TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 357.4 | Formula: C20H23NO5
H donors: 1 H acceptors: 2 LogP: 1.84 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(c(c1)C1/C(=C(/OC)\O)/C(=NC2=C1C(=O)CCC2)C)OC
InChi: 1S/C20H23NO5/c1-11-17(20(23)26-4)18(19-14(21-11)6-5-7-15(19)22)13-10-12(24-2)8-9-16(13)25-3/h8-10,18,23H,5-7H2,1-4H3
InChiKey: HKNHPIWQDVRUOU-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0109	0.0521	0.0475
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0109	0.0521	0.0656
Schistosoma mansoni	hypothetical protein	0.0028	0.0062	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0762	0.1047
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0062	0.0255	0.1446
Mycobacterium ulcerans	hypothetical protein	0.0094	0.0437	0.2488
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0157	0.0795	0.1037
Brugia malayi	hypothetical protein	0.0094	0.0437	0.0603
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0062	0.0255	0.1139
Leishmania major	ethanolamine phosphotransferase, putative	0.0094	0.0437	0.209
Trypanosoma cruzi	transcription factor btf3, putative	0.0074	0.0322	0.144
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.01	0.0051
Toxoplasma gondii	hypothetical protein	0.0027	0.0057	0.0041
Brugia malayi	hypothetical protein	0.0094	0.0437	0.0603
Brugia malayi	AEL166Cp	0.0094	0.0437	0.0603
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0153	0.077	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0598	0.3304	0.4557
Echinococcus multilocularis	Endonuclease G	0.0359	0.1945	0.1906
Loa Loa (eye worm)	jmjC domain-containing protein	0.0058	0.0234	0.0318
Schistosoma mansoni	jumonji domain containing protein	0.0136	0.0678	0.0874
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0273	0.0372
Echinococcus granulosus	transferase	0.0094	0.0437	0.0702
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0096	0.0445	0.112
Entamoeba histolytica	hypothetical protein	0.0035	0.01	0.0171
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0097	0.0454	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0151	0.0762	0.1047
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0096	0.0445	0.2136
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0054	0.0027
Entamoeba histolytica	phosphatidylinositol-glycan biosynthesis class O protein, putative	0.0094	0.0437	0.1096
Brugia malayi	Bromodomain containing protein	0.0032	0.0084	0.0116
Onchocerca volvulus		0.0598	0.3304	0.4531
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.01	0.0093
Trypanosoma brucei	endonuclease G, putative	0.0359	0.1945	1
Brugia malayi	acetyltransferase, GNAT family protein	0.0157	0.0795	0.1098
Echinococcus granulosus	neuropeptide receptor A26	0.0996	0.5571	1
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0062	0.0255	0.0352
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0065	0.0271	0.0223
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0663	0.3674	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0046	0.0164	0.0609
Entamoeba histolytica	transcription factor BTF3, putative	0.0074	0.0322	0.0781
Trypanosoma brucei	endonuclease G, putative	0.0359	0.1945	1
Entamoeba histolytica	acetyltransferase, GNAT family	0.0042	0.0142	0.0287
Onchocerca volvulus	Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog	0.0094	0.0437	0.0553
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0109	0.0521	0.0656
Echinococcus multilocularis	muscleblind protein 1	0.0151	0.0762	0.0716
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0445	0.0801
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0598	0.3304	0.5894
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0054	0.0027
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0038	0.0198
Onchocerca volvulus	Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog	0.0094	0.0437	0.0553
Onchocerca volvulus		0.0167	0.0852	0.1129
Mycobacterium leprae	hypothetical protein	0.0094	0.0437	0.2336
Echinococcus granulosus	transcription factor btf3	0.0074	0.0322	0.0494
Onchocerca volvulus	Alhambra homolog	0.0028	0.0062	0.0034
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0109	0.0521	0.0656
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0598	0.3304	0.3271
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0663	0.3674	1
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0437	0.0598
Brugia malayi	jmjC domain containing protein	0.0026	0.0049	0.0067
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0073	0.0315	0.0428
Schistosoma mansoni	hypothetical protein	0.0094	0.0437	0.0539
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0038	0.0198
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0096	0.0445	0.0399
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0027	0.0057	0.0109
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0598	0.3304	0.5894
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0046	0.0164	0.0609
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0028	0.0062	0.0019
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0322	0.0449
Echinococcus multilocularis	lysine specific demethylase 5A	0.0097	0.0454	0.0407
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0046	0.0164	0.0209
