Detailed information for compound 903171

Basic information

Technical information
  • TDR Targets ID: 903171
  • Name: [[amino-(4-bromophenyl)methylidene]amino] 2-( 4-methoxyphenoxy)propanoate
  • MW: 393.232 | Formula: C17H17BrN2O4
  • H donors: 1 H acceptors: 1 LogP: 4.13 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)OC(C(=O)ONC(=N)c1ccc(cc1)Br)C
  • InChi: 1S/C17H17BrN2O4/c1-11(23-15-9-7-14(22-2)8-10-15)17(21)24-20-16(19)12-3-5-13(18)6-4-12/h3-11H,1-2H3,(H2,19,20)
  • InChiKey: WIEONCVXNWPTGQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [[amino-(4-bromophenyl)methylene]amino] 2-(4-methoxyphenoxy)propanoate
  • 2-(4-methoxyphenoxy)propanoic acid [[amino-(4-bromophenyl)methylene]amino] ester
  • 2-(4-methoxyphenoxy)propionic acid [[amino-(4-bromophenyl)methylene]amino] ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucosylceramidase, putative 0.0515 0.1498 0.6368
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0042 0.0031 0.0133
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0637 0.1874 1
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.0298 0.1279
Entamoeba histolytica hypothetical protein 0.0108 0.0237 0.26
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0027 0.0027
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.035 0.0985 0.2227
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.0881 0.4611
Schistosoma mansoni hypothetical protein 0.0108 0.0237 0.1179
Brugia malayi Pre-SET motif family protein 0.0208 0.0547 0.2345
Loa Loa (eye worm) hypothetical protein 0.0055 0.0073 0.0313
Plasmodium vivax acyl-CoA synthetase, putative 0.0106 0.0231 0.1104
Schistosoma mansoni hypothetical protein 0.0083 0.0158 0.0788
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0069 0.0208
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0822 0.3432
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0011 0.0055
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.0298 0.1279
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0031 0.0133
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0052 0.0052
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0042 0.0031 0.0042
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0073 0.0364
Echinococcus multilocularis geminin 0.068 0.2007 0.2007
Loa Loa (eye worm) hypothetical protein 0.0106 0.0231 0.0991
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0277 0.0759 0.3254
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0822 0.3432
Entamoeba histolytica hypothetical protein 0.0108 0.0237 0.26
Brugia malayi RNA binding protein 0.0128 0.0298 0.1279
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0822 0.3432
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0011 0.0011
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0031 0.0042
Trypanosoma brucei GMP reductase 0.0637 0.1874 1
Toxoplasma gondii IMP dehydrogenas 0.0637 0.1874 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0822 0.3432
Entamoeba histolytica acyl-CoA synthetase, putative 0.0142 0.0343 0.3943
Entamoeba histolytica acyl-CoA synthetase, putative 0.0142 0.0343 0.3943
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0637 0.1874 0.8027
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0088 0.0378
Loa Loa (eye worm) MBCTL1 0.0055 0.0073 0.0313
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0213 0.0911
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0298 0.1487
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0637 0.1874 0.4299
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0042 0.0031 0.0042
Echinococcus granulosus snurportin 1 0.0312 0.0869 0.433
Mycobacterium ulcerans hypothetical protein 0.0166 0.0417 0.0901
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0637 0.1874 1
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0627 0.1843 0.4228
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0106 0.0231 0.0467
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0192 0.0821
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0042 0.0031 0.0133
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0785 0.2334 1
Brugia malayi mbt repeat family protein 0.0049 0.0052 0.0224
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1425 0.4317 1
Onchocerca volvulus 0.0049 0.0052 0.0144
Leishmania major 4-coumarate:coa ligase-like protein 0.0142 0.0343 0.1691
Trichomonas vaginalis glucosylceramidase, putative 0.0785 0.2334 1
Echinococcus multilocularis tar DNA binding protein 0.0128 0.0298 0.0298
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.0869 0.3723
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0142 0.0343 0.0727
Entamoeba histolytica hypothetical protein 0.0108 0.0237 0.26
Leishmania major inosine-5-monophosphate dehydrogenase 0.0637 0.1874 1
Schistosoma mansoni hypothetical protein 0.0312 0.0869 0.433
Echinococcus granulosus tar DNA binding protein 0.0128 0.0298 0.1487
Echinococcus multilocularis expressed conserved protein 0.0188 0.0484 0.0484
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.0822 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0101 0.0213 0.0465
Brugia malayi hypothetical protein 0.0108 0.0237 0.1014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0101 0.0213 0.0465
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0101 0.0213 0.0465
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0637 0.1874 0.9337
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.0495 0.2467
Brugia malayi RNA, U transporter 1 0.0083 0.0159 0.0682
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0142 0.0343 0.0727
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0106 0.0231 0.5
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.0168 0.0836
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0277 0.0759 0.3254
Mycobacterium ulcerans TetR family transcriptional regulator 0.1425 0.4317 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0031 0.0133
Brugia malayi AMP-binding enzyme family protein 0.0142 0.0343 0.1469
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0042 0.0031 0.0155
Brugia malayi jmjC domain containing protein 0.0096 0.0198 0.0847
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0637 0.1874 0.1874
