcus multilocularis fmrfamide receptor 0.0163 0.0909 0.1011
Schistosoma mansoni cathepsin F (C01 family) 0.0257 0.157 0.1756
Onchocerca volvulus 0.0257 0.157 1
Giardia lamblia Cathepsin B precursor 0.0456 0.2965 1
Schistosoma mansoni amine oxidase 0.0103 0.049 0.0538
Echinococcus granulosus rhodopsin orphan GPCR 0.0163 0.0909 0.1011
Schistosoma mansoni hypothetical protein 0.0164 0.0916 0.1018
Loa Loa (eye worm) hypothetical protein 0.0093 0.042 0.0459
Brugia malayi G protein-coupled receptor F59B2.13 0.0163 0.0909 0.1011
Loa Loa (eye worm) fibroinase 0.0257 0.157 0.1756
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0257 0.157 0.5273
Schistosoma mansoni adenoreceptor 0.0163 0.0909 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0257 0.157 0.5294
Entamoeba histolytica cysteine proteinase, putative 0.0151 0.0825 0.4176
Leishmania major cathepsin L-like protease 0.0257 0.157 0.5273
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0257 0.157 0.5294
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Loa Loa (eye worm) hypothetical protein 0.0103 0.049 0.0538
Brugia malayi Tachykinin-like peptides receptor 99D 0.0163 0.0909 0.1011
Trichomonas vaginalis glutaminase, putative 0.0294 0.1827 0.6162
Schistosoma mansoni neuropeptide F-like receptor 0.0163 0.0909 0.1011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1301 0.8879 1
Plasmodium vivax vivapain-3 0.0151 0.0825 0.5217
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0089 0.0395 0.0431
Giardia lamblia Cathepsin L precursor 0.0078 0.0317 0.0708
Leishmania major cathepsin L-like protease 0.0257 0.157 0.5273
Onchocerca volvulus Cathepsin L homolog 0.0257 0.157 1
Brugia malayi fibroinase precursor 0.0078 0.0317 0.0344
Entamoeba histolytica cysteine protease, putative 0.0078 0.0317 0.0205
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0163 0.0909 0.1011
Entamoeba histolytica cysteine protease, putative 0.0078 0.0317 0.0205
Loa Loa (eye worm) hypothetical protein 0.0072 0.0277 0.0298
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0163 0.0909 0.1011
Loa Loa (eye worm) hypothetical protein 0.0118 0.0598 0.066
Brugia malayi G protein-coupled receptor 0.0163 0.0909 0.1011
Schistosoma mansoni opsin-like receptor 0.0163 0.0909 0.1011
Plasmodium falciparum serine repeat antigen 5 0.0078 0.0317 0.1186
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0234 0.1408 0.1574
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0013 0.0043
Brugia malayi Cathepsin L-like precursor 0.0185 0.1062 0.1183
Brugia malayi SWIRM domain containing protein 0.0103 0.049 0.0538
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0163 0.0909 0.1011
Schistosoma mansoni hypothetical protein 0.0163 0.0909 0.1011
Brugia malayi Melatonin receptor type 1A 0.0163 0.0909 0.1011
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0103 0.049 0.0538
Plasmodium falciparum cysteine proteinase falcipain 1 0.0151 0.0825 0.4759
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Echinococcus granulosus cathepsin l1 0.0185 0.1062 0.1183
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0078 0.0317 0.107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0825 0.2751
Brugia malayi hypothetical protein 0.0118 0.0598 0.066
Onchocerca volvulus 0.0163 0.0909 0.5792
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0163 0.0909 0.1011
Plasmodium vivax vivapain-2 0.0257 0.157 1
Plasmodium vivax unspecified product 0.0151 0.0825 0.5217
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0078 0.0317 0.1956
Giardia lamblia Cathepsin B precursor 0.0078 0.0317 0.0708
Leishmania major cysteine peptidase A (CPA) 0.0257 0.157 0.5273
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0163 0.0909 0.1011
Echinococcus granulosus fmrfamide receptor 0.0163 0.0909 0.1011
Leishmania major cathepsin L-like protease 0.0257 0.157 0.5273
Echinococcus granulosus serotonin receptor 0.0163 0.0909 0.1011
Schistosoma mansoni hypothetical protein 0.0163 0.0909 0.1011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0257 0.157 0.5294
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Schistosoma mansoni amine GPCR 0.0163 0.0909 0.1011
Entamoeba histolytica cysteine proteinase, putative 0.0151 0.0825 0.4176
Onchocerca volvulus 0.0257 0.157 1
Brugia malayi Dopamine receptor protein 2 0.0163 0.0909 0.1011
Plasmodium falciparum serine repeat antigen 6 0.0078 0.0317 0.1186
Loa Loa (eye worm) neuropeptide F receptor 0.0163 0.0909 0.1011
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0385 0.2465 0.2766
Onchocerca volvulus 0.0163 0.0909 0.5792
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0139 0.0744 0.0825
Echinococcus granulosus biogenic amine 5HT receptor 0.0163 0.0909 0.1011
Brugia malayi cathepsin L precursor 0.0078 0.0317 0.0344
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0072 0.0277 0.0298
Toxoplasma gondii preprocathepsin c precursor, putative 0.0078 0.0317 0.1032
Loa Loa (eye worm) cysteine protease 0.0257 0.157 0.1756
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0078 0.0317 0.0344
Toxoplasma gondii cathepsin CPL 0.0257 0.157 0.5273
Echinococcus granulosus rhodopsin orphan GPCR 0.0163 0.0909 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0257 0.157 0.5294