Toxoplasma gondii	NAC domain-containing protein	0.0074	0.0322	0.144
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0598	0.3304	0.5894
Brugia malayi	jmjC domain containing protein	0.0026	0.0049	0.0067
Leishmania major	endonuclease G, putative	0.0359	0.1945	1
Schistosoma mansoni	hypothetical protein	0.0094	0.0437	0.0539
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0504	0.2769	0.4925
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0598	0.3304	0.4523
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0052	0.0197	0.1109
Schistosoma mansoni	hypothetical protein	0.0203	0.1058	0.1403
Loa Loa (eye worm)	hypothetical protein	0.0598	0.3304	0.4557
Echinococcus multilocularis	geminin	0.0203	0.1058	0.1014
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0094	0.0437	0.0603
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0663	0.3674	1
Schistosoma mansoni	kinase	0.0049	0.0178	0.0179
Echinococcus granulosus	ectonucleotide	0.0504	0.2769	0.4925
Loa Loa (eye worm)	jmjC domain-containing protein	0.0026	0.0049	0.0063
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0079	0.0352	0.1839
Onchocerca volvulus	GPI ethanolamine phosphate transferase 3 homolog	0.0094	0.0437	0.0553
Leishmania major	DNA/RNA non-specific endonuclease-like protein	0.0359	0.1945	1
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0324	0.1744	1
Schistosoma mansoni	hypothetical protein	0.0203	0.1058	0.1403
Echinococcus multilocularis	neuropeptide s receptor	0.0996	0.5571	0.555
Entamoeba histolytica	hypothetical protein	0.0035	0.01	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0038	0.0048
Echinococcus multilocularis	gpi ethanolamine phosphate transferase 3	0.0094	0.0437	0.039
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0028	0.0062	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0049	0.0063
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0038	0.0053
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0054	0.1449
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0052	0.0197	0.0149
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0038	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0437	0.0598
Trypanosoma cruzi	polo-like protein kinase, putative	0.0096	0.0445	0.2091
Loa Loa (eye worm)	ICD-1 protein	0.0074	0.0322	0.044
Entamoeba histolytica	hypothetical protein	0.0035	0.01	0.0171
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0271	0.1535
Toxoplasma gondii	aldehyde dehydrogenase	0.0065	0.0271	0.117
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.0057	0.1227
Brugia malayi	PHD-finger family protein	0.0028	0.0062	0.0086
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0598	0.3304	0.4523
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0054	0.007
Echinococcus multilocularis	peregrin	0.0032	0.0084	0.0036
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0079	0.0352	0.0304
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0109	0.0521	0.0855
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0352	0.0481
Echinococcus granulosus	muscleblind protein	0.0151	0.0762	0.1291
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0054	0.0027
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0598	0.3304	0.3271
Schistosoma mansoni	peptidase Clp (S14 family)	0.0079	0.0352	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0504	0.2769	0.3818
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.0598	0.3304	0.456
Onchocerca volvulus		0.0598	0.3304	0.4531
Loa Loa (eye worm)	thrombospondin type 1 domain-containing protein	0.129	0.7245	1
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0109	0.0521	0.0475
Echinococcus multilocularis	neuropeptide receptor A26	0.0996	0.5571	0.555
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0598	0.3304	0.4523
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0504	0.2769	0.2733
Schistosoma mansoni	hypothetical protein	0.0035	0.01	0.0071
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0096	0.0445	0.0565
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0663	0.3674	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0062	0.0081
Loa Loa (eye worm)	PHD-finger family protein	0.0028	0.0062	0.0081
Echinococcus multilocularis	gpi ethanolamine phosphate transferase 1	0.0094	0.0437	0.039
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0038	0.0198
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0079	0.0352	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.0663	0.3674	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0054	0.0027
Brugia malayi	Thrombospondin type 1 domain containing protein	0.129	0.7245	1
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0324	0.1744	1
Onchocerca volvulus		0.129	0.7245	1
Echinococcus granulosus	neuropeptide s receptor	0.0996	0.5571	1
Plasmodium vivax	hypothetical protein, conserved	0.0028	0.0062	0.1691
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0049	0.0063
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0062	0.0255	0.1446
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0663	0.3674	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0065	0.0271	0.122
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0322	0.0449