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0052 0.026
Loa Loa (eye worm) hypothetical protein 0.0106 0.0231 0.0991
Loa Loa (eye worm) hypothetical protein 0.0106 0.0231 0.0991
Loa Loa (eye worm) RNA binding protein 0.0128 0.0298 0.1279
Trichomonas vaginalis glucosylceramidase, putative 0.0785 0.2334 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0073 0.0313
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0042 0.0031 0.0042
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0052 0.0224
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0052 0.026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0192 0.0955
Plasmodium falciparum acyl-CoA synthetase 0.0106 0.0231 0.1104
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0192 0.0192
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.0351 0.0746
Schistosoma mansoni hypothetical protein 0.0083 0.0158 0.0788
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0042 0.0031 0.0133
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0042 0.0031 0.0042
Loa Loa (eye worm) hypothetical protein 0.0106 0.0231 0.0991
Schistosoma mansoni patched 1 0.0086 0.0168 0.0836
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0031 0.0042
Onchocerca volvulus Putative GMP reductase 0.0277 0.0759 0.4967
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0213 0.0911
Loa Loa (eye worm) hypothetical protein 0.0042 0.0031 0.0133
Mycobacterium ulcerans acyl-CoA synthetase 0.0142 0.0343 0.0727
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0142 0.0343 0.0766
Loa Loa (eye worm) hypothetical protein 0.0238 0.0639 0.2737
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0142 0.0343 0.0727
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0637 0.1874 0.4299
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0627 0.1843 1
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0287 0.079 0.177
Mycobacterium tuberculosis Conserved hypothetical protein 0.0166 0.0417 0.0939
Entamoeba histolytica acyl-coA synthetase, putative 0.0142 0.0343 0.3943
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0052 0.0223
Loa Loa (eye worm) GMP reductase 0.0277 0.0759 0.3254
Echinococcus granulosus Niemann Pick C1 protein 0.0286 0.0788 0.3927
Brugia malayi jmjC domain containing protein 0.0035 0.0011 0.0047
Trichomonas vaginalis glucosylceramidase, putative 0.0785 0.2334 1
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0637 0.1874 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0316 0.0881 0.4611
Brugia malayi AMP-binding enzyme family protein 0.0142 0.0343 0.1469
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0011 0.0055
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0031 0.0042
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0237 0.0237
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0639 0.3183
Echinococcus multilocularis protein dispatched 1 0.0098 0.0205 0.0205
Mycobacterium ulcerans acyl-CoA synthetase 0.0142 0.0343 0.0727
Loa Loa (eye worm) oxidoreductase 0.0042 0.0031 0.0133
Leishmania major mitochondrial DNA polymerase beta 0.0316 0.0881 0.4611
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0142 0.0343 0.0727
Echinococcus multilocularis protein patched 0.0086 0.0168 0.0168
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0639 0.0639
Brugia malayi hypothetical protein 0.0238 0.0639 0.2737
Trichomonas vaginalis glucosylceramidase, putative 0.0515 0.1498 0.6368
Schistosoma mansoni hypothetical protein 0.0049 0.0052 0.0259
Brugia malayi GMP reductase 0.0277 0.0759 0.3254
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0101 0.0213 0.0465
Schistosoma mansoni hypothetical protein 0.0083 0.0158 0.0788
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0198 0.0986
Echinococcus granulosus expressed conserved protein 0.0188 0.0484 0.2413
Loa Loa (eye worm) hypothetical protein 0.02 0.0522 0.2236
Echinococcus granulosus geminin 0.068 0.2007 1
Trichomonas vaginalis glucosylceramidase, putative 0.0785 0.2334 1
Trichomonas vaginalis set domain proteins, putative 0.0237 0.0636 0.2628
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0637 0.1874 0.5
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.0351 0.0746
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0627 0.1843 1
Brugia malayi TAR-binding protein 0.0128 0.0298 0.1279
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0192 0.0955
Onchocerca volvulus 0.0142 0.0343 0.2125
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0192 0.0821
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0039 0.0044
Trichomonas vaginalis glucosylceramidase, putative 0.0543 0.1583 0.6741
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0073 0.0073
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0192 0.0955
Mycobacterium ulcerans hypothetical protein 0.0142 0.0343 0.0727
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0192 0.0192
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0052 0.026
Loa Loa (eye worm) hypothetical protein 0.0105 0.0228 0.0975
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0042 0.0031 0.0042
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0198 0.0198
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0073 0.0073
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0031 0.0133
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0039 0.0044
Echinococcus granulosus Niemann Pick C1 protein 0.02 0.0522 0.26
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0237 0.1179
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0213 0.0911
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0822 0.3432
Trypanosoma cruzi GMP reductase 0.0637 0.1874 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0168 0.0719
Loa Loa (eye worm) hypothetical protein 0.0042 0.0031 0.0133
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0073 0.0364
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0822 0.3432
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0298 0.1487
Trichomonas vaginalis glucosylceramidase, putative 0.0543 0.1583 0.6741
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0042 0.0031 0.0042
Schistosoma mansoni hypothetical protein 0.0296 0.0817 0.4073
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0168 0.0593