Echinococcus granulosus dna polymerase eta 0.0035 0.0015 0.0003
Onchocerca volvulus 0.0257 0.157 1
Schistosoma mansoni chromobox protein 0.0055 0.0152 0.0157
Echinococcus granulosus neuropeptide Y receptor 0.0163 0.0909 0.1011
Brugia malayi hypothetical protein 0.0163 0.0909 0.1011
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0116 0.0348
Giardia lamblia PHD finger protein 15 0.0054 0.0149 0.0117
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Echinococcus granulosus sex peptide receptor 0.0163 0.0909 0.1011
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0116 0.0348
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Mycobacterium tuberculosis Possible oxidoreductase 0.0103 0.049 0.0515
Giardia lamblia Cysteine protease 0.0078 0.0317 0.0708
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0139 0.0744 0.0825
Echinococcus multilocularis cysteine protease 0.0257 0.157 0.1756
Entamoeba histolytica cysteine proteinase, putative 0.0257 0.157 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0116 0.039
Echinococcus granulosus hypothetical protein 0.0163 0.0909 0.1011
Echinococcus multilocularis neuropeptide Y receptor 0.0163 0.0909 0.1011
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0317 0.107
Brugia malayi Dopamine receptor 0.0163 0.0909 0.1011
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0163 0.0909 0.1011
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0103 0.049 0.3063
Echinococcus multilocularis 0.0103 0.049 0.0538
Entamoeba histolytica cysteine protease, putative 0.0257 0.157 1
Brugia malayi Heterochromatin protein 1 0.0055 0.0152 0.0157
Trypanosoma cruzi major cysteine proteinase, putative 0.0078 0.0317 0.0344
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0257 0.157 0.1756
Echinococcus granulosus insulin receptor 0.0139 0.0744 0.0825
Echinococcus multilocularis allatostatin A receptor 0.0163 0.0909 0.1011
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0078 0.0317 0.1956
Brugia malayi G-protein coupled receptor 0.0163 0.0909 0.1011
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0078 0.0317 0.1956
Trypanosoma brucei DNA polymerase eta, putative 0.0035 0.0015 0.0008
Echinococcus granulosus peptide allatostatin:somatostatin 0.0163 0.0909 0.1011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0163 0.0909 0.1011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0257 0.157 0.5294
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0291 0.0982
Echinococcus multilocularis cathepsin b 0.1301 0.8879 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0163 0.0909 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0078 0.0317 0.107
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0317 0.107
Onchocerca volvulus 0.0163 0.0909 0.5792
Giardia lamblia Cathepsin B precursor 0.0078 0.0317 0.0708
Echinococcus granulosus neuropeptide receptor A26 0.0163 0.0909 0.1011
Echinococcus multilocularis g protein coupled receptor 0.0163 0.0909 0.1011
Onchocerca volvulus Huntingtin homolog 0.0118 0.0598 0.381
Echinococcus multilocularis serotonin receptor 0.0163 0.0909 0.1011
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0163 0.0909 0.5792
Onchocerca volvulus 0.0257 0.157 1
Brugia malayi Cathepsin L-like precursor 0.0257 0.157 0.1756
Loa Loa (eye worm) hypothetical protein 0.0072 0.0277 0.0298
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0151 0.0825 0.2751
Schistosoma mansoni growth hormone secretagogue receptor 0.0163 0.0909 0.1011
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0163 0.0909 0.1011
Trypanosoma brucei polo-like protein kinase 0.0075 0.0291 0.0943
Schistosoma mansoni tyrosine kinase 0.0232 0.1391 0.1554
Echinococcus multilocularis cathepsin L cysteine protease 0.0257 0.157 0.1756
Echinococcus multilocularis rhodopsin orphan GPCR 0.0163 0.0909 0.1011
Schistosoma mansoni amine oxidase 0.0103 0.049 0.0538
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0317 0.107
Loa Loa (eye worm) hypothetical protein 0.0078 0.0317 0.0344
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0075 0.0291 0.0943
Loa Loa (eye worm) G-protein coupled receptor 0.0163 0.0909 0.1011
Loa Loa (eye worm) hypothetical protein 0.0103 0.049 0.0538
Echinococcus multilocularis G protein coupled receptor 139 0.0163 0.0909 0.1011
Trypanosoma cruzi cysteine peptidase, putative 0.0257 0.157 0.1756
Echinococcus multilocularis cathepsin b 0.1301 0.8879 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Trypanosoma cruzi cysteine peptidase, putative 0.0257 0.157 0.1756
Leishmania major cathepsin L-like protease 0.0257 0.157 0.5273
Echinococcus multilocularis rhodopsin orphan GPCR 0.0163 0.0909 0.1011
Plasmodium vivax serine-repeat antigen (SERA) 0.0078 0.0317 0.1956
Entamoeba histolytica cysteine protease, putative 0.0151 0.0825 0.4176
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0103 0.049 0.2399
Entamoeba histolytica cysteine protease, putative 0.0151 0.0825 0.4176
Onchocerca volvulus 0.0035 0.0013 0.0082
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0163 0.0909 0.1011
Echinococcus multilocularis g protein coupled receptor 0.0163 0.0909 0.1011
Onchocerca volvulus 0.0163 0.0909 0.5792