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0054	0.1165
Trypanosoma cruzi	endonuclease G, putative	0.0359	0.1945	1
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0445	0.0801
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0598	0.3304	0.5894
Brugia malayi	jmjC domain containing protein	0.0097	0.0454	0.0626
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0598	0.3304	0.3271
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0038	0.0198
Loa Loa (eye worm)	jmjC domain-containing protein	0.0097	0.0454	0.0622
Treponema pallidum	fructose-bisphosphate aldolase	0.0663	0.3674	1
Echinococcus granulosus	PHD finger protein rhinoceros	0.0028	0.0062	0.0025
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0038	0.0198
Trypanosoma brucei	endonuclease G, putative	0.0359	0.1945	1
Leishmania major	basic transcription factor 3a, putative	0.0074	0.0322	0.1488
Echinococcus multilocularis	transcription factor btf3	0.0074	0.0322	0.0274
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0062	0.0255	0.1446
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0073	0.0315	0.0369
Trypanosoma brucei	polo-like protein kinase	0.0096	0.0445	0.2091
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0038	0.0053
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0598	0.3304	0.5894
Schistosoma mansoni	serine/threonine protein kinase	0.0096	0.0445	0.0551
Loa Loa (eye worm)	type I phosphodiesterase/nucleotide pyrophosphatase	0.0094	0.0437	0.0598
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0038	0.0198
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0079	0.0352	0.2001
Schistosoma mansoni	hypothetical protein	0.0094	0.0437	0.0539
Trypanosoma brucei	transcription factor BTF3, putative	0.0074	0.0322	0.144
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0445	0.0801
Plasmodium falciparum	GPI ethanolamine phosphate transferase 3, putative	0.0094	0.0437	1
Echinococcus granulosus	peregrin	0.0032	0.0084	0.0064
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0054	0.1165
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0663	0.3674	1
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0094	0.0437	0.039
Plasmodium vivax	basic transcription factor 3b, putative	0.0074	0.0322	0.9141
Onchocerca volvulus	GPI ethanolamine phosphate transferase 2 homolog	0.0094	0.0437	0.0553
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0663	0.3674	1
Brugia malayi	Melibiase family protein	0.0073	0.0315	0.0434
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0598	0.3304	0.4523
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0079	0.0352	0.1598
Plasmodium vivax	JmjC domain containing protein	0.0026	0.0049	0.1301
Brugia malayi	serine/threonine-protein kinase plk-2	0.0096	0.0445	0.0615
Trichomonas vaginalis	CAMK family protein kinase	0.0047	0.0171	0.0018
Brugia malayi	Muscleblind-like protein	0.0151	0.0762	0.1051
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0052	0.0197	0.1109
Trypanosoma brucei	GPI ethanolamine phosphate transferase 3, putative	0.0094	0.0437	0.2045
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0062	0.0255	0.0287
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0359	0.1945	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0065	0.0271	0.0402
Brugia malayi	jmjC domain containing protein	0.0026	0.0049	0.0067
Giardia lamblia	Kinase, PLK	0.0096	0.0445	0.106
Echinococcus granulosus	lysine specific demethylase 5A	0.0097	0.0454	0.0733
Echinococcus granulosus	jumonji domain containing protein	0.0039	0.0125	0.0139
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0094	0.0437	0.0539
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0079	0.0352	0.2001
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0073	0.0315	0.0369
Loa Loa (eye worm)	acetyltransferase	0.0157	0.0795	0.1093
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0094	0.0437	0.0702
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0437	0.0598
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0096	0.0445	0.061
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0155	0.0786	0.1335
Toxoplasma gondii	PHD-finger domain-containing protein	0.0028	0.0062	0.0072
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0052	0.0197	0.093
Brugia malayi	hypothetical protein	0.0027	0.0054	0.0075
Brugia malayi	beta-NAC-like protein	0.0074	0.0322	0.0444
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0079	0.0352	0.0549
Toxoplasma gondii	DNA/RNA non-specific endonuclease	0.0359	0.1945	1
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0445	0.0801
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.0322	0.0449
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0598	0.3304	0.3271
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0271	0.1535
Trypanosoma cruzi	polo-like protein kinase, putative	0.0096	0.0445	0.2091
Trypanosoma cruzi	endonuclease G, putative	0.0359	0.1945	1
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0157	0.0795	0.075
Toxoplasma gondii	PHD-finger domain-containing protein	0.0028	0.0062	0.0072
Schistosoma mansoni	transcription factor btf3	0.0074	0.0322	0.0379
Onchocerca volvulus	GPI ethanolamine phosphate transferase 1 homolog	0.0094	0.0437	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0038	0.0048