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0039 0.0044
Echinococcus granulosus Protein patched homolog 1 0.0086 0.0168 0.0836
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.0351 0.0785
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0142 0.0343 0.0727
Toxoplasma gondii hypothetical protein 0.0051 0.006 0.0154
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0637 0.1874 0.9337
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0298 0.1487
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0785 0.2334 1
Trichomonas vaginalis glucosylceramidase, putative 0.0515 0.1498 0.6368
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0052 0.0144
Onchocerca volvulus 0.0237 0.0636 0.4127
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0027 0.0137
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0011 0.0047
Trichomonas vaginalis glucosylceramidase, putative 0.0515 0.1498 0.6368
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0073 0.0364
Trichomonas vaginalis glucosylceramidase, putative 0.0515 0.1498 0.6368
Loa Loa (eye worm) hypothetical protein 0.0106 0.0231 0.0991
Loa Loa (eye worm) hypothetical protein 0.005 0.0057 0.0243
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1425 0.4317 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0286 0.0788 0.0788
Loa Loa (eye worm) hypothetical protein 0.0142 0.0343 0.1469
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.0168 0.0168
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0192 0.0955
Leishmania major 4-coumarate:coa ligase-like protein 0.0142 0.0343 0.1691
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0039 0.0044
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0237 0.1179
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0298 0.1487
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0042 0.0031 0.0042
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0052 0.026
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0137 0.0682
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0142 0.0343 0.0727
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0031 0.0042
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.0365 0.1812
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0042 0.0031 0.0031
Loa Loa (eye worm) IMP dehydrogenase 1 0.0637 0.1874 0.8027
Loa Loa (eye worm) hypothetical protein 0.0142 0.0343 0.1469
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0637 0.1874 0.4323
Trichomonas vaginalis glucosylceramidase, putative 0.0785 0.2334 1
Trichomonas vaginalis glucosylceramidase, putative 0.0515 0.1498 0.6368
Onchocerca volvulus 0.005 0.0055 0.0164
Giardia lamblia Fructose-bisphosphate aldolase 0.0297 0.0822 0.5
Brugia malayi AMP-binding enzyme family protein 0.0142 0.0343 0.1469
Entamoeba histolytica hypothetical protein 0.0108 0.0237 0.26
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0547 0.2345
Echinococcus multilocularis Niemann Pick C1 protein 0.02 0.0522 0.0522
Mycobacterium ulcerans acyl-CoA synthetase 0.0142 0.0343 0.0727
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.0822 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0114 0.0489
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.0495 0.0495
Onchocerca volvulus 0.0049 0.0052 0.0142
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0203 0.0531 0.2648
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0052 0.0052
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0114 0.0489
Brugia malayi Niemann-Pick C1 protein precursor 0.02 0.0522 0.2236
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0822 0.3432
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0637 0.1874 1
Schistosoma mansoni hypothetical protein 0.0069 0.0114 0.0569
Mycobacterium ulcerans transcriptional regulator 0.1425 0.4317 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0052 0.026
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0011 0.0055
Trichomonas vaginalis glucosylceramidase, putative 0.0515 0.1498 0.6368
Leishmania major guanosine monophosphate reductase 0.0637 0.1874 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.0365 0.1812
Onchocerca volvulus Glucosylceramidase homolog 0.0515 0.1498 1
Schistosoma mansoni acetyl-CoA synthetase 0.0042 0.0031 0.0155
Schistosoma mansoni hypothetical protein 0.068 0.2007 1
Schistosoma mansoni tar DNA-binding protein 0.0128 0.0298 0.1487
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0031 0.0133
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.0168 0.0719
Echinococcus multilocularis snurportin 1 0.0312 0.0869 0.0869
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.0881 0.4611
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0142 0.0343 0.0766
Loa Loa (eye worm) hypothetical protein 0.0142 0.0343 0.1469
Trypanosoma cruzi GMP reductase 0.0637 0.1874 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0106 0.0231 0.0507
Treponema pallidum fructose-bisphosphate aldolase 0.0297 0.0822 0.5
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.0365 0.1812
Loa Loa (eye worm) TAR-binding protein 0.0128 0.0298 0.1279
Leishmania major 4-coumarate:coa ligase-like protein 0.0142 0.0343 0.1691
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.035 0.0985 0.2259
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1425 0.4317 1
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0287 0.079 0.177
Schistosoma mansoni hypothetical protein 0.0083 0.0158 0.0788
Brugia malayi CHE-14 protein 0.0086 0.0168 0.0719
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.0822 0.3432
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0031 0.0133
Loa Loa (eye worm) hypothetical protein 0.01 0.0213 0.0911
Brugia malayi mbt repeat family protein 0.0049 0.0052 0.0224
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0192 0.0955
Schistosoma mansoni hypothetical protein 0.068 0.2007 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0052 0.0224
Schistosoma mansoni survival motor neuron protein 0.0049 0.0052 0.0259
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.02 0.0522 0.6208
Trichomonas vaginalis glucosylceramidase, putative 0.0785 0.2334 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.