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0163 0.0909 0.1011
Entamoeba histolytica cysteine protease, putative 0.0151 0.0825 0.4176
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0229 0.0244
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0185 0.1062 0.1183
Loa Loa (eye worm) TYRA-2 protein 0.0163 0.0909 0.1011
Brugia malayi sulfakinin receptor protein 0.0163 0.0909 0.1011
Schistosoma mansoni tyrosine kinase 0.0436 0.2819 0.3165
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0116 0.0116
Schistosoma mansoni neuropeptide receptor 0.0163 0.0909 0.1011
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0163 0.0909 0.1011
Echinococcus multilocularis cathepsin L cysteine protease 0.0257 0.157 0.1756
Giardia lamblia Cathepsin L precursor 0.0078 0.0317 0.0708
Leishmania major cathepsin L-like protease 0.0257 0.157 0.5273
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Echinococcus granulosus neuropeptides capa receptor 0.0163 0.0909 0.1011
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0013 0.0043
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0078 0.0317 0.1956
Entamoeba histolytica cysteine proteinase, putative 0.0185 0.1062 0.6029
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0163 0.0909 0.1011
Giardia lamblia Cathepsin L-like protease 0.0078 0.0317 0.0708
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0116 0.0116
Brugia malayi cathepsin F-like cysteine proteinase 0.0072 0.0277 0.0298
Echinococcus granulosus neuropeptide receptor 0.0163 0.0909 0.1011
Entamoeba histolytica cysteine protease, putative 0.0151 0.0825 0.4176
Echinococcus granulosus lysine specific demethylase 5A 0.0066 0.0229 0.0244
Echinococcus granulosus epidermal growth factor receptor 0.0436 0.2819 0.3165
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0456 0.2965 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0257 0.157 0.5294
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Trypanosoma cruzi cysteine peptidase, putative 0.0257 0.157 0.1756
Schistosoma mansoni opsin-like receptor 0.0163 0.0909 0.1011
Brugia malayi serine/threonine-protein kinase plk-2 0.0075 0.0291 0.0314
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0257 0.157 0.1756
Brugia malayi hypothetical protein 0.0163 0.0909 0.1011
Entamoeba histolytica cysteine protease, putative 0.0151 0.0825 0.4176
Echinococcus multilocularis neuropeptides capa receptor 0.0163 0.0909 0.1011
Loa Loa (eye worm) cathepsin B 0.0456 0.2965 0.333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.0825 0.2783
Echinococcus granulosus 7TM GPCR rhodopsin 0.0163 0.0909 0.1011
Schistosoma mansoni tyrosine kinase 0.0232 0.1391 0.1554
Plasmodium falciparum serine repeat antigen 3 0.0078 0.0317 0.1186
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1301 0.8879 1
Giardia lamblia Hypothetical protein 0.0078 0.0317 0.0708
Echinococcus multilocularis neuropeptide receptor A26 0.0163 0.0909 0.1011
Echinococcus multilocularis chromobox protein 1 0.0055 0.0152 0.0157
Toxoplasma gondii PHD-finger domain-containing protein 0.0054 0.0149 0.0461
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0229 0.0244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0257 0.157 0.5294
Echinococcus granulosus jumonji domain containing protein 0.0075 0.0297 0.0321
Onchocerca volvulus 0.0163 0.0909 0.5792
Plasmodium vivax hypothetical protein, conserved 0.0103 0.049 0.3063
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0163 0.0909 0.1011
Echinococcus granulosus neuropeptides capa receptor 0.0163 0.0909 0.1011
Entamoeba histolytica cysteine protease, putative 0.0151 0.0825 0.4176
Echinococcus granulosus cathepsin l cysteine peptidase 0.0257 0.157 0.1756
Brugia malayi cathepsin Z-like cysteine proteinase 0.0078 0.0317 0.0344
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0151 0.0825 0.0916
Echinococcus multilocularis geminin 0.0164 0.0916 0.1018
Onchocerca volvulus 0.0163 0.0909 0.5792
Loa Loa (eye worm) hypothetical protein 0.0118 0.0598 0.066
Brugia malayi hypothetical protein 0.0163 0.0909 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0257 0.157 0.5294
Giardia lamblia Cathepsin L precursor 0.0078 0.0317 0.0708
Entamoeba histolytica cysteine protease, putative 0.0078 0.0317 0.0205
Onchocerca volvulus Cathepsin L homolog 0.0257 0.157 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0151 0.0825 0.0916
Echinococcus multilocularis somatostatin receptor 0.0163 0.0909 0.1011
Brugia malayi glutaminase DH11.1 0.0294 0.1827 0.2047
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0291 0.0982
Echinococcus granulosus rhodopsin orphan GPCR 0.0163 0.0909 0.1011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0163 0.0909 0.1011
Schistosoma mansoni tyrosine kinase 0.0139 0.0744 0.0825
Echinococcus granulosus tm gpcr rhodopsin 0.0163 0.0909 0.1011
Brugia malayi Furin-like cysteine rich region family protein 0.0436 0.2819 0.3165
Onchocerca volvulus 0.0257 0.157 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0116 0.039
Onchocerca volvulus Alhambra homolog 0.0054 0.0149 0.0948
Echinococcus multilocularis neuropeptides capa receptor 0.0163 0.0909 0.1011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0257 0.157 0.5294