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0079	0.0352	0.8042
Echinococcus multilocularis	Alkaline phosphatase, core domain	0.0094	0.0437	0.039
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.01	0.0071
Brugia malayi	hypothetical protein	0.0167	0.0852	0.1175
Entamoeba histolytica	hypothetical protein	0.0035	0.01	0.0171
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0155	0.0786	0.0741
Echinococcus multilocularis	transferase	0.0094	0.0437	0.039
Schistosoma mansoni	aldehyde dehydrogenase	0.0065	0.0271	0.0308
Plasmodium falciparum	histone acetyltransferase GCN5	0.0042	0.0142	0.3208
Echinococcus multilocularis	ectonucleotide	0.0504	0.2769	0.2733
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0038	0.0198
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0065	0.0271	0.1535
Brugia malayi	jmjC domain containing protein	0.0155	0.0786	0.1085
Giardia lamblia	Histone acetyltransferase GCN5	0.0042	0.0142	0.0222
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0445	0.0801
Echinococcus multilocularis	muscleblind protein	0.0151	0.0762	0.0716
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0445	0.0801
Schistosoma mansoni	hypothetical protein	0.129	0.7245	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0079	0.0352	1
Leishmania major	hypothetical protein, conserved	0.0027	0.0054	0.0084
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0598	0.3304	0.3271
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0027	0.0057	0.1526
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0046	0.0164	0.4618
Leishmania major	hypothetical protein, conserved	0.0026	0.0049	0.0057
Echinococcus multilocularis	jumonji domain containing protein	0.0039	0.0125	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0852	0.1171
Brugia malayi	endonuclease G, mitochondrial precursor	0.0359	0.1945	0.2685
Loa Loa (eye worm)	hypothetical protein	0.0598	0.3304	0.4557
Echinococcus granulosus	geminin	0.0203	0.1058	0.1828
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0062	0.0255	0.0374
Giardia lamblia	Phosphatidylinositol-glycan biosynthesis, class O protein	0.0094	0.0437	0.1036
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0437	0.0598
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0038	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0038	0.0048
Plasmodium falciparum	basic transcription factor 3b, putative	0.0074	0.0322	0.735
Brugia malayi	Probable ClpP-like protease	0.0079	0.0352	0.0486
Schistosoma mansoni	aldehyde dehydrogenase	0.0065	0.0271	0.0308
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0054	0.021	0.0285
Trypanosoma cruzi	transcription factor btf3, putative	0.0074	0.0322	0.144
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0315	0.043
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0598	0.3304	0.3271
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0079	0.0352	0.5
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0079	0.0352	1
Schistosoma mansoni	endonuclease related	0.0359	0.1945	0.2635
Echinococcus granulosus	peptidase Clp S14 family	0.0052	0.0197	0.0268
Loa Loa (eye worm)	jmjC domain-containing protein	0.0026	0.0049	0.0063
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0097	0.0454	0.0563
Brugia malayi	hypothetical protein	0.0035	0.01	0.0138
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0663	0.3674	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0271	0.1535
Entamoeba histolytica	phosphatidylinositol-glycan biosynthesis class O protein, putative	0.0094	0.0437	0.1096
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0663	0.3674	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0663	0.3674	1
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0026	0.0049	0.1046
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0094	0.0437	0.039
Echinococcus granulosus	Endonuclease G	0.0359	0.1945	0.3434
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0109	0.0521	0.0656
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0079	0.0352	0.0816
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0359	0.1945	1
Plasmodium falciparum	phd finger protein, putative	0.0028	0.0062	0.1359
Toxoplasma gondii	melibiase subfamily protein	0.0109	0.0521	0.249
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0324	0.1744	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0096	0.0445	0.0718
Entamoeba histolytica	hypothetical protein	0.0074	0.0322	0.0781
Schistosoma mansoni	hypothetical protein	0.0094	0.0437	0.0539
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0038	0.0198
Brugia malayi	jmjC domain containing protein	0.0026	0.0049	0.0067
Trichomonas vaginalis	CAMK family protein kinase	0.0047	0.0171	0.0018
Loa Loa (eye worm)	jmjC domain-containing protein	0.0026	0.0049	0.0063
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0062	0.0255	0.0208
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0079	0.0352	0.1598
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0038	0.0198
Echinococcus granulosus	gpi ethanolamine phosphate transferase 3	0.0094	0.0437	0.0702
Trichomonas vaginalis	CAMK family protein kinase	0.0096	0.0445	0.0801

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 909099