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0163 0.0909 0.1011
Echinococcus granulosus geminin 0.0164 0.0916 0.1018
Mycobacterium ulcerans monoamine oxidase 0.0103 0.049 0.0478
Echinococcus granulosus orexin receptor type 2 0.0163 0.0909 0.1011
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0163 0.0909 0.1011
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0078 0.0317 0.0344
Brugia malayi hypothetical protein 0.0103 0.049 0.0538
Echinococcus multilocularis insulin receptor 0.0139 0.0744 0.0825
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0163 0.0909 0.1011
Brugia malayi PHD-finger family protein 0.0054 0.0149 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0078 0.0317 0.107
Loa Loa (eye worm) hypothetical protein 0.0035 0.0015 0.0003
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Plasmodium vivax vivapain-2 0.0257 0.157 1
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0257 0.157 0.5294
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0078 0.0317 0.0344
Brugia malayi Cathepsin L-like precursor 0.0257 0.157 0.1756
Onchocerca volvulus 0.0163 0.0909 0.5792
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0151 0.0825 0.0916
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0078 0.0317 0.0205
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0257 0.157 0.5273
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0151 0.0825 0.0916
Schistosoma mansoni kinase 0.0038 0.0036 0.0026
Echinococcus granulosus cathepsin l1 0.0257 0.157 0.1756
Toxoplasma gondii PHD-finger domain-containing protein 0.0054 0.0149 0.0461
Loa Loa (eye worm) glutaminase 0.0294 0.1827 0.2047
Echinococcus multilocularis epidermal growth factor receptor 0.0234 0.1408 0.1574
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0163 0.0909 0.1011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1301 0.8879 1
Trypanosoma cruzi cruzipain precursor, putative 0.0257 0.157 0.1756
Echinococcus multilocularis dro:myosuppressin receptor 0.0163 0.0909 0.1011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0163 0.0909 0.1011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0078 0.0317 0.0344
Entamoeba histolytica cysteine protease, putative 0.0078 0.0317 0.0205
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0075 0.0291 0.0314
Loa Loa (eye worm) hypothetical protein 0.0185 0.1062 0.1183
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0163 0.0909 0.1011
Brugia malayi Papain family cysteine protease containing protein 0.0257 0.157 0.1756
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0163 0.0909 0.1011
Plasmodium vivax unspecified product 0.0078 0.0317 0.1956
Schistosoma mansoni biogenic amine receptor 0.0163 0.0909 0.1011
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Echinococcus multilocularis orexin receptor type 2 0.0163 0.0909 0.1011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0163 0.0909 0.1011
Schistosoma mansoni hypothetical protein 0.0163 0.0909 0.1011
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0116 0.0116
Brugia malayi cathepsin B-like cysteine proteinase 0.1301 0.8879 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0078 0.0317 0.1956
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0291 0.0982
Trichomonas vaginalis esterase, putative 0.0035 0.0013 0.0043
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0078 0.0317 0.0708
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0163 0.0909 0.1011
Onchocerca volvulus 0.0163 0.0909 0.5792
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0078 0.0317 0.107
Schistosoma mansoni hypothetical protein 0.0164 0.0916 0.1018
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0116 0.0116
Echinococcus granulosus biogenic amine 5HT receptor 0.0163 0.0909 0.1011
Echinococcus multilocularis fmrfamide receptor 0.0163 0.0909 0.1011
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0116 0.039
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0163 0.0909 0.1011
Entamoeba histolytica cysteine protease, putative 0.0151 0.0825 0.4176
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0257 0.157 0.5294
Loa Loa (eye worm) heterochromatin protein 1 0.0055 0.0152 0.0157
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0257 0.157 0.5294
Echinococcus granulosus rhodopsin orphan GPCR 0.0163 0.0909 0.1011
Schistosoma mansoni neuropeptide receptor 0.0163 0.0909 0.1011
Brugia malayi hypothetical protein 0.0163 0.0909 0.1011
Mycobacterium ulcerans oxidoreductase 0.0103 0.049 0.0478
Entamoeba histolytica cysteine protease, putative 0.0078 0.0317 0.0205
Loa Loa (eye worm) hypothetical protein 0.0078 0.0317 0.0344
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0257 0.157 0.5294
Brugia malayi putative neuropeptide receptor NPR1 0.0163 0.0909 0.1011
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0075 0.0291 0.0314
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0317 0.107
Echinococcus multilocularis g-protein coupled receptor 0.0163 0.0909 0.1011
Brugia malayi hypothetical protein 0.0163 0.0909 0.1011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0163 0.0909 0.1011
Echinococcus granulosus cathepsin b 0.1301 0.8879 1
Echinococcus multilocularis dna polymerase eta 0.0035 0.0015 0.0003
Giardia lamblia Hypothetical protein 0.0078 0.0317 0.0708
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0163 0.0909 0.1011
Brugia malayi Cathepsin L-like cysteine proteinase 0.0185 0.1062 0.1183
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0078 0.0317 0.0344
Brugia malayi follicle stimulating hormone receptor 0.0385 0.2465 0.2766
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0163 0.0909 0.1011
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0078 0.0317 0.1186
Brugia malayi Papain family cysteine protease containing protein 0.0151 0.0825 0.0916
Loa Loa (eye worm) hypothetical protein 0.0078 0.0317 0.0344
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Schistosoma mansoni tyrosine kinase 0.0139 0.0744 0.0825
Brugia malayi GnHR receptor homolog 0.0163 0.0909 0.1011
Giardia lamblia Cathepsin B precursor 0.0456 0.2965 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0078 0.0317 0.0344
Echinococcus multilocularis G-protein coupled receptor, putative 0.0163 0.0909 0.1011
Schistosoma mansoni neuropeptide receptor 0.0163 0.0909 0.1011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0163 0.0909 0.1011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0257 0.157 0.5294
Entamoeba histolytica cysteine proteinase 1, putative 0.0151 0.0825 0.4176
Echinococcus granulosus alpha 1A adrenergic receptor 0.0163 0.0909 0.1011
Brugia malayi Calcitonin receptor-like protein seb-1 0.0089 0.0395 0.0431
Brugia malayi larval opioid receptor 0.0163 0.0909 0.1011
Schistosoma mansoni neuropeptide receptor 0.0163 0.0909 0.1011
Schistosoma mansoni opsin-like receptor 0.0163 0.0909 0.1011
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0163 0.0909 0.1011
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0257 0.157 1
Echinococcus granulosus g protein coupled receptor 0.0163 0.0909 0.1011
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0078 0.0317 0.1956
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0178 0.1012 0.1128
Echinococcus granulosus lysine specific histone demethylase 1A 0.0103 0.049 0.0538
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0257 0.157 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0054 0.0149 0.0153
Mycobacterium tuberculosis Conserved hypothetical protein 0.0103 0.049 0.0515
Echinococcus granulosus chromobox protein 1 0.0055 0.0152 0.0157
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0163 0.0909 0.1011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0163 0.0909 0.1011
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0163 0.0909 0.1011
Plasmodium falciparum serine repeat antigen 2 0.0078 0.0317 0.1186
Loa Loa (eye worm) hypothetical protein 0.0103 0.049 0.0538
Mycobacterium ulcerans glutaminase 0.0294 0.1827 0.1817
Onchocerca volvulus 0.0035 0.0013 0.0082
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0163 0.0909 0.1011
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0078 0.0317 0.1956
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1461 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0163 0.0909 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0317 0.107
Echinococcus multilocularis rhodopsin orphan GPCR 0.0163 0.0909 0.1011
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1358 0.928 1
Brugia malayi neuropeptide F receptor 0.0163 0.0909 0.1011
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0078 0.0317 0.1186
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0103 0.049 0.2399
Giardia lamblia Kinase, PLK 0.0075 0.0291 0.0616
Echinococcus granulosus tm gpcr rhodopsin 0.0163 0.0909 0.1011
Giardia lamblia Cathepsin L precursor 0.0078 0.0317 0.0708
Trichomonas vaginalis chromobox protein, putative 0.0055 0.0152 0.0512
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0163 0.0909 0.1011
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0072 0.0277 0.0298
Entamoeba histolytica cysteine protease, putative 0.0151 0.0825 0.4176
Loa Loa (eye worm) neuropeptide F receptor 0.0163 0.0909 0.1011
Leishmania major UDP-galactopyranose mutase 0.0103 0.049 0.1615
Trypanosoma cruzi polo-like protein kinase, putative 0.0075 0.0291 0.0314
Brugia malayi Cathepsin L-like precursor 0.0185 0.1062 0.1183
Echinococcus granulosus neuropeptide Y receptor 0.0163 0.0909 0.1011
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0163 0.0909 0.1011
Onchocerca volvulus 0.0185 0.1062 0.6766
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0116 0.0116
Brugia malayi cathepsin Z-like cysteine proteinase 0.0078 0.0317 0.0344
Brugia malayi cathepsin L-like precursor 0.0185 0.1062 0.1183
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0291 0.0982
Loa Loa (eye worm) hypothetical protein 0.0061 0.0197 0.0208
Trypanosoma brucei cysteine peptidase C (CPC) 0.0456 0.2965 1
Schistosoma mansoni chromobox protein 0.0055 0.0152 0.0157
Schistosoma mansoni cathepsin B (C01 family) 0.0078 0.0317 0.0344
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0257 0.157 0.5294
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0103 0.049 0.0538
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0277 0.0298
Loa Loa (eye worm) TK/EGFR protein kinase 0.0436 0.2819 0.3165
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0163 0.0909 0.1011
Trypanosoma cruzi UDP-galactopyranose mutase 0.0103 0.049 0.0538
Loa Loa (eye worm) melatonin receptor type 1A 0.0163 0.0909 0.1011
Onchocerca volvulus Huntingtin homolog 0.0118 0.0598 0.381
Plasmodium falciparum serine repeat antigen 1 0.0078 0.0317 0.1186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0257 0.157 0.5294
Echinococcus multilocularis neuropeptide receptor 0.0163 0.0909 0.1011
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0163 0.0909 0.1011
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0078 0.0317 0.1956
Giardia lamblia Cysteine protease 0.0078 0.0317 0.0708
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Schistosoma mansoni biogenic amine receptor 0.0163 0.0909 0.1011
Brugia malayi putative neuropeptide receptor 0.0163 0.0909 0.1011
Onchocerca volvulus 0.0163 0.0909 0.5792
Schistosoma mansoni cathepsin F (C01 family) 0.0257 0.157 0.1756
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0103 0.049 0.1615
Schistosoma mansoni hypothetical protein 0.0163 0.0909 0.1011
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0257 0.157 0.1756
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0163 0.0909 0.1011
Echinococcus multilocularis PHD finger protein rhinoceros 0.0054 0.0149 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0257 0.157 0.5294
Echinococcus granulosus cathepsin L cysteine proteinase 0.0257 0.157 0.1756
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0257 0.157 0.5273
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0078 0.0317 0.0708
Brugia malayi latrophilin 2 splice variant baaae 0.0061 0.0197 0.0208
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0257 0.157 0.5294
Brugia malayi Cathepsin L-like precursor 0.0257 0.157 0.1756
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0116 0.0116
Echinococcus granulosus 7tm_1 domain containing protein 0.0163 0.0909 0.1011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0257 0.157 0.5273
Brugia malayi Cathepsin L-like precursor 0.0072 0.0277 0.0298
Echinococcus granulosus G protein coupled receptor 139 0.0163 0.0909 0.1011
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Brugia malayi neuropeptide F receptor 0.0163 0.0909 0.1011
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0078 0.0317 0.1186
Schistosoma mansoni biogenic amine receptor 0.0163 0.0909 0.1011
Echinococcus granulosus peregrin 0.0054 0.0149 0.0153
Brugia malayi hypothetical protein 0.0163 0.0909 0.1011
Schistosoma mansoni tyrosine kinase 0.0234 0.1408 0.1574
Leishmania major cathepsin L-like protease 0.0257 0.157 0.5273
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0054 0.0149 0.0153
Schistosoma mansoni cathepsin s 0.0072 0.0277 0.0298
Echinococcus multilocularis cathepsin L 0.0151 0.0825 0.0916
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Giardia lamblia Cathepsin B precursor 0.0456 0.2965 1
Loa Loa (eye worm) glutaminase 2 0.0294 0.1827 0.2047
Plasmodium falciparum protoporphyrinogen oxidase 0.0103 0.049 0.2399
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0078 0.0317 0.0344
Echinococcus granulosus cathepsin L cysteine protease 0.0151 0.0825 0.0916
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0257 0.157 0.5294
Chlamydia trachomatis protoporphyrinogen oxidase 0.0103 0.049 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0029 0.0098
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0149 0.0874
Plasmodium vivax hypothetical protein, conserved 0.0103 0.049 0.3063
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0103 0.049 0.3063
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0078 0.0317 0.107
Trypanosoma cruzi cysteine proteinase, putative 0.0151 0.0825 0.0916
Schistosoma mansoni glutaminase 0.0294 0.1827 0.2047
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0078 0.0317 0.0344
Echinococcus multilocularis neuropeptide Y receptor 0.0163 0.0909 0.1011
Entamoeba histolytica cysteine protease, putative 0.0151 0.0825 0.4176
Entamoeba histolytica hypothetical protein 0.0078 0.0317 0.0205
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0178 0.1012 0.1128
Plasmodium falciparum serine repeat antigen 9 0.0078 0.0317 0.1186
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0317 0.107
Loa Loa (eye worm) hypothetical protein 0.0078 0.0317 0.0344
Schistosoma mansoni alpha-1 adrenergic receptor 0.0163 0.0909 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0151 0.0825 0.2783
Brugia malayi hypothetical protein 0.0163 0.0909 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0257 0.157 0.5294
Trypanosoma cruzi polo-like protein kinase, putative 0.0075 0.0291 0.0314
Echinococcus multilocularis neuropeptide s receptor 0.0163 0.0909 0.1011
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Loa Loa (eye worm) jmjC domain-containing protein 0.0112 0.0553 0.0609
Echinococcus multilocularis jumonji domain containing protein 0.0075 0.0297 0.0321
Brugia malayi Bromodomain containing protein 0.0054 0.0149 0.0153
Plasmodium falciparum cysteine proteinase falcipain 3 0.0257 0.157 1
Giardia lamblia Encystation-specific protease 0.0078 0.0317 0.0708
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0116 0.0116
Echinococcus granulosus g protein coupled receptor 0.0163 0.0909 0.1011
Plasmodium vivax unspecified product 0.0072 0.0277 0.1696
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0116 0.0348
Schistosoma mansoni amine GPCR 0.0163 0.0909 0.1011
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Trypanosoma cruzi cysteine protease, putative 0.0151 0.0825 0.0916
Echinococcus granulosus tm gpcr rhodopsin 0.0163 0.0909 0.1011
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0013 0.0043
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0163 0.0909 0.1011
Echinococcus multilocularis lysine specific demethylase 5A 0.0066 0.0229 0.0244
Onchocerca volvulus 0.0163 0.0909 0.5792
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0163 0.0909 0.1011
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0317 0.0344
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0163 0.0909 0.1011
Leishmania major DNA polymerase eta, putative 0.0035 0.0015 0.0008
Onchocerca volvulus 0.0103 0.049 0.312
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0163 0.0909 0.1011
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0163 0.0909 0.1011
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Brugia malayi RE15519p 0.0163 0.0909 0.1011
Plasmodium vivax vivapain-1 0.0151 0.0825 0.5217
Brugia malayi ORL1-like opioid receptor 0.0163 0.0909 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0185 0.1062 0.3582
Schistosoma mansoni biogenic amine (5HT) receptor 0.0163 0.0909 0.1011
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0078 0.0317 0.1956
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0163 0.0909 0.1011
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0013 0.0043
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.1325 0.1416
Trypanosoma brucei protein kinase, putative 0.0049 0.0116 0.0348
Schistosoma mansoni tyrosine kinase 0.0234 0.1408 0.1574
Echinococcus granulosus rhodopsin orphan GPCR 0.0163 0.0909 0.1011
Brugia malayi Protein kinase domain containing protein 0.0139 0.0744 0.0825
Schistosoma mansoni jumonji domain containing protein 0.0141 0.0757 0.0839
Brugia malayi MAP kinase sur-1 0.0049 0.0116 0.0116
Echinococcus multilocularis neuropeptide receptor 0.0163 0.0909 0.1011
Echinococcus multilocularis 0.0135 0.0713 0.079
Schistosoma mansoni neuropeptide f receptor 76f 0.0163 0.0909 0.1011
Toxoplasma gondii cathepsin B 0.0456 0.2965 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0163 0.0909 0.1011
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0257 0.157 0.5294
Brugia malayi hypothetical protein 0.0163 0.0909 0.1011
Trypanosoma cruzi cysteine proteinase, putative 0.0151 0.0825 0.0916
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1301 0.8879 1
Leishmania major cathepsin L-like protease 0.0257 0.157 0.5273
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0257 0.157 0.5294
Giardia lamblia Cathepsin L-like protease 0.0078 0.0317 0.0708
Loa Loa (eye worm) hypothetical protein 0.0257 0.157 0.1756
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0078 0.0317 0.0344
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0015 0.0003
Schistosoma mansoni neuropeptide F-like receptor 0.0163 0.0909 0.1011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0163 0.0909 0.1011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0163 0.0909 0.1011
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0078 0.0317 0.0344
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0078 0.0317 0.1956
Loa Loa (eye worm) ctsf protein 0.0257 0.157 0.1756
Trichomonas vaginalis chromobox protein, putative 0.0055 0.0152 0.0512
Plasmodium falciparum serine repeat antigen 7 0.0078 0.0317 0.1186
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0163 0.0909 0.1011
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0116 0.0116
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0317 0.107
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0163 0.0909 0.1011
Schistosoma mansoni cathepsin F (C01 family) 0.0185 0.1062 0.1183
Schistosoma mansoni histamine h1 receptor 0.0163 0.0909 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0185 0.1062 0.3582
Brugia malayi AKH receptor 0.0163 0.0909 0.1011
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Loa Loa (eye worm) hypothetical protein 0.0078 0.0317 0.0344
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0078 0.0317 0.0344
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0078 0.0317 0.107
Loa Loa (eye worm) hypothetical protein 0.0072 0.0277 0.0298
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Entamoeba histolytica cysteine protease, putative 0.0151 0.0825 0.4176
Entamoeba histolytica cysteine protease, putative 0.0078 0.0317 0.0205
Giardia lamblia Cathepsin B precursor 0.0078 0.0317 0.0708
Onchocerca volvulus 0.0163 0.0909 0.5792
Echinococcus multilocularis epidermal growth factor receptor 0.0436 0.2819 0.3165
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0257 0.157 0.5273
Brugia malayi Cathepsin L-like precursor 0.0257 0.157 0.1756
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0075 0.0291 0.0314
Brugia malayi Serotonin receptor 0.0163 0.0909 0.1011
Onchocerca volvulus Cathepsin F homolog 0.0257 0.157 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1301 0.8879 1
Entamoeba histolytica cysteine protease, putative 0.0151 0.0825 0.4176
Echinococcus granulosus cathepsin L 0.0151 0.0825 0.0916
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0029 0.0098
Brugia malayi jmjC domain containing protein 0.0178 0.1012 0.1128
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0277 0.0298
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0257 0.157 0.5294
Toxoplasma gondii cathepsin CPC1 0.0078 0.0317 0.1032
Loa Loa (eye worm) hypothetical protein 0.0103 0.049 0.0538
Mycobacterium ulcerans dehydrogenase 0.0103 0.049 0.0478
Brugia malayi Cathepsin L-like precursor 0.0257 0.157 0.1756
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0257 0.157 0.5273
Echinococcus multilocularis serotonin receptor 0.0163 0.0909 0.1011
Echinococcus multilocularis sex peptide receptor 0.0163 0.0909 0.1011
Loa Loa (eye worm) hypothetical protein 0.0103 0.049 0.0538
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Plasmodium falciparum serine repeat antigen 8 0.0078 0.0317 0.1186
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0116 0.039
Trypanosoma cruzi major cysteine proteinase, putative 0.0078 0.0317 0.0344
Echinococcus granulosus g-protein coupled receptor 0.0163 0.0909 0.1011
Onchocerca volvulus 0.0163 0.0909 0.5792
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0257 0.157 0.5294
Brugia malayi jmjC domain containing protein 0.0066 0.0229 0.0244
Echinococcus granulosus lysine specific histone demethylase 1A 0.0103 0.049 0.0538
Schistosoma mansoni hypothetical protein 0.0054 0.0149 0.0153
Loa Loa (eye worm) hypothetical protein 0.0103 0.049 0.0538
Entamoeba histolytica cysteine proteinase, putative 0.0151 0.0825 0.4176
Echinococcus multilocularis rhodopsin orphan GPCR 0.0163 0.0909 0.1011
Echinococcus granulosus allatostatin A receptor 0.0163 0.0909 0.1011
Echinococcus multilocularis neuropeptide FF receptor 2 0.0163 0.0909 0.1011
Brugia malayi cathepsin F-like cysteine proteinase 0.0078 0.0317 0.0344
Brugia malayi cathepsin L-like cysteine proteinase 0.0078 0.0317 0.0344
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0163 0.0909 0.1011
Onchocerca volvulus 0.0078 0.0317 0.2022
Schistosoma mansoni amine GPCR 0.0163 0.0909 0.1011
Brugia malayi Dopamine receptor protein 1 0.0163 0.0909 0.1011
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0317 0.0344
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Onchocerca volvulus Cathepsin L homolog 0.0078 0.0317 0.2022
Onchocerca volvulus 0.0163 0.0909 0.5792
Echinococcus multilocularis chromobox protein 1 0.0055 0.0152 0.0157
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0103 0.049 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0103 0.049 0.0538
Entamoeba histolytica cysteine protease, putative 0.0151 0.0825 0.4176
Onchocerca volvulus 0.0163 0.0909 0.5792
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0103 0.049 0.0538
Echinococcus multilocularis protoporphyrinogen oxidase 0.0103 0.049 0.0538
Echinococcus granulosus cysteine protease 0.0151 0.0825 0.0916
Schistosoma mansoni myosin xvIII 0.0163 0.0909 0.1011
Trypanosoma cruzi cysteine peptidase, putative 0.0151 0.0825 0.0916
Echinococcus granulosus cathepsin L 0.0078 0.0317 0.0344
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0257 0.157 0.5273
Schistosoma mansoni biogenic amine (5HT) receptor 0.0163 0.0909 0.1011
Giardia lamblia Cysteine protease 0.0078 0.0317 0.0708
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0317 0.107
Echinococcus granulosus neuropeptide s receptor 0.0163 0.0909 0.1011
Giardia lamblia Cathepsin B precursor 0.0078 0.0317 0.0708
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Schistosoma mansoni amine GPCR 0.0163 0.0909 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0078 0.0317 0.107
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0317 0.0344
Trichomonas vaginalis CAMK family protein kinase 0.0075 0.0291 0.0982
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0317 0.107
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0456 0.2965 0.333
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0078 0.0317 0.0344
Onchocerca volvulus Neuropeptide F receptor homolog 0.0163 0.0909 0.5792
Echinococcus multilocularis peregrin 0.0054 0.0149 0.0153
Onchocerca volvulus 0.0035 0.0013 0.0082
Loa Loa (eye worm) PHD-finger family protein 0.0054 0.0149 0.0153
Schistosoma mansoni amine GPCR 0.0163 0.0909 0.1011
Loa Loa (eye worm) hypothetical protein 0.0163 0.0909 0.1011
Loa Loa (eye worm) G-protein coupled receptor 0.0163 0.0909 0.1011
Schistosoma mansoni hypothetical protein 0.0061 0.0197 0.0208
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0116 0.0348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0317 0.107
Giardia lamblia Cathepsin B precursor 0.0078 0.0317 0.0708
Echinococcus multilocularis g protein coupled receptor 0.0163 0.0909 0.1011
Brugia malayi hypothetical protein 0.0163 0.0909 0.1011
Echinococcus multilocularis cathepsin L 0.0078 0.0317 0.0344
Trypanosoma cruzi UDP-galactopyranose mutase 0.0103 0.049 0.0538

